Article
Nutrition & Dietetics
Lijing Wang, Cui Zhou, Huiyan Yu, Ling Hao, Mengwei Ju, Wenjing Feng, Zhiting Guo, Xuejing Sun, Qiushi Fan, Rong Xiao
Summary: This study aimed to investigate the effects of co-supplementation with vitamin D, folic acid, and vitamin B-12 on learning and memory ability in vitamin D-deficient mice. The results showed that the co-supplementation significantly improved the learning and memory impairment caused by vitamin D deficiency, possibly through the regulation of CYP27A1 expression and the metabolism of 27-OHC, 25(OH)D, and SAM.
Article
Cell Biology
Rai-Hua Lai, Yueh-Ying Hsu, Feng-Shiun Shie, Che-Ching Huang, Mei-Hsin Chen, Jyh-Lyh Juang
Summary: Observational epidemiological studies have shown an association between vitamin D deficiency and Alzheimer's disease, with increased hippocampal VDR levels in AD despite decreased vitamin D levels. Mechanistic investigations revealed a non-genomic rewiring of VDR to p53, leading to increased neuronal autophagy and apoptosis in AD pathogenesis. Targeting the VDR/p53 pathway may offer potential treatment for AD.
Article
Cell Biology
Rai-Hua Lai, Chih-Cheng Hsu, Ben-Hui Yu, Yu-Ru Lo, Yueh-Ying Hsu, Mei-Hsin Chen, Jyh-Lyh Juang
Summary: Vitamin D deficiency may not be the cause but a consequence of AD. Supplementation of vitamin D in AD mice and humans exacerbates AD and enhances the non-genomic VDR/p53 complex in the brain. Long-term use of vitamin D-3 supplements may increase the risk of dementia and mortality.
Article
Biochemistry & Molecular Biology
Yiming Pan, Yalin Zhang, Ning Liu, Wanyi Lu, Jingxin Yang, Ye Li, Zuwang Liu, Yinghong Wei, Yan Lou, Juan Kong
Summary: This study investigated the mechanism underlying the prophylactic effects of vitamin D on Alzheimer's disease using a mouse model and cell model. The findings showed that vitamin D could alleviate cognitive impairment associated with Alzheimer's disease and suppress the expression of TAU, potentially rescuing methylated PP2A by increasing the expression of LCMT-1 and MTHFR.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiseung Kang, Mincheol Park, Eunkyung Lee, Jieun Jung, Tae Kim
Summary: Low serum vitamin D levels are associated with an increased risk of Alzheimer's disease (AD). Vitamin D deficiency can lead to Aβ accumulation in the brain and impaired microglial Aβ phagocytosis. Vitamin D deficiency in the early stage of AD is associated with earlier memory impairment, while vitamin D administration can reduce Aβ levels and improve memory function.
Article
Clinical Neurology
M. Kyla Shea, Kathryn Barger, Bess Dawson-Hughes, Sue E. Leurgans, Xueyan Fu, Bryan D. James, Thomas M. Holland, Puja Agarwal, Jifan Wang, Gregory Matuszek, Nicholas E. Heger, Julie A. Schneider, Sarah L. Booth
Summary: This study found that higher brain concentrations of 25(OH)D-3 were associated with a lower risk of dementia or mild cognitive impairment. However, there was no association between brain 25(OH)D concentrations and neuropathology outcomes. Further research is needed to understand the specific mechanisms underlying this potentially protective relationship.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Dana N. Broberg, Dickson Wong, Miranda Bellyou, Manuel Montero-Odasso, Olivier Beauchet, Cedric Annweiler, Robert Bartha
Summary: This study investigated the effects of vitamin D deprivation and subsequent treatment with memantine and vitamin D enrichment on gait performance in APPswe/PS1dE9 mice. The results showed that vitamin D deprivation led to an increase in hind stride width, while treatment with memantine and vitamin D prevented this impairment.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, General & Internal
Giuseppe Murdaca, Sara Banchero, Alessandro Tonacci, Alessio Nencioni, Fiammetta Monacelli, Sebastiano Gangemi
Summary: The study suggests that low levels of vitamin D and folic acid may be associated with cognitive decline in Alzheimer's disease patients. Patients with simultaneous low levels of vitamin D and folic acid may have poorer cognitive function.
Review
Neurosciences
Giulia Bivona, Bruna Lo Sasso, Caterina Maria Gambino, Rosaria Vincenza Giglio, Concetta Scazzone, Luisa Agnello, Marcello Ciaccio
Summary: The association between Vitamin D and cognition is well-established, with Vitamin D playing a role in regulating cellular processes in neurons and microglia. Low levels of Vitamin D have been linked to the onset and progression of AD, although its exact role in cognitive decline and AD remains unclear despite numerous studies.
