Article
Biochemistry & Molecular Biology
Anvita Manjunath, G. V. Anoushka Chinmayi, Shruti Renganathan, Vivek Chandramohan, Sasmita Sabat
Summary: This study uses molecular docking and molecular dynamics simulation to demonstrate that Geranyl acetate in Coriandrum sativum has good binding affinity with proteins associated with methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa. The compound may cause abnormal function of cell wall formation. The study aims to provide a basis for further research on Coriandrum sativum as an antimicrobial agent.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Pharmacology & Pharmacy
Kannappan Arunachalam, Poonguzhali Pandurangan, Chunlei Shi, Ricardo Lagoa
Summary: Staphylococcus aureus is a versatile pathogen that causes various infections. It is important to understand its pathogenesis and develop new treatment strategies, especially against drug-resistant strains. Nanomaterials offer a potential solution to control S. aureus infections, including intracellular parasitism and multidrug resistance. This review focuses on the impact of S. aureus on human health, the role of virulence factors and biofilms, the applications of nanoparticles in controlling infections, and the prospects and limitations of nanomaterial-based therapies.
Article
Biotechnology & Applied Microbiology
Xin Bai, Jiawei Yu, Jie Xiao, Yanping Wang, Zhe Li, Hao Wang
Summary: Bone implant-associated infection is a challenging problem. Developing drug-loaded antibacterial coatings for metal implants is of interest but achieving stable local drug release is difficult. This study confirmed the successful assembly of multilamellar membrane structures and showed gradual degradation of the (MMT/HA)(10) multilamellar film structure with concentration-dependent degradation during incubation. The results demonstrated good antibacterial properties and biocompatibility of the (MMT/HA-rifampicin)(10) multilamellar film structure.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Rasmus Birkholm Gronnemose, Ditte Rask Tornby, Sara Schodt Riber, Janni Sovso Hjelmager, Lars Peter Schodt Riber, Jes Sanddal Lindholt, Thomas Emil Andersen
Summary: Surgical site infections are a common and costly healthcare-associated infection. In this study, a novel antimicrobial material concept was developed for use in artificial vascular grafts, aiming to prevent infections caused by the adhesion and colonization of microorganisms. The material was designed for permanent implantation and tested for drug-loading and drug-release properties. The results showed superior antimicrobial properties compared to existing artificial graft materials in in vitro and large-animal studies.
Article
Plant Sciences
Murugan Thulasi Meenu, Grace Kaul, Manjulika Shukla, Kokkuvayil Vasu Radhakrishnan, Sidharth Chopra
Summary: The prenyl flavone Cudraflavone C from the bark of Artocarpus hirsutus exhibits potent antibacterial activity against multidrug-resistant Staphylococcus aureus, especially when used in combination with the standard drug gentamycin. It shows bactericidal activity against a variety of MDR strains, biofilm disruption property, and an enhanced capability to kill intracellular S. aureus, making it a promising antibacterial lead candidate. Moreover, S. aureus does not develop resistance to Cud C even after prolonged exposure, highlighting its potential as an effective antibacterial drug against MDR strains.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Engineering, Biomedical
Hu Qian, Zhimin Ye, Lanping Pi, Jun Ao
Summary: This review summarizes the progress of antimicrobial GSNO applications, focusing on their anti-infective performance, underlying antibacterial mechanisms, and application in anti-infective biomaterials. The accurate overview of the roles and applications of GSNO in antibacterial biomaterials sheds new light on future studies.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Yachen Hou, Sikai Zhu, Yamiao Chen, Moxi Yu, Yongsheng Liu, Mingkai Li
Summary: A series of thiourea derivatives (TDs) were prepared and tested for their antibacterial activities, and TD4 exhibited the most potent antibacterial activity against various strains of Staphylococcus aureus (S. aureus), including methicillin-resistant Staphylococcus aureus (MRSA). It disrupted the integrity of the MRSA cell wall and showed efficacy in reducing bacterial numbers and lesion size in MRSA-induced infection in mice. These findings suggest that TD4 has potential as a lead compound for the development of novel antibacterial agents against MRSA infections.
