Article
Biochemistry & Molecular Biology
Tobias F. Fischer, Anne S. Czerniak, Tina Weiss, Clara T. Schoeder, Philipp Wolf, Oliver Seitz, Jens Meiler, Annette G. Beck-Sickinger
Summary: GPR1 plays a dual role in regulating chemerin activity, acting as a signaling receptor for arrestin-based signaling and as a scavenging receptor with broader ligand specificity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hui Zhou, Xiyan Liao, Qin Zeng, Haowei Zhang, Jianfeng Song, Wanyu Hu, Xiaoxiao Sun, Yujin Ding, Dandan Wang, Yalun Xiao, Tuo Deng
Summary: Accumulation and activation of immunocytes in adipose tissues are important in obesity-induced inflammation and insulin resistance. Chemokines, especially CCL5, play a crucial role in recruiting immunocytes to adipose tissue during obesity. CCL5 deficiency exacerbates adipose inflammation and impairs insulin sensitivity in obese mice. This study provides insights into the role of CCL5 in obesity-induced adipose inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Mirr, Anna Braszak-Cymerman, Aleksandra Ludziejewska, Matylda Kregielska-Narozna, Pawel Bogdanski, Wieslaw Bryl, Maciej Owecki
Summary: This study aimed to investigate the correlation between serum asprosin levels and insulin resistance indices, as well as the correlation between asprosin and obesity indices. The results showed that asprosin concentrations were significantly higher in obese patients, and there was a positive correlation between asprosin concentrations and body mass index, waist circumference, and all tested indices of insulin resistance. Therefore, asprosin can be considered a marker of obesity and insulin resistance.
Review
Immunology
Mengyu Dai, Xiaoying Yang, Yinghua Yu, Wei Pan
Summary: The study highlights that helminth infection may alleviate obesity and metabolic syndromes through various mechanisms, including inducing macrophage M2 polarization, inhibiting adipogenesis, promoting fat browning, and improving glucose tolerance and metabolic inflammation. Additionally, helminth infection may also affect obesity and metabolic syndromes by altering the host's gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Beatriz Fuentes-Romero, Alberto Munoz-Prieto, Jose J. Ceron, Maria Martin-Cuervo, Manuel Iglesias-Garcia, Escolastico Aguilera-Tejero, Elisa Diez-Castro
Summary: Obesity and its associated complications are increasing problems in humans and horses. This study found that plasma resistin concentrations in horses are predominantly related to inflammatory conditions and not to insulin dysregulation, similar to humans.
Article
Cell Biology
Hee-Hoon Kim, Young-Ri Shim, Ha Neul Kim, Keungmo Yang, Tom Ryu, Kyurae Kim, Sung Eun Choi, Min Jeong Kim, Chaerin Woo, Katherine Po Sin Chung, Song Hwa Hong, Hyemi Shin, Jae Myoung Suh, Youngae Jung, Geum-Sook Hwang, Won Kim, Seok-Hwan Kim, Hyuk Soo Eun, Je Kyung Seong, Won-Il Jeong
Summary: Obesity-induced hypoxic stress in white adipose tissue leads to inflammation and interferon-y (IFN-y) production by natural killer (NK) cells. This study reveals that hypoxia promotes glutamate excretion and CXCL12 expression in white adipocytes, recruiting CXCR4+ NK cells. The spatial proximity between adipocytes and NK cells induces IFN-y production by stimulating metabotropic glutamate receptor 5 (mGluR5), which triggers inflammatory activation of macrophages and increases xCT and CXCL12 expression in adipocytes. Inhibition of xCT, mGluR5, or IFN-y receptor in adipocytes or NK cells alleviates obesity-related metabolic disorders in mice and elevated glutamate/mGluR5 and CXCL12/CXCR4 levels are observed in obese patients, suggesting a potential therapeutic target for obesity-related metabolic disorders.
Article
Endocrinology & Metabolism
Bai-Yu Li, Ying-Ying Guo, Gang Xiao, Liang Guo, Qi-Qun Tang
Summary: This study elucidates the role of SERPINA3C in regulating obesity and related metabolic disorders. The results show that deficiency of SERPINA3C leads to more severe obesity and metabolic abnormalities, accompanied by inflammation and apoptosis of adipose tissues. In contrast, overexpression of SERPINA3C protects against diet-induced obesity and metabolic disorders, with reduced inflammation and apoptosis in adipose tissue.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Kuan-Ta Lu, Yu-Cheng Ho, Chen-Lin Chang, Kuo-Chung Lan, Cheng-Chun Wu, Yu-Ting Su
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive disease affecting women's hormone and metabolic status. This study reviewed pain perception in PCOS patients and found that pain perception is more prevalent in patients with PCOS compared to healthy controls. Obesity and infertility may be associated with the development of pain. However, the underlying causes are still not well understood.
Article
Endocrinology & Metabolism
Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair
Summary: Diabetes during pregnancy and chorioamnionitis are associated with increased levels of maternal insulin, leptin, and IL-6. While both leptin and IL-6 play roles in inflammation, they have contrasting effects on neurodevelopment. In a study of cord blood samples from 104 term infants, it was found that maternal diabetes increased levels of leptin and insulin, while chorioamnionitis was associated with elevated IL-6 levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Han Na Jang, Yong Hwy Kim, Jung Hee Kim
Summary: Weight gain post-surgery is common in patients with acromegaly, and diabetes mellitus at the time of diagnosis is a significant predictor of weight and fat gain post-surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Chan Hee J. Choi, William Barr, Samir Zaman, Corey Model, Annsea Park, Mascha Koenen, Zeran Lin, Sarah K. Szwed, Francois Marchildon, Audrey Crane, Thomas S. Carroll, Henrik Molina, Paul Cohen
Summary: This study comprehensively characterized the secretome of different types of adipocytes in mice and identified a metabolic role for leucine-rich alpha-2 glycoprotein 1 (LRG1) as an obesity-regulated adipokine. Overexpression of LRG1 improved glucose homeostasis and reduced white adipose tissue macrophage accumulation and systemic inflammation. The findings suggest that LRG1 has therapeutic potential as an insulin sensitizer through its immunomodulatory function in the context of obesity and inflammation.
Article
Plant Sciences
Ying Xu, Jialing Tang, Qianyu Guo, Yidan Xu, Kaixuan Yan, Lihong Wu, Kang Xie, Anming Zhu, Xianglu Rong, Dewei Ye, Jiao Guo
Summary: Our study aimed to investigate the preventive effect of FTZ on letrozole-induced experimental PCOS and its associated insulin resistance in mice. The results showed that FTZ significantly attenuated letrozole-induced morphological changes in the ovary, reversed PCOS-related disruption of estrous status, and markedly alleviated PCOS-related insulin resistance by enhancing circulating level and transcriptional abundance of adiponectin in adipose tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system regulates inflammation in obese mice by affecting adipose tissue macrophage recruitment and polarization, leading to insulin resistance. Deficiency in CX3CR1 signaling results in a dominant shift towards M1-polarized macrophages, exacerbating insulin resistance in obese mice. Therapies targeting CX3CL1-CX3CR1 system may be beneficial for treating type 2 diabetes by modulating M1/M2 macrophages.
Article
Endocrinology & Metabolism
Mayumi Nagashimada, Kazuki Sawamoto, Yinhua Ni, Hironori Kitade, Naoto Nagata, Liang Xu, Masuko Kobori, Naofumi Mukaida, Tatsuya Yamashita, Shuichi Kaneko, Tsuguhito Ota
Summary: The CX3CL1-CX3CR1 system is crucial in regulating inflammation, particularly in obese mice with adipose tissue inflammation and insulin resistance. Deficiency in CX3CR1 signaling leads to an increase in M1 polarized macrophages, worsening glucose tolerance and insulin resistance in obese mice. Targeting the CX3CL1-CX3CR1 system may be beneficial in treating type 2 diabetes by modulating M1/M2 macrophages.
