Article
Neurosciences
Johan Alsio, Olivia Lehmann, Colin McKenzie, David E. Theobald, Lydia Searle, Jing Xia, Jeffrey W. Dalley, Trevor W. Robbins
Summary: Across-species studies have found an evolutionarily conserved role for serotonin in flexible behavior, including reversal learning. This study aimed to investigate the contribution of serotonin in the orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) to visual discrimination and reversal learning. The findings revealed differential effects of serotonin within the two prefrontal cortex subregions on cognitive flexibility during visual discrimination and reversal learning.
Article
Behavioral Sciences
Anna U. Odland, Rune Sandahl, Jesper T. Andreasen
Summary: Stressful life events can have complex effects on cognitive flexibility, and it is possible to improve cognitive flexibility by altering sensitivity to negative feedback.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Yang Ruan, Kai-Yuan Li, Ran Zheng, Yi-Qun Yan, Zhong-Xuan Wang, Ying Chen, Yi Liu, Jun Tian, Li-Ya Zhu, Hui-Fang Lou, Yan-Qin Yu, Jia-Li Pu, Bao-Rong Zhang
Summary: This study investigates the role of cholinergic neurons in the pedunculopontine nucleus (PPN) in cognitive flexibility. The findings suggest that PPN cholinergic neurons exhibit increased activity correlated with rewards and are sensitive to rule switching. Inhibition of cholinergic activity impairs reversal learning, while activation improves it.
Article
Neurosciences
Brett A. Hathaway, Jackson D. Schumacher, Kelly M. Hrelja, Catharine A. Winstanley
Summary: The study found that the serotonin 2C receptor antagonist RS 102221 can attenuate cue-enhanced risk preference by acting on the lateral orbitofrontal cortex, but not affecting optimal decision-makers or when targeting the prelimbic area.
Article
Biochemistry & Molecular Biology
Miriam Schirru, Florence Veronneau-Veilleux, Fahima Nekka, Mauro Ursino
Summary: This study investigates the role of dopamine-dependent pathways in flexible action selection and learning mechanisms of striatal synapses. The findings suggest that controlling phasic dopamine changes can lead to successful reversal learning, providing insights into the mechanisms of dopamine changes during flexible behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ondrej Zika, Katja Wiech, Andrea Reinecke, Michael Browning, Nicolas W. Schuck
Summary: This study investigates the influence of trait anxiety on hidden-state inference. The results show that trait anxiety is associated with rapid expectation switches after contingency reversals and reduced oddball learning. Furthermore, trait anxiety is related to better fit of a state inference model when contingency changes are large. These findings support the role of hidden-state inference in anxiety-related fear relapse phenomena.
NATURE COMMUNICATIONS
(2023)
Article
Behavioral Sciences
Naama Aljadeff, Arnon Lotem
Summary: Different types of reversal tests can lead to significant differences in reversal behavior, which may be explained by the type of learned stimulus rather than differences in cognitive flexibility. Under conditions of multiple foraging options, preferences that are difficult to reverse may facilitate a flexible shift to novel food types. A two-set (multiple-cue) experimental design can help tease apart the different processes underlying reversal behavior and cognitive flexibility.
Article
Psychology, Biological
Momchil S. Tomov, Eric Schulz, Samuel J. Gershman
Summary: The study shows that participants in complex environments tend to map previously learned strategies to new scenarios, with a strategy that combines successor features and generalized policy iteration predicting behavior best.
NATURE HUMAN BEHAVIOUR
(2021)
Article
Neurosciences
Veronika Samborska, James L. Butler, Mark E. Walton, Timothy E. J. Behrens, Thomas Akam
Summary: The study reveals that the prefrontal cortex and hippocampus play different roles in problem-solving in mice, with the former being more about generalization and the latter being more about specificity.
NATURE NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Courtney A. Bryce, Stan B. Floresco
Summary: The study found that both CRF and acute stress can affect probabilistic reversal learning in rats, leading to reduced motivation, longer decision times, and increased number of trials omitted. Additionally, increased CRF activity reduced negative feedback sensitivity, with females showing higher levels of omissions and choice latencies compared to males.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Zakaria Ouhaz, Brook A. L. Perry, Kouichi Nakamura, Anna S. Mitchell
Summary: Cognitive flexibility is crucial for navigating everyday complexities and is attributed to the frontal cortex. The mediodorsal thalamus (MD), connected to the frontal cortex, may play a role in influencing cognitive flexibility. This study using male rats found that MD lesions resulted in difficulties in learning and updating strategies during a set-shifting task.
