Review
Chemistry, Multidisciplinary
Madhura Murar, Lorenzo Albertazzi, Silvia Pujals
Summary: Nanomedicine utilizes nanotechnology for clinical applications and holds promise for improving cancer treatments. Personalized Medicine aims to match the most effective treatment to individual patients, and nanotheranostics, which combine therapy and diagnostic imaging, can help in treatment selection, monitoring response, and planning therapy.
Review
Biochemistry & Molecular Biology
Fariya Khan, Salman Akhtar, Mohammad Amjad Kamal
Summary: The emerging field of nanoinformatics, combining bioinformatics and nanotechnology, offers new research opportunities for the development of personalized nanomedicine in cancer therapy. This approach has the potential to revolutionize the field of precision medicine by providing non-invasive and versatile treatment options for cancer patients.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Maria Cascallar, Sandra Alijas, Alba Pensado-Lopez, Abi Judit Vazquez-Rios, Laura Sanchez, Roberto Pineiro, Maria de la Fuente
Summary: Discovering new strategies for cancer treatment is critical due to the high number of deaths caused by this disease each year. Nanomedicine-based therapies offer a promising approach for cancer treatment, with numerous formulations already in clinical use. Efficient in vivo models are needed to evaluate these therapies, and zebrafish has emerged as an ideal candidate due to its similarities with the human genome and ability to develop specific cancer models. Zebrafish can be used not only for drug screenings, but also for evaluating novel therapies such as immunotherapies and nanotherapies. Additionally, zebrafish can serve as an avatar model for personalized medicine, making it an attractive choice for evaluating new cancer treatments like nanomedicine.
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Francisco Rodriguez, Pablo Caruana, Noa De la Fuente, Pia Espanol, Maria Gamez, Josep Balart, Elisa Llurba, Ramon Rovira, Raul Ruiz, Cristina Martin-Lorente, Jose Luis Corchero, Maria Virtudes Cespedes
Summary: This review provides an overview of nanomedicine for cancer treatment, focusing on the rationale behind their designs and applications. It highlights the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments. The perspectives and challenges for nanopharmaceuticals in this field are also discussed.
Review
Gastroenterology & Hepatology
Stephen L. Chan, Nathalie Wong, W. K. Jacky Lam, Ming Kuang
Summary: Advances in systemic treatment for hepatocellular carcinoma (HCC) have introduced more options but personalized treatment approaches are crucial due to differing patient responses. Biomarker data and tumor heterogeneity analysis have proven to be effective methods in guiding treatment decisions for HCC patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Information Science & Library Science
Wei Chen, Yixin Lu, Liangfei Qiu, Subodha Kumar
Summary: Breast cancer remains a leading cause of cancer deaths among women globally, with contemporary treatment being complex and requiring highly specialized medical professionals. This research proposes a novel framework for decision support in treatment planning for early stage breast cancer patients undergoing radiotherapy, which consistently outperforms existing practices in simulation experiments. Our study contributes to the potential of healthcare information technologies in delivering cost-effective care and provides pragmatic models and tools for clinical care delivery systems.
INFORMATION SYSTEMS RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Danielle J. Beetler, Damian N. Di Florio, Katelyn A. Bruno, Tsuneya Ikezu, Keith L. March, Leslie T. Cooper Jr., Joy Wolfram, DeLisa Fairweather
Summary: Extracellular vesicles (EVs) are an important intercellular communication network released from all cells in the body, contributing to both health and disease. The specificity of EVs and their accumulation in accessible fluid spaces make them potential biomarkers and therapies for various diseases. This review discusses their use in biomarker identification, drug delivery, and regenerative medicine, highlighting their relevance in viral infections, cancer, and neurological diseases. EV biomarkers and therapeutic approaches show promise for personalized medicine due to their diversity and multifunctionality.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Frederic A. Vallejo, Ganesh Sigdel, Eduardo A. Veliz, Roger M. Leblanc, Steven Vanni, Regina M. Graham
Summary: Pediatric brain tumors continue to be a major health concern, and current treatments face challenges such as the blood-brain barrier and therapeutic toxicity. Carbon dots (CDs), a type of nanoparticle, show potential as a therapy due to their customizable properties and ability to target cancer cells while reducing toxicity. Six studies have investigated nanoparticle treatments for pediatric brain tumors, including nanoparticle drug formulations and liposomal nanoparticle formulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ping Tan, Xiaoting Chen, Hu Zhang, Qiang Wei, Kui Luo
Summary: In the past decade, nanomedicine has seen unprecedented development in disease diagnosis and treatment. Several nanomedicines have been approved for clinical use, demonstrating the potential value of transitioning nanotechnology-modified medicines from the lab to the bedside. The application of artificial intelligence (AI) in the development of nanotechnology-based products has the potential to transform healthcare by enabling the acquisition and analysis of large datasets and tailoring precision nanomedicines for cancer management.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Medicine, General & Internal
Eisuke Iwasaki, Seiichiro Fukuhara, Masayasu Horibe, Shintaro Kawasaki, Takashi Seino, Yoichi Takimoto, Hiroki Tamagawa, Yujiro Machida, Atsuto Kayashima, Marin Noda, Hideyuki Hayashi, Takanori Kanai
Summary: Pancreatic cancer is a deadly solid malignancy that often does not respond to traditional chemotherapy, highlighting the urgent need for personalized medicine. While personalized treatments for pancreatic cancer are still in development, the integration of genomic testing and high-throughput drug sensitivity testing in precision medicine is expected to revolutionize the treatment of this disease.
