期刊
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
卷 18, 期 4, 页码 267-277出版社
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0129065708001580
关键词
STDP; synaptic pruning; cell death; preferred firing sequences; cell assemblies
资金
- European Community Future and Emerging Technologies Complex Systems program
- PERPLEXUS [034632]
Two main processes concurrently re. ne the nervous system over the course of development: cell death and selective synaptic pruning. We simulated large spiking neural networks (100 x 100 neurons at birth) characterized by an early developmental phase with cell death due to excessive. ring rate, followed by the onset of spike timing dependent synaptic plasticity (STDP), driven by spatiotemporal patterns of stimulation. The cell death affected the inhibitory units more than the excitatory units during the early developmental phase. The network activity showed the appearance of recurrent spatiotemporal. ring patterns along the STDP phase, thus suggesting the emergence of cell assemblies from the initially randomly connected networks. Some of these patterns were detected throughout the simulation despite the activity-driven network modifications while others disappeared.
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