Article
Agriculture, Dairy & Animal Science
L. Ding, Y. Shen, M. Jawad, T. Wu, S. K. Maloney, M. Wang, N. Chen, D. Blache
Summary: This study investigates the effect and mechanism of arginine on milk fat production in dairy cows. The results show that intravenous infusion of arginine can enhance the production of milk fat by promoting the synthesis of fatty acids and increasing milk yield.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Cell Biology
Tiemin Liu, Yong Xu, Chun-Xia Yi, Qingchun Tong, Dongsheng Cai
Summary: This review highlights the link between brain dysfunction and genetic mutations, sex, brain inflammation, microbiota, and stress as causes of whole-body pathophysiology. Studies suggest that dysfunction in the brain's perception and processing of internal and external cues can have profound effects on metabolism and other physiological functions.
Article
Biochemistry & Molecular Biology
Stephane Leon, Agnes Nadjar, Carmelo Quarta
Summary: Diet-induced obesity can result from dysregulated activity of hypothalamic neuronal circuits, potentially due to maladaptive communication between neurons and microglial cells. This interaction, crucial for the brain's orchestration of metabolic needs, may become detrimental under prolonged metabolic stress, leading to overfeeding, weight gain, and metabolic disturbances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Yao Yao, Longlong Li, Huihui Wang, Ying Yang, Haitian Ma
Summary: This study revealed the potential mechanisms of AMP-activated protein kinase in controlling the occurrence of fatty liver hemorrhagic syndrome in laying hens, with beneficial effects on relieving lipid metabolism disorders, oxidative stress, and inflammatory response through activating the NRF-2/KEAP1 pathway and inhibiting the NF-kappa B pathway.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Lifang Li, Qiufeng Jia, Lingli Chen, Wenkui Wang
Summary: This study evaluated the metabolic function of the right ventricles in clinical ascitic broilers and found pathological changes in the myocardia, enhanced glycolysis and fatty acid oxidation metabolism, and a diminished TCA cycle.
Article
Biochemistry & Molecular Biology
Lavanya B. Achanta, Donald S. Thomas, Gary D. Housley, Caroline D. Rae
Summary: AMP-activated protein kinase (AMPK) plays an important role in balancing anabolic and catabolic activities, and may have significant impacts on brain metabolism due to its high energy demands. Through NMR spectroscopy, we activated AMPK in guinea pig cortical tissue slices using direct and indirect activators, and found that different activator concentrations had distinct effects on metabolism. Direct activation with PF 06409577 increased Krebs cycle activity and restored pyruvate metabolism, while A769662 increased lactate and alanine production, as well as labeling of citrate and glutamine. These findings highlight the complex metabolic response to AMPK activators in the brain and emphasize the need for further research on their concentration- and mechanism-dependent impact.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Tiange Li, Han Gong, Biyuan Zhan, Xueying Mao
Summary: Chitosan oligosaccharides (COS) attenuate hepatic steatosis by suppressing lipid synthesis and enhancing fatty acid oxidation. AMP-activated protein kinase (AMPK) is involved in the beneficial effects of COS on hepatic steatosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Immunology
Yen-Ju Lin, Alexandra Goretzki, Stefan Schuelke
Summary: Allergic disorders have been on the rise in recent decades, prompting the emergence of a new research field called immune metabolism. It has been found that metabolic changes in T and B cells may play a role in the development and maintenance of allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Brittany A. Stork, Adam Dean, Andrea R. Ortiz, Pradip Saha, Nagireddy Putluri, Maricarmen D. Planas-Silva, Iqbal Mahmud, Kimal Rajapakshe, Cristian Coarfa, Stefan Knapp, Philip L. Lorenzi, Bruce E. Kemp, Benjamin E. Turk, John W. Scott, Anthony R. Means, Brian York
Summary: CaMKK2 plays a central role as a metabolic fuel sensor in the liver, contributing significantly to whole body systems metabolism. The study reveals that CaMKK2 ablation improves peripheral insulin sensitivity by promoting glucose metabolism through phosphorylation and regulation of GAPDH, and by reducing peroxisomal fatty acid catabolism through modulation of PEX3.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Ashley J. Ovens, John W. Scott, Christopher G. Langendorf, Bruce E. Kemp, Jonathan S. Oakhill, William J. Smiles
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in adaptive responses to exercise, and its post-translational modifications extensively influence its activity, subcellular localization, nutrient interactions, and protein stability. Areas for further research include novel regulatory modifications of AMPK and improving characterization of these modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Tae-Jun Song, Choon-Ho Park, Kyu-Ree In, Jong-Bae Kim, Joo Hee Kim, Miran Kim, Hye Jin Chang
Summary: Betulinic acid (BA) is a naturally occurring compound with various biological effects including anti-malarial, anti-inflammatory, anti-cancer, and recently discovered anti-obesity and anti-diabetic activities. BA activates AMPK, leading to reduced blood glucose levels, increased glucose uptake, and enhanced endurance in mice, indicating its therapeutic potential for diabetes.
Article
Chemistry, Multidisciplinary
Xia Wang, Xin-xin Zhu, Shi-yu Jiao, Dan Qi, Bao-qi Yu, Guo-min Xie, Ye Liu, Yan-ting Song, Qing Xu, Qing-bo Xu, Frank J. Gonzalez, Jie Du, Xiao-min Wang, Ai-juan Qu
Summary: Cardiomyocyte PPAR alpha deficiency accelerates pressure overload-induced cardiac hypertrophy and fibrosis by affecting fatty acid metabolism, glycolysis, extracellular matrix genes, and energy production pathways. This study highlights the critical role of cardiomyocyte PPAR alpha in regulating energy metabolism and extracellular matrix homeostasis during cardiac remodeling, providing potential therapeutic targets for cardiac remodeling-related diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Shashank Saurav, Sunil Kumar Manna
Summary: This study uncovers the role of Profilin in autophagy induction and discovers the interaction between Profilin and AMPK, leading to autophagy induction and apoptosis.
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Virology
Luis Didier Gonzalez-Garcia, Macario Martinez-Castillo, Tania Allin Vargas-Pavia, Jose Manuel Ulloa-Aguilar, Haruki Arevalo-Romero, Guadalupe Leon-Reyes, Addy Cecilia Helguera-Repetto, Julio Garcia-Cordero, Moises Leon-Juarez
Summary: Respiratory syncytial virus (RSV) is commonly associated with childhood upper respiratory tract infections, with lipid composition and AMPK activation being key factors in RSV infection. Studies have shown that RSV infection leads to inhibition of AMPK activity, promoting downstream lipogenic effector activation and cellular lipid synthesis in HEp-2 cells.
ARCHIVES OF VIROLOGY
(2021)
