期刊
INTERNATIONAL JOURNAL OF NEUROSCIENCE
卷 118, 期 11, 页码 1609-1627出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00207450802330702
关键词
Mesencephalon; prefrontal cortex; postmortem; human; in situ hybridization; dopamine
资金
- NIH
- NIMH
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZICMH002903, ZIAMH002399] Funding Source: NIH RePORTER
Group II metabotropic glutamate receptors (mGluR2 and mGluR3) are implicated in schizophrenia. We characterized mGluR2 and 3 mRNA in the human prefrontal cortex (PFC) and mesencephalon, and then compared cases with schizophrenia to matched controls. In the human brain, both receptors were expressed in the PFC and, unlike the rodent, in dopaminergic (DA) cell groups. In schizophrenia, we found significantly higher levels of mGluR2 mRNA in the PFC white matter. The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.
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