Review
Medicine, Research & Experimental
Md Jamir Anwar, Sattam Khulaif Alenezi, Ahmad Hamad Alhowail
Summary: Neurological disorders, caused by various factors such as nutrition, environment, and genetics, impair cognitive and motor functions and decrease quality of life. Vitamin D, a hormone that acts as a regulatory factor, plays a crucial role in the pathophysiology of neurological disorders by preserving neuronal structures and influencing brain functions. Epidemiological evidence suggests that vitamin D deficiency is associated with an increased risk of neurological disorders. Understanding the role of vitamin D in the neurobiology of neurodegenerative disorders can improve management of vitamin D-deficient individuals.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Yeonjae (Angel) Lee, Sungjin Yoon, SangYun Kim, Young Chul Youn
Summary: Vitamin D is crucial for brain function, and its deficiency can accelerate cognitive impairment. This study aimed to evaluate the association between blood 25-hydroxyvitamin D levels and structural changes in the brain. Lower 25(OH)D levels were linked to reduced volumes in olfactory and hippocampal regions in elderly patients with cognitive decline, providing insights into the neurological pathophysiology of vitamin D.
FOOD SCIENCE & NUTRITION
(2021)
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Neurosciences
Sadia Sultan
Summary: Evidence suggests a connection between low serum 25 hydroxyvitamin D levels and cognitive impairment, with potential structural changes in the brain, including grey matter atrophy and increased white matter hyperintensities, in individuals with vitamin D deficiency.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Etienne Cavalier, Callum G. Fraser, Harjit P. Bhattoa, Annemieke C. Heijboer, Konstantinos Makris, Candice Z. Ulmer, Hubert W. Vesper, Samuel Vasikaran, Pierre Lukas, Pierre Delanaye, Anna Carobene
Summary: The study evaluated the biological variation of 25(OH)D to set analytical performance specifications for measurement uncertainty. The findings showed that participants were not in a steady state, so APS based on measurement uncertainty appear to be more appropriate.
Article
Pharmacology & Pharmacy
Mohamed M. M. Elseweidy, Mohamed Mahrous, Sousou I. I. Ali, Mohamed A. A. Shaheen, Nahla N. N. Younis
Summary: This study aimed to demonstrate the potential benefits of combining donepezil (DPZ) and vitamin D (Vit D) in counteracting neurodegenerative disorders induced by CuSO4 intake in rats. The results showed that vitamin D supplementation alleviated CuSO4-induced memory deficits and improved neurobehavioral and histological abnormalities. Vitamin D treatment was more effective than DPZ and enhanced the therapeutic potential of DPZ.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Letter
Neurosciences
Masoud Soheili, Mahmoud Salami
NUTRITIONAL NEUROSCIENCE
(2021)
Review
Neurosciences
Mahmoud Salami
Summary: The gut microbiota plays an important role in various physiological functions of the body, and any damage to it can lead to disorders in different body systems. Probiotics can help support or restore the healthy composition of the gut microbiota. Research has shown a close relationship between the gut microbiota and brain function and cognition.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Naheed Aryaeian, Fatemehsadat Amiri, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Afsaneh Gholamrezayi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Elaheh Heshmati, Shahnaz Rimaz
Summary: The study suggests that C. mas extract may decrease BAP, PTH, and hsCRP levels in postmenopausal women, but has no beneficial effect on OC and TC.
PHYTOTHERAPY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Amirhossein Davoodvandi, Farzaneh Fallahi, Omid Reza Tamtaji, Vida Tajiknia, Zarrin Banikazemi, Hadis Fathizadeh, Mohammad Abbasi-Kolli, Michael Aschner, Maryam Ghandali, Amirhossein Sahebkar, Mohsen Taghizadeh, Hamed Mirzaei
Summary: As the prevalence of gastrointestinal cancers increases, they are considered a major global health challenge. Imbalance of gut microbiota has been linked to susceptibility to various chronic diseases, including obesity and cancer. Probiotics have shown potential in preventing cancer development and reducing postoperative inflammation in cancer patients, but further clinical studies are needed for a better understanding of their mechanisms of action.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Elaheh Amirani, Zatollah Asemi, Mohsen Taghizadeh
Summary: The objective of this study was to determine the effects of probiotic plus selenium supplementation on glycemic control and lipid profiles in patients with gestational diabetes mellitus (GDM). The results showed that probiotic plus selenium supplementation significantly improved fasting glucose, insulin concentrations, insulin sensitivity, and lipid profiles in GDM patients.
CLINICAL NUTRITION ESPEN
(2022)
Article
Pharmacology & Pharmacy
Azam Alinaghipour, Ghorbangol Ashabi, Esmail Riahi, Masoud Soheili, Mahmoud Salami, Fatemeh Nabavizadeh
Summary: The present study demonstrated the neuroprotective effects of nano-curcumin on behavioral and electrophysiological aspects of hippocampus-dependent memory in noise-exposed animals. Nano-curcumin treatment improved maze navigation and LTP induction, and reduced serum corticosterone levels.
