Article
Multidisciplinary Sciences
Carolina Morgado-Aguila, Guadalupe Gil-Fernandez, Orlando Rafael Davila-Villalobos, Jesus Perez-Rey, Purificacion Rey-Sanchez, Francisco Jose Rodriguez-Velasco
Summary: This study investigated the association between serum vitamin D levels and non-melanoma skin cancers. Despite all subjects having normal or low levels of vitamin D, it was found that higher vitamin D levels may increase the risk of non-melanoma skin cancer. Further research is needed to fully understand the relationship between vitamin D and skin cancer risk.
Article
Veterinary Sciences
Dohee Lee, Sanggu Kim, Yoonhoi Koo, Yeon Chae, Juwon Wang, Soochong Kim, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Hakhyun Kim
Summary: This study evaluated the expression of vitamin D receptor and two enzymes involved in vitamin D metabolism in the canine pancreas. The results showed a decrease in vitamin D receptor expression in inflamed pancreases, indicating a potential role of the pancreas in regulating vitamin D metabolism and suggesting its involvement in the pathophysiology of pancreatitis.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Arnaud Molin, Sandrine Lemoine, Martin Kaufmann, Pierre Breton, Marie Nowoczyn, Celine Ballandonne, Nadia Coudray, Herve Mittre, Nicolas Richard, Amelie Ryckwaert, Alinoe Lavillaureix, Glenville Jones, Justine Bacchetta, Marie-Laure Kottler
Summary: Mutations in CYP24A1 and SLC34A3 genes were found in patients with hypercalcemia, with most cases associated with renal diseases. Some patients had hypophosphatemia due to CYP24A1 mutations, while others had normal phosphatemia with SLC34A3 mutations. Variations in SLC34A1 and SLC34A3 showed uncertain significance, and some heterozygous relatives may present with biochemical changes in mineral metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Ermira Krasniqi, Arben Boshnjaku, Karl-Heinz Wagner, Barbara Wessner
Summary: The association between vitamin D level and muscle-related traits is influenced by genetic, environmental, and nutritional factors. This review systematically identifies the relationship between SNPs in vitamin D pathway-related genes with vitamin D levels and muscle traits in healthy adults. It provides valuable information for selecting candidate SNPs for further studies and personalized strategies in identifying individuals at risk for vitamin D deficiency.
Article
Biochemistry & Molecular Biology
Emmanouil Karampinis, Athina-Maria Aloizou, Efterpi Zafiriou, Alexandra Bargiota, Zoi Skaperda, Demetrios Kouretas, Angeliki-Viktoria Roussaki-Schulze
Summary: UV radiation has both harmful and beneficial effects on skin health. It can cause oxidative stress, leading to skin cancer and photoaging. However, it is also necessary for the production of vitamin D, which has important antioxidant and anticancer properties. This study found that skin cancer patients have lower levels of vitamin D and increased oxidative stress.
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. Slominski, Andrzej T. Slominski
Summary: The active metabolites of vitamin D-3 and lumisterol have antiaging and photoprotective effects on the skin through immunomodulation, antioxidative responses, and DNA repair mechanisms. They interact with multiple nuclear receptors and have potential for preventing, attenuating, or treating premature skin aging. Further clinical evaluation of topically applied derivatives is needed for future trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Saverio Caini, Patrizia Gnagnarella, Ignazio Stanganelli, Federica Bellerba, Emilia Cocorocchio, Paola Queirolo, Benedetta Bendinelli, Calogero Saieva, Sara Raimondi, Sara Gandini
Summary: The study provided a comprehensive overview of the link between vitamin D and non-melanoma skin cancer, indicating a suggestive association between vitamin D intake and blood concentration with NMSC risk, while no significant association was found between polymorphisms of VDR and VDBP genes and NMSC risk.
