Article
Pediatrics
Kim N. Cajachagua-Torres, Hanan El Marroun, Irwin K. M. Reiss, Susana Santos, Vincent W. V. Jaddoe
Summary: Exposure to maternal tobacco during pregnancy was associated with increased body fat and higher triglyceride concentrations in children, while exposure to maternal cannabis was associated with higher BMI and fat mass. Similar associations were found for paternal substance use, suggesting shared family-based factors may play a role in these cardio-metabolic outcomes.
Article
Endocrinology & Metabolism
Seung Shin Park, Chang Ho Ahn, Sang Wan Kim, Ji Won Yoon, Jung Hee Kim
Summary: Patients with bilateral primary aldosteronism (PA) are more obese and have higher visceral fat area (VFA) levels than those with lateralized PA. Despite a milder form of PA, this metabolically unfavorable visceral fat distribution may lead to a higher metabolic risk in patients with bilateral PA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jung Hee Hong, Hyunsook Hong, Ye Ra Choi, Dong Hyun Kim, Jin Young Kim, Jeong-Hwa Yoon, Soon Ho Yoon
Summary: This study aimed to evaluate the correlation between single- and multi-slice cross-sectional thoracolumbar and whole-body compositions. Retrospective analysis of patients who underwent whole-body PET-CT scans was conducted. The results showed that single-slice L2-3 (abdominal CT range) and L1 (chest CT range) analysis had the best correlation of around 0.90 with whole-body composition. Multi-slice waist averaging provided a slightly higher correlation of 0.92.
INSIGHTS INTO IMAGING
(2023)
Article
Multidisciplinary Sciences
Lisa Dowling, Philip Jakeman, Catherine Norton, Maeve M. Skelly, Hamid Yousuf, Miranda G. Kiernan, Margaret Toomey, Sheila Bowers, Suzanne S. Dunne, J. Calvin Coffey, Colum P. Dunne
Summary: Crohn's disease is a global inflammatory bowel condition that differs from healthy population in terms of body fat distribution, specifically showing elevated gynoid fat and reduced android fat. There is a potential rationale to refer to Crohn's disease as a fatty intestine condition, similar to fatty liver conditions, which may require further investigation in a larger patient cohort.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Elizabeth Buckley, Mary M. Mullen, Rehan A. Nizamuddin, Jonathan H. Stein, Lindsay M. Kuroki, Katherine C. Fuh, Andrea R. Hagemann, Carolyn K. McCourt, David Mutch, Dineo Khabele, Matthew A. Powell, Joseph E. Ippolito, Premal H. Thaker
Summary: This study aimed to determine the association of radiographic measurements of visceral fat with clinical outcomes in patients with endometrial cancer. Through a retrospective review of surgical patients, it was found that visceral fat measurements are predictive of outcomes in patients with advanced stage endometrial cancer. Specifically, VAT to SAT ratios are predictive of overall survival.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Hongjuan Feng, Xiaoyu Wang, Tianming Zhao, Lihong Mao, Yangyang Hui, Xiaofei Fan, Lin Lin, Wei Zhao, Kui Jiang, Bangmao Wang, Qingxiang Yu, Jie Zhang, Chao Sun
Summary: This study found that myopenic obesity (MO) is an independent predictor of higher long-term mortality in cirrhosis patients. The optimal management strategy for MO should focus on reducing visceral fat obesity rather than BMI.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Wouter M. Verduin, Anne-Loes K. Warps, Rick van den Helder, Hieronymus J. Doodeman, Alexander P. J. Houdijk
Summary: Visceral fat was found to be associated with anastomotic leakage in elective colon cancer resections, but not in emergency surgeries. The previously reported risks of male sex and BMI for anastomotic leakage were explained by visceral fat. The effects of visceral fat on anastomotic healing were shown to be local rather than systemic.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Biology
Francisco Brenes-Martin, Victoria Melero-Jimenez, Miguel Angel Lopez-Guerrero, Maria Mercedes Calero-Ruiz, Luis Vazquez-Fonseca, Jessica Abalos-Martinez, Rocio Quintero-Prado, Rafael Torrejon, Francisco Visiedo, Fernando Bugatto
Summary: Maternal adipose tissue growth during pregnancy can increase metabolic risk and gestational problems. The distribution of fat, particularly visceral fat, is more closely linked to cardiovascular disease and metabolic syndrome. This study aims to examine the association between maternal visceral fat thickness, as determined by first-trimester ultrasound, and poor pregnancy outcomes. The findings suggest that greater levels of maternal visceral fat are associated with increased risk of complications, especially gestational diabetes.
