期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 122, 期 11, 页码 619-629出版社
INFORMA HEALTHCARE
DOI: 10.3109/00207454.2012.704455
关键词
brain; CNS; neurology; non-lipid lowering; statins
The hydroxy-methyl-glutaryl-CoA reductase inhibitors, better known as statins, are principally used in the treatment of hyperlipidemia and play a pivotal role in the primary and secondary prevention of atherosclerotic heart disease and stroke. Evidence also exists for the potential benefits from statin use in a variety of other disease processes, conferred via their non-lipid lowering properties, which are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropic effects of statins in neurological disorders. Emphasis is placed on the discussion of randomized, placebo-controlled trials, and their importance in further elucidating this interesting phenomenon.
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