Article
Plant Sciences
Hyeon Ji Yeo, Chang Ha Park, Jae Kwang Kim, Ramaraj Sathasivam, Jae Cheol Jeong, Cha Young Kim, Sang Un Park
Summary: Plants adjust their nutrient balance by regulating primary and secondary metabolisms when exposed to stressful conditions; chilling stress can increase the concentrations of sugars, amino acids, salicylic acid, flavones, and phenolic acids in Scutellaria baicalensis roots.
Article
Biochemistry & Molecular Biology
Wentao Wang, Suying Hu, Jing Yang, Caijuan Zhang, Tong Zhang, Donghao Wang, Xiaoyan Cao, Zhezhi Wang
Summary: This study identified a novel S20 R2R3-MYB regulator, SbMYB12, which positively regulates the biosynthesis of baicalin and wogonoside in Scutellaria baicalensis. These findings enhance our understanding of the transcriptional and regulatory mechanisms of baicalin biosynthesis and provide new insights for metabolic engineering in S. baicalensis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agricultural Engineering
Na Miao, Cholil Yun, Yutong Shi, Yuan Gao, Shuang Wu, Zhonghua Zhang, Shulan Han, Huimei Wang, Wenjie Wang
Summary: This study demonstrates that UV-A radiation can effectively increase the flavonoid content in the aerial parts of Scutellaria baicalensis and enhance its antioxidant activity.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biodiversity Conservation
Yuan Jiang, Zefang Zhao, Yanqing Xiao, Hui Xu
Summary: Plants are essential in traditional medicine systems, and understanding their spatial distribution is crucial for effective utilization and conservation. This study analyzed the distribution and active ingredient content of a traditional Chinese medicinal plant called Scutellaria baicalensis. The results showed that habitats with higher baicalin content were located further south. The findings provide valuable insights for establishing plantations of S. baicalensis.
ECOLOGICAL INDICATORS
(2022)
Article
Biochemistry & Molecular Biology
Anastasia Dmitrieva, Oksana Kozlova, Victor Atuchin, Irina Milentieva, Anna Vesnina, Svetlana Ivanova, Lyudmila Asyakina, Alexander Prosekov
Summary: The antimicrobial properties of baicalin against H. pylori and several probiotic cultures were evaluated. Baicalin exhibited high antimicrobial activity against H. pylori and a stimulating effect on the growth of certain probiotic strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Lin Cheng, Jingjing Yu, Lichao Zhang, Yanying Yao, Zhuo Sun, Mei Han, Yonggang Zhang, Limin Yang
Summary: In this study, the WRKY gene family in S. baicalensis was analyzed, revealing that SbWRKYs of the same subgroup have similar functions and highly conserved structural domains. The expression of SbWRKYs varies under different drought stress conditions. The expression of key enzyme genes affects the expression of SbWRKYs and has an impact on baicalin accumulation.
Article
Agronomy
Na Miao, Cholil Yun, Shulan Han, Yutong Shi, Yuan Gao, Shuang Wu, Zhuowen Zhao, Huimei Wang, Wenjie Wang
Summary: This study investigated the effects of postharvest UV-A radiation on the flavonoid content, composition, and bioactivity in Scuteilaria baicalensis roots. The results showed that postharvest UV-A radiation increased the total flavonoid content in the roots and led to changes in flavonoid composition. Furthermore, UV-A radiation enhanced the antioxidant and antibacterial activities of the root extracts.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Review
Chemistry, Medicinal
Vafa Baradaran Rahimi, Vahid Reza Askari, Hossein Hosseinzadeh
Summary: Studies have shown that Scutellaria baicalensis and its active constituents, baicalin and baicalein, have promising effects on controlling metabolic syndrome and related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their subsequent complications by regulating key signaling pathways in glucose and lipid metabolism.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
ShuTing Li, Dan Xu, Jing Jia, Wenbo Zou, JieYing Liu, Yao Wang, Kun Zhang, Xi Zheng, Yan-Yan Ma, Xuejian Zhang, Deng-Gao Zhao
Summary: In this study, 13 previously undescribed neo-clerodane diterpenoids and 27 known analogs were isolated from Scutellaria barbata. The absolute configurations of the undescribed compounds were determined, and their inhibitory effects on nitric oxide generation in macrophages were evaluated. Compound 36 showed the highest activity and suppressed nitric oxide synthase expression and NF-kappa B signaling.
Article
Chemistry, Multidisciplinary
Shuai Yan, Yinzi Yue, Li Zeng, Lianlin Su, Min Hao, Wei Zhang, Xiaopeng Wang
Summary: An improved electrochemical sensing platform for evaluating antioxidant activity has been proposed in this study, utilizing a hydrogel prepared based on graphene oxide, zinc ions, and chitosan. The platform can evaluate antioxidant activity by comparing current differences and has shown good performance in assessing the antioxidant activity of Scutellaria baicalensis.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Heping Hui, Weijun Gao
Summary: In this study, an arabinogalactoglucan SBP-1 was purified from Scutellaria baicalensis and its structure was characterized. SBP-1 showed antioxidant and hypoglycemic activities, indicating its potential therapeutic value.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Jhana O. Hendrickx, Sofie De Moudt, Elke Calus, Peter Paul De Deyn, Debby Van Dam, Guido R. Y. De Meyer
Summary: This study investigates the association between arterial stiffness and cognitive decline by introducing arterial stiffness in genetic and pharmacological NO dysfunction models. The findings demonstrate that non-selective inhibition of NOS activity leads to cardiac dysfunction, arterial stiffness, and decline in hippocampal-dependent learning and memory, highlighting the importance of neuronal NOS in both cardiovascular and neurological pathophysiology.
Review
Pharmacology & Pharmacy
Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh
Summary: This paper reviews the protective and therapeutic effects of Scutellaria baicalensis and its main components against chemical compounds that can cause intoxication, and discusses the main mechanisms of action.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Polymer Science
Jinshu Liu, Xiaoyan Ma, Wenzhao Shi, Jianwei Xing, Chaoqun Ma, Susong Li, Yayi Huang
Summary: The study demonstrated that PVA films incorporated with baicalin extract exhibit superior UV-blocking, optical, and antioxidant properties, while also reducing water vapor permeability and enhancing mechanical performance.
JOURNAL OF POLYMER ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Ritesh Kumar Raipuria, Sunita Kataria, Anshul Watts, Meeta Jain
Summary: The study suggests that nitric oxide (NO) may be the key signaling molecule in soybean seedlings' tolerance towards UV-B stress under the stimulation of static magnetic field (SMF), while NO synthase (NOS) may be responsible for SMF-induced NO production. The use of NO donor SNP can improve the parameters of seedlings, while inhibitors of NR, NOS, and DPI can reduce this improvement.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2021)