Article
Clinical Neurology
M. Holm, A. Tanskanen, M. Lahteenvuo, J. Tiihonen, H. Taipale
Summary: The aim of the study was to compare the real-world effectiveness of mood stabilizers and antipsychotics in the prevention of psychiatric hospitalizations and treatment failure after lithium discontinuation in a nationwide bipolar cohort. The study found that the use of long-acting injectable antipsychotics and chlorprothixene was associated with a lower risk of hospitalization, while the use of quetiapine and oral olanzapine was associated with a higher risk of psychiatric hospitalizations. Lithium use was associated with a lower risk of treatment failure.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Clinical Neurology
M. Holm, A. Tanskanen, M. Lahteenvuo, J. Tiihonen, H. Taipale
Summary: The study compared the effectiveness of mood stabilizers and antipsychotics in preventing psychiatric hospitalizations after discontinuing lithium in bipolar disorder patients. Results showed that antipsychotic LAIs and specific medications are associated with lower psychiatric hospitalization risk, while quetiapine and oral olanzapine are linked to higher risk of hospitalizations.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Chih-Ken Chen, Shu-Yu Yang, Seon-Cheol Park, Ok-Jin Jang, Xiaomin Zhu, Yu-Tao Xiang, Wen-Chen Ouyang, Afzal Javed, M. Nasar Sayeed Khan, Sandeep Grover, Ajit Avasthi, Roy Abraham Kallivayalil, Kok Yoon Chee, Norliza Chemi, Takahiro A. Kato, Kohei Hayakawa, Pornjira Pariwatcharakul, Margarita Maramis, Lakmi Seneviratne, Kang Sim, Wai Kwong Tang, Tin Oo, Norman Sartorius, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Naotaka Shinfuku, Shih-Ku Lin
Summary: This study investigated the distribution of mood stabilizer prescriptions for different psychiatric diagnoses in 10 Asian countries and found that mood stabilizers are commonly prescribed for conditions other than bipolar disorder, with schizophrenia and other non-mood psychotic disorders being the most common diagnosis. Valproic acid was the most frequently used medication.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Neurosciences
Janusz K. Rybakowski
Summary: The narrative review focuses on mood stabilizers. It provides the author's definition of mood-stabilizing drugs and describes the two generations of drugs that meet this definition. The article presents the clinical experiences with first and second-generation mood stabilizers and discusses their use in preventing recurrences of bipolar mood disorder.
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Neurosciences
Janusz K. Rybakowski
Summary: Antipsychotic drugs have been widely used in the treatment of mood disorders in addition to schizophrenia since their first application in psychiatry seventy years ago. These drugs can be classified into three generations, and each generation has different effects on mood disorders. The second and third generations of antipsychotic drugs have shown efficacy in the treatment of bipolar disorder, including antimanic and antidepressant effects.
