Article
Biochemistry & Molecular Biology
Jung-Taek Kwon, Yoonjin Kim, Seonyoung Choi, Byung-Ll Yoon, Hyun-Sook Kim, Ilseob Shim, Donggeun Sul
Summary: This study provides insights into the cytotoxicity, immunotoxicity, and oxidative stress induced by CuO NPs in rat lungs. Proteomic analysis identified potential toxicological biomarkers of CuO NPs and revealed the underlying toxicity mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Christian Marzahl, Jenny Hill, Jason Stayt, Dorothee Bienzle, Lutz Welker, Frauke Wilm, Joern Voigt, Marc Aubreville, Andreas Maier, Robert Klopfleisch, Katharina Breininger, Christof A. Bertram
Summary: This study introduces a novel, fully annotated multi-species P-Hem dataset, and develops an annotation pipeline using deep learning and data visualization techniques. The dataset is one of the largest publicly available WSIs datasets in terms of the number of annotations, scanned area, and species covered.
Article
Biochemistry & Molecular Biology
Yasuaki Kotetsu, Toyoshi Yanagihara, Kunihiro Suzuki, Hiroyuki Ando, Daisuke Eto, Kentaro Hata, Masako Arimura-Omori, Yuzo Yamamoto, Eiji Harada, Naoki Hamada
Summary: Sarcoidosis is a systemic granulomatous disease caused by unknown immunological abnormalities, with lungs being the most vulnerable organs. Research suggests that PD-1 or TIM-3 expression on T cells in bronchoalveolar lavage fluid may serve as a prognostic factor for pulmonary lesions in sarcoidosis.
Article
Biochemistry & Molecular Biology
Mariaenrica Tine, Tommaso Neri, Davide Biondini, Nicol Bernardinello, Alvise Casara, Maria Conti, Marianna Minniti, Manuel G. Cosio, Marina Saetta, Alessandro Celi, Dario Nieri, Erica Bazzan
Summary: Cell-derived extracellular vesicles (EVs) in the circulation and body fluids can be used as biomarkers for lung and other diseases. This study compared the characteristics of EVs in bronchoalveolar lavage (BAL) and blood samples from smokers with and without COPD. The results showed that there were significant differences in macrophage-derived EVs (CD14-EVs) between nonsmokers, smokers without COPD, and COPD patients in BAL but not in plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Ahmed El-Nawawy, Manal A. M. Antonios, Marwa A. Meheissen, Marwan M. Fahim
Summary: This study aimed to assess viral agents causing severe pneumonia among mechanically ventilated pediatric patients, and found that viral infection rate was high at 73.4%, with rhinovirus and RSV being the most common. The mortality rate for viral-associated severe pneumonia reached 56.36%, with a threefold increase in mortality odds in the presence of comorbid conditions and a tenfold increase with congenital heart disease.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Rodopi Stamatiou, Vasiliki Tsolaki, Apostolia Hatziefthimiou, Epaminondas Zakynthinos, Demosthenes Makris
Summary: This study aimed to standardize bronchial sampling techniques and propose a new mechanical mucus dissolution method, which showed higher levels of cells and proteins in mechanically dissolved mucus. Cell numbers and protein levels were higher in MV patients compared to controls, but protein levels were lower.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Pernilla Darlington, Jonas Melin, Natalia Rivera, Johan Grunewald, Anders Eklund, Susanna Kullberg
Summary: Peripheral blood lymphopenia is associated with a more severe disease phenotype in sarcoidosis patients, and it is correlated with specific human leukocyte antigen (HLA) alleles. The decrease in lymphocytes may not be due to their migration to other organs but could be influenced by the presence of HLA-DRB1*07 allele.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Kara J. Mould, Camille M. Moore, Shannon A. McManus, Alexandra L. McCubbrey, Jazalle D. McClendon, Christine L. Griesmer, Peter M. Henson, William J. Janssen
Summary: Through techniques such as single-cell RNA sequencing, this study identified transcriptional heterogeneity of human cells obtained from BAL, defining multiple subgroups of airspace macrophages in healthy adults, including proinflammatory and metal-binding subgroups. Additionally, comparisons were made between monocyte-like cells in airspaces and peripheral blood mononuclear cells, as well as macrophage and monocyte programming differences between males and females.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Environmental Sciences
Runcheng Fang, Afzaal Nadeem Mohammed, Jagjit Singh Yadav, Jun Wang
Summary: This study investigated the cytotoxicity of ultrafine particles emitted from a desktop 3D printer using three different filaments. The results showed that ABS filament had the most significant particle emission and caution should be exercised when operating multiple printers and filament combinations in poorly ventilated spaces.
Article
Multidisciplinary Sciences
Chin-Wei Kuo, Po-Lan Su, Tang-Hsiu Huang, Chien-Chung Lin, Chian-Wei Chen, Jeng-Shiuan Tsai, Xin-Min Liao, Tzu-Yi Chan, Chi-Chang Shieh
Summary: The expression of angiotensin-converting enzyme 2 (ACE2) in alveolar macrophages (AMs) was found to be positively correlated with smoking pack-year and current smoking. Experiments using human AMs showed that cigarette smoke extract (CSE) increased ACE2 expression and susceptibility to SARS-CoV-2 pseudovirus (CoV-2 PsV). Furthermore, N-acetylcysteine (NAC) was found to decrease ACE2 expression by suppressing intracellular reactive oxygen species (ROS) in human AMs. Therefore, smoking increases susceptibility to SARS-CoV-2 infection by increasing ROS-induced ACE2 expression in AMs.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Jane Alexandra Shaw, Maynard Meiring, Devon Allies, Lauren Cruywagen, Tarryn-Lee Fisher, Kesheera Kasavan, Kelly Roos, Stefan Marc Botha, Candice MacDonald, Andritte M. Hiemstra, Donald Simon, Ilana M. van Rensburg, Marika A. Flinn, Ayanda B. Shabangu, Helena Kuivaniemi, Gerard Tromp, Stephanus Malherbe, Gerhard Walzl, Nelita du Plessis
Summary: Bronchoalveolar lavage (BAL) is a common procedure for studying infectious disease immunology. This study analyzed the factors that influence the outcomes of BAL and identified associations with participant characteristics such as active tuberculosis (TB) disease, HIV infection, and recent SARS-CoV-2 infection. The results showed correlations between BAL volume and cell count in participants with active TB disease and current smokers. Older participants had lower BAL cell and volume yields, and higher neutrophils. Current smokers had lower volumes, higher cell counts, and black pellets. The findings provide insights for researchers to optimize participant selection and assay for projects involving lung immune cells.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Malgorzata Sobiecka, Monika Szturmowicz, Katarzyna B. Lewandowska, Inga Baranska, Katarzyna Zimna, Ewa Lyzwa, Malgorzata Dybowska, Renata Langfort, Piotr Radwan-Rohrenschef, Adriana Rozy, Witold Z. Tomkowski
Summary: This study aimed to determine the value of bronchoalveolar lavage (BAL) total cell count (TCC) and lymphocytosis in distinguishing fibrotic hypersensitivity pneumonitis (fHP) and idiopathic pulmonary fibrosis (IPF). The results showed that BAL TCC and lymphocyte percentage were significantly higher in fHP compared to IPF. BAL lymphocytosis >30% was found in 60% of fHP patients and none of the IPF patients. Logistic regression analysis identified several factors that increased the probability of fHP diagnosis. The optimal cut-off values to differentiate fHP from IPF were 15 x 10(6) for TCC and 21% for BAL lymphocytosis.
Review
Biochemistry & Molecular Biology
Laura Pastor, Elisabeth Vera, Jose M. Marin, David Sanz-Rubio
Summary: Lung diseases are a common cause of death globally, with chronic airway inflammation and abnormal tissue repair playing a role in their pathogenesis. Extracellular vesicles play a key role in the development of LD, serving as potential therapeutic targets and biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Muhammad Waqas Sadiq, Olaf Holz, Birthe D. Ellinghusen, Cornelia Faulenbach, Meike Mueller, Philipp Badorrek, Ulf G. Eriksson, Markus Friden, Stina Stomilovic, Anders J. Lundqvist, Jens M. Hohlfeld
Summary: This study evaluated the lung pharmacokinetics of commonly prescribed drugs by sampling different lung compartments after inhalation and oral administration. The results showed that inhalation of salbutamol resulted in significantly higher lung concentrations compared to plasma, with salmeterol and fluticasone showing even higher concentration ratios. The study concluded that combining data from multiple individuals and techniques sampling different lung compartments enabled the generation of pharmacokinetic profiles for evaluating lung targeting after inhaled and oral drug delivery.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Virology
Raul Recio, Antonio Lalueza, Noelia Moral, Consuelo Pascual, Marina Munoz, Javier Camacho, Jose Maria Caso, Lola Folgueira
Summary: The study retrospectively analyzed patient data from a medical institution from 2015 to 2018 and found that 20.9% of bronchoalveolar lavage samples tested positive for respiratory viruses, which were significantly associated with respiratory symptoms and radiological infiltrates. The most common viruses detected were rhinovirus, influenza virus, and parainfluenza virus, with higher viral detection rates in immunocompromised patients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Chemistry, Physical
Qingyuan Hu, Huimin Liao, Xin Liu, Li Jin, Kexin Song, Yongyong Zhuang, Zhuo Xu, Vladimir Ya Shur, Xiaoyong Wei
Summary: In this study, a thermal annealing and high temperature poling approach is proposed to enhance the piezoelectricity of Pb(In1/2Nb1/2)O3-Pb(Mg1/3Nb2/3)O3-PbTiO3 crystals. The manipulation of defects and defect polarization orientation results in a more polarized crystal. The improved piezoelectric property achieved under a maintained Curie temperature indicates the feasibility of the approach.
JOURNAL OF MATERIOMICS
(2023)
Article
Nanoscience & Nanotechnology
Wen Wang, Leiyang Zhang, Wenjing Shi, Yule Yang, Denis Alikin, Vladimir Shur, Zhihao Lou, Dong Wang, Amei Zhang, Jinghui Gao, Xiaoyong Wei, Hongliang Du, Feng Gao, Li Jin
Summary: In this paper, a cooperative optimization strategy is proposed to achieve outstanding energy-storage performance in NBST-based ceramics. Substituting NN for NBST generates an ergodic state and induces polar nanoregions. Applying VPP to the ceramics further increases compactness and breakdown strength. The optimized ceramics possess improved energy-storage characteristics and temperature adaptability.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Physics, Applied
V. Ya. Shur, M. S. Kosobokov, A. V. Makaev, D. K. Kuznetsov
Summary: The ordering of isolated circular ferroelectric nanodomains was observed in lithium tantalate crystals through multiple scanning with infrared laser irradiation. This ordering effect was attributed to domain formation and growth under the influence of alternating pyroelectric field during heating and cooling processes. Circular domains appeared due to 1D to 2D shape transformation and grew by merging with newly formed domains during subsequent scanning. The ordering of the domain pattern was characterized by an increase in the autocorrelation function peak, indicating domain interaction. This mechanism was confirmed through computer simulation based on the analogy between domain and crystal growth. The discovered domain ordering effect bears similarity to similar effects in magnetic materials.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Materials Science, Ceramics
Fangbin Wei, Yule Yang, Leiyang Zhang, Denis Alikin, Vladimir Shur, Amei Zhang, Hongliang Du, Xiaoyong Wei, Li Jin
Summary: High recoverable energy storage density (W-rec) and high energy storage efficiency (eta) are urgently needed for their potential application in pulse capacitor devices. However, low eta and breakdown strength (BDS) have hindered the achievement of high W-rec at high electric field. In this study, Bi(Mg0.5Ti0.5)O-3 (BMT) was introduced into Ba(Ti0.92Sn0.08)O-3 (BTS) matrix to enhance the relaxor character and reduce electrostrictive strain. The results showed significantly improved BDS and a high W-rec of 4.34 J/cm(3) with excellent temperature stability.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Optics
D. S. Chezganov, E. O. Vlasov, L. V. Gimadeeva, M. M. Neradovskiy, A. R. Akhmatkhanov, M. A. Chuvakova, D. O. Alikin, H. Tronche, F. Doutre, P. Baldi, V. Ya. Shur
Summary: Lithium-niobate-based waveguides are important platforms for integrated optical technologies. In this paper, we propose a method for creating an integrated optical frequency conversion device using focused ion beam (i-beam) periodical poling technique after the soft proton exchange (SPE) process. The study reveals that the SPE process leads to the formation of shallow isolated nanodomains, which is preferable for periodical poling. We successfully create a high-quality 2-μm-period domain structure in a channel waveguide.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Wen-Jing Shi, Lei-Yang Zhang, Yu-Le Yang, D. O. Alikin, V. Ya. Shur, Xiao-Yong Wei, Hong-Liang Du, Li Jin
Summary: Lead-free dielectric ceramics with improved energy storage performance (ESP) were developed using a combinatorial optimization strategy. By introducing Bi-containing complex ions and employing a viscous polymer process, the ceramics exhibited enhanced diffuse phase transition, increased bond coupling, and reduced hysteresis. The optimized composition achieved high recoverable energy storage density (W-rec), high efficiency, and remarkable temperature stability for pulsed power capacitors.
Article
Chemistry, Analytical
Alexander Abramov, Boris Slautin, Victoria Pryakhina, Vladimir Shur, Andrei Kholkin, Denis Alikin
Summary: We studied the electronic transport and resistive switching phenomena in polycrystalline bismuth ferrite using advanced conductive atomic force microscopy (CAFM). Contrary to many macroscopic methods, we demonstrate that resistive switching in bismuth ferrite is caused by pure electronic processes of trapping/releasing electrons and injection of electrons by the scanning probe microscopy tip. The electronic transport is comprehensively described by the combination of the space charge limited current model, while the presence of a built-in subsurface charge makes the Schottky barrier at the interface less important.
Article
Chemistry, Physical
Wen Wang, Leiyang Zhang, Yule Yang, Wenjing Shi, Yunyao Huang, D. O. Alikin, V. Ya. Shur, Zhihao Lou, Amei Zhang, Xiaoyong Wei, Dong Wang, Feng Gao, Hongliang Du, Li Jin
Summary: This study achieved comprehensive exceptional energy storage performance in Na0.5Bi0.5TiO3-Sr0.85Bi0.1TiO3 (NBT-SBT)-based ceramics through stepwise optimization by substituting Bi(Mg0.5Sn0.5)O-3 (BMS) and optimizing the formation process. The introduction of Mg2+ and Sn4+ ions at the B-site induced polar nanoregions, and the viscous polymer process (VPP) improved the polarization difference and breakdown strength. As a result, the ceramics exhibited ultrahigh energy storage density and high efficiency, along with excellent temperature adaptability.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Sergey Kudryashov, Galina Kriulina, Pavel Danilov, Evgeny Kuzmin, Alexey Kirichenko, Nikolay Rodionov, Roman Khmelnitskii, Jiajun Chen, Elena Rimskaya, Vladimir Shur
Summary: Natural IaA+B diamonds were exposed to laser pulses, resulting in the formation of photoluminescent nanostructured microtracks. The laser exposure led to an increase in the yield of NV centers and a decrease in the yield of N3a, H4, and H3 centers. The attachment of vacancies to nitrogen centers and the splitting of highly aggregated nitrogen centers were considered as the mechanisms behind these observations.
