Article
Pharmacology & Pharmacy
Magdalena Jarosz, Jakub Latosinski, Pawel Gumulka, Monika Dabrowska, Mariusz Kepczynski, Grzegorz Dariusz Sulka, Malgorzata Starek
Summary: By synthesizing and determining the optimal composition of celecoxib-beta-cyclodextrin complexes, and using them in nanostructured titanium dioxide layers as drug delivery systems, effective drug release can be achieved, making it suitable for pain treatment, such as orthopedic surgeries.
Article
Polymer Science
Hemat M. Dardeer, Arafat Toghan, Magdi E. A. Zaki, Rokaia B. Elamary
Summary: Polymers and their composites have been widely studied for pharmaceutical and biomedical applications. In this study, three novel PEG-based polymers were synthesized and characterized. These polymers showed promising results as drug carriers, exhibiting superior antibacterial and antibiofilm properties compared to the pure drug.
Article
Chemistry, Multidisciplinary
Maryam Monajati, Ali Mohammad Tamaddon, Samira Sadat Abolmaali, Gholamhossein Yousefi, Mahboobeh Jafari, Reza Heidari, Sedigheh Borandeh, Negar Azarpira, Rasoul Dinarvand
Summary: A self-assembled supramolecular network was synthesized through host-guest chemistry, resulting in the formation of biocompatible nanogels that have potential biomedical applications.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Roberto Zagami, Anna Barattucci, Luigi Monsu Scolaro, Maurizio Viale, Giuseppina Raffaini, Paola Maria Bonaccorsi, Antonino Mazzaglia
Summary: This article introduces the potential application of non-ionic cyclodextrin-based nanoassemblies as nanocomplex adjuvants in anticancer therapy. The nanoassemblies were prepared by solvent evaporation method and characterized by spectroscopic techniques. Theoretical studies were performed to understand the formation and stability of the nanoassemblies. Experimental results showed that the nanoassemblies exhibited similar anticancer activity to free curcumin in different cancer cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Miguel Ferreira, Diana Gomes, Miguel Neto, Luis A. Passarinha, Diana Costa, Angela Sousa
Summary: In this study, chitosan/sulfonyl-ether-beta-cyclodextrin (SBE-beta-CD)-conjugated delivery systems were used to improve the solubility and bioavailability of quercetin in cervical cancer cells. The formulations using high molecular weight chitosan and SBE-beta-CD showed the best results, with nanoparticle sizes of 272.07 +/- 2.87 nm, a polydispersity index (PdI) of 0.287 +/- 0.011, a zeta potential of +38.0 +/- 1.34 mV, and an encapsulation efficiency of approximately 99.9%. The delivery systems exhibited increased cytotoxic effect on HeLa cells, indicating a significant improvement in quercetin bioavailability.
Review
Pharmacology & Pharmacy
Chengyuan Xing, Xiaoming Zheng, Tian Deng, Ling Zeng, Xin Liu, Xinjin Chi
Summary: Cyclodextrins (CyDs) are widely studied in nano drug delivery systems due to their good compatibility, low toxicity, and improved drug pharmacokinetics. The unique internal cavity of CyDs widens their applications in drug delivery. Moreover, the polyhydroxy structure of CyDs allows for inter- and intramolecular interactions and chemical modification, further extending their functions. The versatile functions of CyDs contribute to altering the characteristics of drugs, offering therapeutic promise, stimulus-responsive properties, self-assembly capability, and fiber formation. This review discusses recent strategies and roles of CyDs in nanoplatforms, providing guidance for developing novel nanoplatforms. The future perspectives on CyD-based nanoplatform construction are also discussed, offering potential directions for rational and cost-effective delivery vehicles.
