期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 12, 页码 23640-23657出版社
MDPI
DOI: 10.3390/ijms151223640
关键词
betatrophin; C19orf80; chromosome 19 open reading frame 80; RIFL; lipasin; ANGPTL8; TD26; thyroid hormone; irisin; insulin and lipid
资金
- Chang Gung Molecular Medicine Research Center, Taoyuan, Taiwan [CMRPD 170091-93, NMRP 140513, 170651-53]
- National Science Council of the Republic of China [NSC 96-2320-B-182-007, 97-2320-B-182-025-MY3]
- Chang-Gung Memorial Hospital, Taoyuan, Taiwan [CMRPD190401, CMRPD190402, CMRPD190403, CMRPD190404]
Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications.
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