Article
Biochemistry & Molecular Biology
Zhaosong Meng, Zhe Li, Shuling Guo, Danfeng Wu, Ran Wei, Jiacheng Liu, Lizhi Hu, Lei Sui
Summary: The study found that MED1 deficiency accelerates oral mucosal wound healing, possibly through regulating the expression of Activin A/Follistatin to activate the JNK/c-Jun pathway. In vitro studies showed that knockdown of MED1 enhanced the proliferation and migration of keratinocytes, promoting epithelial regeneration and accelerating the healing of oral mucosal wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Khaled M. Hosny, N. Raghavendra Naveen, Mallesh Kurakula, Amal M. Sindi, Fahad Y. Sabei, Adel Al Fatease, Abdulmajeed M. Jali, Waleed S. Alharbi, Rayan Y. Mushtaq, Majed Felemban, Hossam H. Tayeb, Eman Alfayez, Waleed Y. Rizg
Summary: This study developed a gel containing neomycin sulfate loaded in solid lipid nanoparticles for buccal mucosal wound healing, with enhanced antimicrobial activity. The optimized formulation showed good mechanical and rheological properties, regulated drug release, and increased permeability and antibacterial activity.
Article
Biotechnology & Applied Microbiology
Jie Xu, Zhenghao Zhang, Xiaofeng Ren, Yunan Zhang, Yang Zhou, Xiaorong Lan, Ling Guo
Summary: Oral mucosal wounds are susceptible to inflammation due to exposure to microorganisms. This study investigated the use of ginsenoside Rg1 in a hydrogel scaffold to treat mucosal defects in rats. The results showed that Rg1-hydrogel exhibited excellent properties and significantly improved wound healing, as evidenced by increased re-epithelialization, collagen deposition, and decreased inflammation. Molecular biology studies confirmed that Rg1-hydrogel stimulated repair-related factors and inhibited inflammatory factors secretion. These findings suggest that Rg1-hydrogel holds promise for the therapeutic management of oral mucosal wounds.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Raghuraman Manimaran, Kinnari Dinesh Patel, Venessa Maurice Lobo, Shubham Suresh Kumbhar, Venkata Vamsi Krishna Venuganti
Summary: This study demonstrates the localized application of a photosensitizer-loaded microneedle patch for effective phototherapy in oral carcinoma. The optimized parameters for the treatment were determined, and the microneedle patch showed sufficient penetration into the buccal mucosa. The localized administration of the photosensitizer significantly decreased tumor volume in a xenografted tumor model.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Medicinal
Eirini Filidou, George Kolios
Summary: Inflammatory bowel disease, Crohn's disease, and ulcerative colitis are characterized by chronic inflammation and gut microbiota diversity reduction. Probiotics have been shown to decrease inflammation, ameliorate colitis, and promote mucosal healing in IBD patients, highlighting the significant role of gut microbiota in intestinal wound healing.
Article
Polymer Science
Sook-Luan Ng, Nur Ain Azhar, Siti Balkis Budin, Norliwati Ibrahim, Nur Azurah Abdul Ghani, Norzana Abd Ghafar, Jia-Xian Law
Summary: This study compared the effects of platelet lysate (PL) derived from umbilical cord blood (CB) and peripheral blood (PB) on oral mucosal wound healing. The results showed that both CB-PL and PB-PL gels promoted the proliferation and wound closure of oral mucosal fibroblasts, with no statistical differences between the two gels. Therefore, CB-PL gel could be a potential new source of PL for regenerative treatment of oral mucosal wounds.
Article
Toxicology
Seiya Aizawa, Hidenori Yoshida, Kazuhiko Umeshita, Shinichi Watanabe, Yutaka Takahashi, Shinji Sakane, Hitoshi Sakaguchi, Shinsuke Kataoka
Summary: A method for evaluating oral mucosal irritation of oral care products and lip cosmetics using EpiOral has been developed. The results showed that the method is effective and reproducible in assessing the irritation potential of substances on the oral mucosa.
