Review
Pharmacology & Pharmacy
Oly Banerjee, Siddhartha Singh, Ishita Saha, Swagata Pal, Maitrayee Banerjee, Sudipta Kundu, Alak Kumar Syamal, Bithin Kumar Maji, Sandip Mukherjee
Summary: Bisphenol A (BPA) is an endocrine disrupting chemical that is widely present in industrial production and has potential harmful effects on human health. This review focuses on the different cellular and molecular pathways through which BPA affects pancreatic islets, considering both low and high dose effects. Understanding the mechanisms of BPA action on pancreatic islets provides meaningful insights into the risks associated with exposure to BPA at different doses.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Food Science & Technology
Yun Zhang, Ming Yan, Weiyan Shan, Tao Zhang, Yunchen Shen, Ruirong Zhu, Jian Fang, Hongjiao Mao
Summary: BPA induces pyroptotic death of osteocytes via the ROS/NLRP3/Caspase-1 pathway, increasing apoptosis and up-regulating protein expressions related to inflammation and cell damage. The oxidative stress and mitochondrial dysfunction caused by BPA are reversed by ROS scavengers and mitochondrial antioxidants, highlighting potential therapeutic targets for BPA-induced bone cell damage.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Engineering, Environmental
Maria Carbo, Palak Chaturvedi, Ana Alvarez, Daniela Pineda-Cevallos, Arindam Ghatak, Pablo Rodriguez Gonzalez, Maria Jesus Canal, Wolfram Weckwerth, Luis Valledor
Summary: Microplastics, including Bisphenol A (BPA), are major pollutants in aquatic environments. BPA, one of the most abundant and dangerous components, can lead to endocrine disorders and cancer in mammals. This study aimed to understand the molecular-level effects of BPA on plants and microalgae, specifically Chlamydomonas reinhardtii. The findings revealed that BPA disrupts iron and redox homeostasis, leading to cell dysfunction and ferroptosis. Interestingly, the microalgae showed recovery at both molecular and physiological levels, with starch accumulation after 72 hours of BPA exposure. This study provides valuable insights into BPA toxicology, ferroptosis in microalgae, and potential target genes for microplastic bioremediation.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Shaoxin Zi, Jiale Xu, Yingxin Zhang, Di Wu, Jin Liu
Summary: The behavior of bisphenol A (BPA) and its substitutes in soils was studied, and it was found that bisphenol S (BPS) and bisphenol F (4,4'-BPF) have higher mobility in saturated soils compared to BPA. Additionally, the three isomers of bisphenol F showed variability in mobility in saturated soils with high organic matter content. The results highlight the role of soil organic matter in providing dynamic adsorption sites for the bisphenol analogs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Katerina Makarova, Ewa Olchowik-Grabarek, Krzysztof Drabikowski, Justyna Kurkowiak, Katarzyna Zawada
Summary: The aim of this study was to investigate the possible degradation path of BPA under the Fenton reaction and compare the cytotoxicity of BPA and its intermediate products. The DFT calculations revealed that the formation of hydroquinone was the most energetically favorable path in a water environment. The cytotoxicity tests showed that BPA induced the strongest hemolytic changes in erythrocytes, followed by hydroquinone, phenol and 4-isopropylphenol.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Marta Diana Komarowska, Kamil Grubczak, Jan Czerniecki, Adam Hermanowicz, Justyna Magdalena Hermanowicz, Wojciech Debek, Ewa Matuszczak
Summary: The study revealed significantly higher plasma levels of BPA, BPS, and BPF in children with cryptorchidism compared to control subjects, with BPA being the most commonly detected. All three bisphenols were present in plasma samples of both groups, showing a widespread exposure among prepubertal boys.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jie Yang, Christopher Link, Yoko O. Henderson, Nazmin Bithi, Christopher Hine
Summary: This study found that peripubertal exposure to BPA in mice resulted in decreased lean mass, increased fat mass, reduced serum total thyroid hormone levels, anxiety, and cognitive deficits in aged mice. BPA exposure also disrupted tissue-specific H2S production, which was negatively correlated with memory deficits and oxidative stress.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Chemistry, Physical
Yuhua Wang, Weihua Wang, Zhiqiang Zhang, Ping Li
Summary: The inherent structural features of covalent organic frameworks (COFs) determine their adsorption performance for bisphenol A (BPA). Functional COFs with different functional groups showed enhanced adsorption capacity for BPA in gas phase and aqueous solution. The adsorption amount of BPA by functional COFs is influenced by the electronegativity of functional groups and the pore size.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Electrical & Electronic
Monika Dubey, Ashish Mathur, Ranjit Kumar
Summary: In this study, a highly selective electrochemical sensor for detecting BPA in water using H+-exchanged alpha-MnO2 was developed. The sensor showed high sensitivity and a low limit of detection, as well as stability and reproducibility. It exhibited high selectivity towards BPA and can be used for health safety purposes.
IEEE SENSORS JOURNAL
(2022)
Review
Environmental Sciences
Xin Wang, Rajat Nag, Nigel P. Brunton, Md Abu Bakar Siddique, Sabine M. Harrison, Frank J. Monahan, Enda Cummins
Summary: This review focuses on the contamination of meat products by bisphenol A (BPA) and its potential health risks. BPA has been widely detected in canned and non-canned meat products, with the main source being the migration from can coatings. The European Food Safety Authority has proposed to lower the tolerable daily intake of BPA, indicating the need to address potential health risks. The study also highlights the data gaps and the importance of improving food safety in the meat industry through a unified risk assessment strategy.
ENVIRONMENTAL RESEARCH
(2022)
Article
Engineering, Environmental
Songfeng Wang, Yu Su, Miaomiao Cheng, Qilin Wang, Xuan Wu, Yongfeng Wang, Feifei Sun, Ren Wang, Rong Ji
Summary: 14C-tracers were used to investigate the fate of BPA in flooded soil with or without rice plants. In flooded soil, the dissipation of BPA was accompanied by its mineralization and the formation of non-extractable residues (NERs). The growth of rice significantly accelerated the dissipation of BPA, resulting in a reduction in both the half-life and the amount of NERs. At rice harvest, the majority of the radioactivity accumulated in rice plants as NERs, with trace amounts in seeds and seed shells. The study highlights the importance of considering the release of NERs in flooded soil and the uptake of BPA metabolites by rice in environmental risk assessments of agricultural ecosystems.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Kangyu Hao, Jia Luo, Jing Sun, Honghan Ge, Zhaoguo Wang
Summary: The study found that exposure to BPA and BPS was positively associated with depressive symptoms, especially in men. However, BPS was negatively associated with depressive symptoms in elderly women.
Article
Engineering, Environmental
Yu-Heng Deng, Jemin Jeon, Eun Mi Kim, Shengzhe Ding, Sang Ah Lee, Changseon Ryu, Young Jun Kim, Xiao Su, Hyunjoon Kong
Summary: Immobilization of 8-MnO2 nanosheets on a porous support enhances the degradation rate of BPA, with the ability to be recycled and non-toxic to ecological systems. This technology can be extended to remove various water contaminants. Rating: 8/10.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Food Science & Technology
Elham Khalili Sadrabad, Sayed Aliasghar Hashemi, Azadeh Nadjarzadeh, Elaheh Askari, Fateme Akrami Mohajeri, Fereshteh Ramroudi
Summary: This review discusses possible factors affecting the release of Bisphenol A (BPA) into food and beverages, such as temperature, manufacturing process, food and packaging type, pH, mineral elements, repeated use, irradiation, washing, contact time, and use of detergents. The study found that using PC containers, high temperature and pH, storage under solar irradiation, alkaline detergents, water hardness, and repeated use could increase the release of BPA from containers into food. Considering these parameters and limiting the use of PC containers can help reduce the potential risk of BPA exposure.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Archana Molangiri, Saikanth Varma, M. Satyavani, Saikrishna Kambham, Asim K. Duttaroy, Sanjay Basak
Summary: Early exposure to bisphenol may result in adverse reproductive health issues in later life. This study investigated the effects of orally administered bisphenol S (BPS) and bisphenol A (BPA) on testicular development in rats. The results showed that prenatal exposure to BPS can lead to changes in plasma testosterone levels, testis histology, inflammation, oxidative stress, and sperm DNA damage, potentially affecting male reproductive functions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ana Monteiro, Jessica Cardoso, Nuno Guerra, Edna Ribeiro, Carla Viegas, Sandra Cabo Verde, Antonio Sousa-Uva
Summary: This review article examines the potential health effects of bacterial contamination in healthcare units. The study found that bacteria transmission mainly occurs through contact between healthcare workers and patients or through the handling of contaminated instruments and surfaces. The most common bacterial contaminants identified were Escherichia coli, Pseudomonas aeruginosa, Staphylococcus spp., Staphylococcus aureus, and Micrococcus luteus. The health effects of these contaminants include hospital-acquired infections and infections in immunocompromised individuals. Strict control of disinfection methods and increased frequency are necessary to remove microbial contamination and prevent peaks of contamination.
APPLIED SCIENCES-BASEL
(2022)
Article
Microbiology
Ana Sofia Zeferino, Ana Rita Mira, Mariana Delgadinho, Miguel Brito, Tomas Ponte, Edna Ribeiro
Summary: This study evaluates the potential of epigallocatechin-3-gallate (EGCG) as an antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) and reports its synergistic effects and association with altered expression of epigenetic and drug response modulators genes. The findings suggest that EGCG could be a promising treatment or therapeutic adjuvant against antibiotic-resistant microorganisms.
CURRENT MICROBIOLOGY
(2022)
Article
Agronomy
Giovanni Del Frari, Francesco Calzarano, Ricardo Boavida Ferreira
Summary: This study investigates the factors influencing the leaf stripe symptom in grapevines affected by wood pathogens. It explores the links between fungal presence, wood symptomatology, and the expression of the leaf stripe symptom. The study also proposes three control strategies and introduces the 'edge' hypothesis to explain symptom onset.
PHYTOPATHOLOGIA MEDITERRANEA
(2022)
Article
Nutrition & Dietetics
Joana Mota, Sandra Casimiro, Joao Fernandes, Renata M. Hartmann, Elizangela Schemitt, Jaqueline Picada, Luis Costa, Norma Marroni, Anabela Raymundo, Ana Lima, Ricardo Boavida Ferreira
Summary: The study demonstrates that food fortified with lupin protein concentrate (LPC) can effectively alleviate symptoms of inflammatory bowel diseases, providing significant protective effects against colitis.
Article
Environmental Sciences
Ketlyn Oliveira, Carla Viegas, Edna Ribeiro
Summary: Staphylococcus aureus and particularly methicillin-resistant S. aureus (MRSA) infections are associated with high morbidity and mortality rates worldwide. This study investigated MRSA prevalence in workers from five different Portuguese occupational environments and found high rates of S. aureus carriers in bakery workers, swinery workers, firefighters, and healthcare workers.
Review
Plant Sciences
Ana Luiza Coeli Cruz Ramos, Ana Carolina do Carmo Mazzinghy, Vinicius Tadeu da Veiga Correia, Bruna Vieira Nunes, Lucas Victor Ribeiro, Viviane Dias Medeiros Silva, Reginaldo Ferreira Weichert, Ana Cardoso Clemente Filha Ferreira de Paula, Isabel Maria Nunes de Sousa, Ricardo Manuel de Seixas Boavida Ferreira, Paula Batista-Santos, Raquel Linhares Bello de Araujo, Julio Onesio Ferreira Melo
Summary: Flavonoids are the main beneficial compounds found in plants of the Annonaceae family, especially in their fruits. The most commonly identified flavonoid in fruits of the Annona genus studied is quercetin, with lesser amounts of epicatechin, rutin, and kaempferol also present. The presence of these compounds in Annona fruits makes them promising for potential applications in the pharmaceutical and food industry.
Article
Oncology
Sara Silva, Ana Cavaco, Bianca Basso, Joana Mota, Raquel Cruz-Duarte, Miguel Costa, Lara Carvalho, Ana Lima, Luis Costa, Ricardo Ferreira, Marta Martins
Summary: This study investigated the role of a protein called deflamin in colorectal cancer treatment. The research found that deflamin can inhibit tumor growth and metastasis, promote tumor cell apoptosis, and impair cancer cell migration and invasion by reducing the activity of MMP-2 and MMP-9. The use of a zebrafish model also revealed deflamin's ability to inhibit collagen degradation and angiogenesis in the tumor microenvironment.
Article
Food Science & Technology
Ana Luiza Coeli Cruz Ramos, Elaine Carvalho Minighin, Isabela Iunes Camilo Soares, Ricardo Manuel de Seixas Boavida Ferreira, Isabel Maria Nunes de Sousa, Rodinei Augusti, Renata Adriana Labanca, Raquel Linhares Bello de Araujo, Julio Onesio Ferreira Melo
Summary: This study evaluated the bioaccessibility of bioactive compounds in araticum fruits (peel, pulp, and seeds) from Brazil. The results showed that the food matrix directly influenced the bioaccessibility of the bioactive compounds. It also highlighted the potential of unconventionally used or consumed parts as a source of substances with biological activities, contributing to sustainability by reducing waste.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Vinicius Tadeu da Veiga Correia, Viviane Dias Medeiros Silva, Henrique de Oliveira Prata Mendonca, Ana Luiza Coeli Cruz Ramos, Mauro Ramalho Silva, Rodinei Augusti, Ana Cardoso Clemente Filha Ferreira de Paula, Ricardo Manuel de Seixas Boavida Ferreira, Julio Onesio Ferreira Melo, Camila Argenta Fante
Summary: This study determined the chemical profiles of jabuticaba and jambolan fruits using paper spray mass spectrometry and found that they are rich in phenolic compounds. The different parts of the fruits produced different chemical fingerprints when extracted using different solvents. These compounds in jabuticaba and jambolan have the potential to positively impact human health and nutrition.
Article
Agronomy
Joana Rodrigues, Rita Fragoso, Luisa Brito, David Fangueiro
Summary: Livestock farming produces a large amount of animal slurry, which can be sanitized and used as fertilizer through low-cost treatments by pH adjustment. This study evaluated the impact of sandy soil amendment with dairy slurry treated by pH adjustment on the potential release of nutrients and coliforms into groundwater. The results showed that alkalinized dairy slurry had a lower nitrate leaching potential and reduced the leaching of coliforms compared to raw slurry. However, incomplete sanitization by acidification increased the risk of coliform leaching and groundwater contamination.
Review
Chemistry, Applied
Madalena Gracio, Sabrina Oliveira, Ana Lima, Ricardo Boavida Ferreira
Summary: RuBisCO is a protein widely recognized as suitable for human consumption. Its biochemical composition, characteristics and potential advantages make it a beneficial food additive. Despite the lack of information about its applications, we explored the features of RuBisCO and compared it with other plant protein sources. This information can assist researchers and industry in utilizing RuBisCO as a sustainable source of protein for plant-based food products.
Review
Food Science & Technology
Acacio Salamandane, Manuel Malfeito-Ferreira, Luisa Brito
Summary: This review examines the main causes of foodborne illnesses in developing countries, with a particular focus on the transmission of antibiotic-resistant microbes. The findings reveal that women constitute the majority of street food vendors, who generally have a low level of education and lack knowledge of good hygiene practices. Poor hygiene practices and lack of facilities, such as potable water, were frequently identified as the main causes of food contamination. Enterobacteriaceae bacteria were the most common pathogens found in ready-to-eat street foods. High levels of multidrug resistance were reported in Enterobacteriaceae from several developing countries.
Article
Biology
Acacio Salamandane, Gomes Cahango, Belo Afonso Muetanene, Manuel Malfeito-Ferreira, Luisa Brito
Summary: This study investigated antibiotic resistance, virulence genes, minimum inhibitory concentration (MIC) of benzalkonium chloride (BAC), biofilm formation capacity, and biofilm eradication (MBEC) by BAC in enterococci recovered from Portuguese cheeses made with raw ewe's milk. The study found high resistance to vancomycin, erythromycin, tetracycline, and penicillin, as well as multidrug resistance and the presence of virulence genes in the isolates. Additionally, biofilms produced by the isolates showed resistance to higher concentrations of BAC. These findings highlight the importance of effective control measures to ensure the safety and quality of dairy products.
Article
Biotechnology & Applied Microbiology
Ruben Araujo, Luis Ramalhete, Edna Ribeiro, Cecilia Calado
Summary: Fourier Transform InfraRed spectroscopy (FTIR) has been explored for medical diagnosis due to its simplicity, sensitivity, and specificity. This study compared plasma and serum spectra to evaluate the metabolic state of volunteers who consumed green tea extract rich in EGCG for 90 days. The results showed that both plasma and serum spectra could reflect the impact of EGCG consumption, with slightly higher prediction accuracy in plasma spectra and greater influence on lipid regions in serum spectra.
Article
Biotechnology & Applied Microbiology
Luiz C. Correa-Filho, Diana Santos, Luisa Brito, Margarida Moldao-Martins, Vitor D. Alves
Summary: Tomato pomace is a rich source of important bioactive property carotenoids, such as lycopene. Microencapsulation of tomato pomace extract improves its stability and bioaccessibility, making it a potential ingredient for functional food formulations.
BIOENGINEERING-BASEL
(2022)
