Article
Oncology
Vikas Satyananda, Masanori Oshi, Yoshihisa Tokumaru, Aparna Maiti, Nitai Hait, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Summary: High S1P export, driven by the simultaneous high expression of SphK1 and ABCC1, is associated with enhanced HCC progression and immune response, leading to significantly worse disease-specific survival and overall survival outcomes.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jean-Philip Truman, Christian F. Ruiz, Magali Trayssac, Cungui Mao, Yusuf A. Hannun, Lina M. Obeid
Summary: This study reveals that under conditions of serine starvation, SK1 is degraded in a p53-independent manner, requiring the action of the proteasome. Overexpression of SK1 to compensate for its loss is detrimental to cell growth under serine deprivation, indicating that suppression of SK1 under these conditions is adaptive. The effects of SK1 suppression on intracellular reactive oxygen species were mimicked by D-erythro-sphingosine, suggesting that the accumulation of its substrate, sphingosine, is responsible for these effects.
Article
Cell Biology
Ruiyun Li, Jaladanki N. Rao, Alexis D. Smith, Hee Kyoung Chung, Lan Xiao, Jian-Ying Wang, Douglas J. Turner
Summary: Intestinal epithelial barrier defects commonly occur in various pathological conditions, and the underlying mechanisms are not fully understood. S1P and SphK1 are critical regulators of intestinal epithelial barrier maintenance, with miR-542-5p serving as an effector of c-myc translation. miR-542-5p directly regulates c-myc translation by binding to c-myc mRNA. This research highlights the importance of miR-542-5p in the regulation of S1P-mediated intestinal barrier function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gerhild van Echten-Deckert
Summary: Lipids are essential components of the CNS, and sphingolipids, a type of lipid, are highly concentrated in the brain. Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, has complex effects on the brain, which can be both beneficial and detrimental. However, the role of S1P in brain development and various brain pathologies is still controversial.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Fei Li, Yifan Zhang, Zhoujun Lin, Lizhong Yan, Qiao Liu, Yin Li, Xiaolin Pei, Ya Feng, Xiao Han, Juan Yang, Fangxu Zheng, Tianjiao Li, Yupeng Zhang, Zhenkun Fu, Di Shao, Jane Yu, Chenggang Li
Summary: This study identified rapamycin-insensitive sphingosine metabolic signatures in LAM cells and demonstrated that therapeutic targeting of aberrant SPHK1/S1P/S1PR3 signaling may have potent therapeutic benefit for patients with TSC/LAM or other hyperactive mTOR neoplasms with autophagy inhibition.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Macarena Corro-Moron, Albert Granell, Varbina Ivanova, Elena Domingo, Raul Beltran-Debon, Xavier Barril, Maria-Jesus Sanz, M. Isabel Matheu, Sergio Castillon, Yolanda Diaz
Summary: This study describes the synthesis of new sphingosine derivatives and identifies hydrazino and alkynyl moieties as the best combination for selective SphK2 inhibition. Docking studies reveal that compounds 19a-b can bind to SphK2 through both polar and hydrophobic interactions, leading to their selective activity against SphK2.
BIOORGANIC CHEMISTRY
(2022)
Review
Oncology
Eileen M. McGowan, Yiguang Lin, Size Chen
Summary: Obesity is closely associated with inflammation and increased cancer risk in the digestive system. Saturated fat diets and being overweight can cause chronic inflammation. Bioactive sphingolipids, signaling molecules made from saturated fats, play essential roles in maintaining healthy gastrointestinal immunity. Excessive levels of these molecules can lead to chronic inflammation, but drugs that block their activity have the potential to reduce gastrointestinal cancer risk.
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Ophthalmology
Sarah E. Nicholas, Alexander J. Choi, Thi N. Lam, Sandip K. Basu, Nawajes Mandal, Dimitrios Karamichos
Summary: Corneal haze caused by fibrosis can lead to vision loss. Corneal transplantation is currently used to treat severe fibrosis, but it has limitations. This study investigates the role of sphingolipids and their interactions with TGF-beta signaling in corneal fibrosis.
EXPERIMENTAL EYE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Yanhong Bu, Hong Wu, Ran Deng, Yan Wang
Summary: Sphingosine kinase 1 (SphK1) plays a crucial role in maintaining the dynamic balance of sphingolipid-rheostat in cells and is involved in various cellular processes. Abnormal expression and activity of SphK1 are associated with a variety of inflammatory and immune-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Timon Eckes, Sammy Patyna, Alexander Koch, Anke Oftring, Stefan Gauer, Nicholas Obermueller, Stephanie Schwalm, Liliana Schaefer, Jerold Chun, Hermann-Josef Groene, Josef Pfeilschifter
Summary: This study found that S1P(5) deficiency can improve tubular damage and tubulointerstitial fibrosis in a mouse model of adenine-induced nephropathy, and reduce inflammation. Therefore, targeting S1P(5) may be a promising therapeutic target for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Review
Cell Biology
Yuqing Wu, Yongjie Liu, Erich Gulbins, Heike Grassme
Summary: Sphingolipids play crucial roles in regulating pathobiological processes such as cancer, inflammation, and infectious diseases. Unlike ceramide which promotes microbial infections, sphingosine has bactericidal effects and is an important natural defense component against bacterial pathogens in the respiratory tract. Recent studies suggest that the bactericidal effect of sphingosine may be due to bacterial membrane permeabilization and subsequent bacterial death.
Article
Biochemistry & Molecular Biology
Dorit Avni, Kuzhuvelil B. Harikumar, Arun J. Sanyal, Sarah Spiegel
Summary: In this study, the researchers found that deletion of SphK1 significantly decreased liver damage and mortality rate caused by acute liver failure, likely through regulating the secretion of pro-inflammatory cytokine TNF alpha. The findings suggest that SphK1 may play a crucial role in the development of acute liver failure and could be a potential therapeutic target for fulminant hepatitis.
Article
Cell Biology
Giovanna Mirone, Stefania Perna, Arvind Shukla, Gabriella Marfe
JOURNAL OF CELLULAR PHYSIOLOGY
(2016)
Review
Oncology
Giovanna Mirone, Arvind Shukla, Gabriella Marfe
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2016)
Review
Chemistry, Physical
Chaima Amri, Arvind Kumar Shukla, Jin-Ho Lee
Summary: Early detection is crucial for effective cancer treatment. Circulating cancer biomarkers have shown potential targets for liquid biopsies. Advances in nanoparticle-based biosensors hold promise in overcoming challenges in detection sensitivity.
Review
Biochemistry & Molecular Biology
Raj Kumar Mongre, Chandra Bhushan Mishra, Arvind Kumar Shukla, Amresh Prakash, Samil Jung, Md Ashraf-Uz-Zaman, Myeong-Sok Lee
Summary: This article discusses the crucial role of receptor tyrosine kinases in cancer therapy and the efficacy of TKIs as targeted therapy for various cancers. It emphasizes the signaling transduction and therapeutic effects of TKIs, as well as their applications in clinical trials and preclinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Gabriella Marfe, Stefania Perna, Arvind Kumar Shukla
Summary: This article discusses the new disease SARS-CoV-2 discovered in Wuhan, China at the end of 2019, and the effectiveness and challenges of the four vaccines currently in use worldwide. It also examines the viral elements used in the coronavirus-19 vaccine that can induce a strong immune response and the potential adverse effects they may cause to individuals.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Analytical
Arvind Kumar Shukla, Ge Gao, Byoung Soo Kim
Summary: Induced pluripotent stem cells (iPSCs) are generated by genetic reprogramming of adult cells and have high safety. They have significant potential in tissue engineering and 3D bioprinting technology plays a vital role in this field by applying undifferentiated and differentiated iPSCs.