Article
Parasitology
Davi Alvarenga Lima, Leilane Oliveira Goncalves, Joao Luis Reis-Cunha, Paul Anderson Souza Guimaraes, Jeronimo Conceicao Ruiz, Daniel Barbosa Liarte, Silvane Maria Fonseca Murta
Summary: This study performed comparative transcriptomic analysis of wildtype and benznidazole-resistant T. cruzi populations, revealing metabolic pathways related to clinical drug resistance and identifying promising molecular targets for the development of new drugs for Chagas disease.
PARASITES & VECTORS
(2023)
Article
Public, Environmental & Occupational Health
Liili Abuladze, Luule Sakkeus, Elena Selezneva, Oksana Sinyavskaya
Summary: This study examines the cognitive functioning of Russian-origin immigrants in Estonia and finds that they have lower immediate recall ability compared to native Estonians, but no significant difference compared to Russians in Russia. The results may be due to Russia's higher mortality rate and the selective survival of healthier people. Different cognitive functioning outcomes suggest that migration may primarily affect short-term memory rather than crystallized knowledge. However, there are no differences between groups when defined based on age at migration, indicating that age profile differences explain most of the cognitive functioning disparities.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Yajuan Fan, Yanhua Wu, Yuan Peng, Binbin Zhao, Jian Yang, Ling Bai, Xiancang Ma, Bin Yan
Summary: The study found that sleeping late on weekdays after midnight independently increased the risk of myocardial infarction, emphasizing the importance of a proper bedtime for maintaining cardiovascular health.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Ivet Bayes-Marin, Albert Sanchez-Niubo, Daniel Fernandez, Josep Maria Haro, Beatriz Olaya
Summary: The study aimed to investigate the relationship between chronic obstructive pulmonary disease (COPD), healthy ageing trajectories (HAT), and all-cause mortality in three birth cohorts. The findings revealed three distinct HAT in the cohorts and showed that participants with COPD had an increased mortality risk, particularly in those with a 'low' healthy ageing trajectory. The interaction between COPD and HAT was significant only in the oldest birth cohort, indicating a greater mortality risk for those with a 'low' trajectory.
Article
Geriatrics & Gerontology
Xiyu Zhang, Wenqing Miao, Bing Wu, Yongqiang Lai, Mingli Jiao, Qi Xia, Chenxi Zhang, Wanxin Tian, Zhe Song, Linghan Shan, Lingqin Hu, Xinhao Han, Hui Yin, Xiaonan Cheng, Ye Li, Baoguo Shi, Qunhong Wu
Summary: The study examined the impact of various influencing factors on catastrophic health expenditure using spatiotemporal analysis. The findings suggest regional differences in ICHE incidences, with certain provinces showing persistently high levels. The study recommends regional-target policies and emphasizes the importance of addressing non-stationarity in the relationships between variables to improve health insurance design and governance.
Article
Biochemistry & Molecular Biology
Clara Mancuso, Francesca Re, Ilaria Rivolta, Luca Elli, Elisa Gnodi, Jean-Francois Beaulieu, Donatella Barisani
Summary: The introduction of metallic nanoparticles into the diet may impact gastrointestinal health and potentially contribute to the increasing incidence of celiac disease. Experimental findings suggest that peptic-tryptic-digested gliadin and food-grade metallic nanoparticles could synergistically affect intestinal mucosa, posing a risk factor for the development of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Environmental Sciences
Farooq Ahmad, Samar A. Abubshait, Haya A. Abubshait
Summary: Engineered nanomaterials (ENM) are extensively used in various industries due to their superior properties. These materials can enter the human body through different exposure routes, causing metabolic dysregulation. Advances in metabolomics technology allow us to study the metabolic disturbances induced by ENM.
Review
Infectious Diseases
Paraskevi C. Fragkou, Charalampos D. Moschopoulos, Rieke Reiter, Thilo Berger, Chrysanthi Skevaki
Summary: This article summarizes the data on deregulated immune pathways associated with increased susceptibility to severe viral respiratory tract infections in certain populations. It highlights the compromised innate and adaptive immune responses, particularly in aging, obesity, and diabetes. The study also points out the role of chronic low-grade inflammation and the impact on T cells in these susceptible populations.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Genetics & Heredity
Linda Kachuri, Nilanjan Chatterjee, Jibril Hirbo, Daniel J. Schaid, Iman Martin, Iftikhar J. Kullo, Eimear E. Kenny, Bogdan Pasaniuc, John S. Witte, Tian Ge, Paul L. Auer, Nilanjan Chatterjee, Matthew P. Conomos, David V. Conti, Yi Ding, Linda Kachuri, Ying Wang, Haoyu Zhang, Yuji Zhang
Summary: This review discusses the factors that affect the transferability of polygenic risk scores (PRSs) across different populations and reviews the strengths and weaknesses of existing PRS construction methods. Developing PRSs that benefit global populations in research and clinical settings is essential for health equity.
