期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 6, 期 -, 页码 3281-3293出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S27285
关键词
intracellular pathogen; infection; nanomedicine; nanoparticle; drug delivery
资金
- National Science Foundation [1003907]
- National Institutes of Health [HL091456]
- WVNano
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL091456] Funding Source: NIH RePORTER
Diseases such as tuberculosis, hepatitis, and HIV/AIDS are caused by intracellular pathogens and are a major burden to the global medical community. Conventional treatments for these diseases typically consist of long-term therapy with a combination of drugs, which may lead to side effects and contribute to low patient compliance. The pathogens reside within intracellular compartments of the cell, which provide additional barriers to effective treatment. Therefore, there is a need for improved and more effective therapies for such intracellular-diseases. This review will summarize, for the first time, the intracellular compartments in which pathogens can reside and discuss how nanomedicine has the potential to improve intracellular disease therapy by offering properties such as targeting, sustained drug release, and drug delivery to the pathogen's intracellular location. The characteristics of nanomedicine may prove advantageous in developing improved or alternative therapies for intracellular diseases.
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