期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 6, 期 -, 页码 2375-2384出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S15586
关键词
polyurethane; tissue engineering; biodegradable; fibroblast cells
资金
- Islamic Azad University of Science and Research
Background: Biodegradable polyurethanes have found widespread use in soft tissue engineering due to their suitable mechanical properties and biocompatibility. Methods: In this study, polyurethane samples were synthesized from polycaprolactone, hexamethylene diisocyanate, and a copolymer of 1,4-butanediol as a chain extender. Polyurethane scaffolds were fabricated by a combination of liquid-liquid phase separation and salt leaching techniques. The effect of the NCO: OH ratio on porosity content and pore morphology was investigated. Results: Scanning electron micrographs demonstrated that the scaffolds had a regular distribution of interconnected pores, with pore diameters of 50-300 mu m, and porosities of 64%-83%. It was observed that, by increasing the NCO: OH ratio, the average pore size, compressive strength, and compressive modulus increased. L929 fibroblast and chondrocytes were cultured on the scaffolds, and all samples exhibited suitable cell attachment and growth, with a high level of biocompatibility. Conclusion: These biodegradable polyurethane scaffolds demonstrate potential for soft tissue engineering applications.
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