Article
Nutrition & Dietetics
Lingyu Li, Wenqian Li, Dongsheng Xu, Hua He, Wang Yang, Hanfei Guo, Xiangliang Liu, Wei Ji, Chunhua Song, Hongxia Xu, Wei Li, Hanping Shi, Jiuwei Cui
Summary: This study investigated the impact of adipose tissue indicators on the prognosis of cancer patients and found that visceral fat area (VFA) is a more effective indicator associated with higher risk of mortality in various types of cancer.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Cell Biology
Dylan J. Harney, Michelle Cielesh, Renee Chu, Kristen C. Cooke, David E. James, Jacqueline Stockli, Mark Larance
Summary: Intermittent fasting, particularly every-other-day fasting, results in increased mitochondria protein content and fatty acid synthesis enzymes in subcutaneous and visceral white adipose tissue in mice. It also downregulates lipolysis specifically in visceral WAT and reduces inflammatory collagen IV, leading to improved insulin sensitivity.
Article
Medicine, General & Internal
Tham T. Nguyen, Minh H. Nguyen, Yen H. Nguyen, Thao T. P. Nguyen, Manh H. Giap, Tung D. X. Tran, Thu T. M. Pham, Khue M. Pham, Kien T. Nguyen, Vinh-Tuyen T. Le, Chien-Tien Su, Tuyen Van Duong
Summary: This study explored the association between health literacy (HL) and hypertension, and investigated whether body mass index (BMI), body fat percentage (PBF), and visceral fat (VF) mediated this association. The results showed that the prevalence of hypertension was relatively high. People with better HL were less likely to have hypertension. PBF partially mediated the association between HL and hypertension. Strategic approaches are needed to improve people's HL and reduce body fat, which can help manage hypertension in rural and suburban areas.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Przemyslaw Domaszewski, Mariusz Konieczny, Tomasz Dybek, Katarzyna Lukaniszyn-Domaszewska, Stephen Anton, Ewa Sadowska-Krepa, Elzbieta Skorupska
Summary: The aim of this study was to determine the effectiveness of a six-week time-restricted eating (TRE) intervention in reducing body weight, fat loss, and visceral fat in overweight, older adult men and women. The study showed that the TRE intervention resulted in a significant decrease in body weight in both men and women, as well as a decrease in visceral fat and waist circumference in men. However, no significant changes were observed in women's visceral fat or waist circumference.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Geriatrics & Gerontology
Jong Hyuk Lee, Seung Ho Choi, Keum Ji Jung, Jin Mo Goo, Soon Ho Yoon
Summary: This study investigated the prognostic role of increased visceral fat attenuation (VFA) in long-term mortality and low-grade inflammation. It found that VFA was associated with overall survival, cancer-specific survival, and non-cancer-specific survival. Additionally, VFA could further classify sarcopenic obesity (SO) defined by body mass index (BMI) or visceral fat volume index (VFI) and identify individuals at higher risk of long-term mortality.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Jasenka Zubcevic, Jacqueline Watkins, Cindy Lin, Byrell Bautista, Heather M. Hatch, Sergei G. Tevosian, Linda F. Hayward
Summary: Smoking during pregnancy is strongly associated with adverse outcomes, and the effects of nicotine intake apart from smoking are less explored. This study reveals that changes in the maternal gut microbiome mediate the effects of prenatal nicotine exposure, influencing gene expression and altering fetal exposure to short-chain fatty acids and leptin during in utero development.
Article
Medicine, General & Internal
Yu-Hsuan Chien, Ming-Li Hsieh, Ting-Wen Sheng, Ying-Hsu Chang, Li-Jen Wang, Cheng-Keng Chuang, See-Tong Pang, Chun-Te Wu, I-Hung Shao
Summary: This study evaluated the effect of body composition and pelvic fat distribution on the aggressiveness and prognosis of localized prostate cancer. The results showed a significant correlation between pelvic fat distribution and the aggressiveness and prognosis of prostate cancer.
Article
Computer Science, Interdisciplinary Applications
Sil C. van de Leemput, Mathias Prokop, Bram van Ginneken, Rashindra Manniesing
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laure Fournier, Lena Costaridou, Luc Bidaut, Nicolas Michoux, Frederic E. Lecouvet, Lioe-Fee de Geus-Oei, Ronald Boellaard, Daniela E. Oprea-Lager, Nancy A. Obuchowski, Anna Caroli, Wolfgang G. Kunz, Edwin H. Oei, James P. B. O'Connor, Marius E. Mayerhoefer, Manuela Franca, Angel Alberich-Bayarri, Christophe M. Deroose, Christian Loewe, Rashindra Manniesing, Caroline Caramella, Egesta Lopci, Nathalie Lassau, Anders Persson, Rik Achten, Karen Rosendahl, Olivier Clement, Elmar Kotter, Xavier Golay, Marion Smits, Marc Dewey, Daniel C. Sullivan, Aad van der Lugt, Nandita M. deSouza
Summary: Existing quantitative imaging biomarkers go through a well-understood validation process before being included in clinical trials, while radiomics extracts features from imaging data without prior assumptions. The selection and incorporation of relevant features in radiomics require additional considerations for meaningful imaging endpoints. The large number of radiomic features tested may lead to sample sizes impractical within clinical trials.
EUROPEAN RADIOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Midas Meijs, Frederick J. A. Meijer, Mathias Prokop, Bram van Ginneken, Rashindra Manniesing
MEDICAL IMAGE ANALYSIS
(2020)
Article
Clinical Neurology
A. W. van der Eerden, T. L. van den Heuvel, V. Perlbarg, P. Vart, P. E. Vos, L. Puybasset, D. Galanaud, B. Platel, R. Manniesing, B. M. Goraj
Summary: In patients with moderate to severe traumatic brain injury, microbleed concentration in the subacute phase is associated with the integrity of normal-appearing white matter in the chronic phase. DTI findings reflect white matter integrity in the chronic phase, but interpretation in the subacute phase is more complex. SWI evaluation for microbleeds is straightforward in both phases.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Laure Fournier, Lena Costaridou, Luc Bidaut, Nicolas Michoux, Frederic E. Lecouvet, Lioe-Fee de Geus-Oei, Ronald Boellaard, Daniela E. Oprea-Lager, Nancy A. Obuchowski, Anna Caroli, Wolfgang G. Kunz, Edwin H. Oei, James P. B. O'Connor, Marius E. Mayerhoefer, Manuela Franca, Angel Alberich-Bayarri, Christophe M. Deroose, Christian Loewe, Rashindra Manniesing, Caroline Caramella, Egesta Lopci, Nathalie Lassau, Anders Persson, Rik Achten, Karen Rosendahl, Olivier Clement, Elmar Kotter, Xavier Golay, Marion Smits, Marc Dewey, Daniel C. Sullivan, Aad van der Lugt, Nandita M. deSouza
EUROPEAN RADIOLOGY
(2021)
Review
Pediatrics
Serife Kurul, Kinga Fiebig, Robert B. Flint, Irwin K. M. Reiss, Helmut Kuster, Sinno H. P. Simons, Swantje Voller, H. Rob Taal
Summary: This review highlights the knowledge gaps in the management of late-onset neonatal sepsis in preterm neonates and suggests potential methods to address these gaps. It also emphasizes the importance of implementing personalized medicine and bedside technologies to optimize treatment strategies.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Serife Kurul, H. Rob Taal, Robert B. Flint, Jan Mazela, Irwin K. M. Reiss, Karel Allegaert, Sinno H. P. Simons
Summary: The study aims to determine the optimal dose of Pentoxifylline (PTX) for preterm infants with (suspected) late onset sepsis, utilizing a prospective open label sequential dose-optimization study design.
