Article
Food Science & Technology
Meng Ye, Qi Feng, Ying Jiang, Feng Wang, Xuexia Shi, Xiaobing Yang, Xiangdong Gao, Wei Liu
Summary: The traditional Chinese medicine Notopterygium incisum is commonly used to treat rheumatoid arthritis, and polysaccharides from N. incisum may be its main active components. In this study, a novel polysaccharide named NIP was extracted from N. incisum, which showed potential anti-inflammatory and anti-oxidative stress effects. In vitro and in vivo experiments demonstrated NIP's ability to inhibit inflammatory factors, activate signaling pathways, and restore intestinal flora imbalance, suggesting that NIP could be recommended as a functional food for rheumatoid arthritis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Paul Manka, Svenja Sydor, Nishikant Wase, Jan Best, Malte Brandenburg, Annika Hellbeck, Julia Schanzer, Ramiro Vilchez-Vargas, Alexander Link, Anja Figge, Andreas Jahnert, Ulrike von Arnim, Jason D. Coombes, Francisco-Javier Cubero, Alisan Kahraman, Moon-Sung Kim, Julia Kalsch, Sonja Kinner, Klaas-Nico Faber, Han Moshage, Guido Gerken, Wing-Kin Syn, Scott L. Friedman, Ali Canbay, Lars P. Bechmann
Summary: In this study, the potential relationship between anti-TNF treatment and hepatic steatosis in Crohn's disease was analyzed. Patients on anti-TNF treatment showed reduced hepatic steatosis, higher serum FGF19 levels, and lower levels of neutral lipids such as triglycerides. The abundance of Firmicutes, bacteria involved in bile acid metabolism and FGF19 regulation, was associated with triglyceride levels and showed group-specific alterations.
LIVER INTERNATIONAL
(2021)
Article
Rheumatology
Tate M. Johnson, Harlan R. Sayles, Joshua F. Baker, Michael D. George, Punyasha Roul, Cheng Zheng, Brian Sauer, Katherine P. Liao, Daniel R. Anderson, Ted R. Mikuls, Bryant R. England
Summary: In patients with RA, the use of MTX was associated with a reduced risk of cardiovascular events, particularly HF-related hospitalizations. However, this association was not mediated through reductions in RA disease activity, suggesting that MTX may modify CVD risk in this population through alternative mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Liana Barenbrug, Maarten te Groen, Frank Hoentjen, Joris van Drongelen, Juul M. P. A. van den Reek, Irma Joosten, Elke M. G. J. de Jong, Renate G. van der Molen
Summary: The use of anti-TNF alpha agents during pregnancy in women with immune mediated inflammatory diseases, such as IBD, RA, and PS, is associated with an increased risk of preterm birth and infections in newborns, particularly for women with IBD. However, there was no increased risk for adverse pregnancy outcomes in women with RA and PS. Vaccination in children exposed to anti-TNF alpha seems to be safe and important in reducing the risk of infections.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Rheumatology
Dimitrios A. Pappas, Heather J. Litman, Tamara Lesperance, Greg Kricorian, Elaine Karis, Sabrina Rebello, Winnie Hua, Neil A. Accortt, Scott Stryker
Summary: This study investigated the persistence of etanercept monotherapy and monotherapy with other TNFis in patients first achieving remission/LDA while on combination therapy. Results showed that etanercept demonstrated higher persistence at 6 and 12 months compared to other TNFis, and remission was a key predictor of persistence for both treatments. Patients on etanercept monotherapy experienced greater persistence and less frequent reintroduction of csDMARD compared to other TNFi monotherapies.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Andrea Giachi, Massimo Cugno, Roberta Gualtierotti
Summary: Rheumatoid arthritis is not only related to joint issues, but also to cardiovascular disease. Chronic inflammation plays a key role in accelerating atherosclerosis. Disease-modifying anti-rheumatic drugs can improve cardiovascular risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Saba Ahmed, Benna Jacob, Steven E. Carsons, Joshua De Leon, Allison B. Reiss
Summary: Rheumatoid arthritis (RA) and atherosclerotic cardiovascular disease (ASCVD) are closely related, and there is a need for therapies that can manage both conditions. Although no single therapy has shown optimal atheroprotection, certain drugs have shown promise in reducing cardiovascular adverse events in RA patients. Further research on combination therapies is ongoing.
Article
Rheumatology
Siddharth Jain, Varun Dhir, Amita Aggarwal, Ranjan Gupta, Bidyalaxmi Leishangthem, Shankar Naidu, Aastha Khullar, Supriya Maurya, Veena Dhawan, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain
Summary: This study compared the efficacy and safety of different dose escalation strategies of oral MTX in RA patients over a period of 16-24 weeks. The results showed that a faster escalation strategy was not more effective than the usual strategy, but was associated with higher gastrointestinal adverse events in the initial phase.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Niyaz Yoosuf, Mateusz Maciejewski, Daniel Ziemek, Scott A. Jelinsky, Lasse Folkersen, Malin Muller, Peter Sahlstrom, Nancy Vivar, Anca Catrina, Louise Berg, Lars Klareskog, Leonid Padyukov, Boel Brynedal
Summary: Our study identified new biomarkers for predicting response to anti-TNF treatment, revealed pathways affected by treatment, and proposed new predictive models for RA patients.
Article
Medicine, General & Internal
Daniela Anghel, Carmen Adella Sirbu, Oana-Georgiana Petrache, Daniela Opris-Belinski, Maria Magdalena Negru, Violeta-Claudia Bojinca, Cristina Florentina Plesa, Florentina Ionita Radu
Summary: Videocapillaroscopy is a simple, non-invasive investigation used to study nailfold capillaries. It is commonly used for patients with Raynaud's phenomenon and systemic sclerosis, but can also be used for patients with suspected microcirculation alterations. The study aimed to identify nailfold videocapillaroscopic abnormalities in rheumatoid arthritis and psoriatic arthritis patients and analyze their correlation with 12 months of anti-TNF-α therapy. The findings showed significant improvements in capillary density, dilated and giant capillaries, elongated capillaries, and angiogenesis after 12 months of treatment, with no avascular areas found.
Article
Biochemistry & Molecular Biology
Yezan M. Salamoun, Kishore Polireddy, Yu Kyoung Cho, Matthew R. Medcalf, Ryan S. Funk
Summary: This study found that treatment with MTX led to significant reductions in arthritis activity, affecting levels of 5mTHF, NMI, and quinolone in the blood, which may serve as potential biomarkers for therapeutic response and disease activity.
Article
Medicine, General & Internal
Boglarka Soos, Miklos Fagyas, Agnes Horvath, Edit Vegh, Anita Pusztai, Monika Czokolyova, Alexandra Csongradi, Attila Hamar, Zsofia Petho, Nora Bodnar, Gyoergy Kerekes, Katalin Hodosi, Eva Szekanecz, Szilvia Szamosi, Sandor Szanto, Gabriella Szucs, Zoltan Papp, Zoltan Szekanecz
Summary: The study revealed that anti-TNF therapy may increase ACE and ACE2 levels in the sera of RA and AS patients, and these levels are associated with disease duration, markers of inflammation, and vascular pathophysiology. The changes in ACE and ACE2 are influenced by treatment and other factors such as RF or FMD.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Borja Hernandez-Breijo, Claudia M. Brenis, Chamaida Plasencia-Rodriguez, Ana Martinez-Feito, Marta Novella-Navarro, Dora Pascual-Salcedo, Alejandro Balsa
Summary: The study found that TNFi survival did not depend on seropositivity status, but seropositive patients who received concomitant MTX had significantly longer median survival time. Additionally, the co-administration of prednisone in seropositive patients receiving TNFi was highly associated with TNFi discontinuation.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Davide Ciardiello, Brigida Anna Maiorano, Paola Parente, Maria Grazia Rodriquenz, Tiziana Pia Latiano, Cinzia Chiarazzo, Valerio Pazienza, Luigi Pio Guerrera, Brunella Amoruso, Nicola Normanno, Giulia Martini, Fortunato Ciardiello, Erika Martinelli, Evaristo Maiello
Summary: Biliary tract cancers (BTC) are aggressive tumors with limited therapeutic options. Recent advances in understanding its molecular landscape have provided new possibilities for immunotherapy, but challenges remain. This review critically analyzes completed trials and discusses future directions and potential predictive biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Concetta Panebianco, Davide Ciardiello, Annacandida Villani, Brigida Anna Maiorano, Tiziana Pia Latiano, Evaristo Maiello, Francesco Perri, Valerio Pazienza
