Article
Microbiology
Daria A. Kashtanova, Natalia S. Klimenko, Olga N. Tkacheva, Irina D. Strazhesko, Victoria A. Metelskaya, Natalia V. Gomyranova, Sergey A. Boytsov
Summary: The study revealed a positive association between high gut microbiota diversity and healthy metabolic markers (such as HDL-cholesterol level), while low gut microbiota diversity was negatively associated with conditions such as obesity and dyslipidemia.
Article
Oncology
Josep Guma, Jose Adria-Cebrian, Belen Ruiz-Aguado, Cinta Albacar, Josefa Girona, Ricardo Rodriguez-Calvo, Neus Martinez-Micaelo, Eric W. F. Lam, Luis Masana, Sandra Guaita-Esteruelas
Summary: The study identified a positive association between TG-enriched particles and certain branched amino acids with breast cancer, suggesting a distinct metabolic signature in BC patients that could aid in improved stratification and treatment. This is the first time advanced NMR profiling has been used to identify relevant lipid and amino acid metabolites in BC serum samples for early and reliable diagnosis and prognosis.
Article
Multidisciplinary Sciences
Yohei Kusaba, Ken Kumagai, Kimi Ishikawa, Hyonmin Choe, Hiroyuki Ike, Naomi Kobayashi, Yutaka Inaba
Summary: In this study, the researchers found that anti-VEGF antibody, bevacizumab, promotes in vitro tenogenic differentiation and maturation of tendon stem/progenitor cells derived from rat Achilles tendon. This finding suggests that bevacizumab could be a potential therapeutic option for promoting tendon repair.
Article
Biochemistry & Molecular Biology
Kyung-Hyun Cho, Hyo-Seon Nam, Dae-Jin Kang, Min-Hee Park, Ju-Hyun Kim
Summary: Long-term alcohol consumption, even in small amounts, causes a significant decrease in serum HDL-C and apoA-I levels in middle-aged women, along with atherogenic changes in LDL and HDL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kazuyoshi Yamauchi, Chiaki Taira, Yasushi Kawakami
Summary: The study investigated the redox status of Cys-thiol in serum apolipoprotein E and found a correlation between the number of Cys residues and the ratios of different apoE types. The results contribute to a better understanding of the redox biology of age-related diseases.
BIOSCIENCE REPORTS
(2021)
Article
Multidisciplinary Sciences
Na Rae Park, Snehal S. Shetye, Igor Bogush, Douglas R. Keene, Sara Tufa, David M. Hudson, Marilyn Archer, Ling Qin, Louis J. Soslowsky, Nathaniel A. Dyment, Kyu Sang Joeng
Summary: The study found that Rcn3 plays a critical regulatory role in tendon development, with its deficiency leading to abnormalities in collagen fibrillogenesis and tenocyte maturation, ultimately affecting the mechanical properties of tendons.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Cecilia Bulgarelli, Elena Ciuffoli, Roberta Troia, Robert Goggs, Francesco Dondi, Massimo Giunti
Summary: This study investigates the association of serum Apo-A1 concentration with disease severity, multiorgan dysfunction syndrome (MODS) and outcome in septic dogs, and evaluates its correlation with major canine acute phase proteins (APPs).
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Junfei Guo, Weiming Lai, Yongbing Wu, Huan Li, Zhenhua Fu, Xiaoping Mu
Summary: In this study, the lipoprotein concentration in neonates with sepsis was analyzed and its use in stratifying patients was discussed. Compared with the uninfected group, there was no change in triglyceride concentration while there was a significant decrease in total cholesterol concentration in septic patients. There was no significant difference in serum triglyceride and total cholesterol concentration between Gram-positive and Gram-negative-related septic patients. Serum lipoprotein concentration may be recommended to help diagnose bacteria and evaluate the severity of sepsis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pu Xu, Bin Deng, Bingyu Zhang, Qing Luo, Guanbin Song
Summary: The study implicates the mechanosensitive gene Tnmd in the regulation of tenocyte migration, with its expression being regulated by mechanical loading and actin stress fiber formation as well as chromatin decondensation. This novel role of Tnmd in tenocyte migration sheds light on the molecular mechanisms involved in Tnmd-mediated tendon repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ana Gabriella P. Alves, Beatriz A. C. Cruvinel, Raquel M. Schincaglia, Leonardo S. Godoi, Maria S. Silva
Summary: This study evaluated the effect of cholecalciferol supplementation on children with hypertriacylglycerolemia, showing significant improvement in lipid profile in the supplemented group.