Article
Clinical Neurology
Jonne Lintunen, Markku Lahteenvuo, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
Summary: This study investigated the prevalence of primary non-adherence to medication and its associated factors in patients with bipolar disorder in Finland. The majority of patients did not adhere to their prescribed medications, with factors such as young age, recent diagnosis of bipolar disorder, multiple hospitalizations, and use of benzodiazepines or antidepressants being associated with an increased risk of non-adherence.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Pao-Huan Chen, Shang-Ying Tsai, Po-Yu Chen, Chun-Hung Pan, Sheng-Siang Su, Chiao-Chicy Chen, Chian-Jue Kuo
Summary: This study evaluated the association between the use of mood stabilizers and the risks of mortality in people with bipolar disorder. The results showed that the use of mood stabilizers was significantly associated with decreased risks of all-cause mortality, suicide, and natural mortality, with lithium associated with the lowest risk.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Kelly A. Ryan, Peisong Han, Yuhua Zhang, David F. Marshall, Anastasia K. Yocum, Melvin G. McInnis, Sebastian Zollner
Summary: Individuals with bipolar disorder tend to have higher neuroticism and lower extraversion and consciousness compared to healthy controls. Personality traits show only small changes over time, with neuroticism being the only trait associated with changes in mood state. Other factors beyond mood changes may influence changes in personality traits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Pharmacology & Pharmacy
Luyao Cai, Guanjie Chen, Haichen Yang, Yuanhan Bai
Summary: This review compares the differences in efficacy and safety profiles among common psychotropics for bipolar depression (BPD). Atypical antipsychotics (AAPs) were found to be superior in alleviating acute depressive symptoms, while adverse events varied widely across different drug types due to variations in psychopharmacological mechanisms, dosages, titration, and ethnicities.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Psychiatry
Lauro Estivalete Marchionatti, Thyago Antonelli-Salgado, Isadora Nunes Erthal, Savio Luiz Santos Lopes, Luiza Silveira Lucas, Diego Barreto Reboucas, Ives Cavalcante Passos
Summary: This systematic review on the impact of disease progression in the treatment of bipolar disorder patients found that efficacy decreases with clinical progression, supporting early intervention. However, tailored recommendations cannot be made based on disease stages currently, highlighting the need for further research.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Brett D. M. Jones, Brisa S. Fernandes, M. Ishrat Husain, Abigail Ortiz, Tarek K. Rajji, Daniel M. Blumberger, Meryl A. Butters, Ariel G. Gildengers, Tatiana Shablinski, Aristotle Voineskos, Benoit H. Mulsant
Summary: This study aims to explore the relationships among clinical characteristics of bipolar disorder (BD), cognitive dysfunction, and aging. The results support both an early impairment model and an accelerated aging model, indicating that different cognitive domains are affected differently by BD and aging.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Margherita Barbuti, Giulia Menculini, Norma Verdolini, Isabella Pacchiarotti, Georgios D. Kotzalidis, Alfonso Tortorella, Eduard Vieta, Giulio Perugi
Summary: The present systematic review aimed to summarize the evidence about treatment-emergent mood switches in patients with bipolar disorder (BD). Thirty-two original studies met the inclusion criteria, and the majority focused on manic switches with limited research on depressive switches. Treatment-emergent mania/hypomania ranged from 17.3% to 48.8% and was more frequent with antidepressant monotherapy compared to combination treatment with mood stabilizers. Depressive switches were detected in 5-16% of patients and were associated with antipsychotic use. Methodological heterogeneity and small sample sizes were limitations in the included studies.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Mai Uchida, Qasim Bukhari, Maura DiSalvo, Allison Green, Giulia Serra, Chloe Hutt Vater, Satrajit S. Ghosh, Stephen V. Faraone, John D. E. Gabrieli, Joseph Biederman
Summary: This study developed a quantitative predictive model for bipolar disorder using machine learning algorithms and clinical data. The predictors included behavioral problems, school functioning, and anxiety/depression and aggression scales. The results have important clinical and scientific implications for assessing the risk of bipolar disorder in children.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yuxi Wang, Qian Hui Chew, Shih-Ku Lin, Shu-Yu Yang, Wen-Chen Ouyang, Chih-Ken Chen, Seon-Cheol Park, Ok-Jin Jang, Jun Hyuk Park, Kok-Yoon Chee, Kwong Sen Ding, Jamaline Chong, Ling Zhang, Keqing Li, Xiaomin Zhu, Chonnakarn Jatchavala, Pornjira Pariwatcharakul, Roy Abraham Kallivayalil, Sandeep Grover, Ajit Avasthi, Moin Ansari, Margarita M. Maramis, Paing Phyo Aung, Norman Sartorius, Yu-Tao Xiang, Chay-Hoon Tan, Mian-Yoon Chong, Yong Chon Park, Takahiro A. Kato, Naotaka Shinfuku, Ross J. Baldessarini, Kang Sim
Summary: A study conducted across 13 Asian countries and territories found that the use of relatively high doses of mood stabilizers is more common among young males, those with a longer illness duration, and those receiving antipsychotic medications.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)