TOXICOLOGY IN VITRO
(2023)
Article
Biochemistry & Molecular Biology
Parkash Lohana, Albert Suryaprawira, Emma L. Woods, Jordanna Dally, Edward Gait-Carr, Nadia Y. A. Alaidaroos, Charles M. Heard, Kwok Y. Lee, Fiona Ruge, Jeremy N. Farrier, Stuart Enoch, Matthew P. Caley, Matthew A. Peake, Lindsay C. Davies, Peter J. Giles, David W. Thomas, Phil Stephens, Ryan Moseley
Summary: Unlike skin, oral mucosal wounds heal rapidly and with minimal scarring, possibly due to the enhanced healing properties of oral mucosal fibroblasts (OMFs). This study compared oxidative stress biomarker and antioxidant profiles between oral mucosal/skin tissues and OMFs/skin fibroblasts (SFs) to investigate the role of antioxidant capabilities and oxidative stress in the preferential healing of oral mucosa.
Review
Biotechnology & Applied Microbiology
Jinli Zhang, Changling Liu, Xiaojian Li, Zhihe Liu, Zhi Zhang
Summary: Hydrogels play a significant role in wound nursing by promoting wound healing and tissue remodeling through reducing inflammation, facilitating vascularization, and supporting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hooi Leong Loo, Bey Hing Goh, Learn-Han Lee, Lay Hong Chuah
Summary: With the increasing prevalence of impaired wound healing, there has been a growing interest in the development of novel wound dressings with enhanced healing functions. Nanoparticle-based delivery systems, particularly chitosan-based nanoparticles, have emerged as promising candidates due to their non-toxicity, biocompatibility, and bioactivity. This review focuses on the application of chitosan-based nanoparticle systems in wound treatment, discussing their properties, mechanisms, and potential for improving wound healing. The results show that chitosan-based nanoparticles exhibit superior wound healing effects, either alone or as drug delivery vehicles. Overall, there are great opportunities and potentials for the use of chitosan nanoparticles in wound healing.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Immunology
Valeria Trincado, Rikhav P. Gala, Javier O. Morales
Summary: Mucosal routes of administration for vaccines offer significant advantages in improving patient compliance and inducing more effective immune responses.
Article
Biochemistry & Molecular Biology
Leonie Wittner, Lukas Wagener, Jakob J. Wiese, Iris Stolzer, Susanne M. Krug, Elisabeth Naschberger, Rene Jackstadt, Rudi Beyaert, Raja Atreya, Anja A. Kuehl, Gregor Sturm, Miguel Gonzalez-Acera, Jay V. Patankar, Christoph Becker, Britta Siegmund, Zlatko Trajanoski, Beate Winner, Markus F. Neurath, Michael Schumann, Claudia Guenther
Summary: The paracaspase MALT1 plays a crucial role in mucosal inflammation. It is highly expressed in colonic epithelial cells of UC patients and experimental colitis. Mechanistically, MALT1 protease function inhibits ferroptosis and contributes to NF-kappa B signaling and STAT3 signaling, which are involved in inflammation and tissue healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ali Nili, Shakiba Karimi, Ali Salehi Farid, Pedram Molhem Azar, Zeinab Farimani, Haneyeh Shahbazian, Kamran Balighi, Soheil Tavakolpour, Hamidreza Mahmoudi, Maryam Daneshpazhooh
Summary: This study determines the healing time of lesions on different locations and the contributing factors to the healing time in patients with pemphigus. Buccal and lower gingival lesions are more recalcitrant to treatment, while posterior pharynx lesions heal most rapidly. Older age and gender also impact the time it takes for lesions to improve.