Article
Cardiac & Cardiovascular Systems
Anand Rohatgi, Marit Westerterp, Arnold von Eckardstein, Alan Remaley, Kerry-Anne Rye
Summary: Low high-density lipoprotein cholesterol (HDL-C) is associated with adverse lifestyle choices, cardiovascular diseases, inflammatory disorders, and other conditions. Therapeutic strategies targeting HDL-C levels have not been successful, and future focus should be on optimizing HDL function for better outcomes.
Review
Clinical Neurology
Xiao Feng, Qiaoqiao Tang, Chang Cheng, Shabei Xu
Summary: This study found that total cholesterol (TC) was significantly inversely correlated with prevalent CMBs, while total triglycerides (TG) and High-density lipoprotein (HDL) were significantly inversely associated with prevalent deep CMBs. Low-density lipoprotein (LDL) was negatively associated with incident CMBs. No statistical differences were found between statin and CMBs.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Veronica Ghini, Laura Maggi, Alessio Mazzoni, Michele Spinicci, Lorenzo Zammarchi, Alessandro Bartoloni, Francesco Annunziato, Paola Turano
Summary: The H-1 NMR spectra of sera were used to analyze the changes induced by vaccination with Pfizer-BioNTech vaccine in COVID-19-recovered and COVID-19-naive subjects. The results show that vaccination does not significantly affect the metabolome, but causes changes in lipoprotein levels. The effects differ between the recovered and naive subjects, suggesting that prior infection reduces the vaccine's modulation of lipoprotein composition.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Taiyue Jin, Eun Young Park, Byungmi Kim, Jin-Kyoung Oh
Summary: This study evaluated the association between serum folate concentrations and the prevalence of dyslipidemia and found a possible non-linear relationship. The findings suggest the need for more accurate recommendations regarding folate intake and supplementation.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Multidisciplinary Sciences
Jacob G. Kallenbach, Margaret A. T. Freeberg, David Abplanalp, Rahul G. Alenchery, Raquel E. Ajalik, Samantha Muscat, Jacquelyn A. Myers, John M. Ashton, Alayna Loiselle, Mark R. Buckley, Andre J. van Wijnen, Hani A. Awad
Summary: This study investigates the molecular mechanisms of tendon healing using the MRL mouse model. The results show that injured MRL tendons have reduced fibrotic adhesions and cellular proliferation, with accelerated improvements in biomechanical properties. Gene expression analysis reveals differences in pathways related to fibrosis, immune system signaling, and cell cycle regulation between MRL and C57 mice. These findings provide important insights for improving tendon healing.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Zuzanna Maria Kundi, Jetty Chung-Yung Lee, Jussi Pihlajamaki, Chi Bun Chan, Kin Sum Leung, Stephanie Sik Yu So, Emilia Nordlund, Marjukka Kolehmainen, Hani El-Nezami
Summary: The study investigates the differences in metabolites produced by gut microbiota in response to supplementation with oat or rye bran, showing that both types of bran can improve metabolic disturbances induced by a western diet through altering gut microbiota composition and modulating produced metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Mari Naatanen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen
Summary: In this study, the effects of diets with differing satiety values on fasting appetite-related hormone concentrations after weight loss were investigated. It was found that the macronutrient composition of an isoenergetic diet during weight maintenance did not have an impact on fasting appetite-related hormone concentrations. Furthermore, leptin and insulin adjusted to reduced fat mass, while ghrelin reflected changes in fat-free mass during the initial months of weight maintenance.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Food Science & Technology
Kati Vakevainen, Noora Rinkinen, Roosa-Maria Willman, Jenni Lappi, Kaisa Raninen, Anna Karlund, Santtu Mikkonen, Carme Plumed-Ferrer, Marjukka Kolehmainen
Summary: This study aimed to develop a frozen vegan blackcurrant product with potential probiotic function. The developed product was perceived as pleasant by consumers, but the viability of the probiotic during storage time needs improvement. Blackcurrant berries show potential as raw material for functional frozen food products.
