期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 121, 期 11, 页码 589-597出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/00207454.2011.598981
关键词
astrocytes; microglial cells; neuropathology
Activated astrocytes and microglia, hallmark of neurodegenerative diseases release different factors like array of pro and anti-inflammatory cytokines, free radicals, anti-oxidants, and neurotrophic factors during neurodegeneration which further contribute to neuronal death as well as in survival mechanisms. Astrocytes act as double-edged sword exerting both detrimental and neuroprotective effects while microglial cells are attributed more in neurodegenerative mechanisms. The dual and insufficient knowledge about the precise role of glia in neurodegeneration showed the need for further investigations and thorough review of the function of glia in neurodegeneration. In this review, we consolidate and categorize the glia-released factors which contribute in degenerative and protective mechanisms during neuropathological conditions.
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