Article
Materials Science, Multidisciplinary
Mehrez E. El-Naggar, Ola A. Abu Ali, Dalia Saleh, M. A. Abu-Saied, M. K. Ahmed, E. Abdel-Fattah, S. F. Mansour, El-Refaie Kenawy
Summary: The Tl-HAP@PCL nanofibers, fabricated by encapsulating hydroxyapatite modified with different contributions of thallium ions within polycaprolactone scaffolds, showed variations in roughness, contact angle, and mechanical properties, demonstrating promising wound dressing capability and cell viability.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Biochemistry & Molecular Biology
Mohit Kumar, Devesh Kumar, Yogesh Garg, Syed Mahmood, Shruti Chopra, Amit Bhatia
Summary: Marine-derived polysaccharides have the desirable characteristics of biocompatibility, biodegradability, and low toxicity, making them potential materials for developing various types of wound dressings, such as hydrogels, films, and fibers. These dressings can be personalized to meet specific wound requirements and modified to enhance their properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Gizem Ceylan Turkoglu, Ayse Merih Sariisik, Sinem Yaprak Karavana
Summary: Wound healing is a complex process influenced by various factors. Careful evaluation and decision-making are necessary for wound care. Textile-hydrogel hybrids show promising mechanical and flow properties for mild to moderate exudate wounds.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Materials Science, Textiles
Nihal Atabay, Ayse Merih Sariisik, Sinem Yaprak Karavana, Seda Rencber
Summary: This study developed a medical plaster containing benzoyl peroxide microsponges and successfully transferred the microsponges onto cotton fabrics. The drug contents of the fabrics containing benzoyl peroxide loaded microsponge were within the range of 68.512-102.873%, and more than 40% of the drug was released within 6 hours.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Pharmacology & Pharmacy
Nesrin Coskunmeric, Neslihan Ustundag Okur, Mehmet Evren Okur, Sule Ayla, Aysegul Yoltas, Sinem Yaprak Karavana
Summary: This study developed an effective formulation targeting oral ulcers by loading usnic acid into nanogels, which showed good bioadhesive properties, prolonged drug release, and effective antimicrobial and wound healing activities. Further research is recommended to support its efficacy through pharmacodynamic and pharmacokinetic studies in humans.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Polymer Science
Seda Rencber, Evren Gundogdu, Cinel Koksal Karayildirim, Yucel Baspinar
Summary: The mucoadhesive gel formulation containing PTX-loaded NP demonstrated excellent drug release and adhesion properties, with no cytotoxicity to cells and suitability for vaginal application in treating genital ulcers.
IRANIAN POLYMER JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Meliha Gunes, Sinem Yaprak Karavana
Summary: Parkinson's disease is a chronic and progressive movement disorder that affects daily activities. Treatment strategies for early and advanced stages of PD focus on non-oral drug delivery systems due to GI problems causing motor fluctuations. Oral levodopa is the gold standard medication for controlling motor symptoms.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Physical
Ismail Ivedi, Bahadir Gunesoglu, Sinem Yaprak Karavana, Gulsah Ekin Kartal, Gokhan Erkan, Ayse Merih Sariisik
Summary: The aim of this study was to prepare microcapsules and transfer them to denim and non-denim trousers using different application methods. The spraying method was found to be more sustainable, and shea butter capsules can provide moisturising properties to the fabrics.
JOHNSON MATTHEY TECHNOLOGY REVIEW
(2022)
Review
Biochemistry & Molecular Biology
Seda Rencber, Ece O. Bulbul, Zeynep A. Senyigit, Neslihan U. Okur, Panoraia I. Siafaka
Summary: This review article discusses the applications of bioadhesive nanoparticles in biomedical field, including the categorization and basic characteristics of nanoparticles, as well as the biomedical applications of bioadhesive drug nanocarriers and various administration routes.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mehmet Emin Kaval, Busra Cakir, Elifsu Polatli, Seda Rencber, Sinem Yaprak Karavana, Ayse Nalbantsoy, Pelin Guneri
Summary: The present study evaluated the expression levels of IL-1 beta, IL-6, and TNF-alpha in macrophage cells induced by different medicaments. The combination of benzydamine hydrochloride and chitosan showed promising anti-inflammatory effects.