Article
Engineering, Environmental
Amirhossein Dastneshan, Shabnam Rahiminezhad, Maryam Naderi Mezajin, Hoda Nouri Jevinani, Iman Akbarzadeh, Mohammadreza Abdihaji, Reihane Qahremani, Mehdi Jahanbakhshi, Zahra Asghari Lalami, Hamid Heydari, Hassan Noorbazargan, Ebrahim Mostafavi
Summary: Antibiotics are important for treating bacterial infections, but antibiotic resistance is a growing concern. This study developed a drug delivery mechanism using UIO-66-NH2 nanoparticles to load and release the antibiotic Cefazolin, showing promising antibacterial and antibiofilm effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Infectious Diseases
Stefan Hagel, Christina Bahrs, Richard Schumann, Mathias Pletz, Sebastian Weis
Summary: The study aimed to determine the degree of agreement among infectious diseases physician experts in the management of Staphylococcus aureus bacteraemia (SAB). The experts strongly agreed on the use of combination therapy in certain situations, but there was no consensus on the preferred antibiotic for oral stepdown therapy. This study reveals areas for further investigation.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Chemistry, Applied
Dien Puji Rahayu, Arianna De Mori, Rahmi Yusuf, Roger Draheim, Aikaterini Lalatsa, Marta Roldo
Summary: Chitosan, a natural and sustainable material, can be chemically modified to have antibacterial properties and high solubility. This study successfully synthesized a novel low molecular weight derivative CS3H Lys, which showed superior antibacterial efficacy against Staphylococcus aureus, supporting further research on its application in implant coating materials.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Jiaying Li, Shuxuan Zhang, Chang He, Jue Ling
Summary: In this study, a silk fibroin-based electrospun fiber composite film was successfully fabricated, demonstrating good mechanical properties and hemocompatibility. The material was capable of generating ROS under near infrared irradiation, effectively killing Staphylococcus aureus and promoting wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biophysics
Rita M. Mendes, Ana P. Francisco, Filomena A. Carvalho, Maissa Dardouri, Bruna Costa, Ana F. Bettencourt, Judite Costa, Lidia Goncalves, Fabiola Costa, Isabel A. C. Ribeiro
Summary: This study examined two different approaches using sophorolipids to prevent Staphylococcus aureus biofilm formation on medical grade silicone, and found that acidic sophorolipids effectively inhibit bacterial adhesion, while a release strategy with lactonic sophorolipids had a greater impact.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Medicinal
Feng Cao, Ramakumar Kinthada, Terri Boehm, Napoleon D'Cunha, Inga Leus, Cari Orth, Helen I. Zgurskaya, John K. Walker
Summary: A collection of small molecule compounds was screened against drug-resistant bacterial pathogens, and compound 1 was found to be a potent inhibitor of Staphylococcus aureus and methicillin-resistant S. aureus. However, it showed no activity against Gram-negative bacteria. Further analysis revealed that the N-propyl imidazole moiety was critical for the antibacterial activity.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Simin Tian, Yunan Hu, Xiaoxue Chen, Chang Liu, Yansong Xue, Beizhong Han
Summary: This study focused on the ultrasonic-assisted green synthesis of stable and monodispersed silver nanoparticles with antibacterial and antibiofilm activities. The AgNPs showed significant inhibitory effects on Staphylococcus aureus and effectively suppressed biofilm formation. The development of AgNPs loaded TA/Na-Alg constructs presents a promising strategy for combating S. aureus contamination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Microbiology
Huan Zhou, Lingli Chen, Kehui Ouyang, Qingfeng Zhang, Wenjun Wang
Summary: This study investigated the antibacterial activity and underlying mechanisms of flavonoids from Chimonanthus salicifolius against Staphylococcus aureus. The results showed that the flavonoid extract could destroy the cell wall and membrane, cause the loss of intracellular substance, DNA damage, and cell death. Transcriptome analysis and quantitative RT-PCR confirmed the changes in gene expression related to cell wall and membrane biosynthesis, DNA replication and repair, and energy metabolism.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
An Nguyen-My Le, Nam Minh-Phuong Tran, Thang Bach Phan, Phong A. Tran, Lam Dai Tran, Thi Hiep Nguyen
Summary: This study presented a bilayer hollow tube with a hydrophilic inner layer polyurethane/polycaprolactone/Poloxamer (PU/PCL/Poloxamer) for engineering small-diameter vascular grafts. The Poloxamer blended surface showed complicated attraction and repellent behaviors regulated by the dynamic of PEG chains, exhibiting high bioactive performance compared to other surfaces. Additionally, a hydrophobic outer layer PU/PCL was fabricated to prevent leakage and permeable transmembrane phenomenon in vascular engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shadi Houshyar, Amitava Bhattacharyya, Asma Khalid, Aaqil Rifai, Chaitali Dekiwadia, G. Sathish Kumar, Phong A. Tran, Kate Fox
Summary: The study incorporates functionalized nanodiamond and reduced graphene oxide into biodegradable polycaprolactone to develop a new multifunctional suture with temperature sensing capability and antibiotic coating function. The new suture enhances tensile strength and toughness, showing promise for monitoring and supporting wound closure.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Hien A. Tran, My Hoai Tran, Phong A. Tran
Review
Biochemistry & Molecular Biology
Victoria Wall, Thi-Hiep Nguyen, Nghi Nguyen, Phong A. Tran
Summary: Bone cement is commonly used for bone implants and orthopaedic surgeries. Antibiotic-loaded bone cements are utilized to prevent and treat prosthetic joint infections, but controlling antibiotic release is crucial for infection control and tissue integration. More research is needed to improve the regulation of antibiotic release and enhance in vitro experiment designs for better prediction of in vivo antibiotic concentrations.
Article
Materials Science, Multidisciplinary
Phong A. Tran
Summary: Researchers studied the morphology of blood clots on implanted porous scaffolds and suggested a novel role of the scaffold's microscale pores and surface roughness in supporting bone formation.
