Article
Medicine, General & Internal
David M. Nathan, GRADE Study Res Grp, John M. Lachin, Ashok Balsubramanyam, Henry B. Burch, John B. Buse, Nicole M. Butera, Robert M. Cohen, Jill P. Crandall, Steven E. Kahn, Heidi Krause-Steinrauf, Mary E. Larkin, Neda Rasouli, Margaret Tiktin, Deborah J. Wexler, Naji Younes
Summary: In this trial, all four glucose-lowering medications added to metformin were effective in reducing glycated hemoglobin levels. Glargine and liraglutide showed modestly superior efficacy in achieving and maintaining target glycated hemoglobin levels.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Endocrinology & Metabolism
Nicholas J. Wareham
Summary: This review examines the degree of personalization in existing interventions for preventing type 2 diabetes and suggests ways to achieve greater personalization through better identification of high-risk individuals, subdivision of type 2 diabetes into specific subgroups, and individualization of preventive targets. The use of more dynamic real-time data shows promise but requires further evaluation against clinical outcomes. Future personalized preventive approaches should complement existing individual-level interventions and align with strategies at the societal level.
Review
Endocrinology & Metabolism
Anastasios Serbis, Vasileios Giapros, Eleni P. Kotanidou, Assimina Galli-Tsinopoulou, Ekaterini Siomou
Summary: In the past two decades, there have been reports of an increasing incidence of type 2 diabetes mellitus in children and adolescents, especially among minority ethnic groups, which is closely related to the prevalence of pediatric obesity. Youth T2DM differs from both adult T2DM and type 1 diabetes in children, necessitating specific management and prevention strategies tailored to its unique characteristics.
WORLD JOURNAL OF DIABETES
(2021)
Article
Nutrition & Dietetics
Armando Pena, Micah L. Olson, Stephanie L. Ayers, Dorothy D. Sears, Sonia Vega-Lopez, Abigail T. Colburn, Gabriel Q. Shaibi
Summary: Obesity is linked to chronic inflammation and may increase the risk of type 2 diabetes in youth. This study investigated the relationship between inflammatory biomarkers and insulin sensitivity, beta-cell function, and response to lifestyle intervention in Latino youth with obesity. The findings showed that obesity-related inflammatory mediators were associated with T2D risk factors but were not affected by lifestyle intervention in Latino youth.
Review
Cell Biology
Sarah Weksler-Zangen
Summary: This article discusses the proper diagnosis and treatment of diabetes in patients with inherited mitochondrial diseases, as well as screening for the condition in family members. The severity of mitochondrial-related diabetes depends on the location of the mutation and the number of affected mitochondria copies. The preferred treatment for diabetes in patients with mitochondrial disorders is SGLT-2i and mitochondrial GLP-1-related substances.
Article
Nutrition & Dietetics
Kirthi Menon, Barbora de Courten, Dianna J. Magliano, Zanfina Ademi, Danny Liew, Ella Zomer
Summary: This study assessed the cost-effectiveness of daily 1g carnosine supplementation in addition to standard care for the management of type 2 diabetes and compared it to standard care alone. The results showed that supplemental dietary carnosine may be a cost-effective treatment option for people with type 2 diabetes in Australia.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Pediatrics
Deirdre M. Harrington, Emer M. Brady, Susann Weihrauch-Bluher, Charlotte L. Edwardson, Laura J. Gray, Michelle Hadjiconstantinou, Janet Jarvis, Kamlesh Khunti, Itziar Vergara, Irati Erreguerena, Rogerio T. Ribeiro, Jacqui Troughton, Andriani Vazeou, Melanie J. Davies
Summary: The development of a family-based interactive lifestyle intervention for adolescents at risk of T2D involved a multidisciplinary team from different countries collaborating to gather potential program topics and theoretical frameworks. Through two iterative cycles of piloting, feedback, and refinement, stakeholders were involved in decision-making regarding content and delivery, leading to the creation of an eight-session program tailored to local languages and adaptations. This approach could provide a flexible intervention method for 'at risk' groups and their families.
Article
Public, Environmental & Occupational Health
Lisa T. Crummett, Muhammad H. Aslam
Summary: The study examines the use of specific terms related to causes/risk factors and preventions for type 2 diabetes on diabetes websites and finds that dietary factors are mentioned less frequently, indicating a need for increased emphasis on dietary information to improve public awareness of type 2 diabetes.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Cristina Rey-Renones, Jose Miguel Baena-Diez, Isabel Aguilar-Palacio, Cristina Miquel, Maria Grau
Summary: Individuals with type 2 diabetes are at higher risk for developing and dying from cancer, possibly due to metabolic abnormalities such as obesity. Understanding this link can aid in designing personalized preventive strategies.