PHARMACOLOGICAL REPORTS
(2022)
Article
Nutrition & Dietetics
Mohsen Taghizadeh, Azam Mohammad Zadeh, Zatollah Asemi, Amir Hosein Farrokhnezhad, Mohammad Reza Memarzadeh, Zarin Banikazemi, Mohammad Shariat, Rana Shafabakhsh
Summary: This study showed that the administration of Morus Alba extract had beneficial effects on HDL-cholesterol, insulin, and MDA levels in patients with T2DM but did not affect other metabolic profiles.
CLINICAL NUTRITION ESPEN
(2022)
Article
Behavioral Sciences
Azam Alinaghipour, Mahmoud Salami, Fatemeh Nabavizadeh
Summary: Environmental noise stress leads to anxiety-like behavior and affects the gene expression of tight junctions and NMDA receptor subunits in the hippocampus of rats. Treatment with nanocurcumin can alleviate stress and anxiety, and restore the effects of noise exposure on tight junctions and NMDA receptor subunits.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Review
Medicine, Research & Experimental
Masoud Soheili, Azam Alinaghipour, Mahmoud Salami
Summary: An imbalance of oxidative agents can lead to oxidative stress, while beneficial gut bacteria play a crucial role in producing antioxidants. Modifying gut microbiota and probiotic supplements are suggested treatments to prevent or alleviate symptoms of neurological disorders associated with oxidative stress.
Article
Medicine, General & Internal
Nikan Zargarzadeh, Kiana Tadbir Vajargah, Armin Ebrahimzadeh, Seyed Mohammad Mousavi, Hamidreza Khodaveisi, Camellia Akhgarjand, Fernando M. P. Toyos, Henrique S. Cerqueira, Heitor O. Santos, Mohsen Taghizadeh, Alireza Milajerdi
Summary: This study aims to examine the association between adherence to the Mediterranean diet pattern and COVID-19 severity and symptoms in Iranian hospitalized patients. The results showed that patients who adhered more closely to the Mediterranean diet had better outcomes in terms of COVID-19 severity, symptoms, and inflammatory biomarkers.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Inorganic & Nuclear
Elham Motallebzadeh, Marwah Suliman Maashi, Mustafa Z. Mahmoud, Akbar Aliasgharzedeh, Zarichehr Vakili, Sayyed Alireza Talaei, Mehran Mohseni
Summary: This study determines that N-acetylcysteine (NAC) has a radioprotective effect on radiation-induced oxidative stress in the rats' brainstem. Pre-treatment with NAC decreases oxidative stress and enhances antioxidant activities. NAC effectively reduces the pathological damage caused by radiation.
APPLIED RADIATION AND ISOTOPES
(2022)
Article
Nutrition & Dietetics
Armin Ebrahimzadeh, Mohsen Taghizadeh, Alireza Milajerdi
Summary: This study examined the association between major dietary patterns before COVID-19 diagnosis in recovered patients and the risk of disease severity and symptoms after the disease begins. The results showed that a higher adherence to a healthy dietary pattern was associated with lower CRP and ESR levels, as well as a lower risk of severe COVID-19, hospitalization, and convalescence duration. On the other hand, a higher adherence to unhealthy or traditional dietary patterns was associated with higher CRP and ESR levels, and a higher risk of severe COVID-19 and hospitalization duration. There was a direct association between unhealthy and traditional patterns and the risk of certain COVID-19 symptoms, while an inverse association was found for a healthy dietary pattern.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Shahnaz Rimaz, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Sanaz Jamshidi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Afsaneh Gholamrezayi, Naheed Aryaeian
Summary: This study aims to evaluate the effect of Cornus mas fruit on menopausal symptoms and sex hormones in postmenopausal women. The findings indicate that the extract of C mas fruit can significantly reduce menopausal symptoms, decrease the frequency and duration of hot flushes, and improve sex hormone levels.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Peripheral Vascular Disease
Virginia Boccardi, Mohsen Taghizadeh, Mina Salek, Sadegh Jafarnejad
Summary: The meta-analysis showed that alpha-lipoic acid (ALA) supplementation significantly reduced systolic and diastolic blood pressure, especially in subjects with higher blood pressure.
ARTERIAL HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Masoud Soheili, Mohammad Karimian, Gholamali Hamidi, Mahmoud Salami
Summary: Alzheimer's disease is a common chronic neurodegenerative disease characterized by impaired learning and memory, with both synthetic and herbal medicines used for treatment. Herbal medicines can help alleviate symptoms and prevent disease progression.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)