Article
Multidisciplinary Sciences
Sandra Alvear-Vega, Rodrigo Benavente-Contreras, Hector Vargas-Garrido
Summary: The social determinants associated with Serum 25-hydroxyvitamin D concentrations deficiency in older adults include gender, native origin, urban residence, sunlight exposure, and geographical latitude. Health promotion and prevention programs should be targeted towards older adults in urban areas, with a special focus on women, especially in the southernmost regions.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Vanessa Rosa Retamoso, Fernanda Barbisan, Graziele Meira Moro, Patricia Maurer, Debora Vasquez Rubio, Lauren Flores Viera dos Santos, Lyana Berro Feijoo, Matias Nunes Frizzo, Ivana Beatrice Manica da Cruz, Vanusa Manfredini, Ana Leticia Vargas Barcelos, Jacqueline da Costa Escobar Piccoli
Summary: This study evaluates the effect of the BsmI single nucleotide polymorphism (SNP) of the VDR gene on the expression of VDR, SOD2, and CYP24A1 genes in individuals with low serum vitamin D levels. The results show that the BsmI SNP of the VDR gene leads to overexpression of the CYP24A1 gene and low expression of the SOD2 gene. Therefore, the BsmI SNP of the VDR gene can modulate gene expression without interfering with serum vitamin D levels.
Review
Endocrinology & Metabolism
Fiammetta Romano, Domenico Serpico, Mariateresa Cantelli, Antonella Di Sarno, Carmine Dalia, Rossana Arianna, Mariarosaria Lavorgna, Annamaria Colao, Carolina Di Somma
Summary: Osteoporosis (OP) and Dermatoporosis (DP) are age-related conditions affecting the bones and skin. Both conditions are associated with increased morbidity in elderly individuals, and vitamin D deficiency plays a role in their development. Vitamin D is involved in various mechanisms related to these diseases, including immunomodulation. Deficiency of vitamin D inhibits calcium absorption and optimal bone health, leading to OP. Proper vitamin D is also important in preventing age-related skin issues like DP, as it affects collagen production, epidermal barrier function, inflammation regulation, wound healing, and sun protection.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Nina Lenherr-Taube, Edwin J. Young, Michelle Furman, Yesmino Elia, Esther Assor, David Chitayat, Tami Uster, Susan Kirwin, Katherine Robbins, Kathleen M. B. Vinette, Alan Daneman, Christian R. Marshall, Carol Collins, Kenneth Thummel, Etienne Sochett, Michael A. Levine
Summary: Mild idiopathic infantile hypercalcemia (IIH) is a common disorder in children with a distinctive vitamin D metabolite profile, primarily associated with heterozygous variants in SLC34A1 and SLC34A3. Most patients have common genetic variants, with only a minority showing variants in genes related to hypercalciuria.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Ali K. Alshabrawy, Yingjie Cui, Cyan Sylvester, Dongqing Yang, Emilio S. Petito, Kate R. Barratt, Rebecca K. Sawyer, Jessica K. Heatlie, Ruhi Polara, Matthew J. Sykes, Gerald J. Atkins, Shane M. Hickey, Michael D. Wiese, Andrea M. Stringer, Zhaopeng Liu, Paul H. Anderson
Summary: The regulation of vitamin D-3 actions is mainly through CYP24A1 enzyme activity, which is upregulated in diseases such as chronic kidney disease. A novel C-24 O-methyloxime analogue of vitamin D-3 (VD1-6) with potent CYP24A1 inhibitory properties was designed and synthesized. VD1-6 showed superior binding to CYP24A1 and inhibited its activity, indicating its potential as an alternative therapeutic candidate for treating secondary hyperparathyroidism.
