Article
Multidisciplinary Sciences
Havva Keskin, Shao-Ming Wang, Arash Etemadi, Jin-Hu Fan, Sanford M. Dawsey, Christian C. Abnet, You-Lin Qiao, Philip R. Taylor
Summary: Colorectal cancer is a common cancer in economically developed countries and China. The Linxian NIT cohort study aimed to reduce esophageal/gastric cardia cancer with daily multivitamin/mineral supplements. The study found that CRC risk factors in rural Chinese population are different from Western and urban Asian Chinese populations, with potential benefits for women supplemented with selenium/alpha-tocopherol/beta-carotene.
Review
Oncology
Edward R. Sauter, Brandy Heckman-Stoddard
Summary: Metabolic (bariatric) surgery provides significant weight loss and improvement in type 2 diabetes mellitus and cardiovascular risk in morbidly obese individuals. There is emerging evidence that MBS may also impact cancer risk, although the specific factors influencing this and the underlying mechanisms are still unclear.
Review
Nutrition & Dietetics
Andrea Chierici, Paolo Amoretti, Celine Drai, Serena De Fatico, Jerome Barriere, Luigi Schiavo, Antonio Iannelli
Summary: A meta-analysis found that bariatric surgery significantly reduces the incidence of colorectal cancer in individuals with obesity, regardless of gender and surgical procedure. Further large-scale studies are needed to confirm these findings.
Article
Endocrinology & Metabolism
Faina Tsodikov, Meir Schechter, Rebecca Goldsmith, Lilach Peleg, Vered Baloush-Kleinman, Aliza Rozenberg, Ilan Yanuv, Yuri Gimelfarb, Ofri Mosenzon, Ronit Endevelt
Summary: This study aimed to test the effectiveness of a multi-component lifestyle intervention in reducing cardiometabolic risk factors in severe mental illnesses (SMI) populations residing in mental-health rehabilitation hostels (MHRHs). The results showed that the lifestyle intervention significantly improved BMI, triglycerides, and LDL compared to baseline. However, there were no significant differences in these outcomes between the intervention and usual care groups.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Yaiza Garcia-Delgado, Maria Jose Lopez-Madrazo-Hernandez, Dacil Alvarado-Martel, Guillermo Miranda-Calderin, Arantza Ugarte-Lopetegui, Raul Alberto Gonzalez-Medina, Alba Hernandez-Lazaro, Garlene Zamora, Nuria Perez-Martin, Rosa Maria Sanchez-Hernandez, Adriana Ibarra-Gonzalez, Monica Bengoa-Dolon, Carmen Teresa Mendoza-Vega, Svein Mikael Appelvik-Gonzalez, Yurena Caballero-Diaz, Juan Ramon Hernandez-Hernandez, Ana Maria Wagner
Summary: Bariatric surgery is an effective treatment for obesity, yet the evidence on the role of prehabilitation in this context is limited. This study investigates the impact of physical and respiratory prehabilitation on obese patients awaiting surgery, in addition to standard education and behavioral interventions. Preliminary results suggest low completion rates, indicating a need for strategies to improve adherence.
Article
Surgery
Ahmad Elnahas, Jennifer N. Reid, Melody Lam, Aristithes G. Doumouras, Mehran Anvari, Christopher M. Schlachta, Nawar A. Alkhamesi, Jeff Hawel, David R. Urbach
Summary: This study investigated the risk factors associated with abdominal reoperations in bariatric patients. The results showed that reoperations are more common among obese patients undergoing concurrent hernia procedures, and are not associated with provider-related factors.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Surgery
Joonas H. Kauppila, Giola Santoni, Wenjing Tao, Elsebeth Lynge, Jussi Jokinen, Laufey Tryggvadottir, Eivind Ness-Jensen, Eero Pukkala, My Von Euler-Chelpin, Jesper Lagergren
Summary: This study identified risk factors for suicide after bariatric surgery, including gender, surgery type, and psychiatric disorders. Female patients had a lower risk of suicide compared to males, while gastric bypass surgery had a lower risk compared to other types of bariatric surgery. Patients with a history of depression or anxiety, mania, bipolar disorder, psychosis, schizophrenia, or substance use were at an increased risk of suicide.