Article
Crystallography
Evgeniy Savelyev, Andrey Akhmatkhanov, Mikhail Kosobokov, Herve Tronche, Florent Doutre, Tommaso Lunghi, Pascal Baldi, Vladimir Shur
Summary: This experimental study investigates the kinetics of abnormal domain structure in lithium niobate single crystals with a surface layer modified by soft proton exchange. Two types of domain structure evolution were observed: the traditional growth of hexagonal domains at fields higher than 21.5 kV/mm and the abnormal growth of stripe domains at fields ranging from 3.8 to 21.5 kV/mm. The formation and growth of stripe domains were analyzed using a modified Kolmogorov-Avrami approach, and a controllable creation of quasi-periodic stripe domains was demonstrated. The abnormally low threshold fields were attributed to the presence of a built-in field induced by soft proton exchange.
Article
Materials Science, Ceramics
Xiyu Ma, Wenjing Shi, Yule Yang, D. O. Alikin, Y. Ya Shur, Jinghui Gao, Xiaoyong Wei, Gang Liu, Hongliang Du, Li Jin
Summary: Electrocaloric refrigeration is an emerging solid-state technology with advantages of high efficiency, miniaturization, eco-friendliness, and low cost. This paper investigates Ba(Ti1-xSnx)O-3 ceramics and reveals their structural, dielectric, ferroelectric, electrocaloric, and electrostrictive characteristics. The results show that increasing Sn4+ concentration leads to lower dielectric peaks and a phase diagram is constructed based on dielectric characteristics. The study also demonstrates a giant adiabatic temperature change of 6.36 K in the x = 0.04 ceramic sample and temperature and composition-insensitive electrostrictive behavior.
CERAMICS INTERNATIONAL
(2023)
Article
Materials Science, Multidisciplinary
L. V. Gimadeeva, Q. Hu, X. Wei, D. O. Alikin, V. Ya. Shur
Summary: The influence of cooling rate on the domain structure and piezoelectric properties of barium titanate ceramics was investigated. It was found that a higher cooling rate led to larger domain sizes, resulting in an increased average piezoelectric response due to better polarization alignment.
Article
Chemistry, Physical
Michael Kovalev, Ivan Podlesnykh, Alena Nastulyavichus, Nikita Stsepuro, Irina Mushkarina, Pavel Platonov, Evgeniy Terukov, Sergey Abolmasov, Aleksandr Dunaev, Andrey Akhmatkhanov, Vladimir Shur, Sergey Kudryashov
Summary: Light-trapping structures on various material surfaces have gained significant attention for their role in science and technology. This article explores different methods for manufacturing light-trapping black silicon, including laser, chemical, and hybrid methods. The authors introduce a hybrid chemical/laser texturing method, combining laser post-texturing with pyramidal structures obtained from chemical etching. The results show that laser texturing of chemically microtextured silicon wafers takes significantly less time and results in lower reflectance compared to purely chemical treatment.
Article
Optics
Yulia Gulina, Jiaqi Zhu, Alexey Gorevoy, Mikhail Kosobokov, Anton Turygin, Boris Lisjikh, Andrey Akhmatkhanov, Vladimir Shur, Sergey Kudryashov
Summary: Double-track microstructures were induced in a z-cut lithium niobate crystal using 1030nm 240fs ultrashort laser pulses. The topography of the microstructures was characterized using atomic force microscopy in piezoelectric response mode. The spatial positions of laser-induced modification regions inside the crystal could be predicted using simple analytical expressions.
Article
Materials Science, Ceramics
Nikita A. Boldyrev, Eugene I. Sitalo, Lidia A. Shilkina, Alexander V. Nazarenko, Andrei D. Ushakov, Vladimir Y. Shur, Larisa A. Reznichenko, Ekaterina V. Glazunova
Summary: In this study, ceramics with quasi-binary concentration were prepared and their crystal structure, dielectric properties, and piezoelectric performance were investigated. The results showed that these ceramics had a cluster morphology and exhibited relaxor-like behavior.
CERAMICS-SWITZERLAND
(2023)
