Article
Biophysics
Lin Tang, Xiaoying Chen, Mei Wang, Yuhua Liu, Bowen Li, Yuke Li, Yi Zhang
Summary: This study explores the construction of an organic-inorganic composite scaffold for bone regeneration, using decellularized small intestinal submucosa (SIS) as the organic component and phosphorylated hydroxyapatite nanocrystals (nHA) as the inorganic component. The nHA@SIS scaffold showed superior physicochemical properties and osteogenic ability compared to the SIS scaffold, indicating great potential for bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Huixia He, Lili Wang, Xiangdong Cai, Qi Wang, Peng Liu, Jianxi Xiao
Summary: In this study, a biomimetic collagen composite matrix-hydroxyapatite scaffold was developed for the first time, which closely resembles the composition and structure of natural bone. The scaffold showed excellent biocompatibility and osteogenic differentiation capability, and significantly enhanced bone regeneration in rat models.
MATERIALS & DESIGN
(2023)
Article
Multidisciplinary Sciences
Huachun Wang, Jingjing Tian, Yuxi Jiang, Shuang Liu, Jingchuan Zheng, Ningyu Li, Guiyan Wang, Fan Dong, Junyu Chen, Yang Xie, Yunxiang Huang, Xue Cai, Xiumei Wang, Wei Xiong, Hui Qi, Lan Yin, Yuguang Wang, Xing Sheng
Summary: Bone fractures and defects are major health problems and synthetic scaffolds have been developed to promote bone regeneration. Electrical stimulations are effective in this process. A 3D bio-mimetic scaffold integrated with thin-film silicon microstructures is developed. The scaffold regulates cell behaviors via photo-induced electrical signals and demonstrates improved osteogenesis under optical stimulations in a rodent model.
Article
Nanoscience & Nanotechnology
Meng Chen, Yang Li, Wen-Xiu Hou, Da-Yong Peng, Jing -Kun Li, Hao-Xuan Zhang
Summary: The study developed a high-efficiency vancomycin sustained-release system with nanodiamond (ND) and prepared a composite scaffold for the treatment of infected bone defects. The scaffold exhibited excellent antibacterial effect, biocompatibility, and osteogenesis in vitro and in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Hongyun Ma, Angxiu Suonan, Jingyuan Zhou, Qiling Yuan, Liang Liu, Xiaoming Zhao, Xiaoxiao Lou, Chuncheng Yang, Dichen Li, Yin-gang Zhang
Summary: The article discusses the challenges of large bone defects caused by tumors and traumas, the development of orthopedic implants and bone tissue engineering materials, with a focus on the research progress and advantages of PEEK materials, and their successful clinical applications and achievements.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yanhuizhi Feng, Huai-Ling Gao, Di Wu, Yu-Teng Weng, Ze-Yu Wang, Shu-Hong Yu, Zuolin Wang
Summary: The bio-inspired lamellar chitosan scaffold (LCS), manufactured through a bidirectional freezing method, shows excellent mechanical properties in the hydrated state and accelerates vessel formation and soft tissue regeneration in vivo, as well as inducing macrophage differentiation to M2 macrophages.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wentao Shi, Lu Bian, Yiqing Wu, Zhe Wang, Yao Dai, Yanjun Zhou, Pengfei Meng, Qing Wang, Zhijian Zhang, Xijiang Zhao, Peng Zhao, Xiaojie Lu
Summary: In this study, fibrin-based biomaterials made of ZIF-8 and fibrin gel (Z-FG) were fabricated to enhance skull regeneration. The physical properties of Z-FG were investigated and its potential as an osteoinductive biomaterial was evaluated through assessments of bone-related proteins, calcium deposition, and alkaline phosphatase activity. The in vivo results showed increased bone formation in rat calvarial defects, suggesting that Z-FG may be a suitable biomaterial for skull tissue-engineering applications.
MACROMOLECULAR BIOSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Zhongyang Zhang, Jun Zhou, Chuang Liu, Jiaming Zhang, Yo Shibata, Na Kong, Claudia Corbo, Mitchel B. Harris, Wei Tao
Summary: Biomimetic nanotechnology plays an important role in the treatment of orthopedic diseases by restoring the structure and function of bone tissue and improving therapeutic efficacy. Understanding the pathogenesis can optimize treatment strategies. However, there are still challenges and unmet needs that hinder the clinical implementation of biomimetic nanotechnology.
TRENDS IN CHEMISTRY
(2022)
Article
Engineering, Biomedical
Zhe Liu, Qian Tang, Ruo-Tao Liu, Ming-Zhao Yu, Hao Peng, Chang-Qing Zhang, Zhen-Zhong Zhu, Xiao-Juan Wei
Summary: This article investigates the molecular mechanism and preventive strategies for implant failure in patients using long-term glucocorticoids. A customized implant targeting WNT16 was constructed using a self-assembly coating, which was found to promote bone cell growth and integration while also exhibiting antibacterial properties.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Paul D. Scesa, Eric W. Schmidt
Summary: This study used a semisynthetic strategy to produce the underlying scaffolds of coral compounds in yeast, enabling the first asymmetric synthesis of a coral compound and shedding light on the reaction mechanism. It provides insights for further exploration of the drug potential of coral resources.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Paul D. Scesa, Eric W. Schmidt
Summary: In this study, researchers successfully synthesized the key scaffold of coral terpenes in yeast through semisynthetic methods, and achieved the asymmetric synthesis of two natural products. Biomimetic methods and mechanistic studies shed light on the enzymological reactivity of coral terpenes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Ana Catarina Costa, Patricia Mafalda Alves, Fernando Jorge Monteiro, Christiane Salgado
Summary: Oral-maxillofacial tumor removal can result in bone defects and functional problems. This study developed a bioengineered construct loaded with dental stem cells and a biomimetic hydrogel for tissue imaging in live animals. The bioconstruct promoted oral osteomucosa tissue regeneration and provided insights for patient-specific therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Tierong Bian, Ni Pang, Hongyun Xing
Summary: A parallel-aligned beta-tricalcium phosphate/collagen composite nanofiber scaffold with a microstructure similar to natural bone matrix membrane was fabricated, and crosslinked with glutaraldehyde to enhance its stability. The scaffold not only promotes biomimetic apatite-like mineral deposition and bone integration during repair, but also exhibits compatibility with bone marrow mesenchymal stem cells and strong antibacterial activity against E.coli. This composite nanofiber scaffold provides a new bioactive bone scaffold material for bone defect repair with antibacterial properties.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Engineering, Biomedical
Nooshin Zandi, Banafsheh Dolatyar, Roya Lotfi, Yousef Shallageh, Mohammad Ali Shokrgozar, Elnaz Tamjid, Nasim Annabi, Abdolreza Simchi
Summary: The engineered bilayer scaffolds, composed of gelatin nanofibers and composite hydrogels, show promising potential in accelerating wound healing process. The controlled delivery of growth factors on the bilayer scaffolds enhances wound closure and tissue regeneration. The unique structure of the scaffolds mimics the extracellular matrix, providing a platform for tailored growth factor release and improved adhesion to native tissue.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Yutong Liu, Zhaogang Yang, Lixuan Wang, Lili Sun, Betty Y. S. Kim, Wen Jiang, Yuan Yuan, Changsheng Liu
Summary: By entrapping corticosteroid dexamethasone within biomimetic recombinant human bone morphogenetic protein (rhBMP)-loaded porous mesoporous bioglass scaffolds and regulating their release kinetics, significant degree of ectopic bone formation through endochondral ossification is achieved.