Article
Medicine, General & Internal
Sandra Jumbe, Vichithranie W. Madurasinghe, Wai Yee James, Colin Houlihan, Samantha L. Jumbe, Tammy Yau, Florian Tomini, Sandra Eldridge, Borislava Mihaylova, Liz Steed, Ratna Sohanpal, Darush Attar, Stephanie J. C. Taylor, Chris Griffiths, Robert Walton
Summary: This study aimed to explore a complex intervention to increase the uptake and retention of stop smoking services in community pharmacies. However, the results showed that the intervention had no significant effect on setting a quit date, retention, or quit rate. Additionally, the study found that pharmacy staff had a positive attitude towards the intervention, but other factors may limit the capacity of the service.
Article
Endocrinology & Metabolism
Karin C. Wu, Sisi Cao, Connie M. Weaver, Nicole J. King, Sheena Patel, Hillary Kingman, Deborah E. Sellmeyer, Kathryn McCauley, Danny Li, Susan Lynch, Tiffany Y. Kim, Dennis M. Black, Martin M. Shafer, Mustafa Ozcam, Din L. Lin, Stanley J. Rogers, Lygia Stewart, Jonathan T. Carter, Andrew M. Posselt, Anne L. Schafer
Summary: This study tested the effects of soluble corn fiber (SCF) on fractional calcium absorption, biochemical parameters, and the fecal microbiome in a post-Roux-en-Y gastric bypass (RYGB) population. The results showed that SCF had no significant effects on calcium absorption, calciotropic hormones, or bone turnover markers. However, there was a wide variation in the impact of SCF, which may be due to the degree of gut microbiome alteration. The study demonstrated that daily SCF consumption was well tolerated in the post-RYGB population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Andrea Lazzati, Gilles Chatellier, Luca Paolino, Sarah Batahei, Sandrine Katsahian
Summary: Readmission to a nonindex hospital after bariatric surgery is associated with a 5-fold greater mortality rate compared to readmission to the index facility. Proper management of readmission for complications after bariatric surgery is crucial in reducing potentially preventable deaths.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Oncology
Julie Bulsei, Andrea Chierici, Marco Alifano, Antonio Castaldi, Celine Drai, Serena De Fatico, Edoardo Rosso, Eric Fontas, Antonio Iannelli
Summary: This study evaluated the effect of bariatric surgery on pancreatic cancer incidence in individuals with obesity. It found that bariatric surgery has a protective effect against pancreatic cancer in the 18-50 years population. However, further high-quality prospective studies are needed to confirm these results.
Article
Surgery
Hanna Konttinen, Kajsa Sjoholm, Peter Jacobson, Per-Arne Svensson, Lena M. S. Carlsson, Markku Peltonen
Summary: Higher risks of nonfatal self-harm and suicide were identified in post-bariatric surgery patients, with male sex, history of psychiatric disorders, and sleep difficulties being important predictors. Regular postoperative psychosocial monitoring may be necessary for high-risk patients to reduce the risk of future self-harm behaviors.
Review
Health Care Sciences & Services
Francesco Perone, Annachiara Pingitore, Edoardo Conte, Geza Halasz, Marco Ambrosetti, Mariangela Peruzzi, Elena Cavarretta
Summary: Obesity is associated with an increased risk of cardiovascular disease events and mortality, as well as other complications such as pre-type 2 diabetes and non-alcoholic fatty liver diseases. While physical activity and diet are important in reducing cardiovascular risk, they are not always successful strategies. Pharmacological treatments and bariatric surgery show promise in improving cardiovascular outcomes, but safety issues and cost restrict their use. Cardiac rehabilitation programs have been shown to improve cardiovascular disease risk factors, quality of life, and exercise capacity in obese patients. A multidisciplinary approach is needed to effectively reduce cardiovascular disease risk and mortality.
