Article
Biophysics
Hongbing Liu, Xiaowen Li, Muse Ji, Na Wang, Ying Xu, Yihan Kong, Jingxin Gou, Tian Yin, Haibing He, Yu Zhang, Xing Tang
Summary: In this study, biocompatible materials were used to construct nanoparticles to enhance the efficacy of cisplatin and reduce its side effects. The nanoparticles had a small particle size and high drug loading, with improved drug release and increased bioavailability. The cellular uptake of nanoparticles was enhanced in the acidic tumor microenvironment, leading to improved efficacy and reduced side effects compared to the cisplatin solution in in vivo experiments. These micelle-like nanoparticles have great potential for cancer chemotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Applied
Weihao Meng, Hongnan Sun, Taihua Mu, Marco Garcia-Vaquero
Summary: This review summarizes the types, preparation, and functional properties of chitosan-based Pickering emulsion stabilizers, as well as the bioavailability, regulations, and future applications. Chitosan-based Pickering emulsions improved the bioavailability of compounds and find applications in various fields. However, further research and development are needed to meet consumer demand, manufacturing requirements, and regulations. Potential development trends include optimization of stabilizers, bioavailability studies, 3D-4D printing, fat substitutes, and double emulsions.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Medicinal
Peng Liu, Xiaoxue Xu, Xiaoyu Bai, Xingtong Gao, Kai Liu, Yiming Xu, Aixiang Li, Xinhua Song
Summary: In this study, polyacrylic acid grafted lutein (PAA-g-lutein) nanoparticles were prepared to improve the bioavailability of lutein. The results showed that the saturated solubility and bioaccessibility of lutein nanoparticles were significantly increased compared to free lutein. Pharmacokinetic experiments demonstrated higher plasma concentration and greater accumulation of lutein in various tissues when administered as nanoparticles. This study provides an effective and simple method for enhancing the bioavailability of lutein.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eun Suh Kim, Youjin Baek, Hyun-Jae Yoo, Ji-Soo Lee, Hyeon Gyu Lee
Summary: This study demonstrated the enhanced stability, antioxidant activity, and bioavailability of astaxanthin through encapsulation within chitosan-tripolyphosphate nanoparticles. The nanoparticles prolonged the release of astaxanthin and improved its antioxidant properties. The results suggest the potential of chitosan-tripolyphosphate nanoparticles as a delivery system for astaxanthin.
Article
Pharmacology & Pharmacy
Ayca Gungor Ak, Inci Turan, Hale Sayan Ozacmak, Aysegul Karatas
Summary: This study aimed to enhance the oral bioavailability and gastrointestinal stability of berberine chloride (BER) by preparing chitosan nanoparticles using an ionotropic gelation method. The BER-loaded chitosan nanoparticles showed an encapsulation efficiency of 31.5%, a zeta potential of 41.6 mV, a particle size of 406 nm, and a polydispersity index of 0.462. Stability studies demonstrated that the nanoparticles improved the stability of BER in simulated gastrointestinal fluids.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Guanyu Chen, Darren Svirskis, Weiyue Lu, Man Ying, Hongyu Li, Min Liu, Jingyuan Wen
Summary: In this study, N-trimethyl chitosan (TMC) was used as a mucoadhesive adjuvant to enhance the oral bioavailability and antitumour effects of gemcitabine formulated into nanocomplexes. The results showed that the TMC-modified nanocomplexes significantly improved the oral drug bioavailability and exhibited potent anticancer efficacy.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Vanessa Falchetti Lopes, Camila Nascimento Giongo, Lais de Almeida Campos, Wolf-Rainer Abraham, Rubiana Mara Mainardes, Najeh Maissar Khalil
Summary: The development of biodegradable nanoparticles, particularly chitosan-based systems, has shown promising results in improving the biological transport of chemical compounds. These nanoencapsulated systems enhance the properties of loaded drugs, including permeation, stability, and bioactivity, offering potential benefits for targeted drug delivery.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Yumeng Wei, Ke Li, Wenmei Zhao, Yingmeng He, Hongping Shen, Jiyuan Yuan, Chao Pi, Xiaomei Zhang, Mingtang Zeng, Shaozhi Fu, Xinjie Song, Robert J. Lee, Ling Zhao
Summary: This study successfully developed long-circulating solid lipid nanoparticles containing a novel curcumin derivative and demonstrated their favorable pharmacokinetics and anti-cancer effects in treating MHCC-97H liver cancer cells.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Gajendra Singh Thakur, Charu Misra, Nagarani Thotakura, Ahmed Al Saqr, Saud Almawash, Simran Preet, Kaisar Raza
Summary: The study developed a novel chitosan-based nanoconjugate for intravenous drug delivery to enhance the therapeutic efficacy of docetaxel. The system showed superior efficacy on cancer cells compared to the naive drug, improved drug bioavailability, and enhanced hemocompatibility.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Saeed A. S. Al-Zuhairy, Mahmoud H. Teaima, Nabil A. Shoman, Mohamed Elasaly, Mohamed A. El-Nabarawi, Hossam S. El-Sawy
Summary: A PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrid was developed for intranasal administration to improve the oral bioavailability of metoclopramide hydrochloride (MTC). The stability and release of the nanovesicles were optimized using Draper-Lin Design. The optimized MTC-loaded nano-vesicular in-situ gel formulation demonstrated improved bioavailability, bypassed hepatic metabolism, and enhanced brain targetability compared to other formulations.
Article
Biochemistry & Molecular Biology
Andrew Kerr, Erny Sagita, Edward D. H. Mansfield, Tri-Hung Nguyen, Orlagh M. Feeney, Colin W. Pouton, Christopher J. H. Porter, Joaquin Sanchis, Sebastien Perrier
Summary: In this study, the behavior of molecular bottle-brush and cyclic peptide self-assembled nanotubes was investigated in vitro and in vivo. The results showed that the molecular bottle-brush had the longest circulation time, while the cyclic peptide nanotubes were able to avoid organ accumulation.
Article
Pharmacology & Pharmacy
Miriam E. Klein, Max Rieckmann, Daniel Sedding, Gerd Hause, Annette Meister, Karsten Maeder, Henrike Lucas
Summary: Anionic phospholipids phosphatidylserine (PS) and phosphatidylglycerol (PG) have anti-inflammatory and immunomodulatory activities, but PEGylation of PS and PG liposomes did not effectively prolong circulation time and led to increased uptake in the spleen.
Article
Pharmacology & Pharmacy
Lydia de Salazar, Ignacio Segarra, Francisco Javier Lopez-Roman, Antonio Torregrosa-Garcia, Silvia Perez-Pinero, Vicente Avila-Gandia
Summary: The novel controlled-release powder blend shows 100% higher bioavailability of beta-alanine, opening a new paradigm that shifts from chronic to short or mid-term supplementation strategies to increase carnosine stores in sports nutrition.
Article
Multidisciplinary Sciences
Hisanao Kishimoto, Caroline Ridley, David J. Thornton
Summary: This study reveals the interaction between cyclic peptides and mucins in the gastrointestinal tract, suggesting that the mucus barrier plays a crucial role in regulating the intestinal permeation of cyclic peptides.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Huw D. Summers, Carla P. Gomes, Aida Varela-Moreira, Ana P. Spencer, Maria Gomez-Lazaro, Ana P. Pego, Paul Rees
Summary: The study utilized data simulation techniques to model nanoparticle drug delivery processes, revealing the dynamic nature of dose variation over time, including supply time constant and degradation rate constant. The model successfully replicated the dynamic changes in cell-to-cell dose variation.