Summary: The microbiota, particularly within the gut, plays a crucial role in the development and prognosis of pancreatic cancer by modulating the host immune system and drug metabolism, impacting the tumor microenvironment and cancer therapy success.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Concetta Panebianco, Annacandida Villani, Adele Potenza, Enrica Favaro, Concetta Finocchiaro, Francesco Perri, Valerio Pazienza
Summary: Cancer cachexia is a complex syndrome characterized by weight loss, anorexia, inflammation, and metabolic alterations, which negatively impact cancer patients. Studies have shown a link between gut microbiota and cancer cachexia, suggesting a role for dysbiosis in its pathogenesis. Different manipulation tools of gut microbiota have shown promising improvements in cachexia outcomes, paving the way for future research and clinical interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sara Gomes, Ana Catarina Rodrigues, Valerio Pazienza, Ana Preto
Summary: Finding new therapeutic approaches to colorectal cancer is crucial due to its high prevalence. Current standard therapies have limitations in terms of side effects and resistance. Microbiota-derived short-chain fatty acids have shown antitumorigenic properties and can modulate the tumor microenvironment. Manipulating the gut microbiota to increase the production of these fatty acids may be an important strategy in colorectal cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Behavioral Sciences
A. M. Tartaglione, V. Pazienza, G. Calamandrei, L. Ricceri
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors. The microbiota-gut-brain axis has been recognized as a potential therapeutic target for ASD. This article provides an overview of microbiota changes in ASD murine models and discusses therapeutic approaches targeting the microbiota and neurobehavioral profiles. Despite variations in microbiota composition among different ASD murine models, studying these models under standardized conditions can still yield valuable insights into the effects of manipulating gut microbiota on behavioral abnormalities and the underlying neurobiological mechanisms related to the gut-brain axis.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Nutrition & Dietetics
Alessio Molfino, Giovanni Imbimbo, Maria Ida Amabile, Thomas Ammann, Luana Lionetto, Gerardo Salerno, Maurizio Simmaco, Maria Grazia Chiappini, Maurizio Muscaritoli
Summary: Fatigue is a frequent symptom in HD, and this study confirms the association between IDO activity, fatigue, and muscle mass and function in HD patients. Higher Kyn/Trp ratio and IL-6 levels were observed in fatigued patients, who also had lower muscle mass and strength.
Review
Microbiology
Giovanna Cocomazzi, Silvia De Stefani, Lino Del Pup, Simone Palini, Matteo Buccheri, Mariangela Primiterra, Natale Scianname, Raffaele Faioli, Annamaria Maglione, Giorgio Maria Baldini, Domenico Baldini, Valerio Pazienza
Summary: The vaginal microbiota is crucial for the health of the female genital tract and is associated with gynecological disorders and infertility. Lactobacilli, the dominant species in the female genital tract, prevent the growth of pathogenic microorganisms through the production of lactic acid, hydrogen peroxide, and bacteriocins. Imbalance and dysbiosis of the vaginal microbiota can be caused by factors such as hormonal changes, age of reproduction, sexual practices, menstrual cycle, pregnancy, and antimicrobial drug use.
Article
Cell Biology
Concetta Panebianco, Federica Pisati, Annacandida Villani, Annapaola Andolfo, Marynka Ulaszewska, Edoardo Bellini, Carmelapia Ferro, Renato Lombardi, Fabrizio Orsenigo, Tiziana Pia Latiano, Beatrice Belmonte, Claudio Tripodo, Francesco Perri, Valerio Pazienza
Summary: Pancreatic cancer has a low survival rate due to late diagnosis and resistance to therapies. The authors studied the effects of a specific probiotic blend on mice with pancreatic cancer and found that it reduced chemotherapy side effects and decreased cancer-associated stromatogenesis. The results suggest that manipulating the microbiota could be a desirable strategy to improve the quality of life and increase the chance of cure for pancreatic cancer patients.
