Article
Chemistry, Organic
Efe Dogukan Dincel, Nuray Ulusoy-Guzeldemirci, Dilek Satana, Omer Kucukbasmaci
Summary: A series of novel compounds with potential antibacterial and antifungal activities were designed and synthesized, among which compounds 6d, 7c, and 7d showed promising biological activities. Compound 6d exhibited potent antifungal activity, suggesting its potential as a lead structure for future drug development.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Efe Dogukan Dincel, Cigdem Akdag, Tulay Kayra, Ebru Didem Cosar, Mehmet Onur Aksoy, Gulsen Akalin-Ciftci, Nuray Ulusoy-Guzeldemirci
Summary: A series of novel derivatives were synthesized and evaluated for their cytotoxic activity against lung adenocarcinoma cells and normal mouse fibroblast cell line. The compounds' structures were elucidated and verified by various analytical techniques. Some of the compounds exhibited excellent anticancer activity and were validated in vitro. Molecular docking studies revealed their potential binding interactions with DNA. Structure-activity relationships and virtual ADME studies were conducted to determine the relationship between the biological, chemical, and physical properties of the compounds. These derivatives offer promising structures for future drug development due to their straightforward synthesis and relevant bioactivity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Laurent Gavara, Alice Legru, Federica Verdirosa, Laurent Sevaille, Lionel Nauton, Giuseppina Corsica, Paola Sandra Mercuri, Filomena Sannio, Georges Feller, Remi Coulon, Filomena De Luca, Giulia Cerboni, Silvia Tanfoni, Giulia Chelini, Moreno Galleni, Jean-Denis Docquier, Jean-Francois Hernandez
Summary: Researchers are developing compounds based on the 1,2,4-triazole-3-thione scaffold to target resistance mechanisms in Gram-negative bacteria, with promising potential for broad-spectrum inhibitors. These compounds, particularly those containing a carboxylic group at the 4-position, have shown potent inhibition against VIM-type enzymes. Further exploration is needed to improve outer membrane penetration and efficacy against other carbapenemases.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Ergun Gultekin, Olcay Bekircan, Yakup Kara, Halil Ibrahim Guler, Mustafa Serkan Soylu, Sevgi Kolayli
Summary: In this study, two series of compounds, 1,3,4-thiadiazole and 1,2,4-triazole-5-thione derivatives, were synthesized and evaluated for their urease inhibitory activities. The second series of compounds showed excellent activity, with compound 41b exhibiting the highest inhibitory activity. Urease kinetic studies of compound 41b revealed that it had an un-competitive inhibition potential. In addition, in silico analysis was conducted to understand the interactions responsible for urease activity.
ARCHIV DER PHARMAZIE
(2023)
Article
Crystallography
Ivan Fedyanin, Aida Samigullina, Ivan A. Krutov, Elena L. Gavrilova, Dmitry Zakharychev
Summary: Two polymorphic forms of a conformationally flexible molecule were obtained and characterized, showing that the first form with higher cohesion energy and crystal lattice energy transforms into the second form at room temperature via two endothermic phase transitions due to high energy difference between molecular conformations in crystals.
Article
Chemistry, Physical
Eyup Basaran, Zeynep Demircioglu, Gonca Ozdemir Tari, Umit Ceylan, Aysegul Karakucuk-Iyidogan, Emine Elcin Oruc-Emre, Muhittin Aygun
Summary: In this study, an enantiomerically pure triazole derivative was successfully synthesized, characterized by spectroscopic techniques and X-ray diffraction, and analyzed for various computational properties and chemical activity descriptors. The stability of the molecule, arising from hyperconjugative interactions and charge delocalization, was examined through natural bond orbital analysis, and nonlinear optical properties were explored.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Agriculture, Multidisciplinary
Muhan Ding, Suran Wan, Nan Wu, Ya Yan, Junhong Li, Xiaoping Bao
Summary: In this study, 52 novel compounds were designed, synthesized, and evaluated for their antimicrobial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Rhizoctonia solani. Some of these compounds showed excellent antibacterial activities and good pesticide-likeness, making them potential candidates for agricultural antimicrobial agents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mahdi Shirmohammadi, Saeid Souzangarzadeh, Dadkhoda Ghazanfari, Mohsen Ghodratbeigi, Mohammad Reza Akhgar
Summary: A class of novel compounds based on the 1,2,4-triazole skeleton were synthesized through the reaction of thiocarbohydrazide with long-chain aliphatic carboxylic acids, followed by obtaining Schiff bases in heat and microwave media, with or without a catalyst. Their chemical structures were identified using elemental analysis and spectroscopic methods.