Article
Cardiac & Cardiovascular Systems
Michelle D. Kelsey, Adam J. Nelson, Jennifer B. Green, Christopher B. Granger, Eric D. Peterson, Darren K. McGuire, Neha J. Pagidipati
Summary: Cardiovascular disease is a major concern for individuals with type 2 diabetes mellitus, and aggressive risk factor management is crucial for these high-risk patients. Recommendations and guidelines from professional societies in cardiology, endocrinology, nephrology, and general medicine in the United States and Europe provide guidance on cardiovascular risk reduction for patients with type 2 diabetes mellitus. While there are some differences in risk stratification, treatment targets for low-density lipoprotein-cholesterol and blood pressure, as well as the use of specific medications, overall there is significant alignment across recommendations from different professional societies.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rabina Shrestha, Uday Narayan Yadav, Abha Shrestha, Grish Paudel, Deepa Makaju, Prakash Poudel, Hanako Iwashita, Yuriko Harada, Archana Shrestha, Biraj Karmacharya, Rajendra Koju, Tomohiko Sugishita, Lal Rawal
Summary: This study reviewed the implementation of existing policies and guidelines for diabetes prevention and control at the primary health care level in Nepal. The study found that there were limited implementation of policies into practices, lack of coordination among service providers, lack of trained human resources and inadequate quality services, as well as inadequate access and utilization of diabetes care services at the primary health care level. The study highlighted the need for a multisectoral approach and strengthening the policies implementation process.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Endocrinology & Metabolism
Miranda T. Schram, Willem J. J. Assendelft, Theo G. van Tilburg, Nicole H. T. M. Dukers-Muijrers
Summary: Social networks have been causally related to disease and mortality risk for decades, but research in this field for diabetes care is still in its early stages. Studies have found that living alone and lack of social support are associated with increased risk of type 2 diabetes, while social support has a positive impact on self-management of diabetes.
Article
Endocrinology & Metabolism
Avishai M. Tsur, Shir Hershkovich, Inbar Zucker, Miri Lutski, Orit Pinhas-Hamiel, Asaf Vivante, Maya Fischman, Ofer Amir, Jacob Rotchild, Hertzel C. Gerstein, Tali Cukierman-Yaffe, Limor Friedensohn, Ofri Mosenzon, Estela Derazne, Dorit Tzur, Amir Tirosh, Arnon Afek, Itamar Raz, Gilad Twig
Summary: The study found an association between adolescent stuttering and an increased risk of early-onset type 2 diabetes in men, with this association being stronger in later birth cohorts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Public, Environmental & Occupational Health
Chun-Rui Wang, Tian-Yang Hu, Fa-Bao Hao, Nan Chen, Yang Peng, Jing-Jing Wu, Peng-Fei Yang, Guo-Chao Zhong
Summary: The study aimed to examine the association between a type 2 diabetes-prevention diet and mortality in a US population. The results showed that adhering to this diet was associated with reduced risks of death from all causes, cardiovascular disease, and cancer.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Immunology
David R. Boulware, Thomas A. Murray, Jennifer L. Proper, Christopher J. Tignanelli, John B. Buse, David M. Liebovitz, Jacinda M. Nicklas, Kenneth Cohen, Michael A. Puskarich, Hrishikesh K. Belani, Lianne K. Siegel, Nichole R. Klatt, David J. Odde, Amy B. Karger, Nicholas E. Ingraham, Katrina M. Hartman, Via Rao, Aubrey A. Hagen, Barkha Patel, Sarah L. Fenno, Nandini Avula, Neha Reddy, Spencer M. Erickson, Sarah Lindberg, Regina Fricton, Samuel Lee, Adnin Zaman, Hanna G. Saveraid, Walker J. Tordsen, Matthew F. Pullen, Nancy E. Sherwood, Jared D. Huling, Carolyn T. Bramante
Summary: SARS-CoV-2 vaccine-boosted participants experienced the least severe symptoms during COVID-19, and their symptoms improved the fastest over time. Vaccination against SARS-CoV-2 was found to be associated with reduced symptom severity in a sample of low to moderate risk adults enrolled in an outpatient COVID-19 treatment trial. Booster shots further reduced symptom severity.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, Research & Experimental
Seth A. Berkowitz, Gina R. Kruse, Katharine A. Ball Ricks, Jessica Burch, Ethan Ouimet, Beth Kitzis, Colleen Forrest, Jean Terranova, Paul W. Stewart, John B. Buse, Thomas C. Keyserling, Deborah J. Wexler, Linda M. Delahanty
Summary: This article describes a trial protocol to assess whether medically tailored meals plus lifestyle intervention can improve hemoglobin A1c and participant-reported outcomes compared to a food subsidy for adults with both type 2 diabetes and food insecurity. The trial aims to enroll 200 participants and will use a pragmatic design with random assignment to different interventions. The primary outcome is hemoglobin A1c at 6 months. The results will inform clinical management of food insecurity in the context of type 2 diabetes.
