Article
Clinical Neurology
Alejandro Porras-Segovia, Benedicte Nobile, Emilie Olie, Elia Gourguechon-Buot, Enrique Baca Garcia, Philip Gorwood, Sofia Abascal-Peiro, Philippe Courtet
Summary: This study investigates the factors associated with transitioning from recent suicidal ideation to suicide attempts in depressed outpatients. The study followed up on depressed adult outpatients in France for six weeks. Logistic regressions were used to explore the differences between patients with suicidal ideation who attempted suicide and those who did not.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Oncology
Aleksandr Sokolov, Diana-Maria Manu, Didi O. T. Nordberg, Adrian D. E. Bostrom, Jussi Jokinen, Helgi B. Schioth
Summary: Depression is a complex disorder that has a significant impact on public health. This study found a link between genetic variants in MAD1L1 and differential DNA methylation associated with depression. The findings suggest that methylation at MAD1L1 plays a crucial role in psychiatric health.
CLINICAL EPIGENETICS
(2023)
Article
Clinical Neurology
Tanner J. Bommersbach, Taeho Greg Rhee, Elina A. Stefanovics, Robert A. Rosenheck
Summary: The study found that the majority of individuals with a history of suicide attempts did not attempt suicide again in the past 5 years. Recovery involves not only psychiatric and substance use disorders, but also improvements in key socio-demographic factors and social connectedness over many years.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Shao-Kui Kan, Nuan-Nuan Chen, Ying-Li Zhang
Summary: The purpose of this study was to develop and validate a user-friendly suicide attempt risk nomogram in depression, supporting timely interventions by clinicians. Clinical data of depressed patients were collected, and a visual predicting suicide attempt model was constructed using regression analysis and nomogram function. The evaluation results demonstrated the clinical practicability and effectiveness of the predictive model.
PSYCHIATRY RESEARCH
(2022)
Article
Immunology
Aiste Lengvenyte, Raoul Belzeaux, Emilie Olie, Hind Hamzeh-Cognasse, Maude Seneque, Robertas Strumila, Fabrice Cognasse, Philippe Courtet
Summary: An increasing body of evidence suggests that suicidal ideation and behaviors have biological bases. This study examined the association of various peripheral cells and proteins with suicidal behaviors and ideation in individuals with mood disorders. The results showed that plasma levels of certain proteins were associated with past month suicide attempts and current suicidal ideation. Additionally, higher levels of certain proteins predicted future suicidal events.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Psychology, Clinical
Haiyan Hu, Wenjun Liu, Sisheng Zhang, Jay Pan, Xiaozuo Zheng
Summary: Evidence from China suggests that characteristics of smokers differ from those in high-income countries, with smokers reporting higher pain severity and more depressive symptoms. The mediation analysis indicates that depressive symptoms mediate the relationship between smoking and pain severity in a significant portion of the association.
ADDICTIVE BEHAVIORS
(2021)
Article
Clinical Neurology
Zhuojun Yu, Xinxin Zhu
Summary: This study aimed to understand the relationship between multiple forms of victimization and suicidality, by examining the potential mediators of sleep duration and depression. The results showed that the link between multiple forms of victimization and suicide risk was mediated by sleep duration and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
H. Ihme, E. Olie, P. Courtet, W. El-Hage, X. Zendjidjian, P. Mazzola-Pomietto, J-L Consoloni, C. Deruelle, R. Belzeaux
Summary: This study examined the mediating effect of attachment anxiety and avoidance on suicidal behavior in individuals with childhood trauma and affective disorders. The findings suggest that childhood trauma has a complete mediated effect on prior suicide attempts through avoidant attachment, while emotional abuse directly influences suicidal ideation. It is recommended to screen for attachment early and engage patients in therapeutic approaches focusing on the client-therapist alliance for individuals at high suicide risk.
