Review
Pharmacology & Pharmacy
Mehran Alavi, Ali Nokhodchi
Summary: In this article, we provide an overview of micro- and nanoformulations of paclitaxel (PTX) based on micelles, liposomes, cubosomes, and lipid nanoparticles (LNPs) to improve the therapeutic effects of this drug both in vitro and in vivo.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Shradha Dattani, Xiaoling Li, Charina Lampa, David Lechuga-Ballesteros, Amanda Barriscale, Behzad Damadzadeh, Bhaskara R. Jasti
Summary: The purpose of this study was to compare LDV-targeted lipid-based micelles, liposomes, and solid lipid nanoparticles (SLN) in vitro and in vivo to investigate their therapeutic potential. The nanocarriers were characterized for their physicochemical properties, drug loading efficiency, release behavior, stability, and antitumor efficacy in a melanoma xenograft model. Results showed that SLN had the slowest drug release rate and highest stability, and demonstrated a statistically significant delay in tumor growth compared to the other two formulations. This study highlights the potential of SLN as drug delivery vehicles for anticancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Balaji Maddiboyina, Ramya Krishna Nakkala, Harekrishna Roy
Summary: Numerous nanotech arenas provide a platform to manufacture unique chemical entities for drug delivery. Among various carriers, lipid nanoparticles possess exclusive features for nanostructured dosage forms. The use of lipid nanoparticles as drug delivery systems has many appealing properties and significant implications for the transport and distribution of therapeutic agents.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Pharmacology & Pharmacy
Flavia Laffleur, Alexander Heinz Mayer
Summary: Oral drug delivery is a popular method, but it is limited by physiological and physicochemical barriers in the gastrointestinal tract. Nanoparticulate drug delivery systems based on lipids or polymers have shown promising results in improving bioavailability and treating diseases such as intestinal bowel disease and colorectal cancer.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Pharmacology & Pharmacy
Pratik Kakade, Arkasubhro Chatterjee, Anjali Pandya, John Disouza, Vandana Patravale
Summary: Nanotechnology is an important field for formulation scientists, and lipidic nanosystems with surface modification using carbohydrates have attracted attention in drug delivery. These systems offer interesting properties and can be developed using various methods.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Matheus Aparecido dos Santos Ramos, Luciani Gaspar de Toledo, Larissa Sposito, Gabriel Davi Marena, Laura Caminitti de Lima, Giovanna Capaldi Fortunato, Victor Hugo Sousa Araujo, Tais Maria Bauab, Marlus Chorilli
Summary: The rate of infections caused by resistant bacteria to available antimicrobials is growing exponentially, impacting human health and the global economy. Nanotechnology-based lipid systems have emerged as an innovative tool in improving bacterial infections treatment, offering potential for new antibacterial therapeutic strategies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Alicia Vogelaar, Samantha Marcotte, Jiaqi Cheng, Benazir Oluoch, Jennica Zaro
Summary: Lipid-based nanoparticles (LBNPs) are widely used for delivering various types of drug cargoes. However, issues with manufacturing processes have hindered their development. Microfluidic techniques have emerged as a promising solution, leading to reproducible LBNPs at lower costs and higher yields. This review summarizes the use of microfluidics in preparing LBNPs and discusses the effects of various microfluidic parameters on the properties of LBNPs.
Review
Polymer Science
Amirhossein Sadeghi, Shadi Poureskandar, Esfandyar Askari, Mohsen Akbari
Summary: Polymeric nanomaterials, nanogels, and solid nanoparticles can be made using single or double emulsion methods. These materials show promise for biomedical applications due to their biocompatibility, biodegradability, and ability to interact with body fluids and cells. However, the understanding of the biological behavior of polymeric nanoparticles is incomplete.
Article
Pharmacology & Pharmacy
Leonardo Gomes Souza, Ailton Antonio Sousa-Junior, Bertilha Alves Santana Cintra, Jorge Luiz Vieira dos Anjos, Thais Leite Nascimento, Livia Palmerston Mendes, Marcelo de Souza Vieira, Rafael do Nascimento Ducas, Marize Campos Valadares, Sebastiao Antonio Mendanha, Eliana Martins Lima
Summary: In this study, three types of sunitinib-loaded nanocarriers (polymeric nanospheres, liposomes, and solid lipid nanoparticles) for treating corneal neovascularization were compared. The best nanocarrier of each type was selected based on size, polydispersity index, drug load, and encapsulation efficiency. The selected formulations were characterized by various techniques and showed no toxicity or irritation potential. Solid lipid nanoparticles exhibited better drug release and corneal retention, making them the most suitable nanocarrier for clinical translation in the treatment of corneal neovascularization.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Biomaterials
Yun Li, Zhi Cai, Yihua Yin, Ying Yi, Weiquan Cai, Shengxiang Tao, Mengting Du, Jingli Zhang, Ruyu Cao, Yijing Luo, Wenjin Xu
Summary: In this study, a photoactivated bactericide nanosystem was developed using hematoporphyrin as a photosensitizer and pectin as a carrier. The nanosystem showed good water solubility and demonstrated high photodynamic activity upon esterase stimulation. It exhibited potent antibacterial effects and good adherence to leaves with no apparent toxic effects on plants. This research provides a new strategy for obtaining a photoactivated bactericide nanosystem with high utilization rate, good photostability, and targeting ability.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Biochemistry & Molecular Biology
Zhuoya Wan, Ruohui Zheng, Pearl Moharil, Yuzhe Liu, Jing Chen, Runzi Sun, Xu Song, Qiang Ao
Summary: Nanomedicine-based delivery strategies play a crucial role in improving cancer immunotherapies by enhancing anti-tumor immune response or reducing systemic adverse effects. The versatility of working with biocompatible polymers helps polymeric nanoparticles stand out as a key carrier to improve bioavailability and achieve specific delivery at the site of action.
Review
Pharmacology & Pharmacy
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng
Summary: P-glycoprotein (P-gp) plays a crucial role in the active transport of substrates out of cells, leading to poor intestinal permeation. Utilizing P-gp inhibitors and pharmaceutically inert excipients can help enhance the oral absorption and bioavailability of P-gp substrates. Different formulations with inherent P-gp inhibitory activity have been developed, offering a promising strategy to bypass P-gp and improve drug delivery.
Article
Chemistry, Multidisciplinary
Huaixin Li, Yunshan Liu, Jianzhong Jiang
Summary: This study reports a CO2-switchable surfactant that can stabilize switchable Pickering emulsions with alumina nanoparticles. The emulsions can be rapidly and completely demulsified by bubbling CO2, and the surfactant and nanoparticles can be recovered and reused after removal of CO2. This method is important for emulsion separation and oil product purification, and has potential applications in various fields.
Article
Chemistry, Applied
Sten ten Klooster, Karin Schroe, Claire Berton-Carabin
Summary: Lipid oxidation is a key factor affecting the shelf life of food and emulsion products. This study found that shorter and more hydrophilic lipid oxidation products can transfer between oil droplets in model food emulsions and reach equilibrium within 30 minutes. Adding certain exogenous lipid oxidation products to emulsions led to overall higher lipid oxidation values.
Article
Biochemistry & Molecular Biology
Hong Yu Yang, Jia Meng Du, Moon-Sun Jang, Xin Wang Mo, Xin Shun Sun, Doo Sung Lee, Jung Hee Lee, Yan Fu
Summary: EPNGs were successfully fabricated for CD44-targeted transport of cytochrome c through UV-triggered chemical cross-linking, showing stable and high protein encapsulation efficiency in blood circulation and rapid release in targeted tumor cells.
