Article
Endocrinology & Metabolism
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Qingyu Guo, Yannian Liao, Bingjie Yang, Tiantian Wang, Changsheng Zhou, Bin Lu, Alice P. S. Kong, Alfred S. Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
Summary: This study investigated the expressions of major brown adipose markers in white adipose tissue (WAT) of different ages and their associations with metabolic parameters and key adipokines. The findings suggest that UCP1 and PRDM16 have differential clinical correlations with metabolic features in human WAT in an age-dependent manner. UCP1 and PRDM16 may participate in the pathogenesis of ageing-related metabolic diseases with distinct mechanisms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andreas Schmid, Martin Roderfeld, Jonas Gehl, Elke Roeb, Andrea Nist, Ho-Ryun Chung, Thorsten Stiewe, Thomas Karrasch, Andreas Schaeffler
Summary: Based on the experimental results, it was found that adipocyte CTRP-3 plays a role in adipogenesis and weight gain, without impairing adipocyte differentiation. Additionally, the lack of adipocyte CTRP-3 resulted in an anti-inflammatory phenotype in AT gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lorena Mazuecos, Cristina Pintado, Blanca Rubio, Eduardo Guisantes-Batan, Antonio Andres, Nilda Gallardo
Summary: The study demonstrates that PPAR beta/delta is involved in the up-regulation of FGF21 expression induced by leptin in visceral adipose tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lisa Wrba, Rebecca Halbgebauer, Julian Roos, Markus Huber-Lang, Pamela Fischer-Posovszky
Summary: Despite efforts to improve patient outcomes, trauma remains a significant issue in clinical practice and society, particularly among younger individuals. Adipose tissue plays an essential role in regulating the posttraumatic inflammatory response, both through its secretory products and as an immune target of injured remote organs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sebastian Dommel, Matthias Bluher
Summary: Obesity is associated with adipose tissue dysfunction, leading to metabolic inflammation and increased immune cell infiltration, with CCL2 playing a crucial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Hui Qian, Xiaojuan Chao, Shaogui Wang, Yuan Li, Xiaoxiao Jiang, Zhaoli Sun, Thomas Ruelicke, Kurt Zatloukal, Hong-Min Ni, Wen -Xing Ding
Summary: Loss of SQSTM1/p62 leads to adipose tissue dysfunction and mature-onset obesity in mice. Loss of SQSTM1/p62 leads to brown adipose tissue maladaptation to alcohol consumption resulting in more severe liver injury.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stephan Wueest, Eleonora Seelig, Katharina Timper, Mark P. Lyngbaek, Kristian Karstoft, Marc Y. Donath, Helga Ellingsgaard, Daniel Konrad
Summary: Blocking IL-6 receptor increases circulating adiponectin levels and decreases leptin levels in obese individuals, positively impacting insulin sensitivity.
Review
Endocrinology & Metabolism
Shivshankar Thanigaimani, Jonathan Golledge
Summary: Improved understanding of AAA pathogenesis is crucial to identify potential treatment targets. Evidence from animal and clinical studies suggests that circulating concentrations of leptin and resistin, as well as PVAT levels, may be higher in individuals with AAA compared to controls, but the exact role in aneurysm development remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Marco Bauza-Thorbrugge, Elin Banke, Belen Chanclon, Eduard Peris, Yanling Wu, Saliha Musovic, Cecilia Jonsson, Peter Stralfors, Patrik Rorsman, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm
Summary: This study found that SERCA2 expression is downregulated in adipocytes from obese and type-2 diabetes patients, and ablation of SERCA2 leads to disturbed calcium homeostasis, impaired hormone secretion, and abnormal glucose metabolism in adipocytes. Furthermore, adipocyte-specific SERCA2 knockout also affects glucose uptake in white and brown adipose tissue, which is associated with regulated mitochondrial function.
MOLECULAR METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Ida Bager Christensen, Ida Blom, Tine Lovso Dohlmann, Fabian Finger, Jorn W. Helge, Zachary Gerhart-Hines, Flemming Dela, Steen Larsen
Summary: This study investigated the effects of statin therapy on mitochondrial function and inflammatory status in human subcutaneous white adipose tissue. The results showed that statin treatment was associated with mitochondrial respiratory capacity, but there was no clear link to the inflammatory status of adipose tissue.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ying Cui, Ziying Mo, Penglei Ji, Jingyi Zhong, Zongxin Li, Daochuan Li, Lina Qin, Qilong Liao, Zhini He, Wei Guo, Liping Chen, Qing Wang, Guanghui Dong, Wen Chen, Yongmei Xiao, Xiumei Xing
Summary: Benzene exposure may induce lipodystrophy and disrupt the endocrine function of adipose tissue, leading to disruption of lipid homeostasis and potential associations with hematotoxicity and metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
H. Y. Angeline Tan, M. F. Michelle Sim, Shi-Xiong Tan, Yvonne Ng, Sin Yee Gan, Hongyu Li, Suat Peng Neo, Jayantha Gunaratne, Feng Xu, Weiping Han
Summary: The study revealed the physiological role of HOXC10 in regulating thermogenesis in white adipose tissue and demonstrated that knocking out HOXC10 gene can induce browning. Cold exposure and beta-adrenergic stimulation can reduce HOXC10 protein levels through a proteasome-mediated degradation mechanism.
