Review
Engineering, Biomedical
Nadim Ahamad, Abhinanda Kar, Sourabh Mehta, Mahima Dewani, Vasanthan Ravichandran, Prateek Bhardwaj, Shivam Sharma, Rinti Banerjee
Summary: Inflammatory diseases encompass various illnesses with chronic inflammation as the central manifestation, posing a significant burden on healthcare systems and global socio-economic balance. Current standard therapies are limited in providing relief, whereas immunomodulatory nanosystems present new opportunities for treating inflammatory diseases.
Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Review
Multidisciplinary Sciences
Karen Alvarez, Mauricio Rojas
Summary: Autoimmune diseases are challenging to diagnose and treat. Nanoparticles offer promising strategies for targeting monocyte populations and delivering drugs for the diagnosis and treatment of autoimmune diseases. This field of research is of great importance.
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Ashish Saxena, Sumin Qiu, Sanjay Srivastava, Kota V. Ramana
Summary: The study demonstrates that fidarestat can attenuate Dox-induced immune and inflammatory responses by upregulating mitochondrial biogenesis markers, providing potential evidence for using fidarestat in combination with anthracycline drugs to prevent chemotherapy-induced inflammation and toxicity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Hematology
Vinay Singh Tanwar, Marpadga A. Reddy, Sadhan Das, Vishnu Amaram Samara, Maryam Abdollahi, Suchismita Dey, Vajir Malek, Rituparna Ganguly, Kenneth Stapleton, Linda Lanting, Patrick Pirrotte, Rama Natarajan
Summary: This study found that elevated free fatty acids like palmitic acid (PA) in obesity and diabetes promote chronic inflammation and impaired inflammation resolution associated with cardiometabolic disorders. Long noncoding RNAs (lncRNAs) play important roles in inflammatory processes, but their roles in PA-regulated inflammation and resolution are unclear. The researchers identified a novel lncRNA called PARAIL, which is upregulated in PA-treated macrophages and contributes to inflammation resolution through interactions with ELAVL1 protein.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Fazhan Wang, Jia Lou, Xiaoke Gao, Lijing Zhang, Feifei Sun, Zhaoqing Wang, Tianjiao Ji, Zhihai Qin
Summary: The spleen plays a crucial role in regulating immune responses and holds great potential for preventing and treating immune-related diseases. Novel nanosystems designed for spleen-targeted delivery of immunoregulators have shown promising therapeutic effects in diseases such as cancers, infectious diseases, autoimmune diseases, and pathogenic inflammatory disorders. This review discusses the architecture of the spleen, principles for designing spleen-targeted nanosystems, and their applications in enhancing or suppressing immune responses for disease treatment or prevention.
Article
Immunology
Zongshan Shen, Shuhong Kuang, Min Zhang, Xin Huang, Jiayao Chen, Meiliang Guan, Wei Qin, Hockin H. K. Xu, Zhengmei Lin
Summary: The study showed that Diabetes-associated periodontitis is closely related to persistently elevated levels of CCL2 and proinflammatory monocyte infiltration in periodontal tissues. Oral administration of bindarit reduced bone loss and increased epithelial thickness by suppressing inflammation in periodontal tissues. Bindarit also suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Marc A. Fernandez-Yague, Lauren A. Hymel, Claire E. Olingy, Claire McClain, Molly E. Ogle, Jose R. Garcia, Dustin Minshew, Sofiya Vyshnya, Hong Seo Lim, Peng Qiu, Andres J. Garcia, Edward A. Botchwey
Summary: Understanding the immune response to hydrogel implantation is crucial for designing immunomodulatory biomaterials. Through the use of advanced techniques such as high-dimensional flow cytometry and intravital imaging, the study found that RGD-presenting hydrogels can promote cellular infiltration and revascularization, and can direct the immune response through controlling macrophage cytokine secretion.
Review
Biochemistry & Molecular Biology
Anastasia Kariagina, Andrea I. Doseff
Summary: Flavones, natural phytochemicals found in our diet, possess anti-inflammatory properties that can effectively control the innate immune system and inflammation. They play a significant role in chronic inflammation, particularly in obesity and cancer, by influencing molecular mechanisms. Flavones restore immune landscape by impacting innate immune cell repertoire and reestablish immune homeostasis through NF-kappa B, STAT, COX-2, or NLRP3 inflammasome pathways. With no adverse side effects, flavones could be alternative opportunities for treating and preventing chronic inflammation associated with obesity and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jingxuan Liu, Yueying Yang, Xiao Liu, Andy Samuel Widjaya, Baohong Jiang, Yanyan Jiang
Summary: The study suggests that utilizing nanotherapy, such as PM/TN-CCLP, can significantly prevent and treat aortic dissection by reducing the rupture rate, preventing loss of elastic fibers, and decreasing inflammation at the lesion site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Otorhinolaryngology
Seung Ho Shin, Jee Eun Yoo, Jinsei Jung, Jae Young Choi, Seong Hoon Bae
Summary: This study aimed to investigate the infiltration of monocytes and their transformation into macrophages after noise exposure. The findings revealed that infiltrated monocytes were successfully observed 1 day after noise exposure, preceding the increase in the macrophage population.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2022)
Article
Immunology
Buesra Geckin, Gizem Kilic, Priya A. Debisarun, Konstantin Fohse, Azahara Rodriguez-Luna, Pablo Fernandez-Gonzalez, Ana Lopez Sanchez, Jorge Dominguez-Andres
Summary: The proper functioning of the immune system relies on the balance between pro-inflammation and anti-inflammation. Disruption of this balance can lead to autoimmune or inflammatory diseases. A fungal compound called AM3 has been found to modulate immune responses by decreasing excessive cytokine production and maintaining the capacity of immune cells to respond to stimuli. AM3 may help reduce immune activation and keep immune responses within a normal range.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wenjing Ren, Patrizia Rubini, Yong Tang, Tobias Engel, Peter Illes
Summary: Macrophages are mononuclear phagocytes that can be derived from blood-borne monocytes or exist as resident macrophages in peripheral and central tissues. They have M1 and M2 phenotypes and possess P2X7 receptors that respond to ATP and induce inflammatory responses and diseases. Therefore, P2X7 receptors on macrophages may be important targets for maintaining immune homeostasis and treating inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Qinrui Fu, Leilei Yu, Yin Wang, Peifeng Li, Jibin Song
Summary: Chronic diseases claim millions of lives every year, and it is important to develop advanced drugs for better treatment. Nanotheranostics, which integrate diagnosis and treatment into a single nanosystem, have shown great potential. However, their applications in nanomedicine are still in the early stages.
ADVANCED FUNCTIONAL MATERIALS
(2023)