CELL DEATH DISCOVERY
(2023)
Article
Biology
Luisa Guttieri, Salvatore Raffa, Gerardo Salerno, Rachele Bigi, Flavia Persechino, Vincenzo Visco, Maria Rosaria Torrisi, Danilo Ranieri, Francesca Belleudi
Summary: In this study, we investigated the potential tumor-promoting role of FGFR2c isoform in AK stromal fibroblasts. We found that FGFR2c expression is upregulated in early AK lesions and accompanied by changes in CAF-related gene expression and increased autophagy. Furthermore, our results suggest that FGFR2c may contribute to the release of tumor-promoting factors such as IL-6. Overall, FGFR2c could serve as an early molecular marker predictive for the malignant progression of AK.
Article
Nutrition & Dietetics
Laura Manna, Eleonora Rizzi, Eleonora Bafile, Andrea Cappelleri, Massimiliano Ruscica, Chiara Macchi, Michele Podaliri Vulpiani, Romolo Salini, Emanuela Rossi, Concetta Panebianco, Francesco Perri, Valerio Pazienza, Federica Federici
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that have a significant impact on patients' quality of life. This study aimed to evaluate the effects of oral administration of Lentilactobacillus kefiri SGL 13 and Andrographis paniculata on DSS-treated mice.
FRONTIERS IN NUTRITION
(2023)
Article
Health Care Sciences & Services
Vincenzo Marcotrigiano, Giacomo Domenico Stingi, Prudenza Tiziana Nugnes, Sabrina Mancano, Vita Maria Lagreca, Teresa Tarricone, Gerardo Salerno, Pietro Pasquale, Paola Marchet, Giovanni Andrea Sava, Alessandro Citiulo, Monica Tissi, Stefania Oliva, Sandro Cinquetti, Christian Napoli
Summary: This study evaluates the compliance of collective catering menus in school canteens and healthcare facilities with specific guidelines. From 2018 to 2022, 85 menus were assessed, highlighting potential issues related to the lack of knowledge among nutrition professionals. The preliminary results show non-compliance, emphasizing the need for stronger prevention departments and joint official controls to ensure safe food for the target population.
Article
Immunology
Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti
Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.
Article
Multidisciplinary Sciences
Riccardo Turchi, Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Matteo Audano, Silvia Pedretti, Concetta Panebianco, Veronica Nesci, Valerio Pazienza, Alberto Ferri, Simone Carotti, Valerio Chiurchiu, Nico Mitro, Daniele Lettieri-Barbato, Katia Aquilano
Summary: Friedreich's ataxia (FA) is a neurodegenerative disease caused by a mutation in the FXN gene, leading to deficiency of mitochondrial frataxin. This study investigated the role of visceral white adipose tissue (vWAT) in FA-related metabolic complications. The findings suggest that vWAT abnormalities contribute to metabolic issues in FA, and a butyrate-enriched diet may be a safe and promising adjunct for FA management.
Article
Medicine, General & Internal
Gerardo Salerno, Marina Borro, Vincenzo Visco, Soraya Olana, Francesca Gargano, Salvatore Raffa, Virginia Zamponi, Camilla Mancini, Antongiulio Faggiano, Maurizio Simmaco, Rossella Mazzilli
Summary: This study aimed to evaluate the impact of medications on oxidative stress, inflammatory biomarkers, and semen characteristics in males with idiopathic infertility. The findings suggest a correlation between drug use and activation of the inflammatory response, which could help clarify the pathogenic mechanism of action for several pharmacological classes on male infertility.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Vincenzo Marcotrigiano, Fabio Pattavina, Lorenzo Blangiardi, Gerardo Salerno, Annamaria Dalena, Flavio Del Bianco, Marcella Di Fant, Anna Fabbro, Mariarita Forgiarini, Carola Lanzilotti, Malgorzata Wachocka, Paola Marchet, Mirko Mazzurana, Roberto Rizzi, Carmela Russo, Fabiana Salerno, Mattia Vailati, Giacomo Domenico Stingi, Patrizia Laurenti, Antonio Ferro, Sandro Cinquetti, Christian Napoli
Summary: This study investigated how 960 health visitors and environmental health officers dealt with the reallocation of tasks, fatigue, and pressure during the pandemic. The findings indicate that the synergy among preventive health professions and the complementary training of healthcare workers are crucial in overcoming future public health challenges.