NATURE REVIEWS GENETICS
(2023)
Review
Environmental Sciences
Xinyu Wang, Tianshu Wu
Summary: This review provides a comprehensive and systematic analysis of the adverse effects of quantum dots (QDs) in different organisms based on recently available data. It found that QDs can cause toxicity in the environment and organisms and identified specific organs targeted by QDs. The review also discussed the cellular effects of QDs and highlighted the use of innovative technologies in risk assessment. By overcoming the limitations of previous reviews, this study provides new insights for the better application of QDs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Jacquelyn Cheng, Nikolai Kolba, Alba Garcia-Rodriguez, Claudia N. H. Marques, Gretchen J. Mahler, Elad Tako
Summary: This study investigated the potential effects of food-grade metal oxide nanoparticles on gastrointestinal health and development by using intraamniotic administration in broiler chickens. The results showed that food-grade titanium dioxide and silicon dioxide nanoparticles may have negative effects on intestinal functionality, while zinc oxide nanoparticles may have positive effects on intestinal development. Iron oxide nanoparticles may be a possible option for iron fortification, but may also affect intestinal functionality and health.
Review
Nutrition & Dietetics
Akihiro Kuma, Akihiko Kato
Summary: The prevalence of chronic kidney disease (CKD) has been increasing, and younger and middle-aged individuals with lifestyle-related diseases are at a higher risk of CKD. This article summarizes the predictive factors for CKD in the young population and the management of common diseases like hypertension and diabetes in middle-aged patients. As kidney function is mostly normal in the younger and middle-aged population with a lower risk of incident CKD, this review is important for reducing the prevalence of CKD.
Article
Clinical Neurology
Yingyang Zhang, Xue Li, Vivien K. Y. Chan, Hao Luo, Sandra S. M. Chan, Gloria H. Y. Wong, Ian C. K. Wong, Terry Y. S. Lum
Summary: Longer exposure to depression is significantly associated with an increased risk of cardiovascular disease, particularly in women and individuals under 65.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Pengfei Zhou, Shuai Wang, Ya Yan, Qiang Lu, Jiaxing Pei, Wang Guo, Xiaoguang Yang, Yunming Li
Summary: With the aging of the Chinese population, the prevalence of depression and chronic diseases is increasing among middle-aged and older adults. This study examined the association between chronic diseases and depression in this population. The findings showed that having chronic diseases increased the risk of depression, and the risk further increased with the number of chronic diseases. Diabetes, kidney disease, digestive diseases, and arthritis significantly increased the risk of depression in middle-aged and older adults.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
Summary: This study shows that in elderly and very elderly Asian populations, improvements in cardiovascular health status are associated with a reduced risk of cardiovascular disease, but body mass index and total cholesterol are not sufficiently predictive of all-cause mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Engineering, Environmental
Guohong Liu, Xiliang Yan, Chengjun Li, Song Hu, Jiachen Yan, Bing Yan
Summary: The interactions between transition-metal dichalcogenides (TMDCs) and per- and polyfluoroalkyl substances (PFAS) were explored using experimental methods and machine learning approaches. The study revealed that TMDCs-PFAS interactions have unique toxicity effects on cell lines and enhance the bioaccumulation of TMDCs in zebrafish, leading to oxidative stress and histopathological alterations. This research emphasizes the importance of investigating interactions between emerging and existing contaminants in aquatic environments using state-of-art techniques to safeguard environmental health.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Jingzhou Wang, Jianbo Jia, Dujia Wang, Xiujiao Pan, Haiyan Xiong, Chengjun Li, Yiguo Jiang, Bing Yan
Summary: Inflammation is a major adverse outcome induced by PM2.5, and plays a critical role in PM2.5 exposure-associated diseases. This study identified a novel circRNA, circ_0008553, that is responsible for the PM2.5-activated inflammatory response in human bronchial epithelial cells. The findings highlight the significance of this circRNA in the intervention of PM2.5-induced adverse outcomes.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Engineering, Environmental
Chao Liu, Haiqing Wang, Muhammad Usman, Mengyuan Ji, Jun Sha, Zhenda Liang, Lishan Zhu, Li Zhou, Bing Yan
Summary: The applications of CuO nanoparticles in industrial and agriculture have led to their increased concentrations in wastewater and accumulation in waste activated sludge, raising concerns about their impact on the production of medium-chain carboxylates (MCCs) from anaerobic fermentation of sludge. Our study showed that CuO NPs at 10-50 mg/g-TS significantly inhibit MCCs production, with reactive oxygen species generation being the key factor. However, at lower CuO NPs concentrations (0.5-2.5 mg/g-TS), MCCs production was enhanced. Molecular approaches and metaproteomic analysis revealed the impact of CuO NPs on microbial processes and protein expression levels related to MCCs production.