Article
Orthopedics
L. S. Lohmander, M. Peltonen, J. C. Andersson-Assarsson, C. Maglio, K. Sjoholm, M. Taube, P. Jacobson, P-A. Svensson, L. M. S. Carlsson, S. Ahlin
Summary: This study investigated the long-term effect of obesity and bariatric surgery on the incidences of osteoarthritis and arthroplasty of hip and knee. The results showed that the bariatric surgery group had a lower incidence of hip osteoarthritis but a higher incidence of knee arthroplasty compared to the control group.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Gastroenterology & Hepatology
Hassam Ali, Pratik Patel, Talia Farrukh Malik, Rahul Pamarthy, Babu P. Mohan, Ravishankar Asokkumar, Gontrand Lopez-Nava, Douglas G. Adler
Summary: This study developed an ESG reintervention score (ESG-RS) to determine the individualized risk of reintervention within the first 30 days after endoscopic sleeve gastroplasty (ESG). The ESG-RS identifies factors contributing to a higher risk of reintervention and aids clinicians in preoperative risk stratification of ESG patients.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Multidisciplinary Sciences
O. Spadaro, Y. Youm, I Shchukina, S. Ryu, S. Sidorov, A. Ravussin, K. Nguyen, E. Aladyeva, A. N. Predeus, S. R. Smith, E. Ravussin, C. Galban, M. N. Artyomov, V. D. Dixit
Summary: Research indicates that a 14% caloric restriction in healthy individuals can improve immune cell generation and is associated with pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity. The inhibition of the platelet activating factor acetyl hydrolase gene Pia2g7 may mediate the effects of reducing inflammation and extending healthy lifespan.
Article
Nutrition & Dietetics
Manuel Dote-Montero, Guillermo Sanchez-Delgado, Eric Ravussin
Summary: This review summarizes the effects of different types of intermittent fasting (IF) on human cardiometabolic health. IF regimens improve body composition, ectopic fat, and classic cardiometabolic risk factors, especially in metabolically unhealthy participants. However, it is still unclear whether IF provides additional cardiometabolic benefits as compared to continuous daily caloric restriction (CR).
Article
Nutrition & Dietetics
J. M. A. Alcantara, J. E. Galgani, L. Jurado-Fasoli, M. Dote-Montero, E. Merchan-Ramirez, E. Ravussin, J. R. Ruiz, G. Sanchez-Delgado
Summary: This study evaluated the accuracy and precision of four commercially available metabolic carts in measuring RMR and RER, finding that the Omnical had the lowest measurement error. The results showed discordant estimations of RMR and RER among the four metabolic carts, and the ICcE procedure did not improve measurement concordance.
CLINICAL NUTRITION
(2022)
Article
Geriatrics & Gerontology
Corby K. Martin, Christoph Hoechsmann, James L. Dorling, Manjushri Bhapkar, Carl F. Pieper, Susan B. Racette, Sai Krupa Das, Leanne M. Redman, William E. Kraus, Eric Ravussin
Summary: This study examines the relationship between the level of adherence to a 25% calorie restriction diet and the actual level achieved, highlighting the challenges of setting a single goal and the importance of obtaining real-time valid measures of dietary adherence.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Ursula White, Robbie A. Beyl, Eric Ravussin
Summary: The study found that an increase in small adipocytes during substantial weight gain is associated with impaired metabolic health outcomes, specifically visceral and ectopic fat accumulation.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Geriatrics & Gerontology
Mary N. Woessner, Michael A. Welsch, Mitch D. VanBruggen, Neil M. Johannsen, Daniel P. Credeur, Carl F. Pieper, Richard Sloane, Conrad P. Earnest, Joaquin Ortiz De Zevallos Munoz, Timothy S. Church, Eric Ravussin, William E. Kraus, Jason D. Allen
Summary: This study compared the effectiveness of PRIME and aerobic training in moderating the effects of vascular aging, finding that PRIME had better results in lowering blood pressure, especially suitable for older adults starting an exercise program.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2022)
Review
Endocrinology & Metabolism
Berit Ostergaard Christoffersen, Guillermo Sanchez-Delgado, Linu Mary John, Donna H. Ryan, Kirsten Raun, Eric Ravussin
Summary: This review discusses the failures of weight-loss drugs targeting energy expenditure and explores novel strategies for energy expenditure and lean mass preservation. It suggests that a combination of moderate energy expenditure modulation, lean mass preservation, and efficient appetite reduction is key for significant, safe, and long-lasting weight loss. The review also highlights the importance of revisiting regulatory guidelines to focus on the quality of weight loss and its maintenance.
