期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 19, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms19082371
关键词
ATP; adenosine; inflammatory bowel disease (IBD); purinergic pathway; inter-species communication; commensal bacteria
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) for the Translational Research Network Program (at the University of Tokyo)
- Japan Agency for Medical Research and Development (AMED)
- Japan Society for the Promotion of Science (JSPS)
- Science and Technology Research Partnership for Sustainable Development (SATREPS)
- Senri Life Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Takeda Science Foundation
- Uehara Memorial Foundation
- Sumitomo Foundation
- Naito Foundation
- Yakult Bio-Science Foundation
- Nippon Ham Foundation
- Kato Memorial Bio Science Foundation
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (cMAV)
Extracellular nucleotides, such as adenosine triphosphate (ATP), are released from host cells including nerve termini, immune cells, injured or dead cells, and the commensal bacteria that reside in the gut lumen. Extracellular ATP interacts with the host through purinergic receptors, and promotes intercellular and bacteria-host communication to maintain the tissue homeostasis. However, the release of massive concentrations of ATP into extracellular compartments initiates acute and chronic inflammatory responses through the activation of immunocompetent cells (e.g., T cells, macrophages, and mast cells). In this review, we focus on the functions of ATP as a pathophysiologic mediator that is required for the induction and resolution of inflammation and inter-species communication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据