Review
Pharmacology & Pharmacy
Jacob McCright, Ann Ramirez, Mayowa Amosu, Arnav Sinha, Amanda Bogseth, Katharina Maisel
Summary: This article discusses strategies using nanomaterials to locally target the GI tract and its mucosal immune system to regulate inflammation and disease outcomes.
Article
Multidisciplinary Sciences
Fernanda Raya-Tonetti, Melisa Muller, Jacinto Sacur, Haruki Kitazawa, Julio Villena, Maria Guadalupe Vizoso-Pinto
Summary: Two LysM domains of Limosilactobacillus fermentum were characterized, showing potential as an antigen display platform. Nasal immunization with a complex Venus-Acglu-BLPs027 significantly increased specific immunoglobulin levels and induced cytokine secretion in spleen cells. A Gateway compatible destination vector was constructed for easy fusion of LysM domains to develop mucosal subunit vaccines.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Loreto Gesualdo, Vincenzo Di Leo, Rosanna Coppo
Summary: The pathogenesis of IgA nephropathy may be associated with mucosal immunity, microbiota, genetic factors, food antigens, infections, and mucosal immune response. Potential therapies targeting microbes and mucosal hyperresponsiveness in IgAN patients are currently being evaluated.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Article
Chemistry, Medicinal
Yusuke Torikai, Yuji Sasaki, Keita Sasaki, Akifumi Kyuno, Shunji Haruta, Akihide Tanimoto
Summary: The study evaluated the immune response of a nasal ovalbumin powder formulation using a nasal delivery platform technology in monkeys similar to humans. Results showed that the nasal powder formulation had wider distribution and longer retention time, along with promising immune responses.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anella Saggese, Loredana Baccigalupi, Giuliana Donadio, Ezio Ricca, Rachele Isticato
Summary: The development of efficient mucosal vaccines relies on appropriate vectors. The bacterial spore has been proposed as a vaccine delivery system, displaying antigens on its surface and inducing specific immune responses in animals. The advantages and drawbacks of using the spore and different approaches to display antigens are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
In-Chan Hwang, Valerie Diane Valeriano, Ji Hoon Song, Marcela Pereira, Ju Kyoung Oh, Kyudong Han, Lars Engstrand, Dae-Kyung Kang
Summary: This study investigated the potential of L. plantarum expressing SARS-CoV-2 epitopes as a mucosal vaccine. The surface-displayed epitopes induced both pro-inflammatory and anti-inflammatory cytokines, showing potential immunoregulatory effects. Oral administration of these antigens in mice resulted in significant humoral and mucosal immune responses, suggesting the potential of L. plantarum as a novel approach for SARS-CoV-2 vaccine development.
MICROBIAL CELL FACTORIES
(2023)
Article
Chemistry, Multidisciplinary
Wandi Zhu, Jaeyoung Park, Thomas Pho, Lai Wei, Chunhong Dong, Joo Kim, Yao Ma, Julie A. Champion, Bao-Zhong Wang
Summary: This study explores the use of a novel type of core/shell protein nanoparticle as a vaccine for influenza virus, with the addition of appropriate adjuvants and finding effective mucosal vaccines to combat respiratory infection. The immune-stimulating complexes (ISCOMs)/monophosphoryl lipid A (MPLA) adjuvants boost the immune responses induced by the protein nanoparticles when administered intramuscularly. Furthermore, intranasal delivery of ISCOMs/MPLA-adjuvanted nanoparticles results in significantly strengthened immune responses and higher levels of antigen-specific antibodies in both systemic and local mucosa.
