Article
Pharmacology & Pharmacy
Liangpei Chen, Shihao Huang, Chang Yang, Feilong Wu, Qiuyao Zheng, He Yan, Jie Yan, Yixiao Luo, Ewa Galaj
Summary: Propranolol may reduce relapse by interfering with the reconsolidation of heroin memory, holding potential therapeutic value in opioid addiction treatment and relapse prevention.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Saurabh S. Kokane, Robert D. Cole, Bogdan Bordieanu, Chevin M. Ray, Ishraq A. Haque, James M. Otis, Jacqueline F. McGinty
Summary: The dysregulation of prefrontal cortex (PFC) to nucleus accumbens (NAc) input is a significant factor in cue-induced opioid seeking. The physiological adaptations of different subtypes of PFC neurons after heroin abstinence and relapse were investigated. The activity of protein kinase A (PKA) in these neurons is crucial for both abstinence-induced physiological changes and cue-induced relapse to heroin seeking.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Yu Liu, Gavan P. McNally
Summary: Dopamine plays a crucial role in relapse to drug seeking, with different forms of relapse being driven by distinct dopamine mechanisms. Understanding the diverse dopamine pathways involved in relapse behaviors is essential for developing effective strategies to prevent relapse.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Behavioral Sciences
Kevin T. Ball, Guy M. Bennardo, Jonathan Roe, Kyle J. Wunderlich
Summary: Chronic stress exposure increases vulnerability to future relapse-like behavior in male rats with a history of palatable food self-administration, mediated by dopamine D-1-like receptors, while the anatomical location of chronic stress' dopaminergic mechanism remains unknown. Preliminary experiments suggest that long-term stress potentiates relapse through prelimbic D-1-like receptors in male rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Kevin T. Ball, Brandon J. Arnsberger, Rachel M. McDonald
Summary: Chronic stress exposure has sex-dependent effects on relapse-like behavior in rats with a history of palatable food self-administration. Dopaminergic mechanisms are involved in these effects, with differences observed between male and female rats. Such findings highlight the importance of considering biological sex in developing interventions for dietary relapse and stress-related health problems.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Qingxiao Hong, Wenjin Xu, Zi Lin, Jing Liu, Weisheng Chen, Huaqiang Zhu, Miaojun Lai, Dingding Zhuang, Zemin Xu, Dan Fu, Wenhua Zhou, Huifen Liu
Summary: Epigenetic modifications, such as DNA methylation, play a crucial role in regulating gene expression and may influence neuroplasticity and drug-induced aberrant behaviors. The study in Sprague-Dawley rats showed that heroin self-administration led to hypomethylation of the GABRD gene and transcriptional upregulation in the NAc. Manipulations with DNMT inhibitor and MET affected heroin-seeking behavior, possibly through direct repression of DNMT1 and DNMT3A expression to alter the DNA methylation landscape of the GABRD gene.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Kevin T. Ball, Hunter Edson
Summary: It has been found that male rats are less sensitive to punishment during cocaine self-administration compared to females. Additionally, daily restraint stress increases sensitivity to punishment in males but has no effect on females. This study aimed to determine whether chronic stress-induced dopamine release in the prelimbic medial prefrontal cortex mediates the effect of stress on punished cocaine self-administration.
NEUROSCIENCE LETTERS
(2023)
Article
Neurosciences
Sarah M. Claypool, David J. Reiner, Sana Behdin, Javier Orihuel, Ashley Batista, Kiera E. Caldwell, Jonathan J. Chow, Jennifer M. Bossert, F. Javier Rubio, Bruce T. Hope, Yavin Shaham
Summary: We investigated the role of the piriform cortex (Pir) and its afferent projections in fentanyl relapse using a model of voluntary abstinence-induced relapse. Fentanyl relapse was associated with increased activation of Pir afferents from the anterior insular cortex (AI) and prelimbic cortex (PL). Disconnecting the AI-Pir projections decreased fentanyl relapse, while disconnecting the PL-Pir projections modestly decreased reacquisition. Our findings suggest dissociable roles of AI-Pir and PL-Pir projections in nonreinforced fentanyl seeking and reacquisition after voluntary abstinence.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Roberto Pagano, Ahmad Salamian, Janusz Zielinski, Anna Beroun, Maria Nalberczak-Skora, Edyta Skonieczna, Anna Caly, Nicole Tay, Tobias Banaschewski, Sylvane Desrivieres, Antoine Grigis, Hugh Garavan, Andreas Heinz, Ruediger Bruehl, Jean-Luc Martinot, Marie-Laure Paillere Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Juliane H. Froehner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Katarzyna Kalita, Haruhiko Bito, Christian P. Mueller, Gunter Schumann, Hiroyuki Okuno, Kasia Radwanska
Summary: Alcohol use disorder (AUD) is a chronic and fatal disease with a high likelihood of relapse. This study identifies a mechanism involving the activity-regulated cytoskeleton-associated protein (Arc)/ARG3.1-dependent plasticity of amygdala synapses that selectively controls cue-induced alcohol relapse and AUD symptoms. In humans, single nucleotide polymorphisms and methylation in the ARC gene were associated with amygdala size and frequency of alcohol use, even at the onset of regular consumption. Targeting Arc during alcohol cue exposure may provide a new approach for relapse prevention.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Jasper A. Heinsbroek, Giuseppe Giannotti, Mitchel R. Mandel, Megan Josey, Gary Aston-Jones, Morgan H. James, Jamie Peters
Summary: The study found that heroin choice and relapse involve different neural pathways in the brain, but share a common addiction-limiting circuit in the IL-NAshell pathway. This suggests that different mechanisms may be at play during drug choice and relapse, highlighting the complexity of addiction behaviors.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Benjamin M. Siemsen, Adam R. Denton, Jeffrey Parrila-Carrero, Kaylee N. Hooker, Eilish A. Carpenter, Meagan E. Prescot, Ashley G. Brock, Annaka M. Westphal, Mary-Nan Leath, John A. McFaddin, Thomas C. Jhou, Jacqueline F. McGinty, Michael D. Scofield
Summary: Clinical and preclinical studies have shown that adaptations in corticostriatal neurotransmission play an important role in heroin relapse vulnerability. Specifically, heroin self-administration and extinction lead to cellular adaptations in neurons and astrocytes within the nucleus accumbens core, contributing to cue-induced heroin seeking. Astrocyte glutamate homeostasis can be regulated by drugs like N-acetylcysteine (NAC), preventing cue-induced heroin seeking. Additionally, heroin self-administration and extinction result in changes in cortical dendritic spine morphology and the association of glutamate receptors in corticostriatal neurons, which can be reversed by NAC treatment.
Article
Multidisciplinary Sciences
Mary Tresa Zanda, Gabriele Floris, Stephanie E. Sillivan
Summary: This study found that the dosage of drugs and discriminative drug cues have different effects on the incubation of opioid craving, while the drug intake history also plays a role in the time-dependent drug-seeking.
SCIENTIFIC REPORTS
(2021)
Article
Physics, Multidisciplinary
Shahid Abbas, J. F. Gomez-Aguilar, Ghaus Ur Rahman, Muhammad Asif
Summary: Drug addiction is a neurological disorder that can be studied using mathematical modeling and computer simulations. The global use of methamphetamine is increasing and has reached epidemic levels. Researchers have focused on the social consequences of this epidemic and have introduced a model to describe the dynamics of methamphetamine. The study explores the process of abuse extinction and analyzes the impact of immigrants and relapse on the dynamics of addiction.
EUROPEAN PHYSICAL JOURNAL PLUS
(2023)
Article
Neurosciences
Elizabeth M. Doncheck, Eden M. Anderson, Chaz D. Konrath, Gage T. Liddiard, Margot C. DeBaker, Luke A. Urbanik, Matthew C. Hearing, John R. Mantsch
Summary: This study found that E2 activates ER beta and GPER1 in the PrL-PFC to attenuate the GABA-mediated constraint of key outputs that mediate cocaine seeking.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Haoyu Li, Ting Hu, Yanghui Zhang, Zijin Zhao, Qing Liu, Zihua Chen, Si Chen
Summary: This study confirms that disrupting the reconsolidation of heroin-associated memory mediated by ERK in the BLA brain region can effectively reduce relapse in heroin-seeking behavior. This provides a promising option for treating relapse in opioid addiction.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)