Review
Neurosciences
Lachlan Van Schaik, Christine Kettle, Rodney Green, Helen R. Irving, Joseph A. Rathner
Summary: The impact of brown adipose tissue metabolism on energy balance in humans is a new and exciting research field. Understanding the role of BAT in human energy homeostasis has the potential to offset the energy imbalance associated with obesity. The review discusses the paradoxical effects of caffeine on adenosine receptors and its potential therapeutic effects on metabolism.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Birte Niemann, Saskia Haufs-Brusberg, Laura Puetz, Martin Feickert, Michelle Y. Jaeckstein, Anne Hoffmann, Jelena Zurkovic, Markus Heine, Eva-Maria Trautmann, Christa E. Mueller, Anke Toenjes, Christian Schlein, Azin Jafari, Holger K. Eltzschig, Thorsten Gnad, Matthias Bluher, Natalie Krahmer, Peter Kovacs, Joerg Heeren, Alexander Pfeifer
Summary: This study reveals that inosine, a metabolite released during apoptosis, enhances the thermogenic program in healthy adipocytes and regulates energy expenditure. The equilibrative nucleoside transporter 1 (ENT1) controls inosine levels in brown adipose tissue, affecting thermogenic capacity. In humans, a loss of function mutation in ENT1 is associated with lower body mass index and reduced odds of obesity.
Article
Endocrinology & Metabolism
Gabriella von Essen, Erik Lindsund, Elaina M. Maldonado, Petr Zouhar, Barbara Cannon, Jan Nedergaard
Summary: This study examines the possibility of countering obesity by activating brown or beige adipose tissue and UCP1. The findings show that although UCP1 protein may increase, it is not necessarily utilized for diet-induced thermogenesis. Constant activation of UCP1 is required to effectively ameliorate obesity development.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Haopeng Xiao, Luiz H. M. Bozi, Yizhi Sun, Christopher L. Riley, Vivek M. Philip, Mandy Chen, Jiaming Li, Tian Zhang, Evanna L. Mills, Margo P. Emont, Wenfei Sun, Anita Reddy, Ryan Garrity, Jiani Long, Tobias Becher, Laura Potano Vitas, Dina Laznik-Bogoslavski, Martha Ordonez, Xinyue Liu, Xiong Chen, Yun Wang, Weihai Liu, Nhien Tran, Yitong Liu, Yang Zhang, Aaron M. Cypess, Andrew P. White, Yuchen He, Rebecca Deng, Heiko Schoder, Joao A. Paulo, Mark P. Jedrychowski, Alexander S. Banks, Yu-Hua Tseng, Paul Cohen, Linus T. Tsai, Evan D. Rosen, Samuel Klein, Maria Chondronikola, Fiona E. McAllister, Nick Van Bruggen, Edward L. Huttlin, Bruce M. Spiegelman, Gary A. Churchill, Steven P. Gygi, Edward T. Chouchani
Summary: By studying a genetically diverse cohort of mice, researchers have identified the functional architecture of brown adipose tissue (BAT) proteome and discovered key regulators of BAT. They also found proteins that are associated with protection from or sensitivity to metabolic diseases. These findings provide important insights into the conserved mechanisms of BAT regulation over metabolic physiology.
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi V. Dludla, Sinenhlanhla X. H. Mthembu, Bongani B. Nkambule, Sihle E. Mabhida, Babalwa U. Jack, Tawanda M. Nyambuya, Sithandiwe E. Mazibuko-Mbeje
Summary: Brown adipose tissue (BAT) has been extensively studied as a potential avenue to combat obesity due to its thermoregulatory function and energy expenditure promotion. In obesity, BAT and beige adipose tissue exhibit whitening characteristics, which are associated with various factors including diet, age, genetics, thermoneutrality, and chemical exposure. Whitening is marked by the accumulation of large unilocular lipid droplets, mitochondrial degeneration, and collapsed thermogenic capacity, by the virtue of mitochondrial dysfunction, devascularization, autophagy, and inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Anna-Claire Pilkington, Henry A. Paz, Umesh D. Wankhade
Summary: Adipose tissue is classified based on its characteristics, but differentiating beige adipose tissue (BeAT) remains a challenge. Recent research focuses on identifying different types of adipose tissue through transcript markers to advance understanding of their biology. The development of concrete strategies to distinguish types of adipose tissue may be crucial for improving metabolic health and preventing excessive weight gain.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Okamatsu-Ogura Yuko, Masayuki Saito
Summary: The article provides an overview of brown adipose tissue (BAT), including its functions in health and diseases, the development of inducible thermogenic adipocytes (beige adipocytes), the diversity of thermogenic mechanisms, and BAT's influence on peripheral tissues and systemic homeostasis.
DIABETES & METABOLISM JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Annie Ladoux, Pascal Peraldi, Berengere Chignon-Sicard, Christian Dani
Summary: Adipose tissue is a complex organ consisting of white and brown fat, each with distinct functions. Mature adipocytes are responsible for storing or burning energy, while adipose progenitors play a crucial role in maintaining and expanding the tissue.
Article
Biochemistry & Molecular Biology
Mei Dong, Cheng Gao, Yanxin Jia, Weijia Xu, Yan Liu, Xin Wen, Qingxin Liu, Hai Lin, Haifang Li
Summary: IL-6 plays a regulatory role in the thermogenic capability of brown adipose tissue (BAT). Knockout of IL-6 enhances BAT thermogenesis in young mice and improves glucose homeostasis, but these improvements disappear in elderly mice, possibly due to increased expression of other inflammatory cytokines.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Summary: The study identifies a group of metabolites synthesized in brown adipose tissue that can influence the metabolism of fat tissue and skeletal muscle, with anti-obesity effects in mouse models of obesity and diabetes. Brown and beige adipose tissue appear to have a significant impact on systemic metabolism through secreted signals.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Oana C. Kulterer, Carsten T. Herz, Marlene Prager, Christoph Schmoeltzer, Felix B. Langer, Gerhard Prager, Rodrig Marculescu, Alexandra Kautzky-Willer, Marcus Hacker, Alexander R. Haug, Florian W. Kiefer
Summary: There is a higher prevalence of active brown adipose tissue (BAT) in lean individuals compared to obese individuals. However, the volume and activity of BAT are similar between lean and obese individuals with active BAT. In obese participants, there is a strong negative correlation between visceral fat and BAT volume, glucose uptake, and cold-induced thermogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ming-Sheng Ye, Liping Luo, Qi Guo, Tian Su, Peng Cheng, Yan Huang
Summary: This study reveals that KCTD10 regulates thermogenesis and whole-body metabolic function in brown adipose tissue. Overexpression of KCTD10 reduces thermogenesis and leads to cold intolerance and obesity, while inhibiting Notch signaling restores thermogenesis.
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiroyuki Mori, Colleen E. Dugan, Akira Nishii, Ameena Benchamana, Ziru Li, Thomas S. Cadenhead, Arun K. Das, Charles R. Evans, Katherine A. Overmyer, Steven M. Romanelli, Sydney K. Peterson, Devika P. Bagchi, Callie A. Corsa, Julie Hardij, Brian S. Learman, Mahmoud El Azzouny, Joshua J. Coon, Ken Inoki, Ormond A. MacDougald
Summary: The study shows that adipocytes adapt to temperatures below 37 degrees C by increasing lipid metabolism and oxygen consumption, relying more on fatty acids as energy sources instead of glucose. Exposure to cool temperatures activates a shared gene expression program, including the induction of SCD1 expression and monounsaturated lipid levels.
Article
Endocrinology & Metabolism
Francisco M. Acosta, Guillermo Sanchez-Delgado, Borja Martinez-Tellez, Francisco J. Osuna-Prieto, Andrea Mendez-Gutierrez, Concepcion M. Aguilera, Angel Gil, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: This study found that BAT volume and mean radiodensity are strongly correlated with cardiometabolic risk in young men, suggesting that BAT may act as a compensatory organ in states of metabolic disruption.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Patricia Pazos, Luis Lima, Sulay Tovar, David Gonzalez-Touceda, Carlos Dieguez, Maria C. Garcia
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Patricia Pazos, Luis Lima, Felipe F. Casanueva, Carlos Dieguez, Maria C. Garcia
Article
Endocrinology & Metabolism
Isabel Castro, Luis Lima, Rafael Seoane, Joaquin Lado-Abeal
Article
Endocrinology & Metabolism
Patricia Pazos, Luis Lima, Carlos Dieguez, Maria C. Garcia
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2014)
Article
Endocrinology & Metabolism
M. Lopez, S. Tovar, M. J. Vazquez, R. Nogueiras, L. M. Seoane, M. Garcia, R. M. Senaris, C. Dieguez
INTERNATIONAL JOURNAL OF OBESITY
(2007)
Article
Endocrinology & Metabolism
MC Garcia, I Wernstedt, A Berndtsson, M Enge, M Bell, O Hultgren, M Horn, B Abrén, S Enerback, C Ohlsson, V Wallenius, JO Jansson
Article
Biochemistry & Molecular Biology
MC García, M López, O Gualillo, LM Seoane, C Diéguez, RM Señarís
Review
Developmental Biology
Maria C. Garcia, Miguel Lopez, Clara V. Alvarez, Felipe Casanueva, Manuel Tena-Sempere, Carlos Dieguez
Article
Endocrinology & Metabolism
M Lopez, LM Seoane, S Tovar, M Garcia, R Nogueiras, C Dieguez, RM Senaris
Article
Endocrinology & Metabolism
M Lopez, LM Seoane, MD Garcia, C Dieguez, R Senaris
NEUROENDOCRINOLOGY
(2002)