Article
Immunology
Jun Liu, Xiao-Dan Yan, Xian-Qiang Li, Yu-Hao Du, Li-Li Zhu, Tian-Tian Ye, Ze-Ying Cao, Zhe-Wen Dong, Shu-Tao Li, Xue Xu, Wei Bai, Dan Li, Ji-Wen Zhang, Shu-Jun Wang, Shan-Hu Li, Jin Sun, Xian-Zhen Yin
Summary: Nasal immunization plays a crucial role in defending against pathogens, but the development of nasal vaccines has been hindered due to their weak immunogenicity and lack of appropriate antigen carriers. Plant-derived adjuvants, such as chrysanthemum sporopollenin, show promising potential for vaccine delivery systems. In this study, a novel chrysanthemum sporopollenin vaccine delivery system was successfully fabricated, which exhibited high adhesion and retention in the nasal mucosa.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Fei Shao, Dou Yu, Pengyan Xia, Shuo Wang
Summary: The mucosal immune system is a crucial local defense system that regulates the progression of mucosal diseases by controlling the changes in mucosal immune cells. Innate lymphoid cells play a significant role in defense against pathogens, and their alteration is closely associated with mucosal disease development.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Kai Zhao, Yinzhuo Xie, Xuezheng Lin, Wei Xu
Summary: Mucosal immunization is an effective way to trigger mucosal immune responses, but most vaccines are currently administered through intramuscular injection, resulting in a lack of mucosal immune response. Biodegradable mucoadhesive nanoparticles show promise as vaccine delivery systems for mucosal administration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Gastroenterology & Hepatology
Yashu Wang, Qianru Li, Jiayu Zhang, Pingping Liu, Huaixin Zheng, Lijuan Chen, Zhen Wang, Chen Tan, Min Zhang, Hongxia Zhang, Wenqing Miao, Yuke Wang, Xiaoyan Xuan, Guoqiang Yi, Peng Wang
Summary: This study identified a new risk gene Ring1a for colitis, which regulates the mucosal immune response and intestinal microbiota. Ring1a deficiency exacerbates colitis by impairing the immune system and leads to a pathogenic microenvironment dominated by the Prevotella genus. Metronidazole administration can ameliorate colitis progression in Ring1aKO mice by reducing the abundance of Prevotella genus.
Article
Medicine, Research & Experimental
Kui Fan, Li Zeng, Jing Guo, Shuqin Xie, Yuan Yu, Jianwei Chen, Jin Cao, Qinyanqiu Xiang, Siliang Zhang, Yuanli Luo, Qingyue Deng, Qin Zhou, Yan Zhao, Lan Hao, Zhigang Wang, Ling Zhong
Summary: The study presents a visualized podocyte-targeting and focused ultrasound responsive glucocorticoid nano-delivery system, which accurately gathered to podocyte targets, improved podocyte morphology, reduced systemic side effects, and provided individualized visual guidance and treatment monitoring.
Review
Chemistry, Medicinal
Paola Mura, Francesca Maestrelli, Marzia Cirri, Natascia Mennini
Summary: Chitosan (CS) is a polysaccharide that is obtained from the deacetylation of chitin, making it the second most abundant biopolymer in nature after cellulose. It has attracted great interest in the pharmaceutical field due to its various beneficial features, including biocompatibility, biodegradability, non-toxicity, and simplicity of chemical modifications. CS is capable of forming films, hydrogels, and micro- and nanoparticles, and its cationic character allows for strong interactions with different molecules and exhibits antimicrobial, anti-inflammatory, and hemostatic activities. However, its solubility is pH-dependent and it is susceptible to ions, which may pose challenges. Currently, CS and its derivatives are widely investigated for pharmaceutical applications, particularly in mucosal drug delivery.