Article
Chemistry, Multidisciplinary
Yongyi Wei, Hainan Sun, Bing Yan
Summary: Environmental carbon nanomaterials, such as multi-walled carbon nanotubes and graphene oxides, interact with aromatic hydrocarbon pollutants, resulting in adverse effects on ecosystems and human health. The combined toxicity of carbon nanomaterials and benzo[a]pyrene is still unknown. Among the investigated carbon nanomaterials, MWCNTs-NH2, p-GO, and GO-COOH showed some alleviation of the cytotoxicity induced by benzo[a]pyrene, with GO-COOH exhibiting the strongest inhibitory effect. Mechanistically, GO-COOH reduced benzo[a]pyrene-induced cell apoptosis and cytotoxicity by regulating apoptotic proteins and maintaining mitochondrial membrane potential. These findings highlight the importance of the physicochemical properties of carbon nanomaterials in modulating the cytotoxicity of benzo[a]pyrene.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Juan Ma, Shenqing Wang, Chuanfang Zhao, Xiliang Yan, Quanzhong Ren, Zheng Dong, Jiahuang Qiu, Yin Liu, Qing'e Shan, Ming Xu, Bing Yan, Sijin Liu
Summary: Using computer-aided molecule design and machine learning, researchers have discovered two new broad-spectrum adjuvants that can enhance vaccine responses. These adjuvants can activate dendritic cells through multiple toll-like receptors, promote antigen presentation to T cells, and elicit strong immune responses in mice, effectively suppressing tumor growth and metastasis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Environmental
Jian Liu, Yuting Wen, Yucong Mo, Weizhen Liu, Xiliang Yan, Hongyu Zhou, Bing Yan
Summary: Biochars (BCs) can interact with multivalent metal ions in the environment, causing changes in their ionic valence states and resulting in unknown combined toxicity. In this study, we investigated the interaction between BCs and Cr or As and their combined cytotoxicity in human colorectal mucosal cells. Our results showed that the redox-induced valence state change is a critical factor in the combined cytotoxicity of BCs with Cr/As.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Hai -Yuan Chi, Xiao-Xia Zhou, Min-Rong Wu, Wan-yu Shan, Jing-fu Liu, Jin-quan Wan, Bing Yan, Rui Liu
Summary: This study investigates the effect of constructing a magnetic mesoporous SiO2 shell on the surface of nanoscale zero-valent iron (nZVI). The results show that this structure can regulate the electron transfer pattern, avoid the formation of iron oxide layers, and improve the efficiency of active hydrogen production.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Long Kong, Guizhen Yan, Xinxin Huang, Yanxin Wu, Xin Che, Jian Liu, Jianbo Jia, Hongyu Zhou, Bing Yan
Summary: The probability of occupational exposure to carbon nanotubes (CNTs) is increasing due to their growing production and biomedical applications. As a result, the risk of co-exposure of nanomaterials with environmental pollutants is also increasing. This study investigated the toxicity of pristine single-walled CNTs (p-SWCNTs) and oxidized single-walled CNTs (SWCNT-COOHs) on cell responses to metal ions (Pb2+, Cu2+, and Cr(VI)). The findings suggest that understanding the effects of the exposure sequence of engineered nanomaterials and environmental pollutants on their toxicity is crucial for evaluating combined toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Jiachen Yan, Guohong Liu, Hanle Chen, Song Hu, Xiaohong Wang, Bing Yan, Xiliang Yan
Summary: A comprehensive online database on the toxicity of ionic liquids (ILs) has been developed to aid in the design of environmentally friendly ILs using machine learning. The ILTox database contains manually curated data, including 1183 ILs and over 6700 pieces of toxicity data across different organisms. Machine learning models have been constructed using this database to analyze the relationship between IL structures and toxicities. The database has been used for virtual screening of desired IL properties from a large pool of ILs and has proven to be a valuable resource in understanding IL toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Chemistry, Physical
Huachao Zhao, Wei Ran, Guangzhi He, Hongxin Wei, Jiefang Sun, Xiaoxia Zhou, Shiwei Li, Jingfu Liu, Bing Yan, Rui Liu, Guibin Jiang
Summary: Bond length is an important structural parameter that can affect the activity of catalysts. In core-shell gold-palladium (Au@Pd) nanocatalysts, elongated Pd-Pd bonds resulting from lattice mismatches between Au and Pd are found to exhibit distinct catalytic activity. Surface-enhanced Raman scattering (SERS) spectra of chemisorbed 2,6-dimethylphenyl isocyanide (2,6-DMPI) were used to investigate the elongated Pd-Pd bonds on Au@Pd. The study revealed that strained sites with elongated Pd bonds are more than 100 times more active in a catalyzed Suzuki-Miyaura coupling reaction.