COMPREHENSIVE PSYCHIATRY
(2022)
Article
Clinical Neurology
Massimiliano Orri, Nicholas Chadi, Marilyn N. Ahun, Jean R. Seguin, Richard E. Tremblay, Michel Boivin, Gustavo Turecki, Marie-Claude Geoffroy, Sylvana M. Cote
Summary: The offspring of mothers who smoked persistently and heavily prenatally and postnatally were at increased risk of suicide attempt in adolescence. Children of mothers with a decreasing smoking pattern did not have an increased risk of suicide attempt. Propensity score cannot account for unmeasured confounding factors, and attrition limits the generalizability of the study findings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Lindsay A. Bornheimer, Heather Wastler, Juliann Li Verdugo, Vitalis Im, Heather Burke, Joshua Holzworth, Emma Velasquez, Muminah Mahmood
Summary: Rates of suicide are higher among individuals with schizophrenia spectrum disorders (SSDs) than the general population. This study aimed to explore depression, suicide intent, and suicide plan among adults with and without psychosis symptoms who attempted suicide. The findings showed that a smaller proportion of patients with psychosis had depressive symptoms, suicide intent, or a suicide plan prior to their attempt compared to patients without psychosis. These exploratory findings emphasize the need for assessing suicide risk beyond traditional approaches for patients with psychosis symptoms, considering the possibility of individuals not experiencing depression, suicide intent, or a suicide plan.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Jessica R. Gilbert, Jessica L. Gerner, Courtney R. Burton, Allison C. Nugent, Carlos A. Zarate, Elizabeth D. Ballard
Summary: This study investigated the magnetoencephalographic (MEG) correlates of suicidal ideation (SI) and suicide attempt history in patients with treatment-resistant major depression (TRD), both at baseline and after subanesthetic-dose ketamine infusion. The findings showed that ketamine significantly reduced SI and depression in the sample. Following ketamine infusion, attempters showed improved accuracy on the task, while non-attempters showed reduced accuracy. SI was positively associated with gamma power in frontal and parietal cortices. In an extended amygdalahippocampal region, attempters differed significantly in their emotional reactivity to angry versus happy faces as indexed by theta power differences, regardless of drug. Ketamine also reduced the association between alpha power and SI for angry compared to happy faces in a fronto-insular/anterior cingulate region important for regulating sensory attentiveness.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Anna Karin Hedstrom, Rino Bellocco, Ola Hossjer, Weimin Ye, Ylva Trolle Lagerros, Torbjorn Akerstedt
Summary: The study found no association between nightmares and suicide among participants with depression, but those with nightmares had a higher risk of developing depression during follow-up. Therefore, interventions targeting both depression and nightmares may provide additional therapeutic benefit.
Article
Clinical Neurology
Anna Bankwitz, Annia Ruesch, Atalia Adank, Christoph Hormann, Tania Villar de Araujo, Georgios Schoretsanitis, Birgit Kleim, Sebastian Olbrich
Summary: This study investigated the association between EEG-based connectivity measures within the alpha frequency range and suicidal thoughts, behaviors, and depression. The results showed no significant differences in connectivity between patients after a suicide attempt and healthy controls, but significantly increased nonlinear connectivity was found in patients with a depressive disorder. The nonlinear connectivity within the alpha frequency range outperformed other models in explaining depressive symptom severity.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychiatry
Agnus M. Kim, Sang-Won Jeon, Sung Joon Cho, Young Chul Shin, Jae-Hyun Park
Summary: This study highlights the unique impact of family stress on suicide attempts, emphasizing the importance of family support in suicide prevention. It also underscores the significance of regret for the past as a predictor of suicide attempts. Furthermore, the study suggests the importance of alcohol regulation in preventing suicide attempts compared to suicidal ideation.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Jack Samuels, Joseph Bienvenu, Janice Krasnow, Marco A. Grados, Bernadette A. Cullen, Fernando S. Goes, Nicole C. McLaughlin, Steven A. Rasmussen, Abby J. Fyer, James A. Knowles, James T. McCracken, Dan Geller, Mark A. Riddle, John Piacentini, S. Evelyn Stewart, Benjamin D. Greenberg, Gerald Nestadt, Paul Nestadt
Summary: This study found that individuals with obsessive-compulsive disorder (OCD) and major depression who had a history of suicide attempt were more likely to report experiencing violent or horrific images. This association remained significant even after adjusting for other risk factors of suicide attempt. Further studies are needed to understand the underlying basis of this relationship.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Ikuo Otsuka, Hanga Galfalvy, Jia Guo, Masato Akiyama, Dan Rujescu, Gustavo Turecki, Akitoyo Hishimoto, J. John Mann
Summary: This study found that major psychiatric disorders and diathesis-related traits contribute to suicidal behavior, and there are shared polygenic effects between different psychiatric disorders/traits. Although the sample size is small and limits the analysis, these results are still significant.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Noam Schneck, Sarah Herzog, Jun Lu, Ashley Yttredahl, R. Todd Ogden, Hanga Galfalvy, Ainsley Burke, Barbara Stanley, J. John Mann, Kevin N. Ochsner
Summary: This study investigated the neural dynamics of emotion regulation in healthy control subjects and subjects with major depressive disorder. The results showed that individuals with major depressive disorder exhibited a more rigid neural dynamic of reappraisal, suggesting a diminished ability to flexibly regulate emotion.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Emma O'Brien, Kathrine Whitman, Morgan Buerke, Hanga Galfalvy, Katalin Szanto
Summary: Examining psychological resilience traits associated with successful aging may help to better understand late-life suicide and depression. We investigated the self-reported protective factors in a high suicide-risk sample of depressed older adults and found that higher protective factor values were associated with lower likelihood of depression, depression severity, and suicidal ideation.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Clinical Neurology
Sarah Herzog, John G. Keilp, Hanga Galfalvy, J. John Mann, Barbara H. Stanley
Summary: Suicidal behavior is associated with deficits in cognitive control and suicidal ideation (SI) has inconsistent links to neuropsychological functioning. This study examined attentional control capacities related to variability in SI and severity in individuals with major depressive disorder. The findings showed that SI variability was associated with greater attentional interference and this was independent of SI severity, depressive affect, or baseline depression. However, there was no relationship between attentional control and SI variability or intensity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Rachel Hendricks, John G. Keilp, Mohammad Lesanpezeshki, Rina Muqkurtaj, Steven P. Ellis, Hanga Galfalvy, Ainsley K. Burke, Nadine Melhem, J. John Mann
Summary: This study examined the performance on the CD-RISC in individuals with familial risk for mood disorder and suicidal behavior. The study found that individuals with a history of suicide attempt had the lowest CD-RISC scores. However, CD-RISC scores were strongly correlated with other common risk factors for suicide attempt, such as hopelessness and subjective depression. Group differences in CD-RISC scores were eliminated when these risk factors were accounted for. Rating: 7 out of 10.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Shuqiong Zheng, Jia Guo, Qianqian Xin, Hanga Galfalvy, Youran Ye, Na Yan, Rongrong Qian, J. John Mann, Enze Li, Xiang Xue, Honglei Yin
Summary: This study investigated the association of EPHX2 and P2X2 polymorphisms and mRNA expression with depression and suicidal behavior, as well as the mediating role of cognition in these associations. The results showed that cognitive function played a significant mediator role in the genetic effect on depression. The rs202059124 C allele was associated with increased depression risk, and P2X2 mRNA expression was related to depression. Furthermore, a haploblock (rs9331942 and rs2279590) was associated with suicide attempts. These findings suggest that EPHX2 and P2X2 genes are implicated in depression and suicidal behavior.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Elizabeth A. Bartlett, Francesca Zanderigo, Barbara Stanley, Tse-Hwei Choo, Hanga C. Galfalvy, Spiro P. Pantazatos, Jeffrey M. Miller, Maria A. Oquendo, J. John Mann