Review
Pharmacology & Pharmacy
Shilpa Lekhraj Peswani Sajnani, Yunyue Zhang, Driton Vllasaliu
Summary: Exosomes are membrane-bound nanovesicles secreted by cells and have the ability to carry small molecules, proteins, and nucleic acids to recipient cells over long distances. They show promising potential as drug delivery vehicles due to their superior stability, biocompatibility, and target specificity, thus allowing for effective crossing of biological barriers. This review focuses on discussing the current literature on exosomes used in therapeutic settings, particularly for mucosal drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Nur Aqlili Riana Alias, Winfrey Pui Yee Hoo, Pui Yan Siak, Siti Sarah Othman, Noorjahan Banu Mohammed Alitheen, Lionel Lian Aun In, Raha Abdul Rahim, Adelene Ai-Lian Song
Summary: This study investigates the potential of L. lactis NZ9000 as a host for oral vaccine delivery and proves its ability to evoke the desired mucosal immune response in the gastrointestinal tract of mice through the expression and secretion analysis of KRAS peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jing-yu Weng, Xin-xing Chen, Xiao-hua Wang, Hui-er Ye, Yan-ping Wu, Wan-yang Sun, Lei Liang, Wen-jun Duan, Hiroshi Kurihara, Feng Huang, Xin-xin Sun, Shu-hua Ou-Yang, Rong-rong He, Yi-fang Li
Summary: Psychological stress increases susceptibility to HSV-1 infection, and the underlying molecular mechanisms are unknown. This study explored the antiviral effect of rosmarinic acid (RA) and demonstrated that RA could decrease stress-augmented mortality and reduce symptoms in HSV-1-infected mice. In vitro, RA increased cell viability and inhibited stress-induced elevation of viral proteins and genes. The study revealed the critical role of lipid peroxidation in stress-induced HSV-1 susceptibility and suggested the potential of RA as an effective intervention in anti-HSV-1 therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Ying Liang, Qi Wang, Xinlan Wang, Hanyan Li, Jinshui Wang
Summary: In this study, the correlations between dough rheology and gluten aggregation were investigated by analyzing the rheological properties of low-sodium salt dough and the molecular properties of dough gluten. The results showed that low-sodium salt improved the hardness, extensibility, and compression resistance of the dough, and induced the formation of larger protein clusters. The analysis also revealed that low-sodium salt increased the content of certain glutenin subunits and reduced the content of certain gliadin fractions, resulting in the aggregation of gluten. This study provides new insights and a more comprehensive theoretical basis for sodium reduction.
FOOD HYDROCOLLOIDS
(2023)
Article
Endocrinology & Metabolism
Ming Zhong, Enyi Zhu, Na Li, Lian Gong, Hai Xu, Yong Zhong, Kai Gong, Shan Jiang, Xiaohua Wang, Lingyan Fei, Chun Tang, Yan Lei, Zhongli Wang, Zhihua Zheng
Summary: This study aimed to find key diagnostic markers and therapeutic targets for diabetic kidney disease (DKD) through bioinformatics analysis. Four potential diagnostic markers were identified and their reliability was confirmed through experiments. These results contribute to the understanding and treatment of DKD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaohua Wang, Shuo Yang, Gansheng He, Lin Xie
Summary: This study aimed to investigate the relationship between weight-adjusted waist index (WWI) and total bone mineral density (BMD) in US adolescents. The results showed a significant negative association between WWI and total BMD, with a non-linear relationship and saturation effect.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Wei Gong, Xiaohua Wang, Fengjiao Wang, Jinshui Wang
Summary: Solvent retention capacity (SRC) is a test used to evaluate the solvation of wheat flour. This study analyzed the correlations between flour quality, gluten aggregation, and solvent retention capacity using ten different commercial wheat flour varieties. The results showed significant correlations between protein content, gluten content, swelling index, and torque values with the solvent retention capacity. These findings provide a theoretical basis for assessing the quality of wheat flour.
Article
Immunology
Hui Guan, Ming Zhong, Kongyang Ma, Chun Tang, Xiaohua Wang, Muzi Ouyang, Rencai Qin, Jiasi Chen, Enyi Zhu, Ting Zhu, Yongping Lu, Yu Liu, Chengzi Tian, Zhihua Zheng
Summary: This study comprehensively investigated the roles and mechanisms of HMGB1 in different tumors. HMGB1 was found to be differentially expressed in many tumors and normal tissues, and was closely related to tumor burden, drug resistance, and various pathways of tumors. HMGB1 may serve as a novel biomarker for predicting tumor prognosis and efficacy of immune checkpoint inhibitors, and a potential target for anti-tumor therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dou Ye, Suqing Qu, Yinxiang Yang, Zhaoyan Wang, Qian Wang, Weipeng Liu, Fan Zhang, Qian Guan, Xiaohua Wang, Jing Zang, Xin Li, Hengtao Liu, Ruiqin Yao, Zhichun Feng, Zuo Luan
Summary: Immunosuppressants are not suitable for premature infants, but desensitization can induce immune tolerance. In this study, Wistar rat fetuses were injected with hOPCs-1 and returned to the mother. After desensitization, brain and muscle transplantation was performed with hOPCs-1, hNSCs-1, and hOPCs-2. The desensitized group showed higher levels of hOPCs-1 and hNSCs-1 compared to the control group, while hOPCs-2 were rejected. There were significant differences in Treg, CD4CD28, CD8CD28, and CD45RC between the desensitization and control group. Inflammatory cells were lower in the desensitized group with hOPCs-1 and hNSCs-1. hOPCs-1 could differentiate into myelin in the desensitized group. Wistar rats with desensitization developed immune tolerance.
