期刊
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
卷 24, 期 2, 页码 -出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0129065714300058
关键词
Cortical excitability; cortical stimulation; frequency; intensity; interpulse interval; rats
资金
- junior researcher (Aspirant) grant from the Fund for Scientific Research Flanders (FWO)
- Bijzonder Onderzoeksfond (BOF) from Ghent University Hospital
- FWO
- BOF
- Clinical Epilepsy Grant from Ghent University Hospital
Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 mu A), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 mu A) and/or low frequency (5Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.
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