Article
Biochemistry & Molecular Biology
Lin He, Ruorong Yan, Ziran Yang, Yue Zhang, Xinhua Liu, Jianguo Yang, Xujun Liu, Xiaoping Liu, Lu Xia, Yue Wang, Jiajing Wu, Xiaodi Wu, Lin Shan, Xiaohan Yang, Jing Liang, Yongfeng Shang, Luyang Sun
Summary: The F-box protein JFK promotes lipid accumulation in adipose tissue, leading to the development of metabolic syndrome. Knockout of JFK gene in mice can resist diet-induced metabolic dysfunctions. The interaction between JFK and ING5 disrupts AMPK activity and fatty acid beta-oxidation, suppressing hepatic lipid catabolism and contributing to obesity and metabolic syndrome.
Article
Endocrinology & Metabolism
Fayaz Ahmad Mir, Raghvendra Mall, Ahmad Iskandarani, Ehsan Ullah, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study aimed to evaluate the relationship between circulating miRNAs and clinical features in obese individuals. The results showed that there are certain miRNAs associated with metabolic syndrome in obese individuals, which may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Peripheral Vascular Disease
Daisy Duan, Salman Bhat, Jonathan C. Jun, Aniket Sidhaye
Summary: Clinical studies on time-restricted eating (TRE) show mixed results on blood pressure outcomes, with protocols starting and ending earlier having more pronounced effects on lowering blood pressure. Narrower eating windows also tend to result in lower blood pressure.
CURRENT HYPERTENSION REPORTS
(2022)
Review
Biology
Tea Shehu Kolnikaj, Rok Herman, Andrej Janez, Mojca Jensterle
Summary: The frequent coexistence of mental disorders and PCOS is important in the management of PCOS patients. Assessing and modifying eating disorders and eating-related behavior can improve obesity treatment outcomes and can be used as a tool for personalized obesity treatment in PCOS.
Article
Genetics & Heredity
Rima M. Chakaroun, Lucas Massier, Anna Heintz-Buschart, Nedal Said, Joerg Fallmann, Alyce Crane, Tatjana Schuetz, Arne Dietrich, Matthias Blueher, Michael Stumvoll, Niculina Musat, Peter Kovacs
Summary: The study found that the bacterial signature in the blood is related to metabolic diseases and can be improved after bariatric surgery. This work provides contaminant-aware evidence for the presence of living bacteria in the blood and suggests a putative crosstalk between components of the blood and metabolism in metabolic health regulation.
Review
Medicine, Research & Experimental
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Bluher, Annika Nerstedt, Ulf Smith
Summary: Cell senescence (CS) plays a crucial role in the connection between aging and chronic disorders, and CS is more prevalent in major metabolic tissues with aging. However, CS is also increased in adult obesity, type 2 diabetes (T2D), and nonalcoholic fatty liver disease, regardless of aging. Dysfunction and inflammation are common features of senescent tissues, affecting both progenitor cells and mature differentiated cells. Recent studies have found that hyperinsulinemia and insulin resistance (IR) can promote CS in human adipose and liver cells. Conversely, increased CS also promotes cellular IR, indicating their interdependence. Additionally, increased adipose CS in T2D is not solely determined by age, BMI, or hyperinsulinemia, suggesting premature aging. These findings suggest that senomorphic/senolytic therapy could be important for treating common metabolic disorders.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Felix S. Hussenoeder, Ines Conrad, Christoph Engel, Silke Zachariae, Samira Zeynalova, Heide Glaesmer, Andreas Hinz, Veronika Witte, Anke Toenjes, Markus Loeffler, Michael Stumvoll, Arno Villringer, Steffi G. Riedel-Heller
Summary: Anxiety is significantly positively associated with Disinhibition and Hunger in eating behaviors, but not with Cognitive Restraint. Interventions to help individuals better regulate and cope with anxiety could potentially reduce eating disorders and obesity in the population.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
L. S. Kaertner, M. B. Steinborn, H. Kettner, M. J. Spriggs, L. Roseman, T. Buchborn, M. Balaet, C. Timmermann, D. Erritzoe, R. L. Carhart-Harris
Summary: The study found that psychedelic microdosing may enhance psychological well-being, emotional stability, and reduce anxiety and depressive symptoms, but positive expectancy also plays a significant role in predicting positive outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Delphine Puttaert, Vincent Wens, Patrick Fery, Antonin Rovai, Nicola Trotta, Nicolas Coquelet, Sandra De Breucker, Niloufar Sadeghi, Tim Coolen, Serge Goldman, Philippe Peigneux, Jean-Christophe Bier, Xavier De Tiege
Summary: The study demonstrates a link between alpha brain activity and alterations in episodic memory, showing that a slowing down of alpha rhythmic activity is associated with impairments in the ability to learn and store new information for a short-term period. This suggests that a decreased alpha peak frequency may be considered an electrophysiological correlate of short-term episodic memory dysfunction in pathological aging.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Juanhong Liu, Pan Yi, Feng Liu
Summary: A network meta-analysis compared the effects of early and later time-restricted eating (TRE) interventions on weight loss and metabolic health. The results showed that both early and later TRE were effective in reducing body weight and insulin resistance, with early TRE being more effective in improving insulin resistance. No significant difference was found in weight loss between early and later TRE.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Tany E. Garciduenas-Fimbres, Indira Paz-Graniel, Stephanie K. Nishi, Jordi Salas-Salvado, Nancy Babio
Summary: Recent studies have suggested that faster eating speed and higher eating frequency may be associated with health issues such as obesity and metabolic syndrome, but further intervention trials are needed to clarify their mechanisms.