DENTAL MATERIALS JOURNAL
(2022)
Article
Materials Science, Textiles
Ismail Ivedi, Bahadir Gunesoglu, Sinem Yaprak Karavana, Gokhan Erkan, Gulsah Ekin Kartal, Ayse Merih Sariisik
Summary: The purpose of this study was to prepare antibacterial microcapsules and apply them to denim and canvas trousers. Lavender and sweet almond oil were successfully encapsulated using a spray dryer method, and capsule optimization studies were conducted. The results showed that the microcapsules had a small particle size and exhibited antibacterial properties on denim fabrics.
INTERNATIONAL JOURNAL OF CLOTHING SCIENCE AND TECHNOLOGY
(2022)
Article
Dermatology
Sakine Tuncay Tanriverdi, Evren Homan Gokce, Simtac Bengi Filiz, Fadime Aydin Kose, Sedef Kalayci, Ozgen Ozer
Summary: This study aimed to prepare liposomes suspension loaded with pomegranate peel extract to reduce hair color changing. The formulated liposomes showed a good color protection on hair fibers due to the antioxidant properties of pomegranate peel extract and the film forming effect. The prepared liposomal formulations may serve as a good alternative for reducing dyeing frequency and protecting hair fibers.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Aysu Yurdasiper, Asli Sahiner, Evren Homan Gokce
Summary: This study aimed to develop triclosan nanogels of poly(N-isopropylacrylamide) with thermoresponsive character for the treatment of acne vulgaris. It was observed that the swelling capacity of the nanogel formulations increased with the addition of triclosan and ethanol. All nanogel formulations exhibited viscoelastic behavior at 25℃, with higher elastic modulus G' at that temperature compared to 37℃. The encapsulation efficiency was found to be 47.4% and 63.7%. The nanogel formulation showed superior antibacterial activity against C. acnes compared to the commercial product. Overall, the thermoresponsive nanogel formulation of poly(N-isopropylacrylamide) demonstrated suitability for dermal applications and could potentially be an alternative to conventional formulations for the treatment of acne vulgaris.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biology
Goksel Gokce, Sinem Yaprak Karavana, Alper Bagriyanik, Cetin Pekcetin, Evren Algin Yapar, Gulsen Aybar Tural, Evren Homan Gokce
Summary: Treatment of burn wounds with gels containing antioxidants and bio-adhesives can be effective in promoting wound healing. This new approach shows promise in treating burns caused by oxidative stress.
TURKISH JOURNAL OF BIOLOGY
(2022)
Article
Toxicology
Mehmet Asi Oktan, Cihan Heybeli, Cemre Ural, Ayse Kocak, Gokcen Bilici, Zahide Cavdar, Seda Ozbal, Sevki Arslan, Osman Yilmaz, Caner Cavdar
Summary: Colistin methanesulfonate (CMS) is commonly used as a last-resort treatment for multidrug-resistant gram-negative bacterial infections in critically ill patients, but it can lead to nephrotoxicity. Alpha-lipoic acid (ALA) has been shown to protect against nephrotoxicity induced by colistin in rats by suppressing Nox4 and caspase-3, thereby exerting antioxidant and antiapoptotic effects. This suggests that ALA may be an effective strategy for managing colistin-induced nephrotoxicity.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Applied
Gokce Tetik, Seda Rencber, Ezgi T. Ozoglu, Evren A. Yapar, Sinem Y. Karavana, Ozgen Ozer
Summary: The study aimed to overcome stability and absorption issues of vitamin C through nanogel formulation, resulting in successful topical application. The developed nanogel showed promising antioxidant efficacy, making it suitable for local use.
JOURNAL OF COSMETIC SCIENCE
(2021)