Review
Engineering, Biomedical
Zimeng Zhai, Yiyun Cheng, Jiaxu Hong
Summary: Glaucoma, the leading cause of irreversible blindness worldwide, requires long-term management with drugs, but there is a shortage of effective antiglaucoma drugs due to biological barriers of the human eyes. Nanomedicines have emerged as promising alternatives to conventional ophthalmic formulations, offering improved drug delivery and potential for neuroprotective treatment of damaged nerves in glaucoma.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Namid R. Stillman, Igor Balaz, Michail-Antisthenis Tsompanas, Marina Kovacevic, Sepinoud Azimi, Sebastien Lafond, Andrew Adamatzky, Sabine Hauert
Summary: The EVONANO platform aims to evolve nanomedicines for anti-cancer treatments by simulating tumor growth and using machine learning to optimize nanoparticle designs. It demonstrates how in silico models combined with machine learning can efficiently optimize nanomedicine for cancer treatment.
NPJ COMPUTATIONAL MATERIALS
(2021)
Review
Oncology
Ling-Rui Li, Bo Du, Han-Qing Liu, Chuang Chen
Summary: Artificial intelligence technology plays a crucial role in the diagnosis of thyroid cancers by extracting and analyzing image information, helping to achieve personalized medical strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antonella Barone, Nicola d'Avanzo, Maria Chiara Cristiano, Donatella Paolino, Massimo Fresta
Summary: The incidence of cancer is increasing significantly and the lack of efficacy in cancer therapies can be attributed to various factors such as delayed diagnosis, tumor regrowth, and multidrug resistance. Macrophages play a crucial role in tumor suppression or progression, and macrophage-derived extracellular vesicles (EVs) are important mediators in the tumor microenvironment. Their ability to facilitate cell-cell and organ-cell communication by delivering nucleic acids and proteins makes them potential targets for personalized anticancer nanomedicine.
Editorial Material
Nanoscience & Nanotechnology
Sarah H. Mian, Neel A. Patel, Farina Shah, Sateesh B. Arja, Farooq A. Shiekh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Editorial Material
Biotechnology & Applied Microbiology
Farooq A. Shiekh, Sarah H. Mian, Sateesh B. Arja, M. V. Raghavendra Rao
Editorial Material
Biotechnology & Applied Microbiology
Farooq A. Shiekh, Omar Farooq, Sarah H. Mian, Roxanne L. Bautista, Sateesh B. Arja, Khurshid I. Andrabi
Editorial Material
Nanoscience & Nanotechnology
Farooq A. Shiekh, Abdul-Rahman M. Abu-Izzah, Vivian J. Lee, Syed Mudassar
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Article
Engineering, Biomedical
Larry W. Hunter, Farooq A. Shiekh, George T. Pisimisis, Sung-Hoon Kim, Samuel N. Edeh, Virginia M. Miller, John C. Lieske
ACTA BIOMATERIALIA
(2011)
Letter
Nanoscience & Nanotechnology
Farooq A. Shiekh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2012)
Letter
Nanoscience & Nanotechnology
Farooq A. Shiekh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2012)
Editorial Material
Nanoscience & Nanotechnology
Farooq A. Shiekh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2014)
Article
Immunology
Eric Chabriere, Daniel Gonzalez, Said Azza, Pierrick Durand, Farooq A. Shiekh, Valerie Moal, Jean-Pierre Baudoin, Isabelle Pagnier, Didier Raoult
MICROBIAL PATHOGENESIS
(2014)
Editorial Material
Biotechnology & Applied Microbiology
Farooq A. Shiekh
Correction
Urology & Nephrology
Madhu Khullar, S. K. Sharma, S. K. Singh, Pratibha Bajwa, Farooq A. Shiekh, Vandana Relan, Meera Sharma
UROLOGICAL RESEARCH
(2012)
Editorial Material
Biotechnology & Applied Microbiology
Farooq A. Shiekh, Abdul Hameed, Omar Farooq, Mohammad Uzair Lodhi
Article
Medicine, General & Internal
Shafkat A. Lone, Abdul Hameed, Farooq A. Shiekh
Summary: Unattended children from low-socioeconomic backgrounds presenting with sudden onset obstructive respiratory and/or gastrointestinal symptoms should raise high suspicion for foreign body ingestion. Prompt diagnosis can prevent mismanagement and potentially avoid dire outcomes.
CLINICAL CASE REPORTS
(2021)
Letter
Nanoscience & Nanotechnology
Trueman C. Atughonu, Sateesh B. Arja, Farooq A. Shiekh
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2013)