Article
Clinical Neurology
Anke W. van der Eerden, Thomas L. A. van den Heuvel, Marnix C. Maas, Priya Vart, Pieter E. Vos, Bram Platel, Bozena M. Goraj, Rashindra Manniesing
Summary: The study assessed the longitudinal evolution of microbleeds in patients with moderate/severe TBI using 3T SWI, finding that possible microbleeds showed significant changes at follow-up in many cases.
Article
Pediatrics
Liron Borenstein-Levin, Jarinda A. Poppe, Willem van Weteringen, H. Rob Taal, Ori Hochwald, Amir Kugelman, Irwin K. M. Reiss, Sinno H. P. Simons
Summary: The study showed that the SpO(2) histogram classification system provides an objective measure of response to doxapram therapy in preterm infants. Infants who responded to treatment within 24 hours were less likely to require invasive mechanical ventilation. The classification system allows for bedside assessment of oxygenation status changes in response to respiratory interventions within a few hours.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Jarinda A. Poppe, Sean P. Fitzgibbon, H. Rob Taal, Sjoukje E. Loudon, Angela M. Tjiam, Charles C. Roehr, Irwin K. M. Reiss, Sinno H. P. Simons, Caroline Hartley
Summary: This study examines the ability of physiological data during the first postnatal month to predict laser treatment for retinopathy of prematurity (ROP) in preterm infants. The results show that physiological data already have predictive accuracy, but further validation is needed. These findings suggest the potential of physiological data for future ROP prediction and early interventions to protect infants from abnormal retinal development.
PEDIATRIC RESEARCH
(2023)
Article
Immunology
Niek B. Achten, Jasper V. Been, Sam Schoenmakers, Clementien L. Vermont, Robert M. Verdijk, Irwin K. M. Reiss, H. Rob Taal
Summary: This case confirms the suspicion that Neisseria meningitidis can be transmitted in utero, leading to early-onset sepsis.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Neuroimaging
K. Koschmieder, M. M. Paul, T. L. A. van den Heuvel, A. W. van der Eerden, B. van Ginneken, R. Manniesing
Summary: In this study, three convolutional neural network models were developed to detect traumatic cerebral microbleeds (CMBs), with the U-Net model performing the best and achieving a detection rate of 90% at a low false positive rate.
NEUROIMAGE-CLINICAL
(2022)
Article
Pediatrics
Serife Kurul, Nicky van Ackeren, Tom G. Goos, Christian R. B. Ramakers, Jasper Been, Rene F. Kornelisse, Irwin K. M. Reiss, Sinno H. P. Simons, H. Rob Taal
Summary: The implementation of HRV monitoring combined with determination of inflammatory biomarkers may help in early identification of sepsis patients, leading to reduced sepsis severity without increasing antibiotic usage or number of blood cultures drawn.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Medicine, Research & Experimental
Fleur M. Keij, Bjorn E. Koch, Fernando Lozano Vigario, Sinno H. P. Simons, Johan G. C. van Hasselt, H. Rob Taal, C. A. J. Knibbe, Herman P. Spaink, Irwin K. M. Reiss, Elke H. J. Krekels
Summary: Zebrafish larvae show promise as a preclinical model for neonatal sepsis due to their immune system similarities to humans. Research has demonstrated that zebrafish can be used to study infections causing neonatal sepsis, aiding in the exploration of new treatment approaches and biomarkers.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Critical Care Medicine
Serife Kurul, Sinno H. P. Simons, Christian R. B. Ramakers, Yolanda B. De Rijke, Rene F. Kornelisse, Irwin K. M. Reiss, H. Rob Taal
Summary: Serum IL-6 and PCT levels at the moment of suspected late onset neonatal sepsis offer valuable information about sepsis severity and mortality risk in preterm infants. These biomarkers have a superior discriminative value compared to CRP and may help identify patients requiring more intensive monitoring and therapy.
