期刊
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
卷 17, 期 4, 页码 593-602出版社
OXFORD UNIV PRESS
DOI: 10.1017/S1461145713001351
关键词
basal synaptic transmission; anxiety; exercise; calcium-calmodulin dependent protein kinase II (CaMKII); calcineurin (PP2B); Alzheimer's disease
资金
- University of Houston
- National Institutes of Health [1R15AG039008, NIH R15 G103327]
Previously, we reported that in a rat model of sporadic Alzheimer's disease (AD) generated by exogenous administration of A beta(1-42) (250pmol/d for 2 wk) via mini-osmotic pump, the animals exhibited learning and memory impairment, which could be attributed to the deleterious alterations in the levels of cognition-related signalling molecules. We showed that 4 wk of treadmill exercise totally prevented these impairments. Here, we evaluated the effect of exercise on non-cognitive function and basal synaptic transmission in the Cornu Ammonis 1 (CA1) area using the same AD model. Our results indicated that the anxiety behaviour of A beta-treated rats was prevented by 4 wk of treadmill exercise. Exercised/A beta-infused rats spent a longer time in the centre area of the open field (OF), elevated plus maze (EPM) paradigms and the light area of the light-dark (LD) box, which were similar to those of control and exercise rats. Furthermore, under basal conditions the aberrant up-regulation of calcineurin (PP2B) and reduction of phosphorylated Ca2+/calmodulin dependent protein kinase II (p-CaMKII) levels induced by AD-like pathology were normalised by the exercise regimen. We conclude that regular exercise may exert beneficial effects on both cognitive and non-cognitive functions in this AD model.
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