CONTEMPORARY CLINICAL TRIALS
(2023)
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, John B. Buse, Elizabeth Selvin, Sonia Y. Angell, Vanita R. Aroda, Jessica R. Castle, Alice Y. Y. Cheng, Thomas Danne, Justin B. Echouffo-Tcheugui, Jose C. Florez, Meghana D. Gadgil, Amalia Gastaldelli, Jennifer B. Green, Ania M. Jastreboff, Alka M. Kanaya, Namratha R. Kandula, Csaba P. Kovesdy, Neda Laiteerapong, Kristen J. Nadeau, Rodica Pop-Busui, Camille E. Powe, Casey M. Rebholz, Michael R. Rickels, Naveed Sattar, Jonathan E. Shaw, Emily K. Sims, Kristina M. Utzschneider, Adrian Vella, Cuilin Zhang
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, John B. Buse, Elizabeth Selvin
Article
Endocrinology & Metabolism
Shweta Pathak, Kristina Kearin, Anna R. Kahkoska, Kathryn A. Fuller, Bradley Staats, Joseph Albright, Til Sturmer, John B. Buse, Benjamin Y. Urick
Summary: A policy change by a commercial insurer expanded coverage of continuous glucose monitoring (CGM) through the pharmacy benefit, leading to increased utilization of CGM. The study found that CGM use significantly increased after the policy change, especially among type 1 diabetes mellitus (T1DM) patients. The findings suggest that the policy change had a positive impact on CGM utilization.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Computer Science, Interdisciplinary Applications
Elena Casiraghi, Rachel Wong, Margaret Hall, Ben Coleman, Marco Notaro, Michael D. Evans, Jena S. Tronieri, Hannah Blau, Bryan Laraway, Tiffany J. Callahan, Lauren E. Chan, Carolyn T. Bramante, John B. Buse, Richard A. Moffitt, Til Sturmer, Steven G. Johnson, Yu Raymond Shao, Justin Reese, Peter N. Robinson, Alberto Paccanaro, Giorgio Valentini, Jared D. Huling, Kenneth J. Wilkins
Summary: Healthcare datasets from Electronic Health Records are valuable for assessing associations between patients' predictors and outcomes. However, missing values are common in these datasets, and removing them may introduce bias. Multiple imputation algorithms have been proposed to recover missing information, but there is no consensus on which algorithm works best. Choosing algorithm parameters and data-related modeling choices is also challenging.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Medicine, Research & Experimental
Andrea L. Cherrington, Heidi Krause-Steinrauf, Vanita Aroda, John B. Buse, Basma Fattaleh, Stephen P. Fortmann, Stephanie Hall, Sophia H. Hox, Alexander Kuhn, Tina Killean, Amy Loveland, Lawrence S. Phillips, Analyn Uy Jackson, Andrea Waltje, M. Diane McKee
Summary: This study successfully recruited a diverse population of individuals with relatively new onset of type 2 diabetes mellitus, relying heavily on the use of Electronic Health Record for participant screening. A comprehensive approach to recruitment with frequent monitoring was critical for achieving the recruitment goal.