Article
Cardiac & Cardiovascular Systems
Jiebin Hou, Xin Zhang, Zhen Wu, Yang Liu, Yabin Zhang, Jiahui Zhao, Xiaohua Wang, Hongyu Chen, Guang Yang, Qiang Ma, Qingli Cheng, Qiangguo Ao
Summary: Elderly patients with chronic heart failure (CHF) have a higher incidence of acute kidney injury (AKI), which can lead to poor prognosis. The relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP) in elderly CHF patients has been analyzed in a retrospective cohort study. The results suggest that a decreased change in NT-proBNP during AKI can reduce the risk of more severe AKI and improve survival outcomes. However, an excessive decrease in NT-proBNP is a risk factor for non-recovery of renal function following AKI, especially in elderly survivors with low baseline NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Jiasi Chen, Keping Wu, Yan Lei, Mingcheng Huang, Lokyu Cheng, Hui Guan, Jiawen Lin, Ming Zhong, Xiaohua Wang, Zhihua Zheng
Summary: The role of FABP4 in regulating ferroptosis in diabetic kidney disease was explored. The expression of FABP4 was found to be increased in kidney biopsies of DKD patients. Inhibition of FABP4 in HG-HK2 cells altered the redox state, suppressed the production of reactive oxygen species and iron, and reversed ferroptosis-associated mitochondrial damage.
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Orthopedics
Xiaohua Wang, Lin Xie, Shuo Yang
Summary: This research investigates the correlation between the weight-adjusted-waist Index (WWI) and the incidence of Rheumatoid Arthritis (RA) and Osteoarthritis (OA). The findings reveal a linear positive correlation between WWI and OA prevalence, and a complex non-linear relationship with RA prevalence.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Chemistry, Applied
Xiaohua Wang, Yangyang Chen, Jingjing Zhang, Zewen Wang, Kaijie Qi, Hongxiang Li, Ruiping Tian, Xiao Wu, Xin Qiao, Shaoling Zhang, Hao Yin
Summary: The aroma composition of 202 pear cultivars' mature fruits was analyzed using GC-MS. A total of 221 major volatile components were detected, with aldehydes, esters, and alcohols being the dominant aroma components. Variations in aroma composition and content were observed among different pear varieties, and geographical flavor characteristics were also identified. These findings provide important insights for understanding aroma variations in pear varieties and promoting pear breeding programs.
Article
Clinical Neurology
Xiaohua Wang, Qiyuan Zhu, Zichun Yan, Zhuowei Shi, Yuhui Xu, Yanbing Liu, Yongmei Li
Summary: The volume of choroid plexus (CP) in patients with multiple sclerosis (MS) is larger than that in healthy controls, and it is associated with inflammatory lesions, particularly iron rim lesions (IRLs), and deep gray matter atrophy. Additionally, the larger CP volume is related to higher disability and lower cognitive scores. CP volume may serve as an imaging marker for assessing MS disease activity.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Letter
Medicine, General & Internal
Jiebin Hou, Yabin Zhang, Jie Zhang, Yang Liu, Xiaohua Wang, Zhen Wu, Jiayu Guo, Xiaoli Sun, Qingli Cheng, Qiangguo Ao
CHINESE MEDICAL JOURNAL
(2023)
Article
Optics
Ye Zhe, Yuan Huan, Dingxin Liu, Xiaohua Wang, Aijun Yang, Mingzhe Rong
Summary: In this study, laser-induced breakdown spectroscopy (LIBS) was used to detect particulate matter in transformer oil. Data processing algorithms for baseline correction, dimensionality reduction, and classification of the original data were developed and implemented, improving data-processing efficiency and reducing errors. The results proved the scientificity and robustness of the method and provided a theoretical foundation for LIBS detection of particulate matter in transformer oil.
CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG
(2023)