Article
Public, Environmental & Occupational Health
Elina Jarvela-Reijonen, Suvi Jarvinen, Leila Karhunen, Tiina Fohr, Tero Myllymaki, Essi Sairanen, Sanni Lindroos, Katri Peuhkuri, Maarit Hallikainen, Jussi Pihlajamaki, Sampsa Puttonen, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Urho M. Kujala, Marjukka Kolehmainen, Jaana Laitinen
Summary: The study found that better nocturnal recovery was associated with better diet quality, lower alcohol consumption, and possibly less intuitive eating.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2021)
Article
Nutrition & Dietetics
Gozde Gurdeniz, Matti Uusitupa, Kjeld Hermansen, Markku J. Savolainen, Ursula Schwab, Marjukka Kolehmainen, Lea Brader, Lieselotte Cloetens, Karl-Heinz Herzig, Janne Hukkanen, Fredrik Rosqvist, Stine Marie Ulven, Ingibjorg Gunnarsdottir, Inga Thorsdottir, Matej Oresic, Kaisa S. Poutanen, Ulf Riserus, Bjorn Akesson, Lars Ove Dragsted
Summary: This study characterized a multicenter randomized controlled trial comparing a healthy Nordic diet (HND) to a control diet (CD) using plasma and urine metabolic profiles and associated them with cardiometabolic markers. The results showed that the metaboic profiles of blood and urine were able to distinguish between the two diets and were associated with glucose metabolism and lipoproteins.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
F. Halali, A. Lapvetelainen, K. Aittola, R. Mannikko, T. Tilles-Tirkkonen, E. Jarvela-Reijonen, P. Absetz, M. Kolehmainen, U. Schwab, J. Lindstrom, T. A. Lakka, J. Pihlajamaki, L. Karhunen
Summary: Frequent weight loss attempts may have an unfavorable impact on T2D risk factors and lifestyle intervention outcomes. Further research is needed to understand the effects of weight loss frequency on T2D risk factors and how to design lifestyle interventions for individuals with frequent previous weight loss attempts.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
George Moschonis, George Siopis, Costas Anastasiou, Violeta Iotova, Tanya Stefanova, Roumyana Dimova, Imre Rurik, Anette Si Rado, Greet Cardon, Marieke De Craemer, Jaana Lindstrom, Luis A. Moreno, Pilar De Miguel-Etayo, Konstantinos Makrilakis, Stavros Liatis, Yannis Manios
Summary: The Feel4Diabetes study recruited 12,193 children and their parents from six European countries to investigate the prevalence of childhood obesity and its association with socio-demographic characteristics and parental obesity status. The study found that living in low income or economically crisis countries, having a father with less education, and having one or both parents who were obese were associated with a higher likelihood of childhood obesity. These findings suggest the importance of targeting the whole family and considering socioeconomic factors in childhood obesity prevention programs.