Article
Medicine, Research & Experimental
Luigi Barrea, Claudia Vetrani, Ludovica Verde, Bruno Napolitano, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri
Summary: The study results suggest that eating fast at lunch and dinner increases the risk of dyslipidemia in obese individuals, while eating slowly helps reduce the risk of developing this condition.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Karen L. Lindsay, Jasper Most, Kerrie Buehler, Maryam Kebbe, Abby D. Altazan, Leanne M. Redman
Summary: The study suggests that mindful eating may improve metabolic health outcomes in pregnant women with obesity by reducing insulin resistance and lowering ghrelin concentrations. However, further research is needed to fully understand the effects of mindful eating on weight and fat mass gain during pregnancy.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Endocrinology & Metabolism
Manuel Delpero, Danny Arends, Maximilian Sprechert, Florian Krause, Oliver Kluth, Annette Schuermann, Gudrun A. Brockmann, Deike Hesse
Summary: The study aimed to identify genetic variants associated with impaired glucose metabolism using obese lines BFMI861-S1 and BFMI861-S2. QTL mapping revealed overlapping QTL for gonadal adipose tissue weight and blood glucose concentration on Chr 3 and Chr 17, with additional QTL detected on Chr 15 and Chr 16. The study provided evidence for direct and indirect genetic effects on blood glucose concentration in the insulin-resistant mouse line BFMI861-S1.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Psychology, Developmental
Alexandra Loukas, M. Jane Lewis, C. Nathan Marti, Keryn E. Pasch, Cheryl L. Perry
Summary: This study found that young adults exposed to more tobacco advertisements in magazines reported a slower decline in the number of tobacco products they use. The results suggest that tobacco advertising in magazines contributes to the continuation of tobacco product use among young adults, highlighting the need for increased regulation of tobacco product ads in magazines.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Substance Abuse
Udoka Obinwa, Keryn E. Pasch, Katelyn K. Jetelina, Nalini Ranjit, Adriana Perez, Cheryl Perry, Melissa Harrell
Summary: This study found that tobacco retail outlets (TROs) closer to schools have more tobacco advertisements. Implementing a ban on TROs within 1000 ft of schools or a ban on tobacco advertising within and outside these outlets can help prevent or reduce tobacco use among adolescents.
Article
Psychology, Clinical
Yenan Zhu, Keryn E. Pasch, Alexandra Loukas, Kimberle L. Sterling, Cheryl L. Perry
Summary: The study found that exposure to POS marketing for little cigars and cigarillos had a significant impact on current and future use of these products among young college students, particularly in predicting current cigarette use.
ADDICTIVE BEHAVIORS
(2021)
Article
Substance Abuse
Alexandra Loukas, C. Nathan Marti, Keryn E. Pasch, Melissa B. Harrell, Anna Wilkinson, Cheryl L. Perry
Summary: The study examined the longitudinal trajectory of ENDS use among young Texan adults from 2014 to 2019, finding a significant decline from 2014 to spring 2017, followed by an increase post-2017. This increase was observed only among younger participants, indicating that the surge in vape pods popularity may have influenced ENDS use among younger adults from late 2017 to 2019.
Article
Psychiatry
Jacob E. Thomas, Keryn E. Pasch, C. Nathan Marti, Josephine T. Hinds, Anna Wilkinson, Alexandra Loukas
Summary: This study examines trajectories of depressive symptoms among young adults in Texas through an intersectional lens. The results show an increase in depressive symptoms from 2014-2018, with certain groups experiencing more symptoms. Intersectional identities contribute to a small portion of the variance in depressive symptoms.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Pediatrics
Natalie S. Poulos, Keryn E. Pasch
Summary: The study aimed to identify and describe healthful and youth-oriented qualities of the restaurant food environment around high schools. Results showed that restaurants have room for improvement in offering customers a healthful environment, some are more likely to appeal to youth, and that youth-oriented restaurants were different than restaurants with high healthfulness scores.
