期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 10, 页码 21167-21188出版社
MDPI
DOI: 10.3390/ijms141021167
关键词
diet; phospholipid; fatty acid; lipid mediator; eicosanoid; inflammation; lipoxygenase; cyclooxygenase
资金
- Agriculture and Food Research Initiative Competitive Grants Program from the USDA National Institute for Food and Agriculture [2011-67015-30179, 2012-67011-20019]
- NIFA [2012-67011-20019, 578203, 579717, 2011-67015-30179] Funding Source: Federal RePORTER
The composition of fatty acids in the diets of both human and domestic animal species can regulate inflammation through the biosynthesis of potent lipid mediators. The substrates for lipid mediator biosynthesis are derived primarily from membrane phospholipids and reflect dietary fatty acid intake. Inflammation can be exacerbated with intake of certain dietary fatty acids, such as some -6 polyunsaturated fatty acids (PUFA), and subsequent incorporation into membrane phospholipids. Inflammation, however, can be resolved with ingestion of other fatty acids, such as -3 PUFA. The influence of dietary PUFA on phospholipid composition is influenced by factors that control phospholipid biosynthesis within cellular membranes, such as preferential incorporation of some fatty acids, competition between newly ingested PUFA and fatty acids released from stores such as adipose, and the impacts of carbohydrate metabolism and physiological state. The objective of this review is to explain these factors as potential obstacles to manipulating PUFA composition of tissue phospholipids by specific dietary fatty acids. A better understanding of the factors that influence how dietary fatty acids can be incorporated into phospholipids may lead to nutritional intervention strategies that optimize health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据