Article
Chemistry, Physical
Rajaram Rajamohan, Mika Sillanpaa, Angaiah Subramania
Summary: Nanofibrous mats and cyclodextrins are essential components in drug releasing systems, with cyclodextrins playing a key role in enhancing drug release profile by forming inclusion complexes. This study focused on analyzing the drug release profile of benzocaine using electrospun PVdF nanofibrous mats, with and without beta-cyclodextrin, demonstrating enhanced drug release ability with the presence of beta-CD due to increased solubility of benzocaine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Pharmacology & Pharmacy
Alvaro Sarabia-Vallejo, Maria del Mar Caja, Ana I. Olives, M. Antonia Martin, J. Carlos Menendez
Summary: Many active pharmaceutical ingredients have low oral bioavailability due to factors such as poor solubility and physical and chemical instability. The formation of inclusion complexes with cyclodextrins can improve the oral bioavailability of many drugs. The microencapsulation process can modify key properties of the included drugs. Examples of stabilizing labile drugs and increasing the bioavailability of class IV drugs through inclusion complex formation are discussed. The stabilization and improvement in nutraceuticals used as food supplements is also considered. Cyclodextrin-based nanofibers lead to significant bioavailability enhancements. The synthesis of chemically modified cyclodextrins, polymers, and nanosponges based on cyclodextrins is discussed, as well as analytical techniques for characterizing inclusion complexes.
Review
Chemistry, Applied
Chandrakantsing Pardeshi, Rucha Kothawade, Ashwini R. Markad, Sagar R. Pardeshi, Abhijeet D. Kulkarni, Prashant J. Chaudhari, Marcela R. Longhi, Namdev Dhas, Jitendra B. Naik, Sanjay J. Surana, Monica C. Garcia
Summary: Sulfobutylether fi-cyclodextrin (SBE-fi-CD) is a polyanionic cyclic oligosaccharide with a torus ring-like structure. It has high solubility, stability, and biocompatibility, making it a promising polymer for drug delivery. This review discusses the structure, properties, and preparation methods of SBE-fi-CD-based inclusion complexes (ICs) and their applications in nano-particulate drug delivery systems. It also provides information on patents and FDA-approved products, as well as toxicological aspects and clinical status of SBE-fi-CD-based products.
CARBOHYDRATE POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Krishna Manjari Sahu, Swapnita Patra, Sarat K. Swain
Summary: This review critically analyzes the host-guest mechanism for drug release from polysaccharide-supported beta-CD inclusion complex. It compares various polysaccharides such as cellulose, alginate, chitosan, dextran, etc. and their association with beta-CD in relevant to drug delivery. The drug release capacity, mode of drug release, and characterization techniques of individual polysaccharide-based CD complexes are comparatively established in tabular form. This review provides better visibility for researchers working in the area of controlled release of drugs by carrier consisting of beta-CD associated polysaccharide composite through host-guest mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Marieta Constantin, Bogdan Cosman, Paolo Ascenzi, Bogdan C. Simionescu, Gheorghe Fundueanu
Summary: This study developed a chromatographic method to determine drugs that form the most stable inclusion complexes with cyclodextrins. The results showed that the most stable complexes were not able to gradually release the drugs, possibly due to the continuous association and dissociation of the drug/cyclodextrin complexes in aqueous solution.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Chemistry, Physical
Larissa dos Santos Silva Araujo, Giuseppe Lazzara, Leonardo Chiappisi
Summary: This study provides a comprehensive overview of the thermodynamics aspects of surfactants and CDs inclusion complexes formation in aqueous environment, emphasizing the assessment of interactions, thermodynamic driving forces, and structural aspects. It also discusses the most common analytical techniques used to gather deep insight into CDs complexes, pointing out the perspectives for the surfactant-cyclodextrin complexes.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Karen Escobar, Karla A. Garrido-Miranda, Ruth Pulido, Nelson Naveas, Miguel Manso-Silvan, Jacobo Hernandez-Montelongo
Summary: This review comprehensively covers the chemical properties and synthesis routes of CD/CTR cross-linking, as well as their applications as drug-delivery systems on different substrates. The study found that the CD/CTR biopolymers were nontoxic, environmentally friendly, and inexpensive, making them widely used in coating implants and biomedical materials. The importance of pretreatment methods on substrates and the analysis of release mechanisms, including the Korsmeyer-Peppas mathematical model, were also discussed. The flexibility of CD/CTR in hosting a wide variety of drugs, integrating with diverse implantable materials, and controllable release kinetics provide a range of advantages for future uses.
Article
Polymer Science
Kalyan Ramesh, Chelladurai Karthikeyan Balavigneswaran, Sonita A. P. Siboro, Vignesh Muthuvijayan, Kwon Taek Lim
Summary: Supramolecular micelles based on beta-cyclodextrin and adamantine-terminated linear-poly(lactic-co-glycolide) were successfully developed for on-demand drug release in cancer therapy. The micelles showed enhanced drug release in acidic environments, high cytotoxicity against cancer cells, and biocompatibility with non-cancerous cells, suggesting their potential as a robust and sustained anticancer drug delivery system.
Article
Chemistry, Multidisciplinary
Qianming Lin, Longyu Li, Miao Tang, Shuntaro Uenuma, Jayanta Samanta, Shangda Li, Xuanfeng Jiang, Lingyi Zou, Kohzo Ito, Chenfeng Ke
Summary: The study demonstrates a method for controlling molecular assembly structures through kinetic trapping design and amplifying them to the macroscale, achieving the capturing of transient polypseudorotaxanes from solution and obtaining materials with different physical properties. By 3D printing different shapes of polypseudorotaxane networks, moisture-responsive actuators can be constructed.
Article
Pharmacology & Pharmacy
Susana Barbosa Ribeiro, Aurigena Antunes de Araujo, Maisie Mitchele Barbosa Oliveira, Alaine Maria dos Santos Silva, Arnobio Antonio da Silva-Junior, Gerlane Coelho Bernardo Guerra, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao, Raimundo Fernandes de Araujo Junior, Vinicius Barreto Garcia, Roseane Carvalho Vasconcelos, Caroline Addison Carvalho Xavier de Medeiros
Summary: Oral mucositis, characterized by severe ulcers in the oral region from chemotherapy, lacks effective therapy. Dexamethasone-loaded nanoparticles showed therapeutic effects in a hamster model, reducing inflammation, oxidative stress, and modulating gene expression.
Article
Chemistry, Medicinal
Nayara Sousa da Silva, Nathalia Kelly Araujo, Alessandra Daniele-Silva, Johny Wysllas de Freitas Oliveira, Julia Maria de Medeiros, Renata Mendonca Araujo, Leandro De Santis Ferreira, Hugo Alexandre Oliveira Rocha, Arnobio Antonio Silva-Junior, Marcelo Sousa Silva, Matheus de Freitas Fernandes-Pedrosa
Summary: The study focused on the enzymatic production, characterization, and in vitro evaluation of the cytotoxic, antibacterial, antifungal, and antiparasitic effects of chitooligosaccharides (COSs) obtained from the hydrolysis of chitosan. NMR and mass spectrometry analyses revealed the presence of a mixture with 81% deacetylated COS and acetylated hexamers. COSs demonstrated no cytotoxicity at concentrations below 2 mg/mL, and showed promising activity against bacteria, yeasts, and exhibited time-dependent parasitic inhibition.
Review
Pharmacology & Pharmacy
Virginia Aiassa, Claudia Garnero, Marcela R. Longhi, Ariana Zoppi
Summary: This article discusses the use of amino acids, organic acids and bases, and water-soluble polymers as auxiliary excipients for multicomponent complexation, with a focus on improving properties by including information on various relevant drugs. The review also summarizes the use of multicomponent CD complexes to enhance therapeutic drug effects.
Review
Pharmacology & Pharmacy
Sarah de Sousa Ferreira, Diana Pontes da Silva, Manoela Torres-Rego, Arnobio Antonio Da Silva-Junior, Matheus De Freitas Fernandes-Pedrosa
Summary: Snakebite envenoming is a serious global health issue, and current treatment options have limitations, necessitating the exploration of new alternatives. Research on plant-derived compounds to counter the effects of snake venom has shown promise, particularly the use of phenolic acids. Studies indicate that these acids have potential antiophidic properties and could be a valuable area for future drug development in snakebite treatment.
Article
Pharmacology & Pharmacy
Johny Wysllas de Freitas Oliveira, Mariana Farias Alves da Silva, Igor Zumba Damasceno, Hugo Alexandre Oliveira Rocha, Arnobio Antonio da Silva Junior, Marcelo Sousa Silva
Summary: This study investigated the encapsulation of sodium diethyldithiocarbamate (DETC) by poly-lactic acid (PLA) in nanoparticles for the treatment of Chagas disease caused by Trypanosoma cruzi. The nanoparticles showed reduced toxicity against cells and maintained antiparasitic activity. The physical characterization of the nanoparticles demonstrated a small size and negative zeta potential. The encapsulated DETC exhibited similar efficacy against T. cruzi as the free form.