Article
Substance Abuse
Josephine T. Hinds, C. Nathan Marti, Keryn E. Pasch, Alexandra Loukas
Summary: This study examined the longitudinal trajectories of marijuana use in different tobacco/nicotine products among young adult college students in Texas from 2015 to 2019. The findings showed an increase in vaping marijuana in e-cigarettes and a decline in using marijuana in hookah. This suggests that the popularity of nicotine e-cigarettes has expanded the avenues for marijuana delivery among young adults.
Article
Substance Abuse
M. Pinedo, P. Montero-Zamora, K. E. Pasch, S. J. Schwartz
Summary: The role of immigration policies in shaping the health behaviors of US-born Latinos, particularly in relation to substance misuse, is an understudied area. This study found that immigration-related stressors were associated with increased odds of substance misuse among US-born Latinos. Punitive immigration and enforcement policies create multiple stressors that may contribute to substance misuse as a coping mechanism.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Public, Environmental & Occupational Health
Cassandra A. Stanton, Keryn E. Pasch, Irene Pericot-Valverde, Raul Cruz-Cano, Meghan B. Moran, Melissa H. Abadi, Darren Mays, Melissa Mercincavage, Zhiqun Tang, Julia Chen-Sankey
Summary: This study examined the association between youth e-cigarette marketing exposure and e-cigarette use behavior change one year later, and found that recalled exposure to e-cigarette marketing was associated with reduced harm perceptions and various stages of e-cigarette use.
PREVENTIVE MEDICINE
(2022)
Article
Substance Abuse
Alexandra Loukas, C. Nathan Marti, Melissa B. Harrell, Keryn E. Pasch, Anna V. Wilkinson
Summary: The use of electronic nicotine delivery systems (ENDS) increased significantly after 2017, especially due to the popularity of vape pods containing nicotine salts. The trajectory of ENDS dependence among young adults from 2014 to 2019 was examined, and it was found that the proportion of young adults reporting ENDS dependence increased after 2017. This increase is likely a result of the surge in popularity of vape pods containing nicotine salts, which may lead to more young adults developing nicotine dependence symptoms.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Substance Abuse
Xiaoyin Li, Carole K. Holahan, Alexandra Loukas, Charles J. Holahan, Keryn E. Pasch, C. Nathan Marti
Summary: This study aims to examine transitions in cigarette smoking among college students over 2.5 years and determine if the use of alternative tobacco products (ATPs) is related to these transitions. The results show that ATP use is significantly associated with transitions from never smoking to non-current smoking, from never smoking to very light smoking, and from non-current to very light smoking.
SUBSTANCE USE & MISUSE
(2023)
Article
Health Policy & Services
Sarah A. Buettner, Keryn E. Pasch, Natalie S. Poulos
Summary: Food delivery apps are popular among young adults, who often use them to order calorie-dense foods. This study examined the use of food delivery apps among young adults and found that they used the apps approximately twice a week. The study also identified that non-Hispanic Black and Hispanic/Latinx participants used food delivery apps more frequently. Furthermore, factors such as perceived subjective social status, food insecurity, financial responsibility, and full-time student status were associated with higher frequency of food delivery app use.
JOURNAL OF COMMUNITY HEALTH
(2023)
Article
Family Studies
Pablo Montero-Zamora, Jeancarlo Cordoba, Jacob E. Thomas, Keryn E. Pasch, Miguel Pinedo, Seth J. Schwartz, Eric C. Brown, J. Mark Eddy
Summary: Substance use among Costa Rican youth is a significant public health problem, but there is limited research on its causes. This study conducted secondary analyses of national-level youth data to explore the prevalence and potential etiologic factors of substance use among Costa Ricans aged 15-24. Findings showed a high prevalence of alcohol, cigarette, marijuana, and other illegal drug use, with various sociodemographic and contextual factors being associated with substance use.
CHILDREN AND YOUTH SERVICES REVIEW
(2023)
Article
Psychology, Clinical
Daniel S. Kreitzberg, Keryn E. Pasch, Alexandra Loukas
Summary: This study examined the patterns of concurrent use and co-administration of tobacco and cannabis among young adult college students in Texas from 2016 to 2019. Four latent classes were identified, and most students remained in the same class over the course of the study. The findings suggest the need for prevention and cessation programs that address the constellation of behaviors related to cannabis and tobacco co-use.
ADDICTIVE BEHAVIORS
(2024)
Article
Substance Abuse
Udoka Obinwa, Keryn E. Pasch, Katelyn K. Jetelina, Nalini Ranjit, Adriana Perez, Cheryl L. Perry, Melissa Harrell
Summary: The study found that banning tobacco retail outlets within 1000 ft of schools can reduce tobacco advertising around schools, especially among Hispanic/Latino and economically disadvantaged student populations.
NICOTINE & TOBACCO RESEARCH
(2022)