Article
Sport Sciences
Lee M. Margolis, Kara L. Marlatt, Claire E. Berryman, Emily E. Howard, Nancy E. Murphy, Christopher T. Carrigan, Melissa N. Harris, Robbie A. Beyl, Eric Ravussin, Stefan M. Pasiakos, Jennifer C. Rood
Summary: The study aimed to determine the effects of testosterone enanthate injections on energy expenditure, energy substrate oxidation, and gene expression during energy deficit. The results showed that increased physical activity, rather than exogenous testosterone administration, was the primary determinant of metabolic adaptations during diet and exercise-induced energy deficit.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Correction
Endocrinology & Metabolism
Randall L. Mynatt, Robert C. Noland, Carrie M. Elks, Bolormaa Vandanmagsar, David S. Bayless, Allison C. Stone, Sujoy Ghosh, Eric Ravussin, Jaycob D. Warfel
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Karen D. Corbin, Elvis A. Carnero, Timothy D. Allerton, Joachim Tillner, Christopher P. Bock, Pierre-Philippe Luyet, Britta Gobel, Kevin D. Hall, Stephanie A. Parsons, Eric Ravussin, Steven R. Smith
Summary: This study aimed to test the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would result in less metabolic adaptation and increased lipid oxidation. The results showed that SAR425899 led to a smaller reduction in body composition-adjusted sleeping metabolic rate (SMR) and increased fat oxidation, which are beneficial for weight loss and weight-loss maintenance.
Article
Endocrinology & Metabolism
Prachi Singh, Robbie A. Beyl, Jacqueline M. Stephens, Robert C. Noland, Allison J. Richard, Anik Boudreau, R. Caitlin Hebert, Eric Ravussin, Josiane L. Broussard, Marie-Pierre St-Onge, Kara L. Marlatt
Summary: The aim of this study was to investigate the effect of sleep restriction on insulin sensitivity and energy metabolism in postmenopausal women. The results showed that four nights of sleep restriction reduced insulin sensitivity and fat oxidation in postmenopausal women, highlighting the significant role of insufficient sleep in metabolic dysfunction following menopause.
Review
Biochemistry & Molecular Biology
Radrigo Fernandez-Verdejo, Jacob T. Mey, Eric Ravussin
Summary: The potential of ketogenic approaches to regulate energy balance has gained attention due to their influence on energy expenditure and intake. Strategies such as fasting, dietary manipulation, and exogenous ketone sources can induce ketosis. Ketosis has minimal impact on energy expenditure but promotes substrate utilization towards ketone body oxidation. Low carbohydrate ketogenic diets and higher carbohydrate diets are equally effective for weight loss. However, the intake of medium-chain triglycerides and ketone esters may enhance weight loss by increasing energy expenditure and reducing energy intake. Further controlled studies are needed to isolate the independent effects of ketones.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Endocrinology & Metabolism
Steven B. Heymsfield, Shengping Yang, Cassidy McCarthy, Jasmin B. Brown, Corby K. Martin, Leanne M. Redman, Eric Ravussin, Wei Shen, Manfred J. Mueller, Anja Bosy-Westphal
Summary: The objective of this study was to develop models to predict the reduction in skeletal muscle mass during periods of voluntary calorie restriction and to validate the predictions in longitudinally monitored samples. The results showed that nonelderly males and females with overweight and obesity experience respective reductions in skeletal muscle mass with voluntary calorie restriction, with males losing approximately 2 to 2.5 kg and females losing approximately 1 to 1.5 kg of muscle mass per 10 kg of weight loss.
Biographical-Item
Endocrinology & Metabolism
Eric Ravussin, Sven Enerback, Robert Koza
Article
Medicine, Research & Experimental
Seungjin Ryu, Olga Spadaro, Sviatoslav Sidorov, Aileen H. Lee, Sonia Caprio, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Maxim N. Artyomov, Yun-Hee Youm, Vishwa Deep Dixit
Summary: This study found that long-term caloric restriction can lower inflammation in humans. They discovered that caloric restriction inhibits the expression of a specific protein in adipose tissue, while obesity increases its expression. Additionally, they found that deleting this protein in adipocytes can protect mice from inflammation caused by obesity.
JOURNAL OF CLINICAL INVESTIGATION
(2023)