Article
Medicine, General & Internal
Elisa Neuvonen, Jenni Lehtisalo, Tiia Ngandu, Esko Levaelahti, Riitta Antikainen, Tuomo Hanninen, Tiina Laatikainen, Jaana Lindstrom, Teemu Paajanen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Alina Solomon
Summary: Depressive symptoms may affect improvement in cognitive abilities, with clinically significant symptoms potentially impacting the effectiveness of interventions, warranting further attention in dementia prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Mika Venojarvi, Jaana Lindstrom, Sirkka Aunola, Pirjo Nuutila, Mustafa Atalay
Summary: This study aimed to investigate the effects of long-term exercise and dietary intervention on glucose metabolism in middle-aged obese individuals with impaired glucose tolerance. The intervention resulted in decreased leptin levels, increased adiponectin levels, improved insulin sensitivity and maximal oxygen uptake in responders, but did not affect glucose transporter gene expression.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Riitta Torronen, Suvi Jarvinen, Marjukka Kolehmainen
Summary: Regular consumption of high-protein dairy and energy-enriched berry products as snacks can improve the nutritional and functional status, as well as the quality of life, among vulnerable older people. The high-protein dairy product improves muscle protein and energy metabolism, while the energy-enriched berry products help maintain balanced glycemia.
CLINICAL NUTRITION ESPEN
(2022)
Review
Nutrition & Dietetics
Ratika Sehgal, Vanessa D. de Mello, Ville Mannisto, Jaana Lindstrom, Jaakko Tuomilehto, Jussi Pihlajamaki, Matti Uusitupa
Summary: The relationship between gut microbiota, diet, and the human body is complex, with tryptophan derivative indolepropionic acid (IPA) playing a crucial role in metabolic and immune functions and in the onset and development of metabolic disorders such as T2D and NAFLD. IPA levels are heavily influenced by diet, particularly dietary fiber, and show significant variations among individuals, which may be partially explained by genetic variants associated with specific diseases like T2D.
Article
Nutrition & Dietetics
Mari Naatanen, Anna Karlund, Santtu Mikkonen, Anton Klavus, Otto Savolainen, Marko Lehtonen, Leila Karhunen, Kati Hanhineva, Marjukka Kolehmainen
Summary: This study investigated the effect of two isocaloric 24-week weight maintenance diets on metabolism and identified metabolite features associated with successful weight loss maintenance. It was found that the dietary fiber, protein, and fat content of the diet influenced amino acid and lipid metabolism, and increased abundance of certain phospholipids and free fatty acids was associated with better weight loss maintenance.
CLINICAL NUTRITION
(2023)
Review
Health Care Sciences & Services
Anna Karlund, Isa Paukkonen, Carlos Gomez-Gallego, Marjukka Kolehmainen
Summary: Plant-derived protease inhibitors may have negative effects on dietary protein digestion, but they also have certain benefits. While the complex interactions affecting plant protein digestibility and bioavailability remain unclear, PI supplements can be used for targeted purposes to mitigate inflammation and gastric pain.
Article
Nutrition & Dietetics
Jenni Lappi, Kaisa Raninen, Kati Vakevainen, Anna Karlund, Riitta Torronen, Marjukka Kolehmainen
Summary: This study found that consuming blackcurrant puree and a product with fermented quinoa could lower postprandial blood glucose and insulin levels, resulting in a more stable blood glucose decline curve and improved glycemic profile. Compared to the control group that only consumed water, blackcurrant and the product with fermented quinoa significantly reduced glucose and insulin levels in the first 30 minutes after eating.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemical Research Methods
Anna Karlund, Teemu Kaariainen, Vili M. Kostamo, Tarja Kokkola, Marjukka Kolehmainen, Timo A. Lakka, Jussi Pihlajamaki, Albert Manninen
Summary: Analyzing the isotopic composition of exhaled carbon dioxide may help screen for prediabetes, but further research is needed to apply this method in Finnish individuals with prediabetes. While C-13/C-12 isotopes may assist in identifying prediabetic individuals in some cases, they are not yet reliable as a sole marker for screening prediabetes.
JOURNAL OF BREATH RESEARCH
(2021)