Article
Chemistry, Multidisciplinary
Haiqing Wang, Yongtao Xu, Zhenda Liang, Zhiquan Chen, Li Zhou, Bing Yan
Summary: This study investigated the impact of nanoplastics (NPs) on the spread of antibiotic resistance genes (ARGs) and found that negatively charged polystyrene (PS) and PS-COOH enhanced ARG transfer at low concentrations, while transfer declined at higher concentrations. Conversely, PS-NH2 increased ARG transfer at all tested concentrations, with the highest promotion effect at 500 mg L-1. The effects on ARG transfer were a combination of ROS production-induced promotion and NP agglomeration-caused inhibition at high concentrations.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Cong Li, Xinxin Huang, Weicui Min, Huoqing Zhong, Xiliang Yan, Yan Gao, Jianqiao Wang, Hongyu Zhou, Bing Yan
Summary: Nanoplastics can transport heavy metal ions and pose health risks when ingested through the food chain. This study investigated the induction of inflammatory responses in human cells by ion-adsorbed polystyrene NPs and found that intracellular ions played a role in the inflammation caused by these NPs. Machine learning models identified Cd2+ and Pb2+ as crucial for the increased expression of pro-inflammatory cytokines in different cell types. The activation of NF-kappa B and ERK1/2 pathways were associated with the high expression of pro-inflammatory cytokines in the respective cell types.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Chemistry, Multidisciplinary
Yanxin Wu, Rongtao Liu, Jian Liu, Jianbo Jia, Hongyu Zhou, Bing Yan
Summary: In this study, palladium (Pd) nanocrystals with different crystalline forms were synthesized, and the underlying mechanisms of ROS-mediated cytotoxicity were revealed. Nanocubes and nanooctahedrons/nanotetrahedrons triggered cytotoxicity by generating singlet oxygen (O-1(2)) and hydroxyl radicals (OH), respectively. Nanoconcave-tetrahedrons induced ROS-mediated cytotoxicity via activating the superoxide (O-2(-)) pathway. The alkalization of pH resulting from intracellular ROS conversion was identified as a new biomarker for analyzing cytotoxicity.
Letter
Medicine, General & Internal
Chengjun Li, Huan Zhong, Yuwei Xie, Tian Bai, Bing Yan, Christian Sonne
Article
Chemistry, Multidisciplinary
Xiaokun Liu, Zhiying Zhang, Nikodem Tomczak, Cong Yang, Chengjun Li, Rongrong Liu, Bing Yan
Summary: In this study, a novel antibacterial composite nanomaterial based on spiky mesoporous silica spheres loaded with poly(ionic liquid)s and aggregation-induced emission luminogens (AIEgens) was designed for efficient treatment and imaging of multidrug-resistant (MDR) bacteria. The nanocomposite exhibited excellent and long-term antibacterial activity towards both Gram-negative and Gram-positive bacteria. Additionally, fluorescent AIEgens facilitated real-time bacterial imaging. This study provides a multifunctional platform and a promising alternative to antibiotics for combating pathogenic MDR bacteria.
NANOSCALE ADVANCES
(2023)