Towards a Molecular Understanding of the Biosynthesis of Amaryllidaceae Alkaloids in Support of Their Expanding Medical Use

Plant Sources of Galanthamine: Phytochemical and Biotechnological Aspects

(2014) S. Berkov et al.   BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT

Infestation of Narcissus poeticus by a scathophagid fly, Norellia melaleuca (Diptera: Scathophagidae)

(2014) Giuseppe CHICHIRICCO   EUROPEAN JOURNAL OF ENTOMOLOGY

Environmental Regulation of Embryo Growth, Dormancy Breaking and Germination in Narcissus alcaracensis (Amaryllidaceae), a Threatened Endemic Iberian Daffodil

(2013) J. M. Herranz et al.   AMERICAN MIDLAND NATURALIST

Pre-invasion history and demography shape the genetic variation in the insecticide resistance-related acetylcholinesterase 2 gene in the invasive Colorado potato beetle

(2013) Saija Piiroinen et al.   BMC EVOLUTIONARY BIOLOGY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Seasonal accumulation of major alkaloids in organs of pharmaceutical crop Narcissus Carlton

(2013) Andrea Lubbe et al.   PHYTOCHEMISTRY

De novo Sequence Assembly and Characterization of Lycoris aurea Transcriptome Using GS FLX Titanium Platform of 454 Pyrosequencing

(2013) Ren Wang et al.   PLoS One

Physiological and comparative proteomic analyses in response to nitrogen application in an Amaryllidaceae plant, Lycoris aurea

(2012) Qiaomei Ru et al.   ACTA PHYSIOLOGIAE PLANTARUM

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Production of Galanthamine by Leucojum aestivum Shoots Grown in Different Bioreactor Systems

(2012) Anika Schumann et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Application of cell technologies for production of plant-derived bioactive substances of plant origin

(2012) A. M. Nosov   APPLIED BIOCHEMISTRY AND MICROBIOLOGY

The geographic isolation of Leucojum aestivum populations leads to divergation of alkaloid biosynthesis

(2012) Strahil Berkov et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Production of miltiradiene by metabolically engineeredSaccharomyces cerevisiae

(2012) Zhubo Dai et al.   BIOTECHNOLOGY AND BIOENGINEERING

Lycorine Derivatives Against Trichomonas vaginalis

(2012) Raquel B. Giordani et al.   Chemical Biology & Drug Design

Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity toward Apoptosis-Resistant Glioma Cells

(2012) Giovanni Luchetti et al.   ChemMedChem

Towards a global biotechnology scenario

(2012) Víctor de Lorenzo   CURRENT OPINION IN BIOTECHNOLOGY

Galanthamine production byLeucojum aestivumL. shoot culture in a modified bubble column bioreactor with internal sections

(2012) Vasil Georgiev et al.   ENGINEERING IN LIFE SCIENCES

Daffodils as potential crops of galanthamine. Assessment of more than 100 ornamental varieties for their alkaloid content and acetylcholinesterase inhibitory activity

(2012) Laura Torras-Claveria et al.   INDUSTRIAL CROPS AND PRODUCTS

Metabolic engineering of microorganisms for the synthesis of plant natural products

(2012) Jan Marienhagen et al.   JOURNAL OF BIOTECHNOLOGY

Narciclasine as well as other Amaryllidaceae Isocarbostyrils are Promising GTP-ase Targeting Agents against Brain Cancers

(2012) Gwendoline Van Goietsenoven et al.   MEDICINAL RESEARCH REVIEWS

Wild Argentinian Amaryllidaceae, a New Renewable Source of the Acetylcholinesterase Inhibitor Galanthamine and Other Alkaloids

(2012) Javier Ortiz et al.   MOLECULES

Comparative Analysis of Benzoxazinoid Biosynthesis in Monocots and Dicots: Independent Recruitment of Stabilization and Activation Functions

(2012) R. Dick et al.   PLANT CELL

Integration of deep transcript and targeted metabolite profiles for eight cultivars of opium poppy

(2012) Isabel Desgagné-Penix et al.   PLANT MOLECULAR BIOLOGY

Effects of fungicides on galanthamine and metabolite profiles in Narcissus bulbs

(2012) Andrea Lubbe et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Narciclasine inhibits the responses of Arabidopsis roots to auxin

(2012) Yanfeng Hu et al.   PLANTA

Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae

(2012) J. Jirschitzka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

Mining the Biodiversity of Plants: A Revolution in the Making

(2012) V. De Luca et al.   SCIENCE

Why biosynthetic genes for chemical defense compounds cluster

(2012) Adam M. Takos et al.   TRENDS IN PLANT SCIENCE

Biosynthesis of amphetamine analogs in plants

(2012) Jillian M. Hagel et al.   TRENDS IN PLANT SCIENCE

Convergent Evolution in Plant Specialized Metabolism

(2011) Eran Pichersky et al.   Annual Review of Plant Biology

Alkaloid Diversity in Galanthus elwesii and Galanthus nivalis

(2011) Strahil Berkov et al.   CHEMISTRY & BIODIVERSITY

Polymorphic microsatellite loci for the genetic analysis of Lycoris radiata (Amaryllidaceae) and cross-amplification in other congeneric species

(2011) S.Q. Xuan et al.   GENETICS AND MOLECULAR RESEARCH

Effect of Fertilizers on Galanthamine and Metabolite Profiles inNarcissusBulbs by1H NMR

(2011) Andrea Lubbe et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Insights into Neogene Mediterranean biogeography based on phylogenetic relationships of mountain and lowland lineages ofNarcissus(Amaryllidaceae)

(2011) Rocío Santos-Gally et al.   JOURNAL OF BIOGEOGRAPHY

Amaryllidaceae and Sceletium alkaloids

(2011) Zhong Jin   NATURAL PRODUCT REPORTS

Dementia: A problem for our age

(2011) Alison Abbott   NATURE

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation

(2011) J. Egea et al.   NEUROPHARMACOLOGY

Oxidative stress and mitochondrial dysfunctions are early events in narciclasine-induced programmed cell death in tobacco Bright Yellow-2 cells

(2011) Hongxia Lu et al.   PHYSIOLOGIA PLANTARUM

From hormones to secondary metabolism: the emergence of metabolic gene clusters in plants

(2011) Hoi Yee Chu et al.   PLANT JOURNAL

Genomic clustering of cyanogenic glucoside biosynthetic genes aids their identification inLotus japonicusand suggests the repeated evolution of this chemical defence pathway

(2011) Adam M. Takos et al.   PLANT JOURNAL

A P450-centric view of plant evolution

(2011) David Nelson et al.   PLANT JOURNAL

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

(2010) Gwendoline Van Goietsenoven et al.   FASEB JOURNAL

Lycorine sensitizes CD40 ligand-protected chronic lymphocytic leukemia cells to bezafibrate- and medroxyprogesterone acetate-induced apoptosis but dasatanib does not overcome reported CD40-mediated drug resistance

(2010) R. E. Hayden et al.   HAEMATOLOGICA

Acetylcholinesterases of the cat flea Ctenocephalides felis: identification of two distinct genes and biochemical characterization of recombinant and in vivo enzyme activities

(2010) Thomas Ilg et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity

(2010) Gregory M. Miller   JOURNAL OF NEUROCHEMISTRY

Molecular cloning and characterization of a phenylalanine ammonia-lyase gene (LrPAL) from Lycoris radiata

(2010) Yumei Jiang et al.   MOLECULAR BIOLOGY REPORTS

Production of the Cancer-Preventive Glucoraphanin in Tobacco

(2010) Michael Dalgaard Mikkelsen et al.   Molecular Plant

Norcoclaurine Synthase Is a Member of the Pathogenesis-Related 10/Bet v1 Protein Family

(2010) Eun-Jeong Lee et al.   PLANT CELL

Changes in apolar metabolites during in vitro organogenesis of Pancratium maritimum

(2010) Strahil Berkov et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Manufacturing Molecules Through Metabolic Engineering

(2010) J. D. Keasling   SCIENCE

Phylogenetic selection of target species in Amaryllidaceae tribe Haemantheae for acetylcholinesterase inhibition and affinity to the serotonin reuptake transport protein

(2010) M.G.K. Bay-Smidt et al.   SOUTH AFRICAN JOURNAL OF BOTANY

A subfamilial classification for the expanded asparagalean families Amaryllidaceae, Asparagaceae and Xanthorrhoeaceae

(2009) MARK W. CHASE et al.   BOTANICAL JOURNAL OF THE LINNEAN SOCIETY

Pest Toxicology: The Primary Mechanisms of Pesticide Action

(2009) John E. Casida   CHEMICAL RESEARCH IN TOXICOLOGY

Plant chemistry and insect sequestration

(2009) Sebastian E. W. Opitz et al.   CHEMOECOLOGY

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis

(2009) Nadja Grobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight

(2009) Delphine Lamoral-Theys et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular and Cellular Actions of Galantamine: Clinical Implications for Treatment of Organophosphorus Poisoning

(2009) Edna F. R. Pereira et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regiospecific and Stereoselective Syntheses of (±) Morphine, Codeine, and Thebaine via a Highly Stereocontrolled Intramolecular 4 + 2 Cycloaddition Leading to a Phenanthrofuran System

(2009) Gilbert Stork et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Narciclasine, a plant growth modulator, activates Rho and stress fibers in glioblastoma cells

(2009) F. Lefranc et al.   MOLECULAR CANCER THERAPEUTICS

Amaryllidaceae and Sceletium alkaloids

(2009) Zhong Jin   NATURAL PRODUCT REPORTS

Benzoxazinoid biosynthesis, a model for evolution of secondary metabolic pathways in plants

(2009) Monika Frey et al.   PHYTOCHEMISTRY

Anticancer evaluation of structurally diverse Amaryllidaceae alkaloids and their synthetic derivatives

(2009) Antonio Evidente et al.   PHYTOCHEMISTRY REVIEWS

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis

(2009) P. Belin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galantamine is a novel post-exposure therapeutic against lethal VX challenge

(2009) Corey J. Hilmas et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Alkaloid Biosynthesis: Metabolism and Trafficking

(2008) Jörg Ziegler et al.   Annual Review of Plant Biology

Phylogenetic selection of Narcissus species for drug discovery

(2008) Nina Rønsted et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Chemistry, Biology, and Medicinal Potential of Narciclasine and its Congeners

(2008) Alexander Kornienko et al.   CHEMICAL REVIEWS

Molecular Cloning and Characterization of CYP80G2, a Cytochrome P450 That Catalyzes an Intramolecular C–C Phenol Coupling of (S)-Reticuline in Magnoflorine Biosynthesis, from CulturedCoptis japonicaCells

(2008) Nobuhiro Ikezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial and Antioxidative Activities of Bioactive Constituents from Hydnophytum formicarum Jack.

(2008) Supaluk Prachayasittikul et al.   MOLECULES

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Diversification of an ancient theme: Hydroxynitrile glucosides

(2008) Nanna Bjarnholt et al.   PHYTOCHEMISTRY

The systematic value of nuclear DNA content for all species of Narcissus L. (Amaryllidaceae)

(2008) B. J. M. Zonneveld   PLANT SYSTEMATICS AND EVOLUTION