The Discovery of Potentially Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: A Combination of Pharmacophore Modelling, CoMFA, Virtual Screening and Molecular Docking Studies

Combined Three Dimensional Quantitative Structure Activity Relationships (3D-QSAR) Modeling and Molecular Docking Studies on Naphthoquinone Analogs as Proteasome Inhibitors

(2013) Guanhong Xu et al.   Letters in Drug Design & Discovery

3,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase (nNOS) inhibitors

(2012) Subhash C. Annedi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Three Dimensional Quantitative Structure Activity Relationships (3D-QSAR) and Docking Studies of Curcumin Derivatives as Androgen Receptor Antagonists

(2012) Guanhong Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First-in-Class, Dual-Action, 3,5-Disubstituted Indole Derivatives Having Human Nitric Oxide Synthase (nNOS) and Norepinephrine Reuptake Inhibitory (NERI) Activity for the Treatment of Neuropathic Pain

(2012) Gabriela Mladenova et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: Lead Optimization Studies Resulting in the Identification of N-(1-(2-(Methylamino)ethyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophene-2-carboximidamide as a Preclinical Development Candidate

(2012) Jailall Ramnauth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Monocationic Inhibitors of Neuronal Nitric Oxide Synthase. Binding Mode Insights from Molecular Dynamics Simulations

(2012) He Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A combined 3D QSAR and pharmacophore-based virtual screening for the identification of potent p38 MAP kinase inhibitors: an in silico approach

(2012) Gugan Kothandan et al.   MEDICINAL CHEMISTRY RESEARCH

1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

(2011) Shawn Maddaford et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,5-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors

(2011) Paul Renton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, Synthesis, and Biological Evaluation of 3,4-Dihydroquinolin-2(1H)-one and 1,2,3,4-Tetrahydroquinoline-Based Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors

(2011) Jailall Ramnauth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery ofN-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) for the Treatment of Pain

(2011) Subhash C. Annedi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of cis-N-(1-(4-(Methylamino)cyclohexyl)indolin-6-yl)thiophene-2-carboximidamide: A 1,6-Disubstituted Indoline Derivative as a Highly Selective Inhibitor of Human Neuronal Nitric Oxide Synthase (nNOS) without Any Cardiovascular Liabilities

(2011) Subhash C. Annedi et al.   JOURNAL OF MEDICINAL CHEMISTRY

3D-QSAR and docking studies on pyrazolo[4,3-h]qinazoline-3-carboxamides as cyclin-dependent kinase 2 (CDK2) inhibitors

(2010) Ping Lan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3D-QSAR analysis of human immunodeficiency virus entry-1 inhibitors by CoMFA and CoMSIA

(2010) Somayeh Pirhadi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular modelling studies ond-annulated benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSAR

(2010) Ping Lan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models

(2010) Joseph E. Payne et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-based pharmacophore model of N-Aryl and N-Heteroaryl piperazine α1A-adrenoceptors antagonists using GALAHAD

(2010) Xin Zhao et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

3D-QSAR (CoMFA and CoMSIA) and pharmacophore (GALAHAD) studies on the differential inhibition of aldose reductase by flavonoid compounds

(2010) Julio Caballero   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model

(2010) Silvia L Delker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent, Highly Selective, and Orally BioavailableGem-Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase

(2010) Fengtian Xue et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of Selective Neuronal Nitric Oxide Synthase Inhibitors for the Prevention and Treatment of Neurodegenerative Diseases

(2009) Richard B. Silverman   ACCOUNTS OF CHEMICAL RESEARCH

Nitric oxide and pain: ‘Something old, something new’

(2009) A. MICLESCU et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Hyperinsulinaemia in migraineurs is associated with nitric oxide stress

(2009) H-J Gruber et al.   CEPHALALGIA

Signaling by Gasotransmitters

(2009) A. K. Mustafa et al.   Science Signaling

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice

(2008) Mitsuo Tanabe et al.   NEUROPHARMACOLOGY

Design of fructose-2,6-bisphosphatase inhibitors: A novel virtual screening approach

(2007) M.S. Shaikh et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING