Article
Behavioral Sciences
Kenya Watanabe, Osamu Nakagawasai, Syu-ichi Kanno, Satoru Mitazaki, Hiroshi Onogi, Kohei Takahashi, Kei-ichiro Watanabe, Koichi Tan-No, Masaaki Ishikawa, Lalit K. Srivastava, Remi Quirion, Takeshi Tadano
Summary: Genetic studies have implicated the neuregulin-1 gene as a potential susceptibility gene for schizophrenia. It is involved in regulating receptor expression and function in various brain regions. This study found that neonatal ventral hippocampal lesioned rats showed decreased levels of NRG-1 and p-erbB4 in the prefrontal cortex, and microinjection of NRG-1 improved behavioral deficits in these rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Chun-Xia Li, Zhihao Li, Xiaoping Hu, Xiaodong Zhang, Jocelyne Bachevalier
Summary: The study showed that neonatal hippocampal lesions significantly altered the functional connectivity of H-DLPFC and H-VLPFC in adult monkeys, with a specific impact on working memory performance in the left hemisphere of the brain. This findings provide a potential translational model for developing new therapeutic tools for Schizophrenia.
Article
Psychiatry
Claudia Barth, Stener Nerland, Kjetil N. Jorgensen, Beathe Haatveit, Laura A. Wortinger, Ingrid Melle, Unn K. Haukvik, Torill Ueland, Ole A. Andreassen, Ingrid Agartz
Summary: This study examined sex and diagnostic group differences in hippocampal subfield volumes in individuals with schizophrenia spectrum disorder, bipolar disorders, and healthy controls. The results showed a larger volumetric deficit in male patients compared to female patients when compared with same-sex controls. There were no significant sex differences in the associations between hippocampal volumes and clinical or cognitive measures in schizophrenia and bipolar disorder.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Pharmacology & Pharmacy
Yao Lu, Cassandra J. Hatzipantelis, Christopher J. Langmead, Gregory D. Stewart
Summary: Schizophrenia treatment currently relies on outdated science, and targeting dopamine receptors has limited efficacy and side effects. Non-dopaminergic GPCR-targeting drugs show promise but have not yet been successfully developed for clinical use. Recent attention has focused on non-dopaminergic GPCR-targeting drugs, which have demonstrated efficacy in certain symptoms of schizophrenia.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Joel G. Hashimoto, Mo L. Singer, Calla M. Goeke, Fuming Zhang, Yuefan Song, Ke Xia, Robert J. Linhardt, Marina Guizzetti
Summary: This study investigated the effects of a neonatal handling protocol on dendritic arborization and glycosaminoglycan (GAG) levels in the developing brain. Sex differences were found in both dendritic arborization and HS-GAG levels, with an increase observed in females but not males. Additionally, neonatal handling led to changes in GAG levels in the hippocampus in both males and females, indicating a similar stress response in both sexes.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Peripheral Vascular Disease
Benard O. Ogola, Gabrielle L. Clark, Caleb M. Abshire, Nicholas R. Harris, Kaylee L. Gentry, Shreya S. Gunda, Isabella Kilanowski-Doroh, Tristen J. Wong, Bruna Visniauskas, Dylan J. Lawrence, Margaret A. Zimmerman, Carolyn L. Bayer, Leanne Groban, Kristin S. Miller, Sarah H. Lindsey
Summary: Estrogen may play a protective role in arterial stiffness post-menopause through GPER. Female mice adapt to hypertension by increasing carotid wall thickness, maintaining stiffness, while males show stiffness-related changes in response to blood pressure.
Article
Neurosciences
Francisco Eliclecio Rodrigues da Silva, Rafaela Carneiro Cordeiro, Camila N. de Carvalho Lima, Pablo Leal Cardozo, Germana Silva Vasconcelos, Aline Santos Monte, Lia Lira Olivier Sanders, Silvania Maria Mendes Vasconcelos, David Freitas de Lucena, Breno Fiuza Cruz, Rodrigo Nicolato, Mary V. Seeman, Fabiola Mara Ribeiro, Danielle S. Macedo
Summary: This study found that females with schizophrenia experience more severe symptoms during the pre-ovulation phase of the menstrual cycle, and the administration of estrogen can alleviate these symptoms. The researchers also discovered that alterations in GPER may play a role in the gender differences observed in schizophrenia.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Bellina A. S. Mushala, Bingxian Xie, Ian J. Sipula, Michael W. Stoner, Dharendra Thapa, Janet R. Manning, Paramesha Bugga, Amber M. Vandevender, Michael J. Jurczak, Iain Scott
Summary: Loss of GPR19 impacts whole-body energy metabolism in a sex-dependent manner, promoting increased energy expenditure and decreased activity in both male and female mice. Only male GPR19 KO mice display glucose intolerance and diet-induced hepatomegaly with decreased expression of key fatty acid oxidation genes in the liver.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hao Zhu, Yu Yang, Min Zhu, Xiao Shi, Le Ye, Song Zhang, Hongwei Fang, Wenjuan Yu
Summary: The study revealed that MK-801 treatment enhanced astrocytic viability, elevating the expression and secretion levels of IL1β, IL6, and TNFα, while decreasing IL10 expression, possibly through the regulation of the ERK1/2 and PI3K signaling pathways.
Article
Multidisciplinary Sciences
G. Torromino, V Loffredo, D. Cavezza, G. Sonsini, F. Esposito, A. H. Crevenna, M. Gioffre, M. De Risi, A. Treves, M. Griguoli, E. De Leonibus
Summary: Incidental memory is influenced by retention delay and memory load. This study reveals that female and male mice process high memory load differently, leading to resistance to distraction and memory decay, respectively. The dorsal hippocampus and ventral midline thalamus play important roles in incidental memory, and manipulating the activation of these regions can affect memory differences between sexes.
NATURE COMMUNICATIONS
(2022)
Article
Surgery
Alma D. Genis-Mendoza, Carina Elizalde-Martinez, Jose J. Martinez-Magana, Brenda Cabrera-Mendoza, Axayacatl Morales-Guadarrama, Emilio Sacristan, Isabel Beltran-Villalobos, Carlos A. Tovilla-Zarate, Humberto Nicolini
Summary: The study revealed cell rearrangement during the progression of the lesion in the LVNH model which could be attributed to the activation of immune cells. MRI results showed significant enhancement in hypersignals and increased volume in lateral ventricles in the LVNH group.
CIRUGIA Y CIRUJANOS
(2021)
Review
Pharmacology & Pharmacy
Quynh Nhu Dinh, Antony Vinh, Thiruma V. Arumugam, Grant R. Drummond, Christopher G. Sobey
Summary: Estrogen plays a crucial role in inhibiting cardiovascular disease development in women, but estrogen replacement therapy in postmenopausal women has varying effects on cardiovascular risk. Selective activation of GPER can effectively promote cardiovascular protection, with more significant benefits observed in ovariectomised females or males.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chun Zhang, Jian-Guo Niu, Xue-Rui Kong, Xiao-Juan Mi, Qiang Liu, Fei-Fei Chen, Wei-Fang Rong, Juan Liu
Summary: This study confirmed that GPER1 deficiency affects cognitive function by reducing hippocampal neurogenesis through the PKA/ERK/IGF-I signaling pathway in mice with schizophrenia. GPER1 knockout aggravated depression and decreased cognitive ability in the mouse model of SZ. It also reduced adult hippocampal dentate gyrus neurogenesis and aggravated hippocampal damage induced by MK-801 in mice.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Review
Medicine, General & Internal
Waldemar Kryszkowski, Tomasz Boczek
Summary: Schizophrenia, a severe neuropsychiatric disease, is associated with disrupted glutamate neurotransmission, particularly involving ionotropic NMDA receptor hypofunction. Metabotropic glutamate receptors have emerged as crucial for cognitive and psychomotor function, with potential as molecular targets for novel antipsychotics.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Developmental Biology
Claudia P. Sanchez-Olguin, Sergio R. Zamudio, Sonia Guzman-Velazquez, Mariana Marquez-Portillo, Mario Daniel Caba-Flores, Israel Camacho-Abrego, Gonzalo Flores, Angel Melo
Summary: In this study, the authors found that cognition, locomotor activity, and maternal care were disrupted in female rats with schizophrenia-like deficits, suggesting disturbances in mesocorticolimbic dopaminergic systems and/or social cognition.
DEVELOPMENTAL PSYCHOBIOLOGY
(2022)
Meeting Abstract
Clinical Neurology
I. Tissen, P. M. Vinogradov, P. P. Khokhlov, A. A. Lebedev, E. R. Bychkov, P. D. Shabanov
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Neurosciences
M. Rafiuddin Ahmed, Evgeny Bychkov, Seunghyi Kook, Lilia Zurkovsky, Kevin N. Dalby, Eugenia V. Gurevich
EXPERIMENTAL NEUROLOGY
(2015)
Article
Multidisciplinary Sciences
Mohamed R. Ahmed, Evgeny Bychkov, Lingyong Li, Vsevolod V. Gurevich, Eugenia V. Gurevich
SCIENTIFIC REPORTS
(2015)
Article
Medicine, Research & Experimental
I. V. Karpova, V. V. Mikheev, V. V. Marysheva, E. R. Bychkov, S. N. Proshin
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2016)
Meeting Abstract
Clinical Neurology
I. Y. Tissen, E. R. Bychkov, P. P. Khokhlov, A. A. Lebedev, P. D. Shabanov
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Biochemistry & Molecular Biology
I. Karpova, V. V. Mikheev, V. V. Marysheva, N. A. Kuritcyna, E. R. Byehkov, P. D. Shabanova
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
A. V. Lizunov, I. V. Okunevich, S. V. Orlov, A. A. Lebedev, E. R. Bychkov, L. B. Piotrovskiy, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
M. I. Airapetov, S. O. Eresko, A. A. Lebedev, E. R. Bychkov, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
M. I. Airapetov, S. O. Eresko, E. A. Sekste, A. A. Lebedev, E. R. Bychkov, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
I. Karpova, V. V. Mikheev, V. V. Marysheva, N. A. Kuritcyna, E. R. Byehkov, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
M. I. Airapetov, E. A. Sekste, S. O. Eresko, E. R. Bychkov, A. A. Lebedev, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2019)
Meeting Abstract
Clinical Neurology
P. D. Shabanov, E. A. Sekste, M. I. Airapetov, E. R. Bychkov, P. P. Khokhlov, A. A. Lebedev
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Medicine, Research & Experimental
I. V. Karpova, E. R. Bychkov, V. V. Marysheva, V. V. Mikheev, P. D. Shabanov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
I. V. Karpova, V. V. Mikheev, V. V. Marysheva, N. A. Kuritcyna, N. A. Popkovskii, E. R. Bychkov, P. D. Shabanov
BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
(2018)
Article
Medicine, Research & Experimental
L. K. Khnychenko, E. E. Yakovleva, E. R. Bychkov, P. D. Shabanov
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2017)