期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 11, 页码 23086-23102出版社
MDPI
DOI: 10.3390/ijms141123086
关键词
let-7; cardiovascular disease; cardiovascular differentiation; heart development; biomarker
资金
- National Natural Sciences Foundation of China [81300231]
- Hunan Provincial Natural Sciences Foundation of China [13JJ4112]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2013B101]
- Hunan Provincial Department of Education Program [11Co152]
The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
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