Article
Biochemistry & Molecular Biology
Gabriel Henrique Campolina-Silva, Maria Clara Barata, Hipacia Werneck-Gomes, Bruna Toledo Maria, German Arturo Bohorquez Mahecha, Clemence Belleannee, Cleida Aparecida Oliveira
Summary: The study found that with aging, there were changes in the expression of vitamin D metabolizing enzymes in the prostate, leading to reduced bioavailability of calcitriol and limited vitamin D signaling, increasing the risk of lesion development.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Oncology
Weidong Lin, Heng Zou, Jinggang Mo, Chong Jin, Hao Jiang, Chengyang Yu, Zufu Jiang, Yusha Yang, Bin He, Kunpeng Wang
Summary: miR-1278 is downregulated in CRC, leading to tumor growth arrest and increased sensitivity to oxaliplatin by enhancing apoptosis and DNA damage. It suppresses KIF5B through direct binding to its 3'UTR, inhibiting CRC metastasis; and inhibits metastasis of CRC through upregulation of BTG2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Artur Shariev, Nicole Painter, Vivienne E. Reeve, Nikolas K. Haass, Mark S. Rybchyn, Furkan A. Ince, Rebecca S. Mason, Katie M. Dixon
Summary: Vitamin D reduces melanoma cell viability by targeting PTEN. The exact role of vitamin D in melanoma remains unclear.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Dermatology
Lukasz Kuzbicki, Anna A. Brozyna
Summary: The article evaluates the effectiveness of the most commonly used immunohistochemical melanocyte markers in the diagnosis of intraepidermal lesions, highlighting the different tendencies of various markers in assessing melanocyte numbers and the importance of using multiple markers in diagnosis.
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Review
Oncology
Lukasz Kuzbicki, Anna A. Brozyna
Summary: This review analyzes the effectiveness of 20 molecules as immunohistochemical markers in distinguishing dysplastic and/or Spitz nevi from early melanomas. The results show significant differences in the presence and/or levels of six potential markers in early melanomas compared to dysplastic nevi, and seven potential markers in early melanomas compared to Spitz nevi. The most promising results were obtained for 5-hydroxymethylcytosine, cyclooxygenase-2, and PReferentially expressed Antigen in MElanoma.
CANCER INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Anna A. Brozyna, Radomir M. Slominski, Boguslaw Nedoszytko, Michal A. Zmijewski, Andrzej T. Slominski
Summary: Psoriasis is a systemic, chronic, immune-mediated disease whose etiology and pathogenesis remain unknown. T-cell activation plays a key role in the development of psoriasis. Modulation of the local neuroendocrine system and vitamin D signaling have shown promising results in adjuvant treatment for psoriasis. Phototherapy, especially UVB-based, can affect serum levels of 25(OH)D, but more clinical trials are needed to establish the correlation between these changes and improvement in psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ewelina Madej, Anna A. Brozyna, Agnieszka Adamczyk, Norbert Wronski, Agnieszka Harazin-Lechowska, Anna Muzyk, Krzysztof Makuch, Michal Markiewicz, Janusz Rys, Agnieszka Wolnicka-Glubisz
Summary: RIPK4 kinase has oncogenic functions in melanoma and shows high similarity to BRAF protein, making this kinase sensitive to the BRAF inhibitors vemurafenib and dabrafenib. BRAFi downregulates RIPK4 in both BRAF-mutated and wild-type cells. Although downregulation and upregulation of RIPK4 does not affect signal transduction through the BRAF/MEK/ERK pathway in melanoma, it can inhibit cell proliferation and the FAK/AKT pathway.
Review
Biochemistry & Molecular Biology
Georgeta Bocheva, Radomir M. M. Slominski, Andrzej T. T. Slominski
Summary: The increase in air pollution worldwide poses a global environmental risk to human health. The skin is exposed to harmful air pollutants, which can lead to cutaneous damage. UV radiation can activate photoreactive pollutants, enhancing their detrimental effects on the skin. Air pollution also reduces UVB radiation, inhibiting vitamin D synthesis and compromising cutaneous structural integrity. Moreover, air pollution can interact with skin microbiota and trigger or worsen skin diseases through oxidative stress and inflammatory responses. The aryl hydrocarbon receptor (AhR) plays a crucial role in responding to (photo)pollution and targeting AhR/Nrf2 could be a promising treatment for inflammatory skin diseases caused or exacerbated by air pollutants. Hence, AhR and its downstream regulatory pathways are important signaling systems that regulate the skin phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Robert C. Tuckey, Chloe Y. S. Cheng, Lei Li, Yuhan Jiang
Summary: Our study found that 25-hydroxyvitamin D3 (25(OH)D3) can exist in the human circulation in the sulfated form, and can be metabolized by vitamin D-metabolizing cytochromes P450 (CYPs). Specifically, CYP27A1 can convert vitamin D3 sulfate to 25(OH)D3 3-sulfate, while CYP11A1 can convert vitamin D3 sulfate to 20(OH)D3 3-sulfate, but at a lower rate.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Neurosciences
Radomir M. Slominski, Chander Raman, Jake Y. Chen, Andrzej T. Slominski
Summary: During oncogenesis, tumors can affect local and systemic homeostasis by producing cytokines, immune mediators, neurotransmitters, and other substances. They can control the central neuroendocrine and immune systems to promote their own growth and expansion.
TRENDS IN NEUROSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kinga Linowiecka, Andrzej T. Slominski, Russel J. Reiter, Markus Boehm, Kerstin Steinbrink, Ralf Paus, Konrad Kleszczynski
Summary: The indoleamine hormone melatonin, derived from the pineal gland, regulates various cellular processes including the circadian rhythm, proliferation, apoptosis, oxidative damage, immune regulation, pigmentation, and mitochondrial metabolism. Melatonin has been shown to have effects on DNA methylation, which is involved in cancer initiation and non-malignant diseases development. This review discusses the potential role of melatonin as an epigenetic regulator by modulating DNA methylation through changes in the expression of DNA methyltransferases (DNMTs) and ten-eleven translocation (TET) proteins. The authors suggest that melatonin could be used in combination with epigenetic drugs as a new anticancer strategy.
Article
Biochemistry & Molecular Biology
Warusavithana Gunawardena Manori De Silva, Bianca Yuko McCarthy, Jeremy Han, Chen Yang, Andrew J. A. Holland, Harvey Stern, Katie Marie Dixon, Edith Kai Yan Tang, Robert Charles Tuckey, Mark Stephen Rybchyn, Rebecca Sara Mason
Summary: In this study, it was found that the over-irradiation metabolite 24(OH)L-3 provided photoprotection against UV-induced DNA damage similar to that of 1,25(OH)(2)D-3. The mechanisms involved increased energy availability and DNA repair, as well as decreased reactive oxygen species.
Article
Biochemistry & Molecular Biology
Andrzej T. Slominski, Tae-Kang Kim, Radomir M. Slominski, Yuwei Song, Shariq Qayyum, Wojciech Placha, Zorica Janjetovic, Konrad Kleszczynski, Venkatram Atigadda, Yuhua Song, Chander Raman, Cornelis J. Elferink, Judith Varady Hobrath, Anton M. Jetten, Russel J. Reiter
Summary: Melatonin and its metabolites have various effects, including interactions with AhR and PPAR γ. They can reduce cellular damage at high concentrations and serve as therapeutic agents for skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Dermatology
Andrzej T. Slominski, Robert C. Tuckey, Anton M. Jetten, Michael F. Holick
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lei Li, Robert C. Tuckey
Summary: Vitamin D exists in two forms, D3 produced in the skin and D2 obtained from the diet. The enzyme CYP24A1 plays a crucial role in oxidizing and inactivating both forms of vitamin D, regulating their serum levels. This study aimed to clarify the pathways of oxidation for 25(OH)D2 and 1,25(OH)(2)D2 and compare their metabolism with their vitamin D3 counterparts.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dongxian Wu, Gareth Nealon, Yuchen Liu, Tae-Kang Kim, Andrzej T. Slominski, Robert C. Tuckey
Summary: Lumisterol2 (L2) is a photoproduct of UVB action on ergosterol, which is present in edible mushrooms and human skin. CYP27A1 efficiently metabolizes L2 to produce three major hydroxy-L2 products, while CYP11A1 has minimal effect on L2 metabolism. The major CYP27A1-derived hydroxy-L2 products have anti-proliferative activity on skin-cancer cell lines.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chantal E. Holtkamp, Dawid Warmus, Klaudia Bonowicz, Maciej Gagat, Kinga Linowiecka, Agnieszka Wolnicka-Glubisz, Russel J. Reiter, Markus Boehm, Andrzej T. Slominski, Kerstin Steinbrink, Konrad Kleszczynski
Summary: Melatonin is a powerful antioxidant with various benefits, including anti-inflammatory, immunomodulatory, and anti-tumor properties. It has been found to counteract the intracellular disturbances caused by UVB radiation. The mechanisms of action of melatonin and its derivatives are still not fully understood.