TURKISH JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Anna Makuch-Kocka, Marta Andres-Mach, Miroslaw Zagaja, Anna Smiech, Magdalena Pizon, Jolanta Flieger, Judyta Cielecka-Piontek, Tomasz Plech
Summary: Epilepsy affects around 70 million people worldwide, and despite significant progress in antiepileptic drug research, about 30% of patients still have drug-resistant epilepsy. Recent studies have shown that a 1,2,4-triazole-3-thione derivative TP-315 exhibits anticonvulsant activity in mice without significant toxic effects on internal organs after long-term use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Organic
Fenghai Zhao, Thishana Singh, Yumei Xiao, Wangcang Su, Dongyan Yang, Changqing Jia, Jia-Qi Li, Zhaohai Qin
Summary: An efficient assembly of disubstituted 1,2,4-triazoles was achieved by cyclization of readily accessible N'-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy allows for the formation of amino-1,2,4-triazoles under acidic conditions and nitroimino-1,2,4-triazoles under neutral conditions with water as the solvent.
SYNTHESIS-STUTTGART
(2021)
Article
Biochemistry & Molecular Biology
Renata Paprocka, Malgorzata Wiese-Szadkowska, Przemyslaw Kolodziej, Jolanta Kutkowska, Sara Balcerowska, Anna Bogucka-Kocka
Summary: The aim of this research was to synthesize new 1,2,4-triazole derivatives containing propanoic acid moiety and investigate their anti-inflammatory, antibacterial, and anthelmintic activity. The structures of the derivatives were confirmed through various analysis methods. The compounds 3a, 3c, and 3e exhibited the most beneficial anti-inflammatory effects in cell culture experiments.
Article
Biochemistry & Molecular Biology
Laurent Gavara, Federica Verdirosa, Laurent Sevaille, Alice Legru, Giuseppina Corsica, Lionel Nauton, Paola Sandra Mercuri, Filomena Sannio, Filomena De Luca, Margot Hadjadj, Giulia Cerboni, Yen Vo Hoang, Patricia Licznar-Fajardo, Moreno Galleni, Jean -Denis Docquier, Jean-Francois Hernandez
Summary: Metallo-S-lactamases (MBLs) pose an increasing threat to public health due to their prevalence in opportunistic Gram-negative pathogens worldwide. We are developing a new series of inhibitors with high inhibitory activity against tested MBLs, some of which are broad-spectrum and non-toxic. This series provides a promising basis for further research.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Zhiyun Peng, Guangcheng Wang, Qiao-Hui Zeng, Yufeng Li, Yi Wu, Haiquan Liu, Jing Jing Wang, Yong Zhao
Summary: A series of 1,2,4-triazole hydrazones were synthesized and evaluated for their inhibitory activities on tyrosinase. Compound 9 showed superior inhibitory activity, competitive-noncompetitive mixed inhibition mechanism, potent DPPH scavenging activity, and effective antibrowning effect on fresh-cut potatoes. It also displayed low cytotoxicity against human normal cell line, suggesting its potential as lead molecules for novel antibrowning agents in the food industry.
Article
Biochemistry & Molecular Biology
Magdalena Drabik, Mariusz Gluszak, Paula Wroblewska-Luczka, Zbigniew Plewa, Marek Jankiewicz, Justyna Kozinska, Magdalena Florek-Luszczki, Tomasz Plech, Jarogniew J. Luszczki
Summary: The novel antiepileptic drug TPL-16 showed protective effects in mice models and synergistic interaction with valproate, making it a promising candidate for further experimental and clinical testing. The combination of TPL-16 with carbamazepine, phenobarbital and phenytoin produced additive interaction in protecting mice from tonic-clonic seizures. There were no significant changes in total brain concentrations of classic AEDs after TPL-16 administration in mice.
NEUROCHEMICAL RESEARCH
(2021)
Article
Chemistry, Organic
Pradip Ramdas Thorve, Kakoli Maji, Biplab Maji
Summary: In this study, a practical and regioselective synthesis of 1,2,4-triazoles utilizing amine oxidase-inspired catalysis was reported. The method is atom-economical and environmentally benign, resulting in molecules with varying structural diversity.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
M. I. Gruia, V. Uivarosi, V. Negoita, E. Panait, A. Busca
JOURNAL OF BIOTECHNOLOGY
(2019)
Article
Chemistry, Inorganic & Nuclear
Alexandra Cristina Munteanu, Anna Notaro, Marta Jakubaszek, Joseph Cowell, Mickael Tharaud, Bruno Goud, Valentina Uivarosi, Gilles Gasser
INORGANIC CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Valentina Uivarosi
Article
Chemistry, Applied
Gina Lupascu, Elena Pahontu, Sergiu Shova, Stefania Felicia Barbuceanu, Diana Carolina Ilies, Mihaela Badea, Codruta Paraschivescu, Catalin Ducu, Johny Neamtu, Mihaela Dinu, Robert Viorel Ancuceanu, Doina Draganescu, Cristina Elena Dinu-Pirvu
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Applied
Alexandra-Cristina Munteanu, Mihaela Georgiana Musat, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Flavian Stefan Radulescu, Lorelei Irina Brasoveanu, Valentina Uivarosi
Summary: The synthesis and characterization of four new heteroleptic complexes of lanthanide metals with natural flavonoid and 1,10-phenanthroline were reported. These complexes exhibited cytotoxicity and were found to interact with DNA and serum proteins.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Mihaela Badea, Valentina Uivarosi, Rodica Olar
Article
Biochemistry & Molecular Biology
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Marinela Bostan, Valentina Uivarosi
Article
Chemistry, Applied
Mihaela Badea, Maria Nicoleta Grecu, Mariana Carmen Chifiriuc, Coralia Bleotu, Marcela Popa, Emilia Elena Iorgulescu, Speranta Avram, Valentina Uivarosi, Alexandra-Cristina Munteanu, Daniela Ghica, Rodica Olar
Summary: Six macrocyclic compounds were characterized as mononuclear species through NMR, EPR, UV-Vis spectroscopy and cyclic voltammetry. The pharmacokinetic computational results showed medium to low intestinal absorption, slow blood-brain barrier permeability, low toxicity, and the ability to inhibit protease activity. The most promising complexes for antimicrobial and antitumour applications were identified as (1), (2), (4) and (6).
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Mirela Mihaila, Camelia Mia Hotnog, Marinela Bostan, Alexandra Cristina Munteanu, Ileana Adela Vacaroiu, Lorelei Irina Brasoveanu, Valentina Uivarosi
Summary: Our study focused on the anticancer activity of several ruthenium (Ru) complexes with quinolone antibiotics in colon tumor cell cultures. The results showed dose-dependent increased levels of cell lysis and induction of apoptosis in LoVo cancer cells treated with the Ru(III) complexes. Additionally, a major decrease in cell proliferation, with a G0/G1 cell arrest and modulation of cell cycle phases, was observed, indicating the potential for the Ru(III) complexes in future chemotherapeutic approaches.
APPLIED SCIENCES-BASEL
(2021)
Review
Pharmacology & Pharmacy
Alexandra-Cristina Munteanu, Valentina Uivarosi
Summary: The widespread use of antibiotics has led to the emergence of drug-resistant microorganism populations, necessitating the development of new metal complexes as more effective antimicrobial agents. Ru (II/III) complexes show promise as anticancer drugs and are also being explored for use as antibiotics, antifungals, antiparasitics, or antivirals. This review discusses the advantages and disadvantages of Ru (II/III) frameworks as antimicrobial agents.
Article
Chemistry, Medicinal
Diana-Carolina Visan, Eliza Oprea, Valeria Radulescu, Ion Voiculescu, Iovu-Adrian Biris, Ani Ioana Cotar, Crina Saviuc, Mariana Carmen Chifiriuc, Ioana Cristina Marinas
Summary: This study investigated the essential oil composition from young shoots of various coniferous trees harvested in Romania and their antimicrobial and anti-virulence activity. It found that the Pinus nigra essential oil exhibited the most intensive antimicrobial effect and had a synergistic effect with some antibiotics against Staphylococcus aureus. The subinhibitory concentrations of the coniferous essential oils inhibited the expression of virulence factors and the rhl gene in Pseudomonas aeruginosa, suggesting their potential as virulence-arresting drugs.
Article
Engineering, Chemical
Theodora-Venera Apostol, Mariana Carmen Chifiriuc, Laura-Ileana Socea, Constantin Draghici, Octavian Tudorel Olaru, George Mihai Nitulescu, Diana-Carolina Visan, Luminita Gabriela Marutescu, Elena Mihaela Pahontu, Gabriel Saramet, Stefania-Felicia Barbuceanu
Summary: In this article, the design and synthesis of novel compounds containing an L-valine residue and a 4-[(4-bromophenyl)sulfonyl]phenyl moiety were presented. These compounds belong to various chemotypes and were characterized through different techniques. The compounds were then tested for antimicrobial activity, antioxidant effect, and toxicity. In silico studies were also performed. The results showed promising potential for developing novel antimicrobial agents.
Article
Chemistry, Medicinal
Ana-Madalina Maciuca, Alexandra-Cristina Munteanu, Mirela Mihaila, Mihaela Badea, Rodica Olar, George Mihai Nitulescu, Cristian V. A. Munteanu, Valentina Uivarosi
Summary: Drug repositioning was used to discover new applications for nalidixic acid, which is a member of the quinolone class. Nine new metal complexes with lanthanide cations were synthesized and their cytotoxicity, DNA affinity, and serum protein affinity were studied. The complexes exhibited selective activity against LoVo and preferred binding to the major and minor grooves of DNA.
Review
Pharmacology & Pharmacy
Aura Rusu, Munteanu Alexandra-Cristina, Arbanasi Eliza-Mihaela, Valentina Uivarosi
Summary: The value of antibacterial fluoroquinolones (FQs) is debatable due to their severe adverse effects (AEs), resulting in their withdrawal from the market. New systemic FQs with potent antibacterial activity have been approved, but require more clinical studies to meet regulatory requirements. Post-marketing surveillance will confirm the safety profile of these new drugs. The management of AEs, rational use, and caution of FQs were also outlined.
Article
Chemistry, Multidisciplinary
Aura Rusu, Silvia Imre, Anca Delia Mare, Ioana-Andreea Lungu, Giorgiana-Andreea Pascu, Valentina Uivarosi
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
(2020)