Block of the Mevalonate Pathway Triggers Oxidative and Inflammatory Molecular Mechanisms Modulated by Exogenous Isoprenoid Compounds

Potential Role of Carotenoids as Antioxidants in Human Health and Disease

(2014) Joanna Fiedor et al.   Nutrients

Cytokine targets in airway inflammation

(2013) Martijn J Schuijs et al.   CURRENT OPINION IN PHARMACOLOGY

Mevalonate Kinase Deficiency and Neuroinflammation: Balance between Apoptosis and Pyroptosis

(2013) Paola Tricarico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1β Hypersecretion

(2013) Robert van der Burgh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse model of mevalonate kinase deficiency: comparison of cytokine and chemokine profile with that of human patients

(2013) Annalisa Marcuzzi et al.   PEDIATRIC RESEARCH

Lovastatin induces apoptosis through the mitochondrial pathway in an undifferentiated SH-SY5Y neuroblastoma cell line

(2013) A Marcuzzi et al.   Cell Death & Disease

Mevalonate Kinase Deficiency: Disclosing the Role of Mevalonate Pathway Modulation in Inflammation

(2012) Annalisa Marcuzzi et al.   CURRENT PHARMACEUTICAL DESIGN

Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line

(2012) Annalisa Marcuzzi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Protective effect of lycopene on oxidative stress and antioxidant status inCyprinus carpioduring cypermethrin exposure

(2011) M. Enis Yonar   ENVIRONMENTAL TOXICOLOGY

Cytokines in Autoimmunity: Role in Induction, Regulation, and Treatment

(2011) Kamal D. Moudgil et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The inhibition of mevalonate pathway induces upregulation of NALP3 expression: new insight in the pathogenesis of mevalonate kinase deficiency

(2010) Alessandra Pontillo et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Natural isoprenoids inhibit LPS-induced-production of cytokines and nitric oxide in aminobisphosphonate-treated monocytes

(2010) Annalisa Marcuzzi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

HMG-CoA reductase inhibition induces IL-1  release through Rac1/PI3K/PKB-dependent caspase-1 activation

(2008) L. M. Kuijk et al.   BLOOD

Lycopene inhibits TNF-α-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion

(2008) Chi-Feng Hung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Statin synergizes with LPS to induce IL-1β release by THP-1 cells through activation of caspase-1

(2008) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Plant derived antioxidants – Geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress

(2008) M. Tiwari et al.   TOXICOLOGY IN VITRO

The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria

(2007) Peter Celec et al.   MEDICAL HYPOTHESES