Article
Endocrinology & Metabolism
Yanli Miao, Haojie Qin, Yi Zhong, Kai Huang, Caijun Rao
Summary: This study revealed that the novel adipokine asprosin negatively regulates browning and promotes lipid deposition in adipose tissue through a Nrf2-mediated mechanism. These findings suggest that asprosin may be a promising target for the prevention and treatment of obesity and other metabolic diseases.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Ying Xu, Jialing Tang, Qianyu Guo, Yidan Xu, Kaixuan Yan, Lihong Wu, Kang Xie, Anming Zhu, Xianglu Rong, Dewei Ye, Jiao Guo
Summary: Our study aimed to investigate the preventive effect of FTZ on letrozole-induced experimental PCOS and its associated insulin resistance in mice. The results showed that FTZ significantly attenuated letrozole-induced morphological changes in the ovary, reversed PCOS-related disruption of estrous status, and markedly alleviated PCOS-related insulin resistance by enhancing circulating level and transcriptional abundance of adiponectin in adipose tissue.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Hanna Grasshoff, Helge Mueller-Fielitz, Godwin K. Dogbevia, Jakob Koerbelin, Jacqueline Bannach, Carl M. G. Vahldieck, Kristina Kusche-Vihrog, Olaf Joehren, Oliver J. Mueller, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Summary: By studying the combination of truncated promoters of brain endothelial-specific genes and short regulatory elements, new regulatory sequences have been developed that efficiently control gene expression in brain endothelial cells with greater strength and specificity.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Eva Prida, Sara Fernandez-Gonzalez, Veronica Pena-Leon, Raquel Perez-Lois, Johan Ferno, Luisa Maria Seoane, Mar Quinones, Omar Al Massadi
Summary: This article explores the interaction of melanin-concentrating hormone (MCH) with various endocrine factors and its potential use for the treatment of metabolic complications. MCH regulates energy balance and glucose homeostasis by controlling food intake, lipid metabolism, energy expenditure, and brown adipose tissue thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Ismael Gonzalez-Garcia, Adela Urisarri, Ruben Nogueiras, Carlos Dieguez, Maria L. Couce, Miguel Lopez
Summary: The maintenance and regulation of body temperature in neonates is critical for survival, and infrared thermography is a suitable non-invasive technique that can be safely applied to investigate brown adipose tissue thermogenesis in human babies.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Cell Biology
Javier Lugilde, Sabela Casado, Daniel Beiroa, Juan Cunarro, Montserrat Garcia-Lavandeira, Clara V. alvarez, Ruben Nogueiras, Carlos Dieguez, Sulay Tovar
Summary: Recent data shows that ghrelin and liver-expressed antimicrobial peptide 2 (LEAP-2) have opposite roles in food intake. LEAP-2 inhibits fasting-induced food intake, especially in lean, obese, and high-fat diet-exposed animals. LEAP-2 administration also inhibits ghrelin-induced food intake in various experimental models. The inhibitory effect on glucose levels is observed in specific experimental models, suggesting different mechanisms are involved.
Editorial Material
Gastroenterology & Hepatology
Marc Claret, Ruben Nogueiras
Review
Biochemistry & Molecular Biology
Eva Prida, Sara Alvarez-Delgado, Raquel Perez-Lois, Mateo Soto-Tielas, Ana Estany-Gestal, Johan Ferno, Luisa Maria Seoane, Mar Quinones, Omar Al-Massadi
Summary: Fibroblast growth factor 21 plays a key role in regulating metabolism and has direct effects on the central nervous system. It is involved in maintaining energy homeostasis, glucose and lipid metabolism, and insulin sensitivity. Recombinant fibroblast growth factor 21 therapies have shown efficacy in counteracting obesity and related metabolic disorders in rodents and nonhuman primates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Francois Briand, Valentin Sencio, Cyril Robil, Severine Heumel, Lucie Deruyter, Arnaud Machelart, Johanna Barthelemy, Gemma Bogard, Eik Hoffmann, Fabrice Infanti, Oliver Domenig, Audrey Chabrat, Virgile Richard, Vincent Prevot, Ruben Nogueiras, Isabelle Wolowczuk, Florence Pinet, Thierry Sulpice, Francois Trottein
Summary: Obese patients with non-alcoholic steatohepatitis (NASH) are at a higher risk of severe forms of COVID-19. This study established a diet-induced obesity and NASH model in golden hamsters to simulate the disease in humans. The findings suggest that obesity and NASH impair disease recovery in SARS-CoV-2-infected hamsters, providing a valuable model for understanding the pathophysiology of COVID-19 and evaluating treatments for severe forms of the disease in obese NASH patients.
Article
Biochemistry & Molecular Biology
Andrea G. G. Izquierdo, Marcos C. C. Carreira, Gemma Rodriguez-Carnero, Raquel Perez-Lois, Luisa M. M. Seoane, Felipe F. F. Casanueva, Ana B. B. Crujeiras
Summary: Non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) have a higher incidence in males, possibly due to the specific distribution of fat and the expression profile of genes related to tumor development. The expression pattern of most carcinogenesis-related genes in the liver is similar between obese male and female animals, except for the SURVIVIN/BIRC5 oncogene which shows higher expression in obese male rats. This trend is also observed in leukocytes from obese patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Gastroenterology & Hepatology
Ruben Nogueiras, Patricia Aspichueta
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Vincent Prevot, Ruben Nogueiras
Summary: Food odour recognition is involved in food anticipatory response. A study in Nature Metabolism explains how the olfactory system regulates metabolic adaptations based on energy availability. These effects are controlled by a brain circuit involving the melanocortin system, which regulates systemic lipid utilization through the sympathetic nervous system.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Mikel Etxandi, Isabel Baenas, Bernat Mora-Maltas, Roser Granero, Fernando Fernandez-Aranda, Sulay Tovar, Neus Sole-Morata, Ignacio Lucas, Sabela Casado, Monica Gomez-Pena, Laura Moragas, Amparo Del Pino-Gutierrez, Ester Codina, Eduardo Valenciano-Mendoza, Marc N. Potenza, Carlos Dieguez, Susana Jimenez-Murcia
Summary: Gambling disorder is a prevalent and severe condition, and its neurobiology is not fully understood. This study found that individuals with gambling disorder have distinct abnormalities in endocrine and neuropsychological factors, which can predict the presence of gambling disorder. Further exploration of endophenotypic vulnerability pathways is important for understanding the etiology and therapeutic potential of gambling disorder.
Review
Endocrinology & Metabolism
Matthias Tschoep, Ruben Nogueiras, Bo Ahren
Summary: GLP-1 receptor agonists are established pharmaceutical therapies for type 2 diabetes and obesity. They reduce glucose levels by simulating GLP-1 action and induce satiety through central actions, leading to weight reduction.
Article
Endocrinology & Metabolism
Ruben Nogueiras, Michael A. A. Nauck, Matthias H. H. Tschoep
Summary: The discovery and development of gut hormone co-agonists have revolutionized the treatment of diabetes and obesity. These therapeutics combine multiple gastrointestinal hormones into a single molecule, resulting in synergistic metabolic benefits. The GLP-1-GIP co-agonist tirzepatide, approved in 2022, has shown superior HbA1c reduction and significant weight loss in non-diabetic individuals with obesity.
Review
Endocrinology & Metabolism
Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Summary: This review discusses the key role glial cells play in regulating energy balance, emphasizing their relevance in the pathophysiology of metabolic diseases. Glial cells, located at the interface of blood vessels and neurons, participate in integrating and transmitting peripheral signals to neuronal networks in the brain for whole-body metabolism control. Metabolic diseases like obesity and type 2 diabetes can disrupt the communication mediated by glial cells between the brain and the periphery, highlighting the importance of these cell types in the pathophysiology of such complications.
Article
Endocrinology & Metabolism
Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernandez, Raquel Perez-Lois, Natalia Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia Gonzalez-Saenz, Rocio Vazquez-Cobela, Rosaura Leis, Guadalupe Sabio, Helge Mueller-Fielitz, Markus Schwaninger, Miguel Lopez, Sulay Tovar, Felipe F. Casanueva, Emmanuel Valjent, Carlos Dieguez, Vincent Prevot, Ruben Nogueiras, Luisa M. Seoane
Summary: Delayed weaning can protect rats from diet-induced obesity in adulthood by increasing thermogenesis and energy expenditure. This protective mechanism is mediated by liver-produced FGF21 signaling to the hypothalamus.