Article
Pharmacology & Pharmacy
Rafaella Moreno Barros, Camila Garcia Da Silva, Kammila Martins Nicolau Costa, Arnobio A. Da Silva-Junior, Cassio Rocha Scardueli, Rosemary Adriana Chierici Marcantonio, Leila Aparecida Chiavacci, Joao Augusto Oshiro-Junior
Summary: This study developed hydrophobic membranes with incorporated dexamethasone for the treatment of bone defects. The membranes showed delayed and prolonged release of dexamethasone, indicating their potential for bone regeneration.
Article
Plant Sciences
Maria Jose Sarmento-Filha, Manoela Torres-Rego, Alessandra Daniele-Silva, Moacir Fernandes de Queiroz-Neto, Hugo Alexandre Oliveira Rocha, Celso Amorim Camara, Renata Mendonca Araujo, Arnobio Antonio da Silva-Junior, Tania Maria Sarmento Silva, Matheus de Freitas Fernandes-Pedrosa
Summary: This study investigated the antioxidant and anti-inflammatory potential of Cochlospermum vitifolium flowers. The results showed that the ethanolic extract and ethyl acetate fraction exhibited higher concentrations of phenolic compounds and stronger antioxidant action compared to other fractions. The extract and fraction also demonstrated effectiveness in reducing paw edema and decreasing leukocytes cells, total proteins, and cytokines levels in the inflammation models. This research provides evidence for the antioxidant and anti-inflammatory effects of the ethanolic extract and ethyl acetate fraction of C. vitifolium flowers.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Chemistry, Physical
Guadalupe G. Minambres, Virginia Aiassa, Marcela R. Longhi, Ana K. Chattah, Claudia Garnero
Summary: This study provides comprehensive characterization of clarithromycin polymorphs, comparing an ethanol solvate (form 0) with the currently used form II. The study reveals important intermolecular interactions and characteristics, and investigates the biopharmaceutical properties and physical stability of the ethanol solvate.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Food Science & Technology
Emanuell dos Santos-Silva, Manoela Torres-Rego, Fiamma Glaucia-Silva, Renata Carvalho Feitosa, Ariane Ferreira Lacerda, Hugo Alexandre de Oliveira Rocha, Matheus de Freitas Fernandes-Pedrosa, Arnobio Antonio da Silva-Junior
Summary: This study investigated a novel immunoadjuvant - biocompatible cationic nanoparticles loaded with Bothrops jararaca venom, demonstrating similar or improved immune response in antibody production. These nanoparticles can stably release proteins, activate immune response, and have been proven to be a promising immunoadjuvant.
Article
Pharmacology & Pharmacy
Antonella V. Dan Cordoba, Virginia Aiassa, Jesica A. Dimmer, Camila N. Barrionuevo, Mario A. Quevedo, Marcela R. Longhi, Ariana Zoppi
Summary: In this study, a multicomponent complex between rifampicin, gamma-cyclodextrin, and arginine was prepared to improve the properties of rifampicin. The results showed that the complexation enhanced the water solubility and dissolution rate of rifampicin, as well as its antibacterial and antileishmanial action, and exhibited suitable stability. This approach could be used for developing pharmaceutical dosage forms of rifampicin with increased antimicrobial activities.
Article
Pharmacology & Pharmacy
Maria S. Bueno, Marcela R. Longhi, Claudia Garnero
Summary: In order to improve the stability of oxytetracycline hydrochloride, a novel binary system was developed using beta-cyclodextrin and amino acids as ligands. The formation constants for each system were determined and the structure of the binary system was elucidated. The effect of the binary system on the polymorph's stability in solution was monitored and showed promising results.
Article
Biochemistry & Molecular Biology
Eduardo Augusto da Silva Diniz, Diana Pontes da Silva, Sarah de Sousa Ferreira, Matheus de Freitas Fernandes-Pedrosa, Davi Serradella Vieira
Summary: Snakebite envenoming-induced myotoxicity is a major problem in ophidic accidents, and current serum therapy is ineffective in neutralizing it. An alternative approach is to search for small molecule inhibitors that can target multiple venom components. This study investigates the inhibitory effect of Rosmarinic (RSM) and Chlorogenic (CHL) acids on the catalytic properties of snake venom Phospholipase A(2) (PLA(2)) from Bothrops brazili through experimental and computational approaches, providing important information for future inhibitor design.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
