Cellular Functions Regulated by Phosphorylation of EGFR on Tyr845

EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast Cancer Cells Require Activation of p38 MAPK

(2014) Kelly L. Mueller et al.   Translational Oncology

Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src

(2013) K. Martínez Flores et al.   TOXICOLOGY IN VITRO

Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation

(2012) Guofeng Xie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes

(2012) Hong-Yu Tseng et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial c-Src regulates cell survival through phosphorylation of respiratory chain components

(2012) Masato Ogura et al.   BIOCHEMICAL JOURNAL

Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10

(2012) Etienne Hebert-Chatelain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation

(2012) Oisun Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A Novel Epidermal Growth Factor-Dependent Extracellular Signal-Regulated MAP Kinase Cascade Involved in Sperm Functionality in Sheep1

(2012) Carolina Luna et al.   BIOLOGY OF REPRODUCTION

pEGFR-Tyr 845 expression as prognostic factors in oral squamous cell carcinoma

(2012) Gabriella Aquino et al.   CANCER BIOLOGY & THERAPY

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Diacylglycerol kinase θ counteracts protein kinase C-mediated inactivation of the EGF receptor

(2012) Jürgen van Baal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Src kinases are important regulators of mitochondrial functions

(2012) Etienne Hebert-Chatelain   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Angiotensin II Induces Epithelial-to-Mesenchymal Transition in Renal Epithelial Cells through Reactive Oxygen Species/Src/Caveolin-Mediated Activation of an Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase Signaling Pathway

(2012) J. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR

(2012) X Li et al.   ONCOGENE

Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor

(2012) M Iida et al.   ONCOGENE

Src-Mediated Cross-Talk between Farnesoid X and Epidermal Growth Factor Receptors Inhibits Human Intestinal Cell Proliferation and Tumorigenesis

(2012) Zhongsheng Peng et al.   PLoS One

Membrane microdomain-associated uroplakin IIIa contributes to Src-dependent mechanisms of anti-apoptotic proliferation in human bladder carcinoma cells

(2012) Shigeru Kihira et al.   Biology Open

Interaction between the SH3 domain of Src family kinases and the proline-rich motif of HTLV-1 p13: a novel mechanism underlying delivery of Src family kinases to mitochondria

(2011) Elena Tibaldi et al.   BIOCHEMICAL JOURNAL

Macrophage inhibitory cytokine-1 transactivates ErbB family receptors via the activation of Src in SK-BR-3 human breast cancer cells

(2011) Yun-Jung Park et al.   BMB Reports

Inhibition of human breast cancer Matrigel invasion by Streptolysin O activation of the EGF receptor ErbB1

(2011) Emily H. Hall et al.   CELLULAR SIGNALLING

Angiocidin inhibits breast cancer proliferation through activation of epidermal growth factor receptor and nuclear factor kappa (NF-ĸB)

(2011) Jessica Godek et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Diverse injurious stimuli reduce protein tyrosine phosphatase-μ expression and enhance epidermal growth factor receptor signaling in human airway epithelia

(2011) Sang W. Hyun et al.   EXPERIMENTAL LUNG RESEARCH

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

(2011) Anna N. Cvrljevic et al.   JOURNAL OF CELL SCIENCE

Nanoparticle delivery of a peptide targeting EGFR signaling

(2011) Sang Kyoon Kim et al.   JOURNAL OF CONTROLLED RELEASE

β3 Integrin–EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells

(2011) Nikolas Balanis et al.   MOLECULAR BIOLOGY OF THE CELL

Gamete membrane microdomains and their associated molecules in fertilization signaling

(2011) A.K.M. Mahbub Hasan et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Functional interactions between Choline kinase α, epidermal growth factor receptor and c-Src in breast cancer cell proliferation

(2011) T Miyake et al.   ONCOGENE

Translationally controlled tumor protein induces human breast epithelial cell transformation through the activation of Src

(2011) J Jung et al.   ONCOGENE

Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and mdulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts

(2010) Karuppaiyah Selvendiran et al.   CELL CYCLE

Sialyl Lewis X modification of the epidermal growth factor receptor regulates receptor function during airway epithelial wound repair

(2010) S. Allahverdian et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Regulation of the sperm EGF receptor by ouabain leads to initiation of the acrosome reaction

(2010) Limor Daniel et al.   DEVELOPMENTAL BIOLOGY

Acute ligand-independent Src activation mimics low EGF-induced EGFR surface signalling and redistribution into recycling endosomes

(2010) Medts T. de Diesbach et al.   EXPERIMENTAL CELL RESEARCH

Insulin Induces Swelling-dependent Activation of the Epidermal Growth Factor Receptor in Rat Liver

(2010) Roland Reinehr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p66shcInhibits Insulin-like Growth Factor-I Signaling via Direct Binding to Src through Its Polyproline and Src Homology 2 Domains, Resulting in Impairment of Src Kinase Activation

(2010) Gang Xi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent

(2010) Ting Du et al.   JOURNAL OF NEUROCHEMISTRY

Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173

(2010) Lu Kong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growth

(2010) Paul H. Huang et al.   Molecular BioSystems

X-Radiation-Induced Down-Regulation of the EGF Receptor in Primary Cultured Rat Hepatocytes

(2010) Akiko Maruko et al.   RADIATION RESEARCH

Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 Signaling Pathways and Cell Migration by Hexachlorobenzene in MDA-MB-231 Human Breast Cancer Cell Line

(2010) Carolina A. Pontillo et al.   TOXICOLOGICAL SCIENCES

Roles of ERK, PI3 kinase, and PLC-γ pathways induced by overexpression of translationally controlled tumor protein in HeLa cells

(2009) Moonhee Kim et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States

(2009) Chen Qiu et al.   BIOCHEMISTRY

Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption

(2009) Rohan Samarakoon et al.   CELLULAR SIGNALLING

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells

(2009) Jeanett Fischgräbe et al.   INTERNATIONAL JOURNAL OF CANCER

Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor

(2009) Jihee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor-like Repeats of Thrombospondins Activate Phospholipase Cγ and Increase Epithelial Cell Migration through Indirect Epidermal Growth Factor Receptor Activation

(2009) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK phosphorylation in intact, adult brain by α2-adrenergic transactivation of EGF receptors

(2009) Ting Du et al.   NEUROCHEMISTRY INTERNATIONAL

The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants

(2009) B M Chung et al.   ONCOGENE

EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells

(2009) Lourdes Rodríguez-Fragoso et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of kinin B1receptor triggers differentiation of cultured human keratinocytes

(2008) C.E. Matus et al.   BRITISH JOURNAL OF DERMATOLOGY

Met and c-Src Cooperate to Compensate for Loss of Epidermal Growth Factor Receptor Kinase Activity in Breast Cancer Cells

(2008) K. L. Mueller et al.   CANCER RESEARCH

The Combination of Epidermal Growth Factor Receptor Inhibitors with Gemcitabine and Radiation in Pancreatic Cancer

(2008) M. A. Morgan et al.   CLINICAL CANCER RESEARCH

Localization of PTP-1B, SHP-2, and Src Exclusively in Rat Brain Mitochondria and Functional Consequences

(2008) Amal Arachiche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation

(2008) Elena Tibaldi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Integrin α5-induced EGFR activation by prothrombin triggers hepatocyte apoptosis via the JNK signaling pathway

(2008) Ziqiu Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling

(2008) Rohan Samarakoon et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Immunohistochemical analysis of phosphorylated epidermal growth factor receptor might provide a surrogate marker of EGFR mutation

(2008) Hideki Endoh et al.   LUNG CANCER

Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK

(2008) Klaus Dittmann et al.   Molecular Cancer

Transcription-Dependent Epidermal Growth Factor Receptor Activation by Hepatocyte Growth Factor

(2008) T. E. Reznik et al.   MOLECULAR CANCER RESEARCH

The radioprotector Bowman–Birk proteinase inhibitor stimulates DNA repair via epidermal growth factor receptor phosphorylation and nuclear transport

(2008) Klaus Dittmann et al.   RADIOTHERAPY AND ONCOLOGY

Hexachlorobenzene triggers AhR translocation to the nucleus, c-Src activation and EGFR transactivation in rat liver

(2008) Andrea Silvana Randi et al.   TOXICOLOGY LETTERS

Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression

(2007) Seungchan Yang et al.   EXPERIMENTAL CELL RESEARCH