Summary: This study investigated the relationship between the serotonin system and stress in major depression and suicidal behavior. The results showed that suicide attempters had lower binding potential to 5-HTT and higher binding potential to 5-HT1A in certain brain regions compared to non-attempters, and these differences were associated with their stress levels. These findings suggest that the changes in 5-HTT and 5-HT1A may serve as biological markers for the risk of suicidal behavior.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
C. Wang, J. G. Keilp, H. Galfalvy, J. A. Bridge, A. H. Sheftall, K. Szanto
Summary: This study found that feelings of entrapment and deficits in social problem-solving skills are associated with risk for suicidal behavior in individuals with depression. The association between these risk factors and suicidal behavior varies with age, with entrapment being a better discriminator in older adults. Impulsive problem-solving style is associated with past suicide attempts across the adult lifespan.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Developmental
Randy P. Auerbach, Ranqing Lan, Hanga Galfalvy, Kira L. Alqueza, Jeffrey F. Cohn, Ryann N. Crowley, Katherine Durham, Karla J. Joyce, Lauren E. Kahn, Rahil A. Kamath, Louis-Philippe Morency, Giovanna Porta, Apoorva Srinivasan, Jamie Zelazny, David A. Brent, Nicholas B. Allen
Summary: Suicide is a leading cause of death among adolescents, but there are no clinical tools currently available to detect proximal risk for suicide. This study demonstrates that intensive longitudinal assessment through the use of personal smartphones offers a feasible method to assess variability in adolescents' emotional experiences and suicide risk.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Karolina Krysinska, Dianne Currier, Karl Andriessen
Summary: This study aimed to evaluate the perceived helpfulness of the new online Let's Talk Suicide program for children and adolescents bereaved by suicide. The results showed that the participants and facilitators had a positive view of the program, stating that it provided support for children in their grief after suicide, normalized their experiences, offered social support, and improved their communication and emotion-handling skills. Although longitudinal research is needed, the program seems to address the existing gap in postvention services for children and adolescents bereaved by suicide.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Psychiatry
Hanga Galfalvy, Eileen Shea, Jacqueline de Vegvar, Spiro Pantazatos, Yung-yu Huang, Ainsley K. Burke, M. Elizabeth Sublette, Maria A. Oquendo, Francesca Zanderigo, Jeffrey M. Miller, J. John Mann
Summary: Childhood and lifetime adversity may influence brain serotonergic neurotransmission through epigenetic mechanisms. This study found that recent stress was correlated with DNA methylation of the 5-HT1A receptor gene and binding potential in participants with major depressive disorder (MDD), but not in controls. Childhood adversity was not associated with methylation or binding potential in MDD participants.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Sudan Prasad Neupane, Federico M. Daray, Elizabeth D. Ballard, Hanga Galfalvy, Liat Itzhaky, Aviv Segev, Assaf Shelef, Oren Tene, Mina M. Rizk, J. John Mann, Gil Zalsman
Summary: This study conducted a meta-analysis comparing immune biomarkers between individuals with and without a history of suicidal behavior, finding that suicidal behavior is associated with higher levels of CRP and IL-6, independent of psychiatric disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Shengnan Sun, Qingkun Liu, Zhaoyu Wang, Caroline Wilson, Sharon Alter, Yungyu Huang, M. Elizabeth Sublette, Marianne Goodman, Erin Hazlett, Rachel Yehuda, Victoria Arango, Gorazd Rosoklija, Andrew Dwork, Barbara Stanley, Yongchao Ge, Hanga Galfalvy, J. John Mann, Fatemeh Haghighi
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Jayabhargav Annam, Hanga Galfalvy, Barbara Stanley, John G. Keilp, Norman R. Simpson, Renu Nandakumar, Yung-Yu Huang, J. John Mann, M. Elizabeth Sublette
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Elizabeth Bartlett, Francesca Zanderigo, Barbara Stanley, Tse-Hwei Choo, Hanga Galfalvy, Akiva Mintz, M. Elizabeth Sublette, Jeffrey Miller, J. John Mann
BIOLOGICAL PSYCHIATRY
(2023)