Article
Nanoscience & Nanotechnology
Hien A. Tran, Phong A. Tran
Summary: This study focused on a new method for treating and preventing biofilm infections, finding that silver/PDA coatings were effective in reducing Staphylococcus aureus growth in standard bacterial monoculture, but showed lower antimicrobial activity in co-culture with bacteria and osteoblastic cells. These interactions between bacteria and tissue cells surrounding implants may significantly contribute to their resistance to antimicrobial treatment.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Jessica L. Pelloth, Phong A. Tran, Andreas Walther, Anja S. Goldmann, Hendrik Frisch, Vinh X. Truong, Christopher Barner-Kowollik
Summary: Photoresponsive hydrogels have great potential in advanced biomedical applications, and this study reports a wavelength-dependent degradation method for bio-orthogonal poly(ethylene glycol) hydrogels, allowing fine-tuning of the hydrogel networks using different chromophores without toxicity to cells.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Thien Bui-Thuan Do, Tien Ngoc-Thuy Nguyen, Minh Hieu Ho, Nghi Thi-Phuong Nguyen, Thai Minh Do, Dai Tan Vo, Ha Thi-Ngoc Hua, Thang Bach Phan, Phong A. Tran, Hoai Thi-Thu Nguyen, Toi Van Vo, Thi-Hiep Nguyen
Summary: The study revealed that the PCLGelAg membrane was most effective in wound healing and preventing infection, serving as a practical solution for treating severe burn injuries and other infection-related skin complications.
Article
Materials Science, Biomaterials
Marsilea A. Booth, Leon Pope, Peter C. Sherrell, Alastair Stacey, Phong A. Tran, Kate E. Fox
Summary: The study investigated the surface properties of polycrystalline diamond (PCD) coated titanium scaffolds and compared it with uncoated scaffolds, finding similar levels of fibrous encapsulation in vivo.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Electrochemistry
Indika Herath, Joseph Davies, Geoffrey Will, Phong A. Tran, Amar Velic, Madjid Sarvghad, Majedul Islam, Phani Kumari Paritala, Alka Jaggessar, Michael Schuetz, Kaushik Chatterjee, Prasad K. D. V. Yarlagadda
Summary: This study successfully developed nanostructured stainless steel for biomedical and hospital applications through optimized anodization conditions. The results demonstrate the potential of electrochemical treatment in restricting bacterial and viral adhesion on metal surfaces and highlight the importance of careful optimization for surface roughness and corrosion resistance.
ELECTROCHIMICA ACTA
(2022)
Article
Materials Science, Ceramics
Chaoqun Xia, Shi Liu, Baining Cui, Mingjun Li, Hongshui Wang, Chunyong Liang, Phong A. Tran, Yan Wang, Huan Zhou, Lei Yang
Summary: This study successfully suppressed the photocatalytic activity of zinc oxide (ZnO) by incorporating amorphous selenium (Se) nanoparticles, while maintaining its ultraviolet (UV) absorption property. The research also demonstrated the improved biocompatibility and bacteriostasis ability of ZnO-Se composite.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Muhammad Saqib, Phong A. Tran, Batur Ercan, E. Yegan Erdem
Summary: Janus particles have asymmetrical nature which make them superior to conventional particles. Microfluidic-based techniques are popular for their versatility and control over reaction conditions, leading to complex functionalities being imparted to the Janus particles.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Pharmacology & Pharmacy
Tara Shabab, Onur Bas, Bronwin L. Dargaville, Akhilandeshwari Ravichandran, Phong A. Tran, Dietmar W. Hutmacher
Summary: This study combines melt-extrusion based 3D printing and porogen leaching to develop tunable multiphasic scaffolds for dental tissue regeneration. The scaffolds are highly adjustable in terms of mechanical properties, degradation kinetics, and surface morphology. The research also demonstrates improved cell attachment, proliferation, and extracellular matrix production on these multiscale scaffolds compared to single-scale counterparts, indicating their potential for enhanced tissue regeneration. Furthermore, the study explores the use of these scaffolds as drug delivery devices and shows that sustained drug release can be achieved. These findings strongly support further development of these scaffolds for dental tissue regeneration applications.
Article
Engineering, Biomedical
Sattwikesh Paul, Karsten Schrobback, Phong Anh Tran, Christoph Meinert, Jordan William Davern, Angus Weekes, Travis Jacob Klein
Summary: In this study, injectable and highly adhesive hydrogels were developed for cartilage repair and regeneration. These hydrogels showed improved mechanical properties and integration with surrounding cartilage. Preliminary results demonstrated their potential for tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Sattwikesh Paul, Karsten Schrobback, Phong Anh Tran, Christoph Meinert, Jordan William Davern, Angus Weekes, Udhaya Nedunchezhiyan, Travis Jacob Klein
Summary: Untreated osteochondral defects can lead to osteoarthritis and pose significant challenges to patients and orthopedic surgeons. This study developed a GelMA-glycol chitosan (GelMA-GC) hydrogel that is biodegradable, biocompatible, mechanically robust, and highly adhesive for cartilage repair. The hydrogel showed promising results in terms of mechanical properties, chondrocyte viability, adhesive strength, and gene expression, suggesting its potential for tissue regeneration.
APL BIOENGINEERING
(2023)