Article
Neurosciences
Eileen Oberwelland Weiss, Jana A. Kruppa, Gereon R. Fink, Beate Herpertz-Dahlmann, Kerstin Konrad, Martin Schulte-Ruether
Summary: This study used computational modeling to investigate cognitive flexibility in reversal learning in children and adolescents, finding that children make more errors and regressive errors, but less perseverative errors compared to adolescents. The study also revealed differences in how children and adolescents utilize new information to update their stimulus-reward associations.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Alexander Bublitz, Guido Dehnhardt, Frederike D. Hanke
Summary: Octopuses demonstrate sensitivity to incorrect choices in reversal learning tasks, showing significant improvement in learning time and performance. These findings suggest that octopuses exhibit behavioral flexibility in reversal learning tasks, going beyond mere discrimination learning.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jonathan W. Kanen, Annemieke M. Apergis-Schoute, Robyn Yellowlees, Frederique E. Arntz, Febe E. van der Flier, Annabel Price, Rudolf N. Cardinal, David M. Christmas, Luke Clark, Barbara J. Sahakian, Molly J. Crockett, Trevor W. Robbins
Summary: Serotonin plays a crucial role in updating responses to changing environmental circumstances, optimising behavior, and modifying autonomic responses to threats. Depleting serotonin precursor tryptophan leads to impairments in updating actions and autonomic responses, exacerbating reversal deficits in individuals.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Liang Gong, Ronghua Xu, Dan Yang, Jian Wang, Xin Ding, Bei Zhang, Xingping Zhang, Zhengjun Hu, Chunhua Xi
Summary: This study used a machine learning approach to differentiate chronic insomnia disorder (CID) patients with depressive symptoms from those without depressive symptoms based on orbital frontal cortex (OFC) functional connectivity. The classification model based on OFC functional connectivity showed a total accuracy of 76.92%.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Pirathiv Kugathasan, Jessica Waller, Ligia Westrich, Aicha Abdourahman, Joseph A. Tamm, Alan L. Pehrson, Elena Dale, Maria Gulinello, Connie Sanchez, Yan Li
JOURNAL OF PSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
Elena Dale, Morten Grunnet, Alan L. Pehrson, Kristen Frederiksen, Peter H. Larsen, Jacob Nielsen, Tine B. Stensbol, Bjarke Ebert, Haolan Yin, Dunguo Lu, Huiquing Liu, Thomas N. Jensen, Charles R. Yang, Connie Sanchez
Article
Neurosciences
Elizabeth A. Fucich, Denisse Paredes, Madeleine O. Saunders, David A. Morilak
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Pablo D. Perez, Zhiwei Ma, Christina Hamilton, Connie Sanchez, Arne Mork, Alan L. Pehrson, Christoffer Bundgaard, Nanyin Zhang
Article
Clinical Neurology
N. Hlavacova, Y. Li, A. Pehrson, C. Sanchez, I. Bermudez, A. Csanova, D. Jezova, M. Franklin
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Review
Clinical Neurology
Milena Girotti, Samantha M. Adler, Sarah E. Bulin, Elizabeth A. Fucich, Denisse Paredes, David A. Morilak
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Article
Pharmacology & Pharmacy
Alan L. Pehrson, Christian S. Pedersen, Kirstine Sloth Tolbol, Connie Sanchez
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Daniela Felice, Jean-Philippe Guilloux, Alan Pehrson, Yan Li, Indira Mendez-David, Alain M. Gardier, Connie Sanchez, Denis J. David
FRONTIERS IN PHARMACOLOGY
(2018)
Article
Clinical Neurology
Denisse Paredes, Jeri D. Silva, David A. Morilak
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Todd M. Hillhouse, Christina R. Merritt, Douglas A. Smith, Manuel Cajina, Connie Sanchez, Joseph H. Porter, Alan L. Pehrson
FRONTIERS IN PHARMACOLOGY
(2018)
Review
Behavioral Sciences
Denisse Paredes, David A. Morilak
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Alexandra M. Sharp, Suphada Lertphinyowong, Samantha S. Yee, Denisse Paredes, Jonathan Gelfond, Teresa L. Johnson-Pais, Robin J. Leach, Michael Liss, April L. Risinger, Anna C. Sullivan, Ian M. Thompson, David A. Morilak
PSYCHOPHARMACOLOGY
(2019)
Article
Neurosciences
Milena Girotti, Jeri D. Silva, Christina M. George, David A. Morilak
Review
Neurosciences
A. L. Pehrson, D. Roberts, A. Khawaja, R. McNair
Summary: This paper aims to understand how serotonergic mechanisms participate in rapid antidepressant mechanisms. By reviewing the relevance of serotonergic neurotransmission for rapid antidepressant effects and evaluating the role of 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4 receptors in synaptic plasticity, BDNF signaling, and GSK-3 beta activity, we develop hypotheses on the relationship of these receptor systems to rapid antidepressant effects.
PSYCHOPHARMACOLOGY
(2022)
Article
Biology
Elizabeth A. Fucich, David A. Morilak