Editorial Material
Endocrinology & Metabolism
Steven E. Kahn, Cheryl A. M. Anderson, Mark A. Atkinson, George L. Bakris, John B. Buse, Frank B. Hu, Stephen S. Rich, Matthew C. Riddle, Elizabeth Selvin
Article
Endocrinology & Metabolism
John B. Buse, Helene Nordahl Christensen, Brian J. Harty, Julie Mitchell, Benjamin P. Soule, Emily Zacherle, Mark Cziraky, Vincent J. Willey
Summary: SEPRA is an ongoing pragmatic clinical trial that aims to compare the effects of once-weekly subcutaneous semaglutide with standard care in patients with type 2 diabetes. It collects data from routine clinical practice to support decision-making by clinicians, payers, and policy makers. Key outcomes of the study include glycemic control, weight loss, healthcare utilization, and patient-reported outcomes.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Medicine, Research & Experimental
John B. Buse, Christopher P. Austin, S. Claiborne Johnston, Freda Lewis-Hall, Andrew N. March, Carolyn K. Shore, Pamela Tenaerts, Joni L. Rutter
Summary: Clinical trial processes are inefficient and costly, hindering the translation of medical discoveries into treatments. A group of experts developed a framework for clinical trial site readiness based on existing qualifications. The framework includes six domains and aims to reduce inefficiencies, improve reach, and benefit trial sponsors, organizations, participants, and the public. Novice and experienced sites can use the framework for preparation, assessment, and engagement with stakeholders.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Jessica A. Regan, Robert J. Mentz, Maggie Nguyen, Jennifer B. Green, Lauren K. Truby, Olga Ilkayeva, Christopher B. Newgard, John B. Buse, Harald Sourij, C. David Sjostrom, Naveed Sattar, Robert W. Mcgarrah, Yinggan Zheng, Darren K. Mcguire, Eberhard Standl, Paul Armstrong, Eric D. Peterson, Adrian F. Hernandez, Rury R. Holman, Svati H. Shah
Summary: This study reveals the heterogeneity of major adverse cardiovascular event (MACE) risk in individuals with type 2 diabetes mellitus (T2D) and identifies circulating metabolites reflecting mitochondrial dysfunction that can predict incident MACE. These metabolites remain associated with MACE in multivariate models and show favorable changes with exenatide therapy. The findings suggest that these biomarkers may improve cardiovascular risk prediction models and highlight emerging risk mechanisms.
Article
Psychology, Clinical
Larissa Vierl, Susanne Hoerz-Sagstetter, Cord Benecke, Carsten Spitzer, Florian Juen
Summary: This study compares two widely used questionnaires based on psychodynamic theories for assessing personality functioning (PF), finding that while highly correlated, they tap into distinct domains of PF. Exploratory Graph Analysis (EGA) and bootEGA were used to explore the dimensionality and stability of the questionnaires. These findings have important implications for clinical and scientific practice.
JOURNAL OF PERSONALITY ASSESSMENT
(2023)
Article
Medicine, Research & Experimental
Nandini Avula, Dustin Kakach, Christopher J. Tignanelli, David M. Liebovitz, Jacinda M. Nicklas, Kenneth Cohen, Michael A. Puskarich, Hrishikesh K. Belani, John B. Buse, Nichole R. Klatt, Blake Anderson, Amy B. Karger, Katrina M. Hartman, Barkha Patel, Sarah L. Fenno, Neha V. Reddy, Spencer M. Erickson, David R. Boulware, Thomas A. Murray, Carolyn T. Bramante
Summary: The COVID-19 pandemic has led to the advancement of decentralized clinical trials (DCT). DCTs have proved to be an effective and pragmatic method for assessing health outcomes during the pandemic. This report highlights the successful implementation of the COVID-OUT trial, which utilized decentralized strategies to rapidly deliver study drugs and remotely monitor participant outcomes.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Lauren E. Dang, Edwin Fong, Jens Magelund Tarp, Kim Katrine Bjerring Clemmensen, Henrik Ravn, Kajsa Kvist, John B. Buse, Mark van der Laan, Maya Petersen
Summary: This study presents three designs for evaluating the difference in risk of major adverse cardiovascular events between oral semaglutide and standard-of-care. Simulation results show that Designs 1 and 2 perform similarly, while Design 3 integrates external controls in 84% of cross-validation folds. The estimated risk difference using Design 3 is -1.53%-points.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Mustafa Tosur, Laura Gandolfo, Ashok Balasubramanyam, Rochelle N. Naylor, Toni I. Pollin, Neda Rasouli, Sara J. Cromer, John B. Buse, Maria J. Redondo
Summary: The incidence of diabetes in underrepresented racial and ethnic groups is increasing and has worse outcomes compared to non-Hispanic White individuals. This study aimed to recruit a diverse study population, however, the participation of underrepresented groups was low. Strategies to enhance their recruitment and retention are needed.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)