Review
Physiology
N. Nikolic, S. W. Goergens, G. H. Thoresen, V. Aas, J. Eckel, K. Eckardt
Article
Endocrinology & Metabolism
Martin Roehling, Alexander Strom, Gidon Boenhof, Sonja Puettgen, Kalman Bodis, Karsten Muessig, Julia Szendroedi, Daniel Markgraf, Stefan Lehr, Michael Roden, Dan Ziegler
Article
Endocrinology & Metabolism
Dan Ziegler, Erwin Schleicher, Alexander Strom, Birgit Knebel, Thomas Fleming, Peter Nawroth, Hans-Ulrich Haering, Nikolaos Papanas, Julia Szendroedi, Karsten Muessig, Hadi Al-Hasani, Michael Roden
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2017)
Article
Endocrinology & Metabolism
K. S. Weber, K. Strassburger, G. Pacini, B. Nowotny, K. Muessig, J. Szendroedi, C. Herder, M. Roden
Article
Endocrinology & Metabolism
Henrike Sell, Christine Poitou, Christiane Habich, Jean-Luc Bouillot, Juergen Eckel, Karine Clement
Article
Pharmacology & Pharmacy
Ira Indrakusuma, Tania Romacho, Juergen Eckel
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Multidisciplinary Sciences
Tuula Saukkonen, Shivaprakash Jagalur Mutt, Jari Jokelainen, Anna-Maria Saukkonen, Ghulam Shere Raza, Toni Karhu, Pirjo Harkonen, Juergen Eckel, Karl-Heinz Herzig, Ulla Rajala, Sirkka Keinanen-Kiukaanniemi
SCIENTIFIC REPORTS
(2018)
Review
Endocrinology & Metabolism
Juergen Eckel
Article
Endocrinology & Metabolism
Oana P. Zaharia, Klaus Strassburger, Alexander Strom, Gidon J. Boenhof, Yanislava Karusheva, Sofia Antoniou, Kalman Bodis, Daniel F. Markgraf, Volker Burkart, Karsten Muessig, Jong-Hee Hwang, Olof Asplund, Leif Groop, Emma Ahlqvist, Jochen Seissler, Peter Nawroth, Stefan Kopf, Sebastian M. Schmid, Michael Stumvoll, Andreas F. H. Pfeiffer, Stefan Kabisch, Sergey Tselmin, Hans U. Haering, Dan Ziegler, Oliver Kuss, Julia Szendroedi, Michael Roden
LANCET DIABETES & ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Tapia Romacho, Henrike Sell, Ira Indrakusuma, Diana Roehrborn, Tamara R. Castaneda, Tomas Jelenik, Daniel Markgraf, Sonja Hartwig, Juergen Weiss, Hadi Al-Hasani, Michael Roden, Juergen Eckel
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Endocrinology & Metabolism
Jana-Luise Kueck, Gidon J. Boenhof, Alexander Strom, Oana-Patricia Zaharia, Karsten Muessig, Julia Szendroedi, Michael Roden, Dan Ziegler
Editorial Material
Physiology
Juergen Eckel
Editorial Material
Physiology
Juergen Eckel
Article
Endocrinology & Metabolism
Sven W. Goergens, Tim Benninghoff, Kristin Eckardt, Christian Springer, Alexandra Chadt, Anita Melior, Jakob Wefers, Andrea Cramer, Jorgen Jensen, Kare I. Birkeland, Christian A. Drevon, Hadi Al-Hasani, Juergen Eckel
Article
Endocrinology & Metabolism
Wolfgang Rathmann, Klaus Strassburger, Brenda Bongaerts, Pavel Bobrov, Oliver Kuss, Karsten Muessig, Daniel F. Markgraf, Julia Szendroedi, Christian Herder, Michael Roden
DIABETES OBESITY & METABOLISM
(2017)