Structure-Based Search for New Inhibitors of Cholinesterases

Design, Synthesis and Evaluation of Novel 2-(Aminoalkyl)-isoindoline-1,3-dione Derivatives as Dual-Binding Site Acetylcholinesterase Inhibitors

(2012) Michalina Ignasik et al.   ARCHIV DER PHARMAZIE

Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation

(2012) Jin-Wu Yan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation

(2011) Yan-Ping Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APPSWE/PSEN1dE9 Mouse Model of Alzheimer Disease

(2011) Sultan Darvesh et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A Mesogenic Triphenylene−Perylene−Triphenylene Triad

(2011) Xiangfei Kong et al.   ORGANIC LETTERS

Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors

(2010) Xinyu Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation

(2010) Wen Luo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates

(2010) Pelayo Camps et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Tacrine Derivatives and Alzheimers Disease

(2010) V. Tumiatti et al.   CURRENT MEDICINAL CHEMISTRY

Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors

(2010) Anna Więckowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

(2010) Miroslaw Cygler et al.   PROTEIN SCIENCE

Persistent treatment with cholinesterase inhibitors and/or memantine slows clinical progression of Alzheimer disease

(2009) Susan D Rountree et al.   Alzheimers Research & Therapy

Flexibility of Aromatic Residues in the Active-Site Gorge of Acetylcholinesterase: X-ray versus Molecular Dynamics

(2008) Yechun Xu et al.   BIOPHYSICAL JOURNAL

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY