Review
Physiology
Daniel J. Hoffman, Theresa L. Powell, Emily S. Barrett, Daniel B. Hardy
Summary: Nearly 2 billion adults worldwide are overweight, with over half classified as obese, and nearly one-third of global children experience poor growth and development. The global epidemic of obesity and double burden of malnutrition, where overweight coexists with underweight and micronutrient deficiencies, poses a significant challenge to human health. Understanding the developmental origins of health and disease (DOHaD) is crucial in addressing the global issues of obesity and chronic diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Review
Nutrition & Dietetics
Long T. Nguyen, Carol A. Pollock, Sonia Saad
Summary: The developmental programming hypothesis suggests that adverse environmental insults during critical developmental periods increase the risk of diseases in later life. Kidneys are susceptible to such insults, particularly due to peri-gestational nutrition, which affects kidney development and metabolism. Recent studies have identified oxidative stress, mitochondrial dysfunction, epigenetic modifications, and metabolic changes as potential novel pathways for therapeutic intervention.
Article
Multidisciplinary Sciences
Margarete Diaz-Cuadros, Teemu P. Miettinen, Owen S. Skinner, Dylan Sheedy, Carlos Manlio Diaz-Garcia, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R. Manalis, William M. Oldham, Olivier Pourquie
Summary: Animals display inter-species variation in embryonic development rates, with differences in biochemical reaction rates being thought responsible for species-specific rates. This study establishes an in vitro system using pluripotent stem cells to simulate the twofold difference in developmental rates between mouse and human embryos. The mass-specific metabolic rates were found to scale with developmental rate, higher in mouse cells than in human cells. Manipulating metabolic rates could control developmental rate and have translational applications.
Review
Biochemistry & Molecular Biology
Liya Kerem, Elizabeth A. Lawson
Summary: This review comprehensively describes both the central and peripheral effects of oxytocin on eating behavior and metabolism, as well as discussing the association between endogenous oxytocin levels and weight status, metabolic syndrome, and bone health. The review also highlights the potential of intranasal oxytocin as a therapeutic option for obesity treatment and the challenges of translating oxytocin research into clinical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Alessia Perino, Kristina Schoonjans
Summary: Bile acids are amphipathic steroid acids that play a crucial role in the regulation of metabolic responses. Their actions through activation of specific receptors control energy homeostasis and alterations in bile acid signaling are associated with metabolic diseases. Modulation of the bile acid pool could be a potential therapeutic approach.
Article
Endocrinology & Metabolism
Kyle H. Flippo, Matthew J. Potthoff
Summary: FGF21, a non-canonical fibroblast growth factor, acts as an endocrine hormone signaling to various targets in the body. Initially recognized for its potential in correcting metabolic dysfunction and reducing body weight associated with diabetes and obesity, new functions of FGF21 signaling have emerged, demonstrating its ability to regulate macronutrient preference and energy balance.
Article
Multidisciplinary Sciences
Billy Langlet, Fannie Vestermark, Josefin Stolt, Modjtaba Zandian, Per Sodersten, Cecilia Bergh
Summary: Individuals with Anorexia Nervosa are often described as restless, hyperactive and having disturbed sleep. The study aimed to quantify the physical activity and sleep behavior of anorexia nervosa patients and to increase result reproducibility and generalisability. Most patients spent most of their time inactive at the beginning of treatment and failed to meet sleep recommendations.
Review
Peripheral Vascular Disease
Empar Lurbe, Julie Ingelfinger
Summary: This review critically considers the association between birth weight, growth trajectories, and cardiometabolic disease, highlighting the importance of early life interventions in reducing disease burden and improving public health outcomes.
Review
Pharmacology & Pharmacy
Alexandra D. Hudson, Alexander S. Kauffman
Summary: Kisspeptin signaling plays a significant role in metabolism and energy balance, and may regulate multiple physiological parameters. The findings highlight the importance of further research on the non-reproductive actions of Kisspeptin signaling.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Georgina Kingshott, Kalina Biernacka, Alex Sewell, Paida Gwiti, Rachel Barker, Hanna Zielinska, Amanda Gilkes, Kathryn McCarthy, Richard M. Martin, J. Athene Lane, Lucy McGeagh, Anthony Koupparis, Edward Rowe, Jon Oxley, Jeff M. P. Holly, Claire M. Perks
Summary: IGF-II is a potent growth factor implicated in various cancers, sharing its locus with H19. IGF-II and H19 are imprinted genes, with only the maternal copy expressed, while the paternal copy is silenced in many cancers.
Article
Nutrition & Dietetics
Elena Lopez-Gonzales, Lisa Lehmann, Francisco Javier Ruiz-Ojeda, Rene Hernandez-Bautista, Irem Altun, Yasuhiro Onogi, Ahmed Elagamy Khalil, Xue Liu, Andreas Israel, Siegfried Ussar
Summary: Weight regain after fasting is a common issue in obesity treatment. Supplementing with L-serine can reduce weight regain and increase energy expenditure, which addresses a major problem in current obesity therapies.
Article
Endocrinology & Metabolism
Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre-Philippe Luyet, Britta Gobel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith
Summary: This study aimed to test the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would result in less metabolic adaptation and increased lipid oxidation. The results showed that SAR425899 led to a smaller reduction in body composition-adjusted sleeping metabolic rate (SMR) and increased fat oxidation, which are beneficial for weight loss and weight-loss maintenance.
Article
Endocrinology & Metabolism
Anna Mikolajczak, Nada A. Sallam, Radha D. Singh, Taylor B. Scheidl, Emma J. Walsh, Sebastian Larion, Carol Huang, Jennifer A. Thompson
Summary: This study demonstrated that accelerated adipogenesis during the perinatal period predisposes offspring to hypertrophic adipocyte dysfunction later in life, compromising the buffering function of subcutaneous fat depot.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Stephanie M. Kereliuk, Vernon W. Dolinsky
Summary: Globally, cardiovascular disease remains the leading cause of death, and the increasing cardiovascular risk factors among youth, such as obesity, diabetes, and hypertension, contribute to the development of earlier and more severe cardiovascular disease. Recent evidence suggests that maternal obesity and diabetes during pregnancy have lifelong effects on cardiovascular risk factors and heart disease development in the offspring, although the mechanisms for these observations are unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Tongzhi Wu
Summary: Bile acids are now recognized as important signaling molecules that regulate blood glucose, lipid, and energy metabolism, with FXR and TGR5 signaling playing a crucial role in mediating these effects. This may help explain the metabolic benefits of bile acid sequestrants, metformin, and bariatric surgery.
Letter
Dermatology
J. J. Kohorst, A. J. Bruce, R. R. Torgerson, L. A. Schenck, M. D. P. Davis
BRITISH JOURNAL OF DERMATOLOGY
(2015)
Article
Dermatology
John J. Kohorst, Alexa B. Kimball, Mark D. P. Davis
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2015)
Review
Allergy
John J. Kohorst, Alison J. Bruce, Rochelle R. Torgerson
CURRENT ALLERGY AND ASTHMA REPORTS
(2016)
Article
Dermatology
John J. Kohorst, Christian L. Baum, Clark C. Otley, Randall K. Roenigk, Louis A. Schenck, John H. Pemberton, Eric J. Dozois, Nho V. Tran, Alex Senchenkov, Mark D. P. Davis
DERMATOLOGIC SURGERY
(2016)
Article
Chemistry, Multidisciplinary
Ge Li, Li-song Huang, Ming-hong Jiang, Hui-ling Wu, Jing Chen, Yin Huang, Yan Shen, SaiYin He-Xi-Ge, Wei-wei Fan, Zhi-qiang Lu, Da-ru Lu
ACTA PHARMACOLOGICA SINICA
(2010)
Article
Endocrinology & Metabolism
Ge Li, John J. Kohorst, Wenjuan Zhang, Eleonora Laritsky, Govindarajan Kunde-Ramamoorthy, Maria S. Baker, Marta L. Fiorotto, Robert A. Waterland
Article
Medicine, General & Internal
John J. Kohorst, Alison J. Bruce, Rochelle R. Torgerson, Louis A. Schenck, Mark D. P. Davis
MAYO CLINIC PROCEEDINGS
(2014)
Article
Cardiac & Cardiovascular Systems
John J. Kohorst, J. Martijn Bos, Donald J. Hagler, Michael J. Ackerman
CONGENITAL HEART DISEASE
(2014)
Article
Dermatology
John J. Kohorst, Christian L. Baum, Clark C. Otley, Randall K. Roenigk, John H. Pemberton, Eric J. Dozois, Nho V. Tran, Mark D. P. Davis
DERMATOLOGIC SURGERY
(2017)
Article
Dermatology
John J. Kohorst, Clinton Hagen, Christian L. Baum, Mark D. P. Davis
JOURNAL OF DRUGS IN DERMATOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Yin Huang, Jing Chen, Ge Li, Tian-yue Cheng, Ming-hong Jiang, Shu-yu Zhang, Jun Lu, Shi Yan, Wei-wei Fan, Da-ru Lu
ACTA PHARMACOLOGICA SINICA
(2007)
Article
Gastroenterology & Hepatology
Yongxiang Li, Ge Li, Weiping Dong